LOCUS       NM_001272063            2537 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens MAGE family member D4 (MAGED4), transcript variant 1,
            mRNA.
ACCESSION   NM_001272063
VERSION     NM_001272063.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2537)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2537)
  AUTHORS   Uno,Y., Kanda,M., Sato,Y., Shimizu,D., Umeda,S., Hattori,N.,
            Hayashi,M., Tanaka,C., Kobayashi,D., Yamada,S., Nakayama,G.,
            Motoyama,S., Koike,M. and Kodera,Y.
  TITLE     Expression, Function, and Prognostic Value of MAGE-D4 Protein in
            Esophageal Squamous Cell Carcinoma
  JOURNAL   Anticancer Res 39 (11), 6015-6023 (2019)
   PUBMED   31704827
  REMARK    GeneRIF: High MAGED4 expression is associated with Esophageal
            Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 2537)
  AUTHORS   He,S., Gu,Y., Xiao,S., Zhang,Q., Chen,F., Luo,B., Fu,J. and Xie,X.
  TITLE     [Preparation and application of melanoma-associated antigen D4
            polyclonal antibody]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33 (1), 104-108 (2017)
   PUBMED   28031124
  REMARK    GeneRIF: The MAGE-D4 polyclonal antibody with high specificity and
            sensitivity has been successfully prepared.
REFERENCE   4  (bases 1 to 2537)
  AUTHORS   Oya,H., Kanda,M., Koike,M., Iwata,N., Niwa,Y., Shimizu,D.,
            Takami,H., Sueoka,S., Hashimoto,R., Ezaka,K., Nomoto,S., Yamada,S.,
            Fujii,T., Nakayama,G., Sugimoto,H., Fujiwara,M. and Kodera,Y.
  TITLE     Detection of serum melanoma-associated antigen D4 in patients with
            squamous cell carcinoma of the esophagus
  JOURNAL   Dis Esophagus 29 (6), 663-669 (2016)
   PUBMED   25951896
  REMARK    GeneRIF: Preoperative serum MAGED4 was significantly higher in
            esophageal squamous cell carcinoma patients than in controls.
REFERENCE   5  (bases 1 to 2537)
  AUTHORS   Oya,H., Kanda,M., Takami,H., Hibino,S., Shimizu,D., Niwa,Y.,
            Koike,M., Nomoto,S., Yamada,S., Nishikawa,Y., Asai,M., Fujii,T.,
            Nakayama,G., Sugimoto,H., Fujiwara,M. and Kodera,Y.
  TITLE     Overexpression of melanoma-associated antigen D4 is an independent
            prognostic factor in squamous cell carcinoma of the esophagus
  JOURNAL   Dis Esophagus 28 (2), 188-195 (2015)
   PUBMED   24147998
  REMARK    GeneRIF: Results suggest that MAGE-D4 overexpression influences
            tumor progression, and MADE-D4 can be a prognostic marker and a
            potential molecular target in squamous cell esophageal cancer.
REFERENCE   6  (bases 1 to 2537)
  AUTHORS   Zhang,Q.M., He,S.J., Shen,N., Luo,B., Fan,R., Fu,J., Luo,G.R.,
            Zhou,S.F., Xiao,S.W. and Xie,X.X.
  TITLE     Overexpression of MAGE-D4 in colorectal cancer is a potentially
            prognostic biomarker and immunotherapy target
  JOURNAL   Int J Clin Exp Pathol 7 (7), 3918-3927 (2014)
   PUBMED   25120768
  REMARK    GeneRIF: These findings suggest MAGE-D4 may serve as a potentially
            prognostic biomarker and an attractive target of immunotherapy in
            colorectal cancer
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2537)
  AUTHORS   Zhang,Q.M., Shen,N., Xie,S., Bi,S.Q., Luo,B., Lin,Y.D., Fu,J.,
            Zhou,S.F., Luo,G.R., Xie,X.X. and Xiao,S.W.
  TITLE     MAGED4 expression in glioma and upregulation in glioma cell lines
            with 5-aza-2'-deoxycytidine treatment
  JOURNAL   Asian Pac J Cancer Prev 15 (8), 3495-3501 (2014)
   PUBMED   24870746
  REMARK    GeneRIF: MAGED4 (mRNA and protein) is frequently and highly
            expressed in glioma and is partly regulated by DNA methylation.
REFERENCE   8  (bases 1 to 2537)
  AUTHORS   Ito,S., Kawano,Y., Katakura,H., Takenaka,K., Adachi,M., Sasaki,M.,
            Shimizu,K., Ikenaka,K., Wada,H. and Tanaka,F.
  TITLE     Expression of MAGE-D4, a novel MAGE family antigen, is correlated
            with tumor-cell proliferation of non-small cell lung cancer
  JOURNAL   Lung Cancer 51 (1), 79-88 (2006)
   PUBMED   16225959
REFERENCE   9  (bases 1 to 2537)
  AUTHORS   Kawano,Y., Sasaki,M., Nakahira,K., Yoshimine,T., Shimizu,K.,
            Wada,H. and Ikenaka,K.
  TITLE     Structural characterization and chromosomal localization of the
            MAGE-E1 gene
  JOURNAL   Gene 277 (1-2), 129-137 (2001)
   PUBMED   11602350
REFERENCE   10 (bases 1 to 2537)
  AUTHORS   Sasaki,M., Nakahira,K., Kawano,Y., Katakura,H., Yoshimine,T.,
            Shimizu,K., Kim,S.U. and Ikenaka,K.
  TITLE     MAGE-E1, a new member of the melanoma-associated antigen gene
            family and its expression in human glioma
  JOURNAL   Cancer Res 61 (12), 4809-4814 (2001)
   PUBMED   11406556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK289458.1 and BC063838.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001272063.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an alternate exon in the coding region, compared to variant
            4. It encodes isoform 1, which is shorter than isoform 3. Variants
            1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.135415.1,
                                           SRR7410570.689571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471932.6/ ENSP00000507908.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1049              AK289458.1         1-1049
            1050-2537           BC063838.1         997-2484
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..2537
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /note="MAGE family member D4"
                     /db_xref="GeneID:728239"
                     /db_xref="HGNC:HGNC:23793"
                     /db_xref="MIM:300702"
     exon            1..78
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..319
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2335
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanoma-associated antigen D4; MAGE-D4 antigen; MAGE-E1
                     antigen; melanoma antigen family D, 4; melanoma antigen
                     family D4"
                     /codon_start=1
                     /product="melanoma-associated antigen D4 isoform 1"
                     /protein_id="NP_001258992.1"
                     /db_xref="CCDS:CCDS94608.1"
                     /db_xref="GeneID:728239"
                     /db_xref="HGNC:HGNC:23793"
                     /db_xref="MIM:300702"
                     /translation="MAEGSFSVQSESYSVEDMDEGSDEVGEEEMVEGNDYEEFGAFGG
                     YGTLTSFDIHILRAFGSLGPGLRILSNEPWELENPVLAQTLVEALQLDPETLANETAA
                     RAANVARAAASNRAARAAAAAARTAFSQVVASHRVATPQVSGEDTQPTTYAAEAQGPT
                     PEPPLASPQTSQMLVTSKMAAPEAPATSAQSQTGSPAQEAATEGPSSACAFSQAPCAR
                     EVDANRPSTAFLGQNDVFDFTQPAGVSGMAFPRPKRPAPAQEAATEGPSAASGVPQTG
                     PGREVAATRPKTTKSGKALAKTRWVEPQNVVAAAAAKAKMATSIPEPEGAAAATAQHS
                     AEPWARMGGKRTKKSKHLDDEYESSEEERETPAVPPTWRASQPSLTVRAQLAPRPPMA
                     PRSQIPSRHVLCLPPRNVTLLQERANKLVKYLMIKDYKKIPIKRADMLKDVIREYDEH
                     FPEIIERATYTLEKKFGIHLKEIDKEEHLYILVCTRDSSARLLGKTKDTPRLSLLLVI
                     LGVIFMNGNRASEAVLWEALRKMGLRPGVRHPFLGDLRKLITDDFVKQKYLEYKKIPN
                     SNPPEYEFLWGLRARHETSKMRVLRFIAQNQNRDPREWKAHFLEAVDDAFKTMDVDMA
                     EEHARAQMRAQMNIGDEALIGRWSWDDIQVELLTWDEDGDFGDAWARIPFAFWARYHQ
                     YILNSNRANRRATWRAGVSSGTNGGASTSVLDGPSTSSTIRTRNAARAGASFFSWIQH
                     R"
     exon            320..1153
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1357
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1421
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1501
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1593
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1673
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1716
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1779
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1894
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2325
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2537
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2519..2524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /note="hexamer: ATTAAA"
     polyA_site      2537
                     /gene="MAGED4"
                     /gene_synonym="MAGE-D4; MAGE-E1; MAGE1; MAGEE1"
                     /note="major polyA site"
ORIGIN      
        1 gtgctggcag cagtaggcga gggcgcggct gcggggttcc tggtgctgag gacggacgcc
       61 attggagttc ccgagaaggc tgagctctca tctccctggg acccgcagca tggctgaggg
      121 aagcttcagc gtgcaatcgg aaagctacag tgttgaagac atggatgagg gtagcgacga
      181 agtcggggag gaagagatgg ttgaaggcaa cgactatgaa gaattcggtg cgtttggtgg
      241 ctatggcacc ctcaccagct ttgacatcca tatcctcaga gccttcggaa gcttgggtcc
      301 aggccttcgc atcttatcga atgagccctg ggaactggaa aaccctgtgc tggcccagac
      361 cctggtggag gcattgcagc tggatccgga aacacttgcc aatgagacgg ccgcccgtgc
      421 tgccaacgta gcccgcgccg ccgcctccaa ccgtgcggct cgggccgctg ccgccgctgc
      481 ccgtaccgcc ttcagtcagg tggtcgctag ccaccgggtg gccacgccgc aggtctcagg
      541 agaggatacc cagcccacga cctacgccgc cgaggctcag gggcccaccc ctgagccacc
      601 ccttgcttct ccgcagacct cccagatgtt agtcaccagt aagatggctg cccccgaggc
      661 tccggcaacc tccgcacagt cccagacagg ctccccggcc caggaggctg ctactgaggg
      721 ccctagtagc gcctgtgctt tctctcaggc tccgtgtgcc agggaggtgg acgccaaccg
      781 gcccagcaca gccttcctgg gccagaatga tgtcttcgat ttcactcagc cggcaggtgt
      841 cagtggcatg gccttcccgc gccccaagag acctgcccca gcccaagagg ctgccacaga
      901 gggccccagt gctgcctctg gtgtgcccca gacgggacct ggcagggagg tggcagccac
      961 ccggcccaag accaccaagt cggggaaggc gctggccaag actcggtggg tggagcctca
     1021 gaatgttgtg gcagcagctg ctgccaaggc caagatggcc acgagcatcc ctgagccgga
     1081 gggtgcagct gctgccactg ctcagcacag tgctgagccc tgggccagga tgggaggcaa
     1141 gaggaccaag aagtccaagc acctggatga tgagtatgag agcagcgagg aggagagaga
     1201 gactcccgcg gtcccaccca cctggagagc atcacagccc tcattgacgg tgcgggctca
     1261 gttggcccct cggcccccga tggccccgag gtcccagata ccctcaaggc acgtactgtg
     1321 cctgcccccc cgcaacgtga cccttctgca ggagagggca aataagttgg tgaaatacct
     1381 gatgattaag gactacaaga agatccccat caagcgcgca gacatgctga aggatgtcat
     1441 cagagaatat gatgaacatt tccctgagat cattgaacga gcaacgtaca ccctggaaaa
     1501 gaagtttggg atccacctga aggagatcga caaggaagaa cacctgtata ttcttgtctg
     1561 cacacgggac tcctcagctc gcctccttgg aaaaaccaag gacactccca ggctgagtct
     1621 cctcttggtg attctgggcg tcatcttcat gaatggcaac cgtgccagcg aggctgtcct
     1681 ctgggaggca ctacgcaaga tgggactgcg ccctggggtg aggcacccat tcctcggcga
     1741 tctgaggaag ctcatcacag atgactttgt gaagcagaag tacctggaat acaagaagat
     1801 ccccaacagc aacccacctg agtatgaatt cctctggggc ctgcgagccc gccatgagac
     1861 cagcaagatg agggtcctga gattcatcgc ccagaatcag aaccgagacc cccgggaatg
     1921 gaaggctcat ttcttggagg ctgtggatga tgctttcaag acaatggatg tggatatggc
     1981 cgaggaacat gccagggccc agatgagggc ccagatgaat atcggggatg aagcgctgat
     2041 tggacggtgg agctgggatg acatacaagt cgagctcctg acctgggatg aggacggaga
     2101 ttttggcgat gcctgggcca ggatcccctt tgctttctgg gccagatacc atcagtacat
     2161 tctgaatagc aaccgtgcca acaggagggc cacgtggaga gctggcgtca gcagtggcac
     2221 caatggaggg gccagcacca gcgtcctaga tggccccagc accagctcca ccatccggac
     2281 cagaaatgct gccagagctg gcgccagctt cttctcctgg atccagcacc gttgacgaac
     2341 tgcagcgatc ttactggcca agccagagcg cctcctctca gattccttct cgacacagca
     2401 ccctaggcgg cttcttcctg tcagtcggag gtggcatgca agatgaagct ctctttgctc
     2461 ttcctgcttt cattttgtgc ttttccttgt gttttcatgt tttgggtatc agtgttacat
     2521 taaagttgca aaattaa
//
