LOCUS       NM_014061               1440 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens MAGE family member H1 (MAGEH1), mRNA.
ACCESSION   NM_014061
VERSION     NM_014061.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Shin,G.T., Park,J.E. and Lee,M.J.
  TITLE     MAGEH1 interacts with GADD45G and induces renal tubular cell
            apoptosis
  JOURNAL   PLoS One 16 (11), e0260135 (2021)
   PUBMED   34788311
  REMARK    GeneRIF: MAGEH1 interacts with GADD45G and induces renal tubular
            cell apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Wang,P.C., Hu,Z.Q., Zhou,S.L., Zhan,H., Zhou,Z.J., Luo,C.B. and
            Huang,X.W.
  TITLE     Downregulation of MAGE family member H1 enhances hepatocellular
            carcinoma progression and serves as a biomarker for patient
            prognosis
  JOURNAL   Future Oncol 14 (12), 1177-1186 (2018)
   PUBMED   29316827
  REMARK    GeneRIF: MAGEH1 expression was downregulated in HCC tumor tissues
            compared with adjacent normal liver tissues and in samples from
            patients with tumor recurrence. MAGEH1 reduced HCC cell
            proliferation, migration and invasion ability.
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Zheng,J., Li,Q., Wang,W., Wang,Y., Fu,X., Wang,W., Fan,L. and
            Yan,W.
  TITLE     Apoptosis-related protein-1 acts as a tumor suppressor in
            cholangiocarcinoma cells by inducing cell cycle arrest via
            downregulation of cyclin-dependent kinase subunits
  JOURNAL   Oncol Rep 35 (2), 809-816 (2016)
   PUBMED   26572808
  REMARK    GeneRIF: our data showed that Apr-1 plays a crucial role in cell
            proliferation by controlling cell cycle progression, implying a
            tumor-suppressor function of Apr-1 in cholangiocarcinoma
            carcinogenesis
REFERENCE   6  (bases 1 to 1440)
  AUTHORS   Yan,W., Wang,W.L., Zhu,F., Cheng,S.Q., Li,Q.L., Wang,L. and
            Wang,C.J.
  TITLE     [Cloning and subcellular localization of apr-1--a new gene of tumor
            specific antigen family]
  JOURNAL   Ai Zheng 24 (2), 129-134 (2005)
   PUBMED   15694019
REFERENCE   7  (bases 1 to 1440)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   8  (bases 1 to 1440)
  AUTHORS   Tcherpakov,M., Bronfman,F.C., Conticello,S.G., Vaskovsky,A.,
            Levy,Z., Niinobe,M., Yoshikawa,K., Arenas,E. and Fainzilber,M.
  TITLE     The p75 neurotrophin receptor interacts with multiple MAGE proteins
  JOURNAL   J Biol Chem 277 (51), 49101-49104 (2002)
   PUBMED   12414813
REFERENCE   9  (bases 1 to 1440)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   10 (bases 1 to 1440)
  AUTHORS   Zhu,F., Yan,W., Zhao,Z.L., Chai,Y.B., Lu,F., Wang,Q., Peng,W.D.,
            Yang,A.G. and Wang,C.J.
  TITLE     Improved PCR-based subtractive hybridization strategy for cloning
            differentially expressed genes
  JOURNAL   Biotechniques 29 (2), 310-313 (2000)
   PUBMED   10948432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF143235.4 and AA634056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014061.4.
            
            Summary: This gene belongs to the non-CT (non cancer/testis)
            subgroup of the melanoma-associated antigen (MAGE) superfamily. The
            encoded protein is likely associated with apoptosis, cell cycle
            arrest, growth inhibition or cell differentiation. The protein may
            be involved in the atRA (all-trans retinoic acid) signaling through
            the STAT1-alpha (signal transducer and activator of transcription
            1-alpha) pathway. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF320912.1, AF143235.4 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342972.3/ ENSP00000343706.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1401              AF143235.4         35-1435
            1402-1440           AA634056.1         2-40                c
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..1440
                     /gene="MAGEH1"
                     /gene_synonym="APR-1; APR1; MAGEH"
                     /note="MAGE family member H1"
                     /db_xref="GeneID:28986"
                     /db_xref="HGNC:HGNC:24092"
                     /db_xref="MIM:300548"
     exon            1..1440
                     /gene="MAGEH1"
                     /gene_synonym="APR-1; APR1; MAGEH"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..908
                     /gene="MAGEH1"
                     /gene_synonym="APR-1; APR1; MAGEH"
                     /note="restin; apoptosis-related protein 1; melanoma
                     antigen family H, 1; melanoma antigen family H1"
                     /codon_start=1
                     /product="melanoma-associated antigen H1"
                     /protein_id="NP_054780.2"
                     /db_xref="CCDS:CCDS14369.1"
                     /db_xref="GeneID:28986"
                     /db_xref="HGNC:HGNC:24092"
                     /db_xref="MIM:300548"
                     /translation="MPRGRKSRRRRNARAAEENRNNRKIQASEASETPMAASVVASTP
                     EDDLSGPEEDPSTPEEASTTPEEASSTAQAQKPSVPRSNFQGTKKSLLMSILALIFIM
                     GNSAKEALVWKVLGKLGMQPGRQHSIFGDPKKIVTEEFVRRGYLIYKPVPRSSPVEYE
                     FFWGPRAHVESSKLKVMHFVARVRNRCSKDWPCNYDWDSDDDAEVEAILNSGARGYSA
                     P"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEH1"
                     /gene_synonym="APR-1; APR1; MAGEH"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="MAGEH1"
                     /gene_synonym="APR-1; APR1; MAGEH"
                     /note="major polyA site"
ORIGIN      
        1 aattttgctg agctttctcg cgggcttgca gctgcggcaa gtgctggcgg cggctgctcg
       61 cgcaagtcag ctggcgtggg aactaccctt tgtagctgag aacggcttgt ttattgctac
      121 aaagactcta ttgacattgg tagcttcagc ggcagcagct tcttacggta taaagctgtt
      181 gcttcctgaa gaggctacaa gcatccttcc ctaggactgc tgtaagcttt gagcctctag
      241 caggagacat gcctcgggga cgaaagagtc ggcgccgccg taatgcgaga gccgcagaag
      301 agaaccgcaa caatcgcaaa atccaggcct cagaggcctc cgagacccct atggccgcct
      361 ctgtggtagc gagcaccccc gaagacgacc tgagcggccc cgaggaagac ccgagcactc
      421 cagaggaggc ctctaccacc cctgaagaag cctcgagcac tgcccaagca caaaagcctt
      481 cagtgccccg gagcaatttt cagggcacca agaaaagtct cctgatgtct atattagcgc
      541 tcatcttcat catgggcaac agcgccaagg aagctctggt ctggaaagtg ctggggaagt
      601 taggaatgca gcctggacgt cagcacagca tctttggaga tccgaagaag atcgtcacag
      661 aagagtttgt gcgcagaggg tacctgattt ataaaccggt gccccgtagc agtccggtgg
      721 agtatgagtt cttctggggg ccccgagcac acgtggaatc gagcaaactg aaagtcatgc
      781 attttgtggc aagggttcgt aaccgatgct ctaaagactg gccttgtaat tatgactggg
      841 attcggacga tgatgcagag gttgaggcta tcctcaattc aggtgctagg ggttattccg
      901 ccccttaagt agatctgagg cagacccttg ggggtgtaaa agagagtcac aggtacccca
      961 aggagtagat gccagggtcc taagttgaaa atgatgtcga ttgggggcgg gggacactgt
     1021 atttgatatt tgtgatcagt gatcattgtt caactgcgaa atagagtgtt tgcttttgat
     1081 aatggaaaat tgtattcgtt ttaaaattcc gtttgttgag aataacaata tgtttaaaaa
     1141 tataattgaa caaatttttt tctttgtttc ctgtcattga catttagtat aacagttttg
     1201 ctaacgttct aaaatgaagt cgttccatca taatctatga tcttgtacag cacttataga
     1261 aataagctgt tcttttgaag ttgaaatacc cagtaaaatg ttgaagaagg atggaggatt
     1321 tcttcatatc tgacgtttct gaaacccttt gtgtctgctg ttgtgtgaag attgacattt
     1381 accatgattt tccttagtta ctgcagaaca tagagaaaaa taaaagccta acgaatagta
//
