LOCUS       NM_020932               3633 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens MAGE family member E1 (MAGEE1), mRNA.
ACCESSION   NM_020932
VERSION     NM_020932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Doyle,J.R., Lane,J.M., Beinborn,M. and Kopin,A.S.
  TITLE     Naturally occurring HCA1 missense mutations result in loss of
            function: potential impact on lipid deposition
  JOURNAL   J Lipid Res 54 (3), 823-830 (2013)
   PUBMED   23268337
  REMARK    GeneRIF: Data suggest that lipid homeostasis may be altered in
            carriers of selected HCA1 missense variants.
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Doyle,J.M., Gao,J., Wang,J., Yang,M. and Potts,P.R.
  TITLE     MAGE-RING protein complexes comprise a family of E3 ubiquitin
            ligases
  JOURNAL   Mol Cell 39 (6), 963-974 (2010)
   PUBMED   20864041
REFERENCE   7  (bases 1 to 3633)
  AUTHORS   Caballero,O.L., Zhao,Q., Rimoldi,D., Stevenson,B.J., Svobodova,S.,
            Devalle,S., Rohrig,U.F., Pagotto,A., Michielin,O., Speiser,D.,
            Wolchok,J.D., Liu,C., Pejovic,T., Odunsi,K., Brasseur,F., Van den
            Eynde,B.J., Old,L.J., Lu,X., Cebon,J., Strausberg,R.L. and
            Simpson,A.J.
  TITLE     Frequent MAGE mutations in human melanoma
  JOURNAL   PLoS One 5 (9), e12773 (2010)
   PUBMED   20862285
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[PLoS One. 2010;5(11). doi:
            10.1371/annotation/3ee2788f-0c44-429f-85c3-d626c9fedc21]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3633)
  AUTHORS   Albrecht,D.E. and Froehner,S.C.
  TITLE     DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in
            dystrophin complexes
  JOURNAL   J Biol Chem 279 (8), 7014-7023 (2004)
   PUBMED   14623885
  REMARK    GeneRIF: a new dystrobrevin-associated protein that may play a
            signaling role in brain, muscle, and peripheral nerve
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA411859.1 and AB046807.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020932.2.
            
            Summary: This gene encodes an alpha-dystrobrevin-associated MAGE
            (melanoma-associated antigen) protein, which is a member of the
            MAGE family. The protein contains a nuclear localization signal in
            the N-terminus, 30 12-amino acid repeats beginning at nt 60 with
            the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the
            C-terminus. It may play a signaling role in brain, muscle, and
            peripheral nerve. This gene is located on X chromosome in a region
            containing loci linked to cognitive disability. [provided by
            RefSeq, Mar 2010].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.100158.1, SRR1660805.38997.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361470.4/ ENSP00000354912.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA411859.1         58-71
            15-3633             AB046807.1         1-3619
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.3"
     gene            1..3633
                     /gene="MAGEE1"
                     /gene_synonym="DAMAGE; HCA1"
                     /note="MAGE family member E1"
                     /db_xref="GeneID:57692"
                     /db_xref="HGNC:HGNC:24934"
                     /db_xref="MIM:300759"
     exon            1..3633
                     /gene="MAGEE1"
                     /gene_synonym="DAMAGE; HCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3095
                     /gene="MAGEE1"
                     /gene_synonym="DAMAGE; HCA1"
                     /note="dystrobrevin-associated MAGE protein;
                     hepatocellular carcinoma-associated HCA1; MAGE-E1 antigen;
                     hepatocellular carcinoma-associated protein 1; melanoma
                     antigen family E1; alpha-dystrobrevin-associated MAGE
                     Protein; melanoma antigen family E, 1"
                     /codon_start=1
                     /product="melanoma-associated antigen E1"
                     /protein_id="NP_065983.1"
                     /db_xref="CCDS:CCDS14433.1"
                     /db_xref="GeneID:57692"
                     /db_xref="HGNC:HGNC:24934"
                     /db_xref="MIM:300759"
                     /translation="MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSD
                     VPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTISEGPGT
                     SVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVP
                     STSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATE
                     GLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAA
                     SDGQSISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPP
                     TATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLV
                     QPTAPDGPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKASVDSDSEGP
                     KGAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELLQFLLVKDQS
                     KYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYILLNKLGP
                     VPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNP
                     KRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMD
                     WPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVPSPDSEVSSYSSKYAPHSW
                     PESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVY
                     GTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESA
                     VWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKA
                     LRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR"
     regulatory      3612..3617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEE1"
                     /gene_synonym="DAMAGE; HCA1"
                     /note="hexamer: AATAAA"
     polyA_site      3633
                     /gene="MAGEE1"
                     /gene_synonym="DAMAGE; HCA1"
                     /note="major polyA site"
ORIGIN      
        1 acagtgagac tagcattcac tgctggccag tgcctgcctt tttcaccacc tctaatttca
       61 gcttcagcag ttgcttggaa ctttggttct ggcagcagca gcaacatcat taccgctagc
      121 ggcagttttg tgccgaggca cctacacacc tcccgtcctc tctgccagat cgcgggcctg
      181 tcggtgtctg ctcctacacg ccaacgccgg tgggcaggac catgtctctg gtaagccaga
      241 attcgcgccg ccgccgccgc cgcgttgcaa aggctactgc gcacaacagc agctggggcg
      301 aaatgcaggc ccctaatgcc cccggtctcc ccgctgatgt gccaggctca gacgtccccc
      361 agggtcccag cgattcccag atcctccagg gcctctgcgc ctctgagggc ccaagcacct
      421 ccgttctgcc cacctccgct gagggcccaa gcacctttgt gccgcccacc atctctgagg
      481 cctcaagcgc ctccgggcag cccaccatct ctgagggacc tggcacctcc gtgctgccca
      541 cccccagtga gggcctaagc acctccgggc ctcccaccat ctctaagggg ctgtgcacct
      601 ctgtgacgct tgccgcctct gagggccgga acacctccag gccgcccact tcctctgagg
      661 aacctagcac ctccgtgccg cccaccgcct ctgaggtacc gagcacctcc ctgccgccca
      721 cccctggtga gggaacgagc acctccgtgc cgcccacagc ctatgaggga ccaagcacct
      781 ccgtggtgcc cacccctgat gagggaccaa gcacctccgt gctgcctaca cctggtgagg
      841 gaccaggcac ctccgtgccg ctcgccgcca ctgagggcct gagcacctcc gtgcaggcca
      901 ctcctgatga gggaccgagc acctccgtgc cgcccaccgc cactgagggc ctaagcaccc
      961 ccgtgccacc cacccgtgat gagggaccga gcacctccgt gccggccact cctggtgagg
     1021 gaccgagcac ctccgtgctg cccgccgcct ctgacggaca aagcatctcc ttggtgccca
     1081 cccgcggtaa gggatcaagc acctccgtgc cccccaccgc caccgagggc ctgagcacct
     1141 ccgtgcagcc cactgctggt gagggatcga gcacctccgt gccgcccacc cctggtgggg
     1201 gactgagcac ctccgtgccg cccaccgcca ctgaggagtt gagcacctcc gtgccgccca
     1261 ctcccggtga gggaccaagc acttccgtac tgccaatccc cggtgaggga ctgagcacct
     1321 ctgtgccgcc caccgcctct gatggatcgg acacctccgt gccgcccact cctggtgagg
     1381 gcgcaagcac cttagtgcag cccaccgccc ctgacggacc gggaagctcc gtgctgccta
     1441 accctggtga gggcccgagc acattgttta gctctagtgc ttctgtggac cggaacccct
     1501 ccaagtgttc ccttgttttg ccaagcccta gggtaaccaa ggcctccgtg gactcagatt
     1561 ctgagggtcc taagggtgca gaaggcccta tagaattcga ggtcctgaga gactgtgaga
     1621 gccccaactc cattagtatt atgggcctca atacttcccg ggttgcaatt accctgaagc
     1681 cccaagaccc tatggaacag aacgtagctg agctgttgca gttcctgctg gtgaaggatc
     1741 agagcaagta ccctatccgg gagtctgaaa tgcgggaata tattgttaaa gaatatcgca
     1801 accagtttcc tgagatactc aggcgagcag cagcccacct ggagtgcatt tttaggtttg
     1861 aattgagaga acttgaccct gaggcacaca cctacattct gttaaacaaa ctgggacctg
     1921 tgccctttga agggttagaa gagagcccaa atgggccaaa gatgggcctc ctgatgatga
     1981 ttctaggcca aatattcctg aatggcaacc aagccaagga ggctgagatt tgggaaatgc
     2041 tctggaggat gggggtgcag cgggaaagga ggctttccat ttttgggaac ccaaagagac
     2101 ttctgtctgt ggagtttgta tggcagcgtt acttagacta caggccagta actgactgta
     2161 aaccagtgga gtatgagttt ttctggggcc caagatccca cctagaaacc accaagatga
     2221 aaattctgaa gttcatggcg aaaatatata acaaagatcc tatggattgg ccagagaaat
     2281 acaacgaagc tctggaagaa gatgctgcca gagcctttgc tgagggttgg caggctctcc
     2341 ctcactttag gaggcccttt tttgaggaag ctgctgcaga ggtaccatcc cctgattcag
     2401 aggtttccag ctattcctca aaatatgccc cacattcatg gcctgagtca agattggaga
     2461 gcaaggcaag gaagctggtg cagttatttc tgcttatgga ttcaactaag ctgcctatac
     2521 caaagaaagg aattctgtac tacattggcc gagagtgcag caaagtgttc cctgacctcc
     2581 tgaatcgtgc tgcccgcacc ctgaaccatg tctatgggac agaactagtg gtacttgatc
     2641 ccaggaatca ctcctatact ctgtacaacc gaagggagat ggaagaaact gaggagatcg
     2701 tagacagtcc aaacaggcct ggcaacaact ttttgatgca ggtcctaagc ttcatcttta
     2761 ttatgggcaa ccatgccagg gagtctgcag tctgggcctt tctgcggggc ttaggggttc
     2821 aagctgggag aaagcatgtg attacctgca gatacttgag tcagcgctat atagacagtt
     2881 tacgggttcc tgacagtgat ccagtgcaat atgagtttgt atggggtcct agagcccgtt
     2941 tggaaacctc taagatgaaa gccttgcgat atgtggccag aatccacaga aaggaaccac
     3001 aggactggcc acagcagtac agggaggcaa tggaagatga ggccaataga gctgatgttg
     3061 ggcacaggca aatctttgtt cacaacttca ggtagaggaa tgcatggcag tcagaggggc
     3121 cttgcaagga ggggcctttg agcctcagtt ctcatgtatt ggggggtggg ggtgggtaca
     3181 tattgtattt ggtatttgtg ttccagttat atttatgtct tttcatattt agttctggtg
     3241 tggtgtctgg aaatgtttca actgttttaa tatattgtct gattgggtaa atgtgattga
     3301 ccacttgctg tctctgttgt attttggtat gagttttgat agctctataa aatgttttgg
     3361 aaatctttcc atcttgttgc attatctaga aaagaatata gcatatagct atagatatag
     3421 gcttttcctt gaaagcttga aaaaaattcg ccagtaaaat aatctagctt aaagtgataa
     3481 actaacaaac aaatataaca acaactgaaa aggcactcta aattgtggct ggcttccctt
     3541 tctgtctgct attgtatgaa gaatactgat gtttacctgt atttgctttg ctgtactaaa
     3601 atgtaatgaa aaataaaaga ttaataaatg aaa
//
