LOCUS       NM_001033057            7851 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens membrane associated guanylate kinase, WW and PDZ
            domain containing 1 (MAGI1), transcript variant 3, mRNA.
ACCESSION   NM_001033057
VERSION     NM_001033057.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7851)
  AUTHORS   Xiang,Y., Sun,M., Wu,Y. and Hu,Y.
  TITLE     MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced
            by Diabetic Nephropathy
  JOURNAL   Pharmacology 109 (2), 98-109 (2024)
   PUBMED   38325349
  REMARK    GeneRIF: MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury
            Induced by Diabetic Nephropathy.
REFERENCE   2  (bases 1 to 7851)
  AUTHORS   Worthmuller,J., Disler,S., Pradervand,S., Richard,F., Haerri,L.,
            Ruiz Buendia,G.A., Fournier,N., Desmedt,C. and Ruegg,C.
  TITLE     MAGI1 Prevents Senescence and Promotes the DNA Damage Response in
            ER+ Breast Cancer
  JOURNAL   Cells 12 (15), 1929 (2023)
   PUBMED   37566008
  REMARK    GeneRIF: MAGI1 Prevents Senescence and Promotes the DNA Damage
            Response in ER[+] Breast Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7851)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7851)
  AUTHORS   Davuluri,K.S., Singh,A.K., Kumar,V., Singh,S.V., Singh,A.V.,
            Kumar,S., Yadav,R., Kushwaha,S. and Chauhan,D.S.
  TITLE     Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3
            promote mycobacterial dissemination in extrapulmonary tuberculosis
            patients and Cavia porcellus model of tuberculosis
  JOURNAL   Tuberculosis (Edinb) 135, 102224 (2022)
   PUBMED   35763913
  REMARK    GeneRIF: Stimulated expression of ELR+ chemokines, VEGFA and
            TNF-AIP3 promote mycobacterial dissemination in extrapulmonary
            tuberculosis patients and Cavia porcellus model of tuberculosis.
REFERENCE   5  (bases 1 to 7851)
  AUTHORS   Araujo-Arcos,L.E., Montano,S., Bello-Rios,C.,
            Garibay-Cerdenares,O.L., Leyva-Vazquez,M.A. and Illades-Aguiar,B.
  TITLE     Molecular insights into the interaction of HPV-16 E6 variants
            against MAGI-1 PDZ1 domain
  JOURNAL   Sci Rep 12 (1), 1898 (2022)
   PUBMED   35115618
  REMARK    GeneRIF: Molecular insights into the interaction of HPV-16 E6
            variants against MAGI-1 PDZ1 domain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7851)
  AUTHORS   Mino,A., Ohtsuka,T., Inoue,E. and Takai,Y.
  TITLE     Membrane-associated guanylate kinase with inverted orientation
            (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1)
            as a scaffolding molecule for Rap small G protein GDP/GTP exchange
            protein at tight junctions
  JOURNAL   Genes Cells 5 (12), 1009-1016 (2000)
   PUBMED   11168587
REFERENCE   7  (bases 1 to 7851)
  AUTHORS   Shiratsuchi,T., Futamura,M., Oda,K., Nishimori,H., Nakamura,Y. and
            Tokino,T.
  TITLE     Cloning and characterization of BAI-associated protein 1: a PDZ
            domain-containing protein that interacts with BAI1
  JOURNAL   Biochem Biophys Res Commun 247 (3), 597-604 (1998)
   PUBMED   9647739
REFERENCE   8  (bases 1 to 7851)
  AUTHORS   Dobrosotskaya,I., Guy,R.K. and James,G.L.
  TITLE     MAGI-1, a membrane-associated guanylate kinase with a unique
            arrangement of protein-protein interaction domains
  JOURNAL   J Biol Chem 272 (50), 31589-31597 (1997)
   PUBMED   9395497
REFERENCE   9  (bases 1 to 7851)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   10 (bases 1 to 7851)
  AUTHORS   Pirozzi,G., McConnell,S.J., Uveges,A.J., Carter,J.M., Sparks,A.B.,
            Kay,B.K. and Fowlkes,D.M.
  TITLE     Identification of novel human WW domain-containing proteins by
            cloning of ligand targets
  JOURNAL   J Biol Chem 272 (23), 14611-14616 (1997)
   PUBMED   9169421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145425.5, BC062367.1,
            AF401654.1, AK023358.1 and AC121493.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001033057.1.
            
            Summary: The protein encoded by this gene is a member of the
            membrane-associated guanylate kinase homologue (MAGUK) family.
            MAGUK proteins participate in the assembly of multiprotein
            complexes on the inner surface of the plasma membrane at regions of
            cell-cell contact. The product of this gene may play a role as
            scaffolding protein at cell-cell junctions. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks two segments in the
            coding region, one of which leads to a frameshift, compared to
            variant 1. The resulting isoform (c) contains a shorter and
            distinct C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF401656.1, SRR18074969.3276626.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402939.7/ ENSP00000385450.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC145425.5         19611-19694         c
            85-1367             BC062367.1         1-1283
            1368-3026           AF401654.1         758-2416
            3027-4244           AF401654.1         2501-3718
            4245-4999           AF401654.1         3808-4562
            5000-5417           AK023358.1         355-772
            5418-7146           AC121493.1         132600-134328       c
            7147-7851           AC121493.1         131895-132599       c
FEATURES             Location/Qualifiers
     source          1..7851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..7851
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 1"
                     /db_xref="GeneID:9223"
                     /db_xref="HGNC:HGNC:946"
                     /db_xref="MIM:602625"
     exon            1..923
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..4999
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /note="isoform c is encoded by transcript variant 3; WW
                     domain-containing protein 3; BAI1-associated protein 1;
                     atrophin-1-interacting protein 3; membrane-associated
                     guanylate kinase inverted 1; trinucleotide
                     repeat-containing gene 19 protein"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 1 isoform c"
                     /protein_id="NP_001028229.1"
                     /db_xref="CCDS:CCDS33780.1"
                     /db_xref="GeneID:9223"
                     /db_xref="HGNC:HGNC:946"
                     /db_xref="MIM:602625"
                     /translation="MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYV
                     GAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAV
                     RQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYN
                     FLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQST
                     PKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSII
                     AAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCL
                     NKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVL
                     EAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPARE
                     VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA
                     LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPN
                     TSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGY
                     PNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKE
                     GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKD
                     SQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQS
                     RSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRS
                     GDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS
                     HHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVE
                     IRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI
                     LAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP
                     SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMD
                     LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG
                     DGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAH
                     ARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKR
                     RSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLL
                     EQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQ
                     DAGRSSRHPPEQRRRPYKECSTDLSI"
     exon            924..1040
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1160
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1367
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1569
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1652
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1688
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1746
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1880
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1973
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2156
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2777
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2809
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..3026
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3118
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3311
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3605
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3806
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3900
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..3961
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4105
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4244
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4245..7851
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7821..7826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /note="hexamer: AATACA"
     polyA_site      7851
                     /gene="MAGI1"
                     /gene_synonym="AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1;
                     MAGI-1b; Magi1d; TNRC19; WWP3"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcgcgc gtctcctgtc gccggccgct gcgctccgcg gcgcggaata gaatgaactg
       61 taacaaaaca agccgagcct ttgtatctgc ttaaaggggc cgcgagcact tacctcccgc
      121 cctgctcccc gccgccccgc caccgcgtct tcagggctcc cggcaactgg ctggaagggc
      181 ttccctcacc ctcagtaaca gcctgccagc gaggagaggc gagccgggcg ggaggcaaag
      241 aggaggcacc gcatttgtaa aaggcaagag agaaaggaag gaaggaaaaa aaaataaccc
      301 gagcggcgca gagtggactc tggtccggga gagcacgggc gggcgccgga acgtggaccc
      361 agaggcaccg gaatgcaaac aaagctcgcg ggcgcctgtg cggggctcgc ggggaagccc
      421 agaaagtttg ttttatgatg gcttgagtgc gcgagcgtgt gcaggggagc gaggctgcca
      481 agtttctctc tcctgttttg tgatttgggg agagatgttt ctcccatgaa caagcggagg
      541 cttgggggct cgtgctgtgg ggggcacctg tctctcgttt tatttttttg gaggaggggt
      601 gtaactcatc atgtccaaag tgatccagaa gaagaaccac tggactagca gggttcacga
      661 atgcaccgtg aagcggggac cccagggcga gctgggggtg acggtgctgg gaggcgcgga
      721 gcacggggag tttccgtacg tcggagcggt ggcggcggtc gaggcagcgg ggcttcccgg
      781 cggcggcgag ggcccgaggc tgggcgaagg ggagctgctt ctggaggtgc agggggtccg
      841 ggtgtccggc ttgccccgct atgacgtgct gggggtcatc gacagctgca aggaggccgt
      901 caccttcaag gccgtcagac aaggaggaag gctgaacaag gacctgcgac attttctcaa
      961 tcagcgattc cagaaggggt ctcctgatca tgagctccag cagaccataa gggataacct
     1021 ttaccgccat gctgtgcctt gcacaacccg atctcccaga gaaggagaag tgcctggcgt
     1081 ggactataac tttctgactg tgaaggagtt cttggacctc gagcagagtg ggactcttct
     1141 ggaagtcggc acctatgaag gaaactatta tgggacaccc aagcctccta gccagccagt
     1201 cagtgggaaa gtgatcacga cggatgcctt gcacagcctt cagtctggct ctaagcagtc
     1261 gaccccgaag cgaaccaagt cctacaatga tatgcaaaat gctggcatag tccacgcgga
     1321 gaatgaggag gaggatgacg ttcctgaaat gaacagcagc tttacagccg attctggtga
     1381 acaagaggag cacactctcc aagaaacagc attaccacct gtgaatagta gcatcatcgc
     1441 tgctcccatc acggaccctt ctcagaagtt ccctcaatac ctacctcttt ctgcagagga
     1501 taatttaggt cctctacctg aaaactggga gatggcctat actgaaaatg gagaagtcta
     1561 ttttatagac cataacacga aaacaacatc ttggttagac cctcggtgcc taaacaagca
     1621 gcagaagcca ctggaagagt gtgaagatga tgaaggggta cacaccgagg agctggacag
     1681 tgaactagaa ctgcctgctg gttgggaaaa gattgaagac cctgtctatg gtatctacta
     1741 tgtagaccac atcaacagga agacacaata tgagaacccg gttctagaag ccaaacggaa
     1801 gaagcagctt gagcagcagc agcagcagca acagcagcag caacagcagc agcagcagca
     1861 gcagcagcag cagacagaag aatggacaga agatcactca gcccttgtgc ctcctgttat
     1921 tccaaaccac cctccaagca atccagagcc agccagagaa gttccacttc agggcaaacc
     1981 cttttttaca cgaaaccctt ctgagttgaa aggcaagttc attcacacaa agctgcggaa
     2041 aagcagtcgt ggctttggct tcacggtggt tggaggggat gaacctgatg agtttctcca
     2101 gatcaagagc ttggtcctag atggtcctgc tgcattggat ggcaagatgg aaacagggga
     2161 tgtgattgta agtgtgaatg acacctgtgt tttgggacac acacatgctc aagttgtgaa
     2221 gatcttccag tccatcccca ttggtgccag cgtggacctt gaactctgcc gaggttatcc
     2281 attgcctttt gatccagatg accccaatac aagtttagtg acctcggtag ccattttgga
     2341 taaagaacca attattgtga atgggcaaga gacctatgat tcaccagcta gccacagtag
     2401 taaaacaggc aaagtcaatg gcatgaagga tgccaggcca agcagcccag cggacgtggc
     2461 ttcaaatagt tctcatggtt atcctaatga cactgtttct ttggcttcct ccatagccac
     2521 tcagccagaa ctcataactg ttcatattgt caaagggcca atgggctttg gttttactat
     2581 cgcagacagt cctggtgggg gtggccaaag agtgaaacag attgttgaca gcccaaggtg
     2641 ccgaggcctg aaagaagggg atctcatagt ggaagttaat aagaagaacg tgcaggccct
     2701 aactcacaac caagtggtgg atatgctggt tgagtgtcct aagggaagtg aggtcacatt
     2761 gttggtgcaa cgaggagggc tgccagttcc caagaagagc ccaaagtcgc aaccactgga
     2821 aaggaaagac agccagaata gttctcagca cagtgtttcc agccaccgaa gcctgcacac
     2881 agcatcccca agccacagca cacaggtgct ccccgagttc ccacctgcag aggcccaagc
     2941 tccagatcaa actgacagct ctggccagaa aaaaccagat ccttttaaaa tctgggccca
     3001 gtccaggagc atgtatgaaa accgacttcc agattaccag gaacaggaca tcttcctctg
     3061 gagaaaagag actggatttg gatttaggat tctgggtgga aatgaaccag gggaacctat
     3121 ttatattggt cacatcgtac cactgggtgc tgctgatact gacggccgcc tgaggtctgg
     3181 agatgaatta atctgtgtgg atgggacgcc agtaattgga aaatcacacc agcttgtggt
     3241 ccagcttatg caacaagctg ccaagcaagg ccacgtcaat ctcacggtgc ggcgtaaagt
     3301 ggtttttgcg gtgcccaaaa ccgagaacga ggtgccctcg ccagcctcct ctcatcacag
     3361 tagcaaccag ccggcctcgc tgacagaaga gaagcgcact ccgcagggca gccagaactc
     3421 gctgaacacg gtgagctcgg gcagcggcag caccagcggc atcggcagtg gcggcggcgg
     3481 gggcagcggc gtggtcagca ccgtggtgca gccctacgac gtggagatcc ggcgcgggga
     3541 gaacgagggc ttcggcttcg tcatcgtgtc ctcggtgagc aggcccgaag caggcacgac
     3601 ctttggcaat gcatgtgtgg ctatgcctca caaaataggt cggattattg aggggagccc
     3661 tgctgaccgc tgtggcaagc tgaaagtagg agaccggatc ttggcagtaa atggatgttc
     3721 catcaccaac aaatcccatt cagacattgt gaacctaatc aaggaagcgg gaaacacagt
     3781 taccctccgc atcattcctg gggatgagtc ctcgaatgcc accttgctga ccaatgcaga
     3841 gaagattgcc accatcacca ccacacacac cccttctcag caagggaccc aggagacaag
     3901 gaataccacc aaaccaaagc aggaatctca atttgagttc aaagcacccc aagcaacaca
     3961 ggagcaagat ttttacactg tggaactgga aagaggagcc aagggatttg gctttagcct
     4021 tcgaggaggc cgagagtata acatggacct ctatgttctg cgcttagcag aggacggtcc
     4081 tgcggagagg tgtggaaaga tgaggattgg tgatgaaatt ttagagatca atggtgagac
     4141 caccaaaaac atgaagcatt ctcgagctat agaactgatt aagaatggtg gccgcagagt
     4201 tcgtctgttt ctgaagcggg gagacggctc agtaccagaa tatgacccca gcagcgaccg
     4261 ccacggcccc gccaccggtc cacaaggtgt tccggaagtg agggccgggc ccgaccgccg
     4321 gcagcatccg tcattggagt ccagttaccc acccgatctt cacaaatcat caccacatgg
     4381 ggaaaagcgg gcacacgcaa gggatccgaa aggcagcaga gagtatagca gacaacccaa
     4441 tgaacaccac acctggaatg ggacttcgag gaaacccgac agcggggcat gccgacccaa
     4501 ggaccgggcg ccggagggac ggagggacgc gcaggccgag cgcgcggcag ccgccaacgg
     4561 ccccaagagg cggtccccag agaagcggag ggagggcacc cgcagcgccg acaacacttt
     4621 ggagaggagg gagaagcacg agaagagacg agacgtctct ccggagcgga ggcgagagcg
     4681 gtcacccacc cgcaggagag acggctcccc cagccggcgg agacggtctc tggagagact
     4741 cctggagcag aggaggtccc ccgagcgcag gagagggggc tcgcccgagc gcagggccaa
     4801 gtccaccgac cggaggcgcg cacgctcccc cgagcgcagg agagagcggt ccctggacaa
     4861 aaggaacaga gaggacagag ccagccaccg agaaagggaa gaggcgaatc tgaaacagga
     4921 tgccggcaga agttccagac atcccccgga gcagagaagg cgaccttaca aagaatgtag
     4981 caccgacctc agtatctgag acgctgagtc acattccaac ctttaccgtg tcaaaggttc
     5041 taagaggaaa gtcacaaacc tgaaattatt tagtttctta cctaatgaag catctgacac
     5101 ctgatgatcc tatgaataac aacaaacatt ttatgcattt gaaatcttat aagaaaaaat
     5161 atatatgaaa agtattgtgc ctgatgtatc atattaaaga aagtattttt aaatgcatac
     5221 ttttttggaa attatttgcc aaatgctggc ccaaagggat ataaattttg tttctacgta
     5281 acctgtagaa tcgtcaagaa ttgttcccgt tttggggcaa tctttttctc tcctggttaa
     5341 atggggctgt tgatcatttt ctctacgtaa gggaatttat tgattaagtt taattaattt
     5401 gatatagact gtcatgtagt gatgtagtgc tatactgtag tcggaagttt ttcttaaaag
     5461 caaagagcaa aaatgcaaag ttttatttgt aaaagctgag gacccttggg gatggattag
     5521 gtttgccgat gatcctaaaa gtaagcaaac tgtatgacaa gactactatt gcaaatgaag
     5581 gatatttata gctaaactgc gcagcacaaa gaagttttat attgtgagtt atagttggtt
     5641 cagaaaacag tttgtactct ccctggccca ggaaggcaca cagacaaaaa tgtcggccac
     5701 ttttactcaa atacagccca agcacagaca gtcaggttcg tgatcatcac caacatctga
     5761 taaaatctca ttgaaggcaa tgccatcaca gctttgctca attactacga ggaagagaca
     5821 acaagcatct ttcgtgttgt ctcgtctgat tggaggctga atagtagatg gaatgggggg
     5881 acagtgtgcc tggtgtgagg aagacgtaag atccccaatt tggaaagcat gcccccctcc
     5941 cttttagtag aagcccatgg ttgccctttg ccaaactggg gaggaggcaa tgagccttgg
     6001 tggaaggaac ctctctgttg atatttaaag aagtgagggc tgtgggtatt cattgttaga
     6061 aatgccaatt tcactttgaa accatagtcc aagtctctag gttggtagaa gggaaaggaa
     6121 ggaagtggtc ccagtgattc taggtctggt tgggaaactt ctgcctcatg actctgtcct
     6181 ttgagtcctt tggacagcag cacaaaacat aacaattttt atttttaaac agacccattc
     6241 tttttgatcc cacaggagct gtggttgggt cggccgtagc cccgggatgt ggtttaagtg
     6301 gattactgcc tagctgagcc aaaatgtttg cttgtacctg ttggaccact acagcaaacc
     6361 gctgcttaca gtgcattgtg tatttctgta gtactgtttt gcattttcca tagagacaga
     6421 aaactttgca agtcaatcac tgttgttccc atggtactgt aagaaaaaaa aaaaggaaaa
     6481 agaaaaaaaa aaagaaaacc agccaatcat tgcgtgtaca gagctaaaaa ttgtaattaa
     6541 tagagcctgt tgggaaaaaa aagaaaacaa ctgttgcctt tttttcttgt ataaaagaga
     6601 atttatgaca aaatttagct gtgaggaatg tgatacgtgt ttatatttct gaatatggaa
     6661 caaattgatt catggggata tattttaatg taaactaaat caggtatgta aagttgtttt
     6721 aaaatgggag actatataag taattctcta aagctttagt tggtttgaat atcatcattt
     6781 cctccatggt gagcctgctt gtgaattatt aagcacttgt ttgcattctc tgttcttcac
     6841 tcatttattt cttgcagtgt gctatggact taatgctctt tctgtattga tgaaaagcag
     6901 tatgtgggcc aatcttttta taaaacacta tgcatatata aatattacat tgttcatagc
     6961 tttatttgac ttatgggttt atacataaca ttagaatgag tagctgtagt tgtgtggaca
     7021 tttataaaac aagttccttt cctggaacag acacaatata cattctgtag ctaaaaagga
     7081 gggaaaagtc tgtgaatgct atttttatta ttaaagtttt ccatacaaag catacattga
     7141 gctgtagtaa ggctgaggaa gagtacaact gaataatgat gttctttttc atcaagttcc
     7201 taagagctga cttggagatt ttattcccag ggctccactg ctaggattct tctcactagt
     7261 tctaacaaaa tctgtgatgt taaatgactg atgctctcaa ttgtgatcca gagttttaaa
     7321 taaatgaaat caaggtggat tttgggaata tatcctgaag ttaacatctt gatgtccttc
     7381 ttgttgtaag atgatatttg gcaatttaaa atctatgtgc tacccacctg ggcttgtctc
     7441 aatccgtgga ctttttggtg tggcagtttc acctgaattc cacacatcag atttgtttgg
     7501 aaatattgta ctgtacaggg actatgcatt atgcagaaag atatagtttt ctttgaactg
     7561 ctgtaacctt aaattggaaa ctgattcttg tgagcctact ttccttaatc ccgccgcccc
     7621 cctcccccac ttaatgtaaa tgtcttgatg agagataatg gatgagtatt ttgtatgatg
     7681 aaatcaaacg atttaggaat ttgtctccct ccgttacaca gttgatgcct gaaagaatgt
     7741 tgggggggag gactcaacac cctaattgta ttttttaagt ttcttttgtg aaagattttt
     7801 taatgcattt ttactgtaaa aatacatgga aatgtatgca ttccacaacc a
//
