LOCUS       NM_138702               1932 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens MAGE family member C3 (MAGEC3), transcript variant 1,
            mRNA.
ACCESSION   NM_138702
VERSION     NM_138702.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Markovics,A., Toth,K.F., Sos,K.E., Magi,J., Gyongyosi,A., Benyo,Z.,
            Zouboulis,C.C., Biro,T. and Olah,A.
  TITLE     Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes
            via activating hydroxycarboxylic acid receptor 2 (HCA2)
  JOURNAL   J Cell Mol Med 23 (9), 6203-6214 (2019)
   PUBMED   31273921
  REMARK    GeneRIF: Nicotinic acid suppresses sebaceous lipogenesis of human
            sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 ).
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Ivonnet,P., Unwalla,H., Salathe,M. and Conner,G.E.
  TITLE     Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes
            in epithelial barrier function
  JOURNAL   Respir Res 17, 15 (2016)
   PUBMED   26857816
  REMARK    GeneRIF: The data support an important role for prostaglandin
            activation of sAC and PKA in H2O2-induced barrier disruption.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Lucas,S., De Plaen,E. and Boon,T.
  TITLE     MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the
            MAGE family with tumor-specific expression
  JOURNAL   Int J Cancer 87 (1), 55-60 (2000)
   PUBMED   10861452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF490508.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is a member of the MAGEC gene family. The
            members of this family are not expressed in normal tissues, except
            for testis, and are expressed in tumors of various histological
            types. The MAGEC genes are clustered on chromosome Xq26-q27. Two
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF490508.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298296.1/ ENSP00000298296.1
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.2"
     gene            1..1932
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /note="MAGE family member C3"
                     /db_xref="GeneID:139081"
                     /db_xref="HGNC:HGNC:23798"
                     /db_xref="MIM:300469"
     CDS             1..1932
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen family 7, member 2;
                     melanoma-associated antigen C3; hepatocellular
                     carcinoma-associated protein HCA2; MAGE family testis and
                     tumor-specific protein; MAGE-C3 antigen; cancer/testis
                     antigen 7.2; hepatocellular carcinoma-associated antigen
                     2; melanoma antigen family C, 3; melanoma antigen family
                     C3"
                     /codon_start=1
                     /product="melanoma-associated antigen C3 isoform 1"
                     /protein_id="NP_619647.1"
                     /db_xref="CCDS:CCDS14676.1"
                     /db_xref="GeneID:139081"
                     /db_xref="HGNC:HGNC:23798"
                     /db_xref="MIM:300469"
                     /translation="MLLPCHWVLDATFSDGSLGQWVKNTCATYALSPVVLPPQPQPRK
                     KATDKDYSAFHLGHLREVRLFLRGGTSDQRMDSLVLCPTYFKLWRTLSGSPGLQLSDL
                     HFGSQPEGKFSLRRAVSVKQREEPQDWPLNEKRTLWKDSDLPTWRRGTGYTLSLPAVS
                     PGKRLWGEKAGSLPESEPLFTYTLDEKVDKLVQFLLLKYQAKEPLTRAEMQMNVINTY
                     TGYFPMIFRKAREFIEILFGISLTEVDPDHFYVFVNTLDLTCEGSLSDEQGMPQNRLL
                     ILILSVIFIKGNCASEEVIWEVLNAIGPWSALAGFADVLSRLALWESEGPEAFCEESG
                     LRSAEGSVLDLANPQGLAGHRQEDGRRGLTEASPQQKKGGEDEDMPAAGMPPLPQSPP
                     EIPPQGPPKISPQGPPQSPPQSPLDSCSSPLLWTRLDEESSSEEEDTATWHALPESES
                     LPRYALDEKVAELVQFLLLKYQTKEPVTKAEMLTTVIKKYKDYFPMIFGKAHEFIELI
                     FGIALTDMDPDNHSYFFEDTLDLTYEGSLIDDQGMPKNCLLILILSMIFIKGSCVPEE
                     VIWEVLSAIGPIQRPAREVLEFLSKLSSIIPSAFPSWYMDALKDMEDRAQAIIDTTDD
                     ATAMASASPSVMSTNFCPE"
     exon            1..123
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            124..258
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            259..515
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            516..909
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1048
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1123
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1728
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1932
                     /gene="MAGEC3"
                     /gene_synonym="CT7.2; HCA2; MAGE-C3; MAGEC4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgctgc cctgccactg ggtgttggat gccaccttca gtgatggcag tctaggccag
       61 tgggtgaaaa acacatgtgc cacatatgcc ttatccccag tggtgctccc acctcagccc
      121 cagccccgga aaaaggccac agataaggac tattctgcct ttcatcttgg gcatctgagg
      181 gaggtgaggc tttttctgag gggtggaact tcagatcagc gaatggatag tcttgtcctc
      241 tgccccacat acttcaagct ctggaggacc ctatcagggt ccccaggttt acaactttct
      301 gacttgcatt ttgggagtca gccggagggg aagttttctc tgaggagggc agtttcagtt
      361 aagcagaggg aggaacccca ggactggcca ctcaacgaga agagaactct gtggaaggac
      421 agtgaccttc caacatggag gagaggcaca ggctacaccc tttcccttcc tgccgtcagc
      481 cctggaaaaa ggttgtgggg ggagaaagcg gggagcttgc cagagagcga gcccttgttc
      541 acttatacac tggatgaaaa ggtggacaag ttggtgcagt ttcttctcct caaatatcaa
      601 gcaaaagagc ctctcacaag agcagagatg cagatgaatg tcatcaacac atacacgggc
      661 tactttccta tgatcttcag gaaagcccgt gagttcatag agattctttt tggcatttcc
      721 ctgacagaag tggaccccga ccatttctat gtctttgtaa acacattaga cctcacctgt
      781 gaggggagtc tgagtgatga gcagggcatg ccccagaacc gcctcctgat tcttattctg
      841 agtgtgatct tcataaaggg caactgtgca tctgaggagg tcatctggga agtgctgaat
      901 gcaatagggc cctggtcagc cttggcaggg ttcgcggatg tgctttcccg acttgcactg
      961 tgggagtctg aaggacctga agcattttgc gaggagtctg gactcaggtc agcagaggga
     1021 agcgtcttag acctggccaa tcctcaagga cttgcaggcc acagacagga agatggccgc
     1081 cgagggctga ccgaggcgtc cccacaacag aagaagggag gagaagatga ggatatgcct
     1141 gctgctggga tgccacctct tccccagagt cctcctgaga ttcctcccca gggtcctccc
     1201 aagatctctc cccagggtcc tccgcagagt cctccccaga gtcctctaga ctcctgctca
     1261 tcccctcttt tgtggacccg attggatgag gagtccagca gtgaagagga ggatacagct
     1321 acttggcatg ccttgccaga aagtgaatcc ttgcccaggt atgccctgga tgaaaaggtg
     1381 gctgagttgg tgcagtttct tctcctcaaa tatcaaacaa aagagcctgt cacaaaggca
     1441 gagatgctga cgactgtcat caagaagtat aaggactatt ttcccatgat cttcgggaaa
     1501 gcccatgagt tcatagagct aatttttggc attgccctga ctgatatgga ccccgacaac
     1561 cactcctatt tctttgaaga cacattagac ctcacctatg agggaagcct gattgatgac
     1621 cagggcatgc ccaagaactg tctcctgatt cttattctca gtatgatctt cataaagggc
     1681 agctgtgtcc ccgaggaggt catctgggaa gtgttgagtg caatagggcc cattcagagg
     1741 ccagcaagag aagtcttaga gtttttatcc aagctatcca gtatcatccc tagtgccttt
     1801 ccatcctggt acatggatgc tttgaaagat atggaagaca gagcccaggc cataattgac
     1861 accacagatg atgctactgc catggccagt gcaagcccca gtgtcatgtc caccaacttc
     1921 tgtcctgagt ga
//
