LOCUS       NM_022149               1701 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAGE family member F1 (MAGEF1), mRNA.
ACCESSION   NM_022149
VERSION     NM_022149.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1701)
  AUTHORS   Weon,J.L., Yang,S.W. and Potts,P.R.
  TITLE     Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a
            Cancer-Amplified Ubiquitin Ligase
  JOURNAL   Mol Cell 69 (1), 113-125 (2018)
   PUBMED   29225034
  REMARK    GeneRIF: MAGE-F1 specifies the cytosolic iron-sulfur assembly
            pathway protein MMS19 for ubiquitination and degradation.
REFERENCE   4  (bases 1 to 1701)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1701)
  AUTHORS   Doyle,J.M., Gao,J., Wang,J., Yang,M. and Potts,P.R.
  TITLE     MAGE-RING protein complexes comprise a family of E3 ubiquitin
            ligases
  JOURNAL   Mol Cell 39 (6), 963-974 (2010)
   PUBMED   20864041
REFERENCE   6  (bases 1 to 1701)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   7  (bases 1 to 1701)
  AUTHORS   Stone,B., Schummer,M., Paley,P.J., Crawford,M., Ford,M., Urban,N.
            and Nelson,B.H.
  TITLE     MAGE-F1, a novel ubiquitously expressed member of the MAGE
            superfamily
  JOURNAL   Gene 267 (2), 173-182 (2001)
   PUBMED   11313144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107294.7, BQ070043.1,
            BQ058163.1 and BC010056.2.
            
            On May 17, 2019 this sequence version replaced NM_022149.4.
            
            Summary: This intronless gene encodes a member of the MAGE
            superfamily. It is ubiquitously expressed in normal tissues and in
            tumor cells. This gene includes a microsatellite repeat in the
            coding region. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.224019.1,
                                        SRR7410570.228493.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317897.5/ ENSP00000315064.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC107294.7         15502-15517         c
            17-700              BQ070043.1         2-685
            701-1142            BQ058163.1         291-732
            1143-1698           BC010056.2         1084-1639
            1699-1701           AC107294.7         13817-13819         c
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..1701
                     /gene="MAGEF1"
                     /gene_synonym="MAGE-F1"
                     /note="MAGE family member F1"
                     /db_xref="GeneID:64110"
                     /db_xref="HGNC:HGNC:29639"
                     /db_xref="MIM:609267"
     exon            1..1701
                     /gene="MAGEF1"
                     /gene_synonym="MAGE-F1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1167
                     /gene="MAGEF1"
                     /gene_synonym="MAGE-F1"
                     /note="MAGE-F1 antigen; melanoma antigen family F, 1;
                     melanoma antigen family F1"
                     /codon_start=1
                     /product="melanoma-associated antigen F1"
                     /protein_id="NP_071432.2"
                     /db_xref="CCDS:CCDS3269.1"
                     /db_xref="GeneID:64110"
                     /db_xref="HGNC:HGNC:29639"
                     /db_xref="MIM:609267"
                     /translation="MLQTPESRGLPVPQAEGEKDGGHDGETRAPTASQERPKEELGAG
                     REEGAAEPALTRKGARALAAKALARRRAYRRLNRTVAELVQFLLVKDKKKSPITRSEM
                     VKYVIGDLKILFPDIIARAAEHLRYVFGFELKQFDRKHHTYILINKLKPLEEEEEEDL
                     GGDGPRLGLLMMILGLIYMRGNSAREAQVWEMLRRLGVQPSKYHFLFGYPKRLIMEDF
                     VQQRYLSYRRVPHTNPPEYEFSWGPRSNLEISKMEVLGFVAKLHKKEPQHWPVQYREA
                     LADEADRARAKARAEASMRARASARAGIHLW"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEF1"
                     /gene_synonym="MAGE-F1"
                     /note="hexamer: AATAAA"
     polyA_site      1701
                     /gene="MAGEF1"
                     /gene_synonym="MAGE-F1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggcc cctcgcgcgg gcgcggactg aggctgcgcg ccgcaggttc cggctgctgg
       61 cggcgttgcg gccgcaggtt tgactcccgt gcggtgcggc ccagcagcca caaagctccc
      121 gctgccattg ctccttgtac tcccgccgtc actgccgctg tccaacccct cccccggggc
      181 ttgcgcggcg gctcccacac ccctcggccc gtgtacgcgc tctgcacctg cctgcccgaa
      241 aacatgttgc agacaccaga gagcaggggg ctcccggtcc cgcaggccga gggggagaag
      301 gatggcggcc atgatggtga gacccgggcc ccgaccgcct cgcaggagcg ccccaaggag
      361 gagcttggcg ccgggaggga ggagggggct gcggagcccg ccctcacccg gaaaggcgcg
      421 agggccttgg cggccaaagc cttggcaagg cgcagggcct accgccggct gaatcggacg
      481 gtggcggagt tggtgcagtt cctcctggtg aaagacaaga agaagagtcc catcacacgc
      541 tcggagatgg tgaaatacgt tattggagac ttgaagattc tgttcccgga catcatcgca
      601 agggccgcag agcatctgcg gtatgtcttt ggttttgagc tgaaacagtt tgaccgcaag
      661 caccacactt acatcctgat caacaaacta aaacctctgg aggaggagga ggaggaggat
      721 ctgggaggag atggccccag attgggtctg ttaatgatga tcctgggcct tatctatatg
      781 agaggtaata gcgccaggga ggcccaggtc tgggagatgc tgcgtcggtt gggggtgcaa
      841 ccctcaaagt atcatttcct ctttgggtat ccgaagaggc ttattatgga agattttgtg
      901 cagcagcgat atctcagtta caggcgggtg cctcacacca atccaccaga atatgaattc
      961 tcttggggtc cccgaagcaa cctggaaatc agcaagatgg aagtcctggg gttcgtggcc
     1021 aaactgcata agaaggaacc gcagcactgg ccagtgcagt accgtgaggc cctagcagac
     1081 gaggccgaca gggccagagc caaggccaga gctgaagcca gtatgagggc cagggccagt
     1141 gctagggccg gcatccacct ctggtgaggg ttggtgaaaa gttggccagt gggtccccgt
     1201 gaggacgaac tactgtcctg agtcataagt aatatgggtg gggcgagggt cttatttctg
     1261 tagaaatcgt gtgactttaa ggatttagat tttgtatctt atgttttgta acatttaata
     1321 attactgtta aaatgctgtt tgtaaatgag attggtctac tttttcctgt aggattttat
     1381 tgtagagttt tgctggtttt gtaaaatgga tggaagaact ttgtatttat actgtgattt
     1441 tgaacagatt atgcaacatt ggaaggaagg ctgtactttg atggtttgaa ggaactcagc
     1501 agtatgatga tctggttcca ggggaaaaaa atagctggtt ggtgtctagc cccccaacac
     1561 ttttgtctgt tgtgtataaa agaagaaaga ctggcatgta ccttcatttg cttagctatt
     1621 tgagtatcta gagaaaaatt aaaatgcaat gagttagcag tataccctgg cacacttaat
     1681 aaattaaaca tttgtggagc a
//
