LOCUS       NM_012301               6975 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens membrane associated guanylate kinase, WW and PDZ
            domain containing 2 (MAGI2), transcript variant 1, mRNA.
ACCESSION   NM_012301
VERSION     NM_012301.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6975)
  AUTHORS   Zhang,Z., Yi,Y., Wang,Z., Zhang,H., Zhao,Y., He,R., Luo,Y. and
            Cui,Z.
  TITLE     LncRNA MAGI2-AS3-Encoded Polypeptide Restrains the Proliferation
            and Migration of Breast Cancer Cells
  JOURNAL   Mol Biotechnol 66 (6), 1409-1423 (2024)
   PUBMED   37358745
  REMARK    GeneRIF: LncRNA MAGI2-AS3-Encoded Polypeptide Restrains the
            Proliferation and Migration of Breast Cancer Cells.
REFERENCE   2  (bases 1 to 6975)
  AUTHORS   Wang,T., Li,C., Wang,X. and Liu,F.
  TITLE     MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease
            through communication with TGF-beta-Smad3/nephrin pathway
  JOURNAL   FASEB J 37 (12), e23305 (2023)
   PUBMED   37950637
  REMARK    GeneRIF: MAGI2 ameliorates podocyte apoptosis of diabetic kidney
            disease through communication with TGF-beta-Smad3/nephrin pathway.
REFERENCE   3  (bases 1 to 6975)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   4  (bases 1 to 6975)
  AUTHORS   Zhang,W., Wang,R., Yuan,J., Li,B., Zhang,L., Wang,Y., Zhu,R.,
            Zhang,J. and Huyan,T.
  TITLE     The TLR4/NF-kappaB/MAGI-2 signaling pathway mediates postoperative
            delirium
  JOURNAL   Aging (Albany NY) 14 (6), 2590-2606 (2022)
   PUBMED   35294925
  REMARK    GeneRIF: The TLR4/NF-kappaB/MAGI-2 signaling pathway mediates
            postoperative delirium.
REFERENCE   5  (bases 1 to 6975)
  AUTHORS   He,Y., Liu,H., Luo,S., Amos,C.I., Lee,J.E., Li,X., Nan,H. and
            Wei,Q.
  TITLE     Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway
            genes are independent predictors of cutaneous melanoma-specific
            survival
  JOURNAL   Cancer Sci 112 (10), 4355-4364 (2021)
   PUBMED   34375487
  REMARK    GeneRIF: Genetic variants of SDCCAG8 and MAGI2 in mitosis-related
            pathway genes are independent predictors of cutaneous
            melanoma-specific survival.
REFERENCE   6  (bases 1 to 6975)
  AUTHORS   Wu,X., Hepner,K., Castelino-Prabhu,S., Do,D., Kaye,M.B., Yuan,X.J.,
            Wood,J., Ross,C., Sawyers,C.L. and Whang,Y.E.
  TITLE     Evidence for regulation of the PTEN tumor suppressor by a
            membrane-localized multi-PDZ domain containing scaffold protein
            MAGI-2
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4233-4238 (2000)
   PUBMED   10760291
REFERENCE   7  (bases 1 to 6975)
  AUTHORS   Shoji,H., Tsuchida,K., Kishi,H., Yamakawa,N., Matsuzaki,T., Liu,Z.,
            Nakamura,T. and Sugino,H.
  TITLE     Identification and characterization of a PDZ protein that interacts
            with activin type II receptors
  JOURNAL   J Biol Chem 275 (8), 5485-5492 (2000)
   PUBMED   10681527
REFERENCE   8  (bases 1 to 6975)
  AUTHORS   Ohtsuka,T., Hata,Y., Ide,N., Yasuda,T., Inoue,E., Inoue,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G
            protein that interacts with synaptic scaffolding molecule (S-SCAM)
  JOURNAL   Biochem Biophys Res Commun 265 (1), 38-44 (1999)
   PUBMED   10548487
REFERENCE   9  (bases 1 to 6975)
  AUTHORS   Ide,N., Hata,Y., Deguchi,M., Hirao,K., Yao,I. and Takai,Y.
  TITLE     Interaction of S-SCAM with neural plakophilin-related
            Armadillo-repeat protein/delta-catenin
  JOURNAL   Biochem Biophys Res Commun 256 (3), 456-461 (1999)
   PUBMED   10080919
REFERENCE   10 (bases 1 to 6975)
  AUTHORS   Wood,J.D., Yuan,J., Margolis,R.L., Colomer,V., Duan,K., Kushi,J.,
            Kaminsky,Z., Kleiderlein,J.J., Sharp,A.H. and Ross,C.A.
  TITLE     Atrophin-1, the DRPLA gene product, interacts with two families of
            WW domain-containing proteins
  JOURNAL   Mol Cell Neurosci 11 (3), 149-160 (1998)
   PUBMED   9647693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004945.1, AF038563.1,
            AC007237.3, AB014605.2, AC004808.1, AA448362.1 and AC004990.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012301.3.
            
            Summary: The protein encoded by this gene interacts with
            atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion
            of which is responsible for dentatorubral and pallidoluysian
            atrophy. This encoded protein is characterized by two WW domains, a
            guanylate kinase-like domain, and multiple PDZ domains. It has
            structural similarity to the membrane-associated guanylate kinase
            homologue (MAGUK) family. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF038563.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000354212.9/ ENSP00000346151.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC004945.1         106135-106227       c
            94-1360             AF038563.1         1-1267
            1361-1361           AC007237.3         21085-21085         c
            1362-3197           AF038563.1         1269-3104
            3198-3550           AB014605.2         3044-3396
            3551-3770           AC004808.1         76488-76707         c
            3771-6024           AB014605.2         3617-5870
            6025-6027           AA448362.1         247-249
            6028-6147           AB014605.2         5874-5993
            6148-6973           AC004990.1         120553-121378       c
            6974-6975           AC004990.1         120551-120552       c
FEATURES             Location/Qualifiers
     source          1..6975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..6975
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 2"
                     /db_xref="GeneID:9863"
                     /db_xref="HGNC:HGNC:18957"
                     /db_xref="MIM:606382"
     exon            1..648
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..4715
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activin receptor interacting protein 1;
                     membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 2; atrophin-1-interacting
                     protein 1; atrophin-1-interacting protein A;
                     membrane-associated guanylate kinase inverted 2"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_036433.2"
                     /db_xref="CCDS:CCDS5594.1"
                     /db_xref="GeneID:9863"
                     /db_xref="HGNC:HGNC:18957"
                     /db_xref="MIM:606382"
                     /translation="MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYL
                     GEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGG
                     IVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITV
                     EDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRN
                     KSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPV
                     YSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR
                     LAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNM
                     PHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFL
                     QVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCR
                     GYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPP
                     HSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPT
                     GQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRG
                     GFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKP
                     DPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEP
                     GQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNL
                     TVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH
                     SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVG
                     DRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQ
                     SPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPF
                     TDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYF
                     TVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRD
                     MTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGL
                     APFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP
                     QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELC
                     RREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKV
                     PGSDKLPSVLKPGASAASR"
     exon            649..765
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            766..885
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1101
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1312
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1392
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1450
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1572
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1755
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2394
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2426
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2616
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2658
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2750
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2943
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3192
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3378
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3550
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3770
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3914
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4053
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..6975
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5194..5199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="hexamer: AATAAA"
     polyA_site      5217
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="major polyA site"
     regulatory      6934..6939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="hexamer: AATAAA"
     regulatory      6939..6944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="hexamer: AATATA"
     polyA_site      6954
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
                     /note="major polyA site"
     polyA_site      6975
                     /gene="MAGI2"
                     /gene_synonym="ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2;
                     NPHS15; SSCAM"
ORIGIN      
        1 acacccgctc accagctcgg ctactgctcg ctccggctgc cgccgccgcc gccgccgacg
       61 ccaccaccac tgcttcctct gctgcggggc cacagccttg agtgtcattc aagggacagc
      121 acaacctcat ccaagctctc ctacctctgc ccagccgtcc ctctcatcct ccccattcct
      181 cgtccacact ccatccaaag aagagggaaa gcaccgaata gaggggggcg aaggcaaagt
      241 ctgctgttct tccccctggg cccccttgct cctccatcct cattctctca ccaccagccc
      301 ccctaacccc aaggagccca ggaactgagg cgactcgccc cactgccatg tccaaaagct
      361 tgaaaaagaa aagccactgg actagcaaag tccatgagag tgtcattggc aggaacccgg
      421 agggccagct gggctttgaa ctgaaggggg gcgccgagaa tggacagttc ccctacctgg
      481 gggaggtgaa gcccggcaag gtggcctatg agagcggcag caaattggtg tcggaggagc
      541 tgctgctgga ggtgaacgag acccccgtgg cggggctcac catcagggac gtgctggccg
      601 tgatcaaaca ctgcaaggac cccctccggc tcaagtgtgt caagcaagga ggaattgttg
      661 ataaagacct tcgtcactac ctcaacttac gatttcaaaa gggttctgtg gaccatgagc
      721 ttcagcaaat cattcgtgac aacctctacc tccgcacggt gccatgcacc acaaggccac
      781 ataaggaggg tgaggtccct ggagtggatt atattttcat cactgttgaa gattttatgg
      841 aattggagaa aagtggtgct ctcctagaaa gtgggactta tgaagacaat tactacggta
      901 ccccaaagcc gccagcagaa ccagcaccat tattgttaaa tgtaacagac cagatacttc
      961 caggagccac tccaagtgct gaaggaaaac ggaagaggaa taaatcagtg agcaacatgg
     1021 agaaagccag tatagagcct cctgaggagg aagaggaaga gaggcctgtg gtcaatggaa
     1081 atggagtagt agtaacacca gaatccagtg aacatgaaga caaaagtgca ggtgcctcag
     1141 gggagatgcc ctcccagcct tatcctgcac cagtgtacag tcagcctgag gagctgaagg
     1201 agcagatgga tgacacaaag ccaactaaac ctgaagacaa tgaggaacca gacccattgc
     1261 ctgataactg ggaaatggcc tatacagaga agggcgaagt ctacttcatt gaccataaca
     1321 caaagacaac atcatggctg gatccacgac ttgcgaaaaa ggctaaacct ccagaagagt
     1381 gcaaagaaaa tgagcttcca tatggctggg aaaaaatcga tgatcccatt tatggcactt
     1441 attatgttga ccacataaat agaagaacac agtttgaaaa tcctgtcctg gaagcaaaaa
     1501 ggaagctaca gcaacataac atgccccaca cagaacttgg aacaaagccc ctgcaggccc
     1561 caggtttccg agaaaaacca ctcttcaccc gggatgcatc ccagttgaag ggaacattcc
     1621 tcagcaccac cctaaaaaag agcaacatgg gctttggatt taccatcatt ggtggagacg
     1681 agcctgatga gtttctgcag gtgaaaagtg tgattccgga tgggcctgca gcacaggatg
     1741 gaaaaatgga aacaggtgat gtcattgtct atattaatga agtttgtgtc cttggacaca
     1801 ctcatgcaga tgttgtcaaa cttttccagt ctgttcctat tggtcagagt gtcaacctgg
     1861 tgttgtgtcg tggctaccct ttgccctttg atcctgaaga ccctgctaac agcatggtgc
     1921 caccccttgc aataatggag aggccacctc cagtgatggt caatggaaga cacaactatg
     1981 aaacatattt ggagtacatt tctcggacct cacagtcagt tccagatata acagatcggc
     2041 cgcctcattc tctgcactcc atgccaactg atggtcagct agacggcacg tatccaccgc
     2101 ccgtccatga tgacaatgtg tctatggctt catctggggc cacccaagct gaacttatga
     2161 ccttaaccat tgtgaaaggt gcccagggct tcggcttcac tattgccgac agtcctacag
     2221 gacagcgggt gaaacaaata cttgacattc agggatgccc tggcctgtgt gaaggcgacc
     2281 tcattgttga gatcaaccag cagaatgtac agaacctgag ccatacagaa gtagtggata
     2341 tacttaagga ctgtcccatt ggaagtgaaa cttctttgat tatccatcga ggaggtttct
     2401 tttctccatg gaaaactcca aagcctataa tggaccgatg ggagaatcaa ggcagtcctc
     2461 aaacgagttt atctgctccg gccataccgc agaacctgcc cttcccacct gcccttcaca
     2521 ggagctcctt tcctgactca acagaggcct ttgacccacg gaagcctgat ccatatgagc
     2581 tctacgagaa atctagggcc atttatgaaa gtaggcaaca agtgccaccc aggaccagtt
     2641 ttcgaatgga ttcctctggt ccagattata aggaattgga tgttcatctt cggaggatgg
     2701 agtctggatt tggcttcaga atcctcgggg gagatgagcc tggacagcct attttgattg
     2761 gagctgtcat tgccatgggc tcagccgaca gagatggccg ccttcaccca ggagatgagc
     2821 ttgtgtatgt tgatgggatt ccagtagccg gcaaaaccca ccgctatgtc atcgacctca
     2881 tgcaccacgc agcccgcaat gggcaggtca acctcactgt gagaagaaag gtgctatgtg
     2941 gaggggagcc ctgcccagag aacgggagaa gtccaggctc tgtatccacc caccacagct
     3001 ctccacgcag tgactacgca acctacacca acagcaacca cgctgccccc agtagcaatg
     3061 cctctccccc tgaaggcttc gcctcccaca gcctgcagac cagtgatgtg gtcattcacc
     3121 gcaaagagaa tgagggcttc ggctttgtca tcatcagctc cctgaacagg cctgagtctg
     3181 gatccactat aactgtgccc cataaaatcg gacgcatcat tgatgggagt cctgcagatc
     3241 gctgtgcaaa actaaaagtg ggagaccgga tcctagcagt gaatggccag tctatcatca
     3301 acatgcctca cgctgacatc gtgaagctca tcaaggatgc aggtcttagt gtcacccttc
     3361 gcatcattcc tcaggaggag ctcaacagcc ccacctcggc acccagctca gagaagcaga
     3421 gtcccatggc gcagcagagt cccctggcac agcagagtcc cctggcccag ccaagcccag
     3481 ccacccccaa cagccccatc gcccagccag caccacctca accacttcag ctgcaaggac
     3541 acgaaaatag ttacaggtcg gaagtgaaag caaggcaaga tgtgaaacca gacatccgac
     3601 agcctccatt cacagactac aggcagcccc cgctggatta caggcaaccc ccaggagggg
     3661 actaccagca gcccccaccc ttggactaca ggcagcctcc cctactggac tacaggcagc
     3721 actcccccga caccaggcag taccctctgt cggactacag acaaccccag gattttgatt
     3781 atttcactgt ggacatggag aaaggagcca aaggatttgg attcagcatt cgtggaggaa
     3841 gggaatacaa aatggatttg tatgtgttga gactggcaga agatggacca gcaataagga
     3901 atgggaggat gagggtagga gatcaaatca ttgaaatcaa tggggaaagc acaagggaca
     3961 tgacacatgc cagagcaata gaactcatca aatctggagg aagacgagtg aggctgctgc
     4021 tcaagagagg cacgggacag gtcccagaat atgacgaacc cgccccctgg agttctcccg
     4081 ctgccgccgc cccaggtctg ccggaagtag gcgtctccct ggacgacggc ctcgctccat
     4141 tctctccatc acatccagcc ccaccctccg acccttccca ccagataagc ccaggcccaa
     4201 cttgggatat caaacgggaa cacgacgtta ggaaaccaaa ggagctttca gcctgcggcc
     4261 agaagaagca gcgcctcggg gagcagaggg agcgctcggc gagtccgcag agggccgcgc
     4321 ggccgaggct cgaggaggcg cccggcggcc aggggcggcc cgaggccggc aggcccgcct
     4381 cggaggccag ggcgcccggg ctcgcggcgg cagacgcggc ggacgcggcg cgggcgggcg
     4441 ggaaggaggc gccccgtgcg gcggcgggct ccgagctctg ccggcgcgaa ggcccggggg
     4501 ctgcgccggc gtttgccggc ccgggcggcg gcggcagcgg cgcgctggag gccgagggca
     4561 gggcgggtgc gcgcgcgggt ccccggccgg gcccgcgacc cccggggggc gccccggcgc
     4621 gcaaggccgc cgtcgcgccg gggccctgga aggtgccggg ttctgacaag ctgcccagcg
     4681 tcctcaaacc cggcgcctcg gccgccagca gatgagccgc gcggccacgg ccaacccgcc
     4741 cgccccggcg caggcagttc ttcttaggtt ccgtctcacg gcgttttaat ttattttcac
     4801 tgtcacacgc atagatccac gaggcaccaa ggcctgggag catcgacgtg aagtcccacg
     4861 tgtccggtgt gcttgggcgg catcgcatca acgcgcagac ctaaactgat cctaaagccc
     4921 ccggttccct tgtgggggct ttggcagcta tggaagaacc aaaataacgt gaagaacatc
     4981 acagagagac agtgcagtgt agctttagtt taagaaaaaa aaatattcct ccccactgca
     5041 tgaaggactt ggatgtcatc caaactttat atcaagaaac aggacaaagt taagagcaat
     5101 cacaaactgg aatatcgcct taaaaatcaa actgcacgga gcaagctgaa actgagacaa
     5161 gattatatct tttaattgat ctaaagcgtt gtaaataaat tgttctcgac atatctagac
     5221 aggggttaaa gggtttcttt gacacattcg gaaccgttca cccatgacat gtttccatgg
     5281 ctcacccttg gcatccatcc tcggtgttag cagcagcgtt ccctgcctcc tgcaggatga
     5341 cttagaaatc tagtgagttt cttggtgtga tgccattttt attgcccttt ctgtgatcaa
     5401 atcatatttc tgtacatttt cagtggtaga aaaaaaaggt tttaaaaatt gtatcctagg
     5461 gaacagtttg ccataagtca gaattttgca gtttagctca tagatcttaa ttggtttttc
     5521 tctaaaatat gaattttata attgaaggac cacaatttgt ttaatcaaga taggcaacgc
     5581 tgcagttcct ttatgaagag gcttttctgt cgtcccaggc tagcagagat ggatagcttc
     5641 tttgtcagca atgtgatttc acttatttta ttgtcttatt ttaaaccctg tctccatgac
     5701 ttcatttgca ctttgacaga gcagaggcag agtatttgtc ttatatttct cagattataa
     5761 tattaaaaaa ttacaatcaa tttattttca ttaaagaacg tgagtctttt tagcattcct
     5821 ttctgcttat ccttctttcc ttaccctttg tccttttgtt tccattagtt ttctttcgtc
     5881 ttgtattcct tgccacttta ttttgttagc aacttctaga tgtttatctt catggatcta
     5941 tgattgacct cctagtaaaa ttctaagtct tgcctttctt ccctgctgtt ttagcatttc
     6001 tttgtaaaat gttagcttca attaattagc cattggtact tactgtagct acacatatta
     6061 aaaggcaaag tgtttctgaa ggcaatttct ttttaatatg cccgaatgaa tgaggcttca
     6121 tcctttccat attcttactc tttacaggag ttcaaatgca aataagctcc acctccctgc
     6181 acttgtagtc taaaaagtaa aaggggcgat caggtccatc tcaaaggtca cacgtaatag
     6241 cctccctggg ctgatcattc cctctccttg taattgcagt atcctgagta gcagtttaat
     6301 tttcatcaaa catcggagta gtttagttgt ttgacaggag gagaataagg ctgaaagcct
     6361 caagtgaagg atcttgcagc ttgtaaaagc aatttccaaa aatgaaaccc attcatcgta
     6421 aacaaaagca caaacacttg tagcagttta taatgctttt ggtttaatct caattagtct
     6481 ttctcccctg gactagaaat ccagtatagt ttgccattaa tttattgaat ctggttttgg
     6541 acaatgcttc tgtagtgtag ctgcacgtcc tggtactgta tcctctgact ttattttcca
     6601 tgtattacaa aaggaaaaaa aaattgagat tacactggca taaactctag tttgcacagt
     6661 tcacagctac tacttgtgca gtaattgctt tatgcggctg taatccataa cctgtgaaga
     6721 cagcacatca tctaaatccc attccaaata atatttgtgt agtgttagct gtgaatttac
     6781 cctgtacagc tgtatctcta taaatataat tccatgtatt aatagtcaca gaaagactgt
     6841 aagtgagcaa ctatttttat gaaacgtacc actatggata aattaacttt tacagaaatc
     6901 ttgtttactg tatgatattc taaaacactg tcaaataaaa tatatatcca aaaatctttt
     6961 ctttttccaa ctata
//
