LOCUS       NM_024859               3512 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens MAGI family member, X-linked (MAGIX), transcript
            variant 1, mRNA.
ACCESSION   NM_024859
VERSION     NM_024859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3512)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 3512)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 3512)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC231657.2.
            
            On Jun 26, 2021 this sequence version replaced NM_024859.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595224.6/ ENSP00000471299.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC231657.2         192067-192247
            182-328             AC231657.2         193092-193238
            329-411             AC231657.2         194016-194098
            412-639             AC231657.2         194172-194399
            640-811             AC231657.2         194499-194670
            812-3512            AC231657.2         195383-198083
FEATURES             Location/Qualifiers
     source          1..3512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..3512
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /note="MAGI family member, X-linked"
                     /db_xref="GeneID:79917"
                     /db_xref="HGNC:HGNC:30006"
     exon            1..181
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1137
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /note="isoform a is encoded by transcript variant 1; PDZ
                     domain-containing protein MAGIX; PDZ domain containing, X
                     chromosome"
                     /codon_start=1
                     /product="PDZ domain-containing protein MAGIX isoform a"
                     /protein_id="NP_079135.3"
                     /db_xref="CCDS:CCDS48106.1"
                     /db_xref="GeneID:79917"
                     /db_xref="HGNC:HGNC:30006"
                     /translation="MEPRTGDAADPRGSRGGRGPSPLAGPSARQLLARLDARPLAARA
                     AVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNA
                     PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDG
                     PAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRG
                     VGEPRKGVVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAA
                     ADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH
                     "
     exon            182..328
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     exon            329..411
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     exon            412..639
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     exon            640..811
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     exon            812..3512
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1351..1356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /note="hexamer: AATAAA"
     polyA_site      1370
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /note="major polyA site"
     polyA_site      1522
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
                     /note="hexamer: CATAAA"
     polyA_site      1640
                     /gene="MAGIX"
                     /gene_synonym="JM10; PDZX"
ORIGIN      
        1 gcgggtccgg gagccaggca cgggacccgc cagcttcagc ctccagggcc tgggcgggcc
       61 gccaggtgag cgcgccccag agctcaaaat tcgtagctgg cagccctgcg tccacccggc
      121 ggactactgg ccatggagcc gcgcacaggg gacgccgcgg accctagggg gagcagagga
      181 ggccgcggcc cctccccgct cgcgggccct agcgcccggc agctcctggc gcggttggac
      241 gcgcgccccc tggcggcgcg agctgcggtc gacgtggcag cgctggtacg cagggcgggc
      301 gccacattgc gcctgcgccg gaaggaggct gttagcgtgc tggactctgc ggacatagag
      361 gtcacagaca gtcgcctgcc tcatgccact attgtggatc accggcccca gcaccgttgg
      421 ttagagacat gtaacgcacc tccccaattg atccagggta aggcacgtag tgctccgaag
      481 ccatcccagg cctctggtca tttctctgtg gagctggttc gcggttacgc aggctttggc
      541 ctcaccttag gtgggggccg ggatgtagct ggggacactc cgctggccgt gcgcgggctg
      601 ctgaaggatg gcccagcaca gcgctgtggt cgtttggagg tcggggacct cgtgctccac
      661 atcaacggag agtcaacgca gggcctcacc catgcccagg ccgtggagcg gatccgagct
      721 ggaggccccc agctccacct ggttattcgt cggcctctgg agacccaccc tggcaagcct
      781 cgaggggtgg gagagccccg aaaaggagtt gtcccgtcat ggccagatcg cagcccagat
      841 cctggagggc cggaggtaac ggggtctcgc agcagcagca cttccctagt tcagcaccct
      901 ccatcccgga cgacgctcaa gaagacccgg ggcagcccgg agcctagtcc agaggcggcc
      961 gccgatggcc ccacggtttc tcctcctgag cgccgcgctg aggatcccaa cgaccagatc
     1021 ccgggttccc cggggccctg gctagtgccc agcgaggaac ggctctcgcg ggccctaggg
     1081 gtccgggggg cagcgcagct cgctcaggag atggcagccg gaaggcggag acactgagcc
     1141 tacctctgac agcgcggggc tcactagtta ccgcccaacc tggatccggc gcgtgtggcc
     1201 gctgggcact tggcacctcc ccaagagctt ccacttggtt tggtcccccc acccgctgct
     1261 cagtggctct gaccacactc ccctcgcagc gtcagtggta cgacccttcc agccggctag
     1321 cctgcgcttc tggttctggg agggggaggt aataaaatgg ttcgatccgg tcttgacttg
     1381 ccaggcgctc gaggcggggt ggggctgccc gggccactct gtaaaggagc aggtgggtcg
     1441 atcctgcttg agtaatcgct gacgagcttc gtgctgctgc tttcctgctt gcacatgtta
     1501 tctttgcttc tgccggtcct cagtctggcg tgctttcttt ttctcttcgc cgtctcctgc
     1561 tcctctcctt attcattaat ttcacctttt tggaggtgta cagggtctca cacataaatt
     1621 attgtgcatg gcatggagaa tgcagaggtg agcctgtcgt ggcaggactg caccagtgta
     1681 tccacagtcc tgtctcggaa tcatacagac cctcagctga cgtcgggata gcaaggctag
     1741 aagcctagaa gcagggcagc ttccttcgcc agaggcctgc ggtctcccac ttccggccta
     1801 gtctgccagc ttttgctggc acgtaggcta ccactctccg ggcaccggct ggggtcctgg
     1861 agcccccttt ggggcggagt ggggaaggtg tgagtcagcg cccctggacg ggccgggcta
     1921 aaaaaggctg ttagaacctt tgggccgtgc ccccattttc cgtacatggt gaagaactgc
     1981 agccgggctt gtgtgcacac gccacacact gggcgttccc ggcacgggag aggcccagag
     2041 tttccttcac cctgggaaca gagccctaca gccagggctt atatggccag cgggactcca
     2101 accggggtag ccgcgaggaa ggcgctggca gaggacagaa atgtccagtc acctccgctg
     2161 tcaccacatc ctgagcactc ggccccatcc ccccacagga gggaagctgt ggtctgacgg
     2221 aatgggcaac tttcgcccct gtggggaggg gacggggaag gaagaaagaa tttaaaggac
     2281 cggaatgcga gagtccaggt ggccttggag aggaaagagg aacggtgaag acaagctgcg
     2341 agagctggga gctggagggt gaagaggtga acacttgagt ggttagagct gtagatagac
     2401 attgtgggga agtgtgccag ggtggcttcc agctacccct gacttagagc ctggtggagg
     2461 tgtggttctt cagaagtcag caaagggctc aagagcccca gtctataaat acagtcacac
     2521 ccaggagact aataatagta accccagcca ccatgtactt agttttatcc ctgctactgg
     2581 ctttattgca atatttattt tcatctacaa tagttgcaca tctactcaac tatccgaata
     2641 tgtccatttc gcagaggagg aaagtgaggc ccagggagtg cagatagcta cagagaggag
     2701 ggtcaaagca cgatttaatc aaggcctgat tcccaagtct gtcctctcaa tttcacctgc
     2761 attgacaagt attaattgaa ccccaactgt atatgttgca ctgtgctagg tactgtggag
     2821 atgctggagg aacaagacat aaaatttctt tgtgtagctg atgtatgtaa tgagagtaga
     2881 cagatgtcag acaaaaaaga cgagaaaatg aataaataaa aaaccaggcc aggcgtggtg
     2941 gctcacgcct gtaatcccag cactttggga ggccgaggct ggtggatcac gaggtcaaga
     3001 gttcaagagc agcctggcca agatggtgaa accccgtctc tactgaaaat acaaaaatta
     3061 gccaggtgtg gtagcaggtg cctgtaatca cagctactcg ggaggctgag gcagagaatt
     3121 gcttgaaccc aggaggtgga ggttgcagcg agccaagatc gcaccactgc actccagcct
     3181 gggtgacaga gcgagaatca gtctcaaaaa aaaaaaaaaa aaaaaaaaaa acttcaggcc
     3241 agacatggtg gtttgtgcct gtaatcccag tactttggga ggcggaggcg ggtggattgt
     3301 ttgagcctac aagtttgata ccagcctggg caacatagac cttgtctcta caaaaagttt
     3361 aaaaattagc tgggagtggt ggctcatgcc tgtagtccca actacttggg acactgaggt
     3421 gggaggatca cttgagcctg ggaggtcaag gctgcagtga gccatgattg caccattcca
     3481 ctctagctgg agtgacagtg agaccttatc tc
//
