LOCUS       NM_138703               2268 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAGE family member E2 (MAGEE2), mRNA.
ACCESSION   NM_138703
VERSION     NM_138703.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 2268)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391495.16, DA793762.1 and
            AK094624.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138703.4.
            
            Summary: This gene encodes a member of the E subfamily of MAGE
            (melanoma antigen-encoding gene) gene family. The gene is
            intronless and the encoded protein has two of the MAGE domains
            which are characteristic of MAGE family proteins. [provided by
            RefSeq, Sep 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803613.177892.1,
                                        SRR1803614.172611.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373359.4/ ENSP00000362457.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL391495.16        72805-72814         c
            11-251              DA793762.1         1-241
            252-2073            AK094624.1         234-2055
            2074-2268           AL391495.16        70547-70741         c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.3"
     gene            1..2268
                     /gene="MAGEE2"
                     /gene_synonym="HCA3"
                     /note="MAGE family member E2"
                     /db_xref="GeneID:139599"
                     /db_xref="HGNC:HGNC:24935"
                     /db_xref="MIM:300760"
     exon            1..2268
                     /gene="MAGEE2"
                     /gene_synonym="HCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1775
                     /gene="MAGEE2"
                     /gene_synonym="HCA3"
                     /note="hepatocellular carcinoma-associated protein HCA3;
                     MAGE-E2 antigen; hepatocellular carcinoma-associated
                     protein 3; melanoma antigen family E, 2; melanoma antigen
                     family E2"
                     /codon_start=1
                     /product="melanoma-associated antigen E2"
                     /protein_id="NP_619648.1"
                     /db_xref="CCDS:CCDS14431.1"
                     /db_xref="GeneID:139599"
                     /db_xref="HGNC:HGNC:24935"
                     /db_xref="MIM:300760"
                     /translation="MSLVSQNARHCSAEITADYGDGRGEIQATNASGSPTSMLVVDAP
                     QCPQAPINSQCVNTSQAVQDPNDLEVLIDEQSRRLGALRVHDPLEDRSIALVNFMRMK
                     SQTEGSIQQSEMLEFLREYSDQFPEILRRASAHLDQVFGLNLRVIDPQADTYNLVSKR
                     GFQITDRIAESLDMPKASLLALVLGHILLNGNRAREASIWDLLLKVDMWDKPQRINNL
                     FGNTRNLLTTDFVCMRFLEYWPVYGTNPLEFEFLWGSRAHREITKMEALKFVSDAHDE
                     EPWSWPEEYNKALEGDKTKERSLTAGLEFWSEDTMNDKANDLVQLAISVTEEMLPIHQ
                     DELLAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYLLVQQPESEEEQVM
                     LESLGRPTQEYVMPILGLIFLMGNRVKEANVWNLLRRFSVDVGRKHSITRKLMRQRYL
                     ECRPLSYSNPVEYELLWGPRAHHETIKMKVLEYMARLYRKRPQNWPEQYREAVEDEEA
                     RAKSEATIMFFLDPT"
     regulatory      2247..2252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEE2"
                     /gene_synonym="HCA3"
                     /note="hexamer: AATAAA"
     polyA_site      2268
                     /gene="MAGEE2"
                     /gene_synonym="HCA3"
                     /note="major polyA site"
ORIGIN      
        1 gcggcaaaat aacgctctga ggcttgcagt cgttgctggc cagcacttgt gtagaaagat
       61 cgctcttcac accagatttc acttttgatc cttccagctc cagggtctcg ggcttcagct
      121 ttgtgccgag gcaccaacac tgctgcggtc ctctctccga ctgatcgctg atctcaccgt
      181 tcccgctcct gtctcctgga accatgtctc tggtaagcca gaatgcacgc cactgtagcg
      241 cagagatcac tgcagattac ggcgacggca gaggtgaaat acaagctact aacgcctccg
      301 ggtcccccac ctccatgcta gtcgttgatg ccccccagtg ccctcaggcg ccaatcaact
      361 ctcagtgtgt caacacttcc caggccgttc aggacccgaa tgacctggag gtcctgatcg
      421 acgagcagtc cagacgtttg ggggcgctca gggtccatga ccctctagaa gacaggtcga
      481 ttgctttggt gaatttcatg agaatgaaaa gccagacgga ggggtctatc cagcagtccg
      541 agatgctgga gtttctcaga gagtactcag atcagttccc tgagatcctc agacgagcct
      601 cagctcacct ggaccaggtc tttgggttga acctgagagt tattgatcct caggctgaca
      661 cctacaattt agtcagcaaa cggggtttcc agatcaccga taggatagcg gagtccctgg
      721 acatgccaaa agcaagtctc ctggccctag tcctaggcca catcctcttg aatgggaacc
      781 gagcaagaga ggcctccatt tgggacttgc tgctaaaagt tgatatgtgg gataagcctc
      841 agaggatcaa caacctcttt gggaacacaa ggaacctcct cactactgac tttgtgtgca
      901 tgcgattctt ggagtactgg ccggtgtatg gcactaatcc ccttgagttt gagttcttgt
      961 ggggctctag agcccacagg gaaatcacaa agatggaagc cctgaagttt gtgtcagatg
     1021 cccatgatga agaaccctgg agctggccag aagaatataa taaggccctg gaaggtgaca
     1081 aaaccaaaga aagaagcctg actgctggct tagagttctg gtcggaggac actatgaatg
     1141 ataaggcaaa tgatttggtc cagttggcta ttagtgtcac tgaggagatg ctgcctatac
     1201 atcaggatga gctattggct cacactggca aagaatttga ggatgtgttc ccaaatatcc
     1261 tcaatagagc tactctaatt cttgatatgt tctatgggtt gtctctgatt gaggttgata
     1321 ccagtgagca catctacctc cttgtccagc aaccagaatc agaggaagag caagtgatgc
     1381 tagagagcct ggggagaccc actcaagaat atgtaatgcc aatcctaggt ttgatcttcc
     1441 tgatgggcaa ccgtgtcaaa gaggccaatg tctggaactt gcttcgaaga tttagtgtgg
     1501 atgtagggag aaagcattcc atcacccgta agcttatgag acagcgctat ctggaatgca
     1561 ggccactgtc ctactctaat ccagttgaat atgagcttct atggggtcct cgagctcacc
     1621 atgaaaccat caaaatgaaa gtcttggagt acatggccag gctctacaga aagcgaccac
     1681 agaactggcc agaacaatat agggaggctg tggaagatga ggaggccaga gccaaatctg
     1741 aggcaactat catgtttttc cttgacccca cgtgaagtct agggaatatg tatcacttca
     1801 gctgagtggc ataagttaaa gatgccttgg taaaataggc attggggctc taaattagaa
     1861 tccaggtagg gcttgtgtgg gaagtacaaa ttgtgcttgc tgtctgtgtt ccaattctag
     1921 tagtatttcc ttccttttaa tatactcttg gattaggtta atgaccaata tttataaatg
     1981 gaatttttca tttgccatcc cggtcttgtt tcagcataaa agttcagaca gctctgtaaa
     2041 atgtattgat aatatttaca tctttgaaat aatcagtaaa atggtctggt acaggagtta
     2101 aataacaatg acacacacac aacaaaacaa acacaaaacc actgatctgt gattgctctc
     2161 cctttgtgtc tactgccgta tacatatata caactatata tacacaaata tatatataca
     2221 caaaactgtc atttacctgt atttgcaata aaagcataat gaattaga
//
