LOCUS       NM_030801               2513 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens MAGE family member D4B (MAGED4B), transcript variant
            1, mRNA.
ACCESSION   NM_030801
VERSION     NM_030801.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Takami,H., Kanda,M., Oya,H., Hibino,S., Sugimoto,H., Suenaga,M.,
            Yamada,S., Nishikawa,Y., Asai,M., Fujii,T., Nomoto,S. and Kodera,Y.
  TITLE     Evaluation of MAGE-D4 expression in hepatocellular carcinoma in
            Japanese patients
  JOURNAL   J Surg Oncol 108 (8), 557-562 (2013)
   PUBMED   24068544
  REMARK    GeneRIF: Overexpression of MAGE-D4 may be a predictive marker of
            early recurrence and mortality in patients with hepatocellular
            carcinoma (HCC).
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Chong,C.E., Lim,K.P., Gan,C.P., Marsh,C.A., Zain,R.B.,
            Abraham,M.T., Prime,S.S., Teo,S.H., Silvio Gutkind,J., Patel,V. and
            Cheong,S.C.
  TITLE     Over-expression of MAGED4B increases cell migration and growth in
            oral squamous cell carcinoma and is associated with poor disease
            outcome
  JOURNAL   Cancer Lett 321 (1), 18-26 (2012)
   PUBMED   22459352
  REMARK    GeneRIF: Our data suggest that MAGED4B over-expression is a driver
            in oral carcinogenesis
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Germano,S., Kennedy,S., Rani,S., Gleeson,G., Clynes,M., Doolan,P.,
            McDonnell,S., Hughes,L., Crown,J. and O'Driscoll,L.
  TITLE     MAGE-D4B is a novel marker of poor prognosis and potential
            therapeutic target involved in breast cancer tumorigenesis
  JOURNAL   Int J Cancer 130 (9), 1991-2002 (2012)
   PUBMED   21618523
  REMARK    GeneRIF: MAGE-D4B was found to correlate with tumor progression and
            to be an independent prognostic marker for poor outcome in term of
            relapse-free and overall survival, with potential predictive
            relevance in relation to response to chemotherapy
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Ito,S., Kawano,Y., Katakura,H., Takenaka,K., Adachi,M., Sasaki,M.,
            Shimizu,K., Ikenaka,K., Wada,H. and Tanaka,F.
  TITLE     Expression of MAGE-D4, a novel MAGE family antigen, is correlated
            with tumor-cell proliferation of non-small cell lung cancer
  JOURNAL   Lung Cancer 51 (1), 79-88 (2006)
   PUBMED   16225959
  REMARK    GeneRIF: MAGE-D4 plays some roles in tumor cells proliferation in
            NSCLC, but MAGE-D4 expression status did not provided a prognostic
            significance.
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Kawano,Y., Sasaki,M., Nakahira,K., Yoshimine,T., Shimizu,K.,
            Wada,H. and Ikenaka,K.
  TITLE     Structural characterization and chromosomal localization of the
            MAGE-E1 gene
  JOURNAL   Gene 277 (1-2), 129-137 (2001)
   PUBMED   11602350
  REMARK    GeneRIF: The MAGE-E1 gene is composed of 13 exons, and three of
            these (exon 2, exon 3 and exon 12) are alternatively spliced in
            each variant (E1a-c). MAGE-E1 gene is located in Xp11 through the
            analysis of radiation hybrid panels.
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Sasaki,M., Nakahira,K., Kawano,Y., Katakura,H., Yoshimine,T.,
            Shimizu,K., Kim,S.U. and Ikenaka,K.
  TITLE     MAGE-E1, a new member of the melanoma-associated antigen gene
            family and its expression in human glioma
  JOURNAL   Cancer Res 61 (12), 4809-4814 (2001)
   PUBMED   11406556
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB058762.2 and BC001207.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 21, 2020 this sequence version replaced NM_030801.4.
            
            Summary: This gene is a member of the MAGED gene family. It is
            expressed only in brain and ovary, and some transcript variants of
            this gene are specifically expressed in glioma cells. This gene is
            clustered with other MAGED genes on chromosome Xp11. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1. Variants 1 and 2 encode the same
            isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081566.1, AL136582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335504.10/ ENSP00000335385.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2511              AB058762.2         66-2576
            2512-2513           BC001207.1         2617-2618
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..2513
                     /gene="MAGED4B"
                     /note="MAGE family member D4B"
                     /db_xref="GeneID:81557"
                     /db_xref="HGNC:HGNC:22880"
                     /db_xref="MIM:300765"
     exon            1..54
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            55..295
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2311
                     /gene="MAGED4B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanoma-associated antigen D4; MAGE-D4 antigen; MAGE-E1
                     antigen; melanoma antigen family D, 4B; melanoma antigen
                     family D4B"
                     /codon_start=1
                     /product="melanoma-associated antigen D4 isoform 1"
                     /protein_id="NP_110428.2"
                     /db_xref="CCDS:CCDS14338.1"
                     /db_xref="GeneID:81557"
                     /db_xref="HGNC:HGNC:22880"
                     /db_xref="MIM:300765"
                     /translation="MAEGSFSVQSESYSVEDMDEGSDEVGEEEMVEGNDYEEFGAFGG
                     YGTLTSFDIHILRAFGSLGPGLRILSNEPWELENPVLAQTLVEALQLDPETLANETAA
                     RAANVARAAASNRAARAAAAAARTAFSQVVASHRVATPQVSGEDTQPTTYAAEAQGPT
                     PEPPLASPQTSQMLVTSKMAAPEAPATSAQSQTGSPAQEAATEGPSSACAFSQAPCAR
                     EVDANRPSTAFLGQNDVFDFTQPAGVSGMAFPRPKRPAPAQEAATEGPSAASGVPQTG
                     PGREVAATRPKTTKSGKALAKTRWVEPQNVVAAAAAKAKMATSIPEPEGAAAATAQHS
                     AEPWARMGGKRTKKSKHLDDEYESSEEERETPAVPPTWRASQPSLTVRAQLAPRPPMA
                     PRSQIPSRHVLCLPPRNVTLLQERANKLVKYLMIKDYKKIPIKRADMLKDVIREYDEH
                     FPEIIERATYTLEKKFGIHLKEIDKEEHLYILVCTRDSSARLLGKTKDTPRLSLLLVI
                     LGVIFMNGNRASEAVLWEALRKMGLRPGVRHPFLGDLRKLITDDFVKQKYLEYKKIPN
                     SNPPEYEFLWGLRARHETSKMRVLRFIAQNQNRDPREWKAHFLEAVDDAFKTMDVDMA
                     EEHARAQMRAQMNIGDEALIGRWSWDDIQVELLTWDEDGDFGDAWARIPFAFWARYHQ
                     YILNSNRANRRATWRAGVSSGTNGGASTSVLDGPSTSSTIRTRNAARAGASFFSWIQH
                     R"
     exon            296..1129
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1333
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1397
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1477
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1569
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1649
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1692
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1755
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1870
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2301
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2513
                     /gene="MAGED4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGED4B"
                     /note="hexamer: ATTAAA"
     polyA_site      2513
                     /gene="MAGED4B"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgcgg ggttcctggt gctgaggacg gacgccattg gagttcccga gaaggctgag
       61 ctctcatctc cctgggaccc gcagcatggc tgagggaagc ttcagcgtgc aatcggaaag
      121 ctacagtgtt gaagacatgg atgagggtag cgacgaagtc ggggaggaag agatggttga
      181 aggcaacgac tatgaagaat tcggtgcgtt tggtggctat ggcaccctca ccagctttga
      241 catccatatc ctcagagcct tcggaagctt gggtccaggc cttcgcatct tatcgaatga
      301 gccctgggaa ctggaaaacc ctgtgctggc ccagaccctg gtggaggcat tgcagctgga
      361 tccggaaaca cttgccaatg agacggccgc ccgtgctgcc aacgtagccc gcgccgccgc
      421 ctccaaccgt gcggctcggg ccgctgccgc cgctgcccgt accgccttca gtcaggtggt
      481 cgctagccac cgggtggcca cgccgcaggt ctcaggagag gatacccagc ccacgaccta
      541 cgccgccgag gctcaggggc ccacccctga gccacccctt gcttctccgc agacctccca
      601 gatgttagtc accagtaaga tggctgcccc cgaggctccg gcaacctccg cacagtccca
      661 gacaggctcc ccggcccagg aggctgctac tgagggccct agtagcgcct gtgctttctc
      721 tcaggctccg tgtgccaggg aggtggacgc caaccggccc agcacagcct tcctgggcca
      781 gaatgatgtc ttcgatttca ctcagccggc aggtgtcagt ggcatggcct tcccgcgccc
      841 caagagacct gccccagccc aagaggctgc cacagagggc cccagtgctg cctctggtgt
      901 gccccagacg ggacctggca gggaggtggc agccacccgg cccaagacca ccaagtcggg
      961 gaaggcgctg gccaagactc ggtgggtgga gcctcagaat gttgtggcag cagctgctgc
     1021 caaggccaag atggccacga gcatccctga gccggagggt gcagctgctg ccactgctca
     1081 gcacagtgct gagccctggg ccaggatggg aggcaagagg accaagaagt ccaagcacct
     1141 ggatgatgag tatgagagca gcgaggagga gagagagact cccgcggtcc cacccacctg
     1201 gagagcatca cagccctcat tgacggtgcg ggctcagttg gcccctcggc ccccgatggc
     1261 cccgaggtcc cagataccct caaggcacgt actgtgcctg cccccccgca acgtgaccct
     1321 tctgcaggag agggcaaata agttggtgaa atacctgatg attaaggact acaagaagat
     1381 ccccatcaag cgcgcagaca tgctgaagga tgtcatcaga gaatatgatg aacatttccc
     1441 tgagatcatt gaacgagcaa cgtacaccct ggaaaagaag tttgggatcc acctgaagga
     1501 gatcgacaag gaagaacacc tgtatattct tgtctgcaca cgggactcct cagctcgcct
     1561 ccttggaaaa accaaggaca ctcccaggct gagtctcctc ttggtgattc tgggcgtcat
     1621 cttcatgaat ggcaaccgtg ccagcgaggc tgtcctctgg gaggcactac gcaagatggg
     1681 actgcgccct ggggtgaggc acccattcct cggcgatctg aggaagctca tcacagatga
     1741 ctttgtgaag cagaagtacc tggaatacaa gaagatcccc aacagcaacc cacctgagta
     1801 tgaattcctc tggggcctgc gagcccgcca tgagaccagc aagatgaggg tcctgagatt
     1861 catcgcccag aatcagaacc gagacccccg ggaatggaag gctcatttct tggaggctgt
     1921 ggatgatgct ttcaagacaa tggatgtgga tatggccgag gaacatgcca gggcccagat
     1981 gagggcccag atgaatatcg gggatgaagc gctgattgga cggtggagct gggatgacat
     2041 acaagtcgag ctcctgacct gggatgagga cggagatttt ggcgatgcct gggccaggat
     2101 cccctttgct ttctgggcca gataccatca gtacattctg aatagcaacc gtgccaacag
     2161 gagggccacg tggagagctg gcgtcagcag tggcaccaat ggaggggcca gcaccagcgt
     2221 cctagatggc cccagcacca gctccaccat ccggaccaga aatgctgcca gagctggcgc
     2281 cagcttcttc tcctggatcc agcaccgttg acgaactgca gcgatcttac tggccaagcc
     2341 agagcgcctc ctctcagatt ccttctcgac acagcaccct aggcggcttc ttcctgtcag
     2401 tcggaggtgg catgcaagat gaagctctct ttgctcttcc tgctttcatt ttgtgctttt
     2461 ccttgtgttt tcatgttttg ggtatcagtg ttacattaaa gttgcaaaat taa
//
