LOCUS       NM_016249               1994 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MAGE family member C2 (MAGEC2), mRNA.
ACCESSION   NM_016249 XM_003403863
VERSION     NM_016249.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Beasley,H.K., Widatalla,S.E., Whalen,D.S., Williams,S.D.,
            Korolkova,O.Y., Namba,C., Pratap,S., Ochieng,J. and Sakwe,A.M.
  TITLE     Identification of MAGEC2/CT10 as a High Calcium-Inducible Gene in
            Triple-Negative Breast Cancer
  JOURNAL   Front Endocrinol (Lausanne) 13, 816598 (2022)
   PUBMED   35355564
  REMARK    GeneRIF: Identification of MAGEC2/CT10 as a High Calcium-Inducible
            Gene in Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Pascucci,F.A., Ladelfa,M.F., Toledo,M.F., Escalada,M.,
            Suberbordes,M. and Monte,M.
  TITLE     MageC2 protein is upregulated by oncogenic activation of MAPK
            pathway and causes impairment of the p53 transactivation function
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (3), 118918 (2021)
   PUBMED   33279609
  REMARK    GeneRIF: MageC2 protein is upregulated by oncogenic activation of
            MAPK pathway and causes impairment of the p53 transactivation
            function.
            Erratum:[Biochim Biophys Acta Mol Cell Res. 2024
            Aug;1871(6):119767. doi: 10.1016/j.bbamcr.2024.119767.. PMID:
            38833988]
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Hodgson,A., Jungbluth,A.A., Katabi,N., Xu,B. and Downes,M.R.
  TITLE     Evaluation of cancer testis antigen (CT10, PRAME) and MHC I
            expression in high-grade urothelial carcinoma of the bladder
  JOURNAL   Virchows Arch 476 (4), 535-542 (2020)
   PUBMED   31485721
  REMARK    GeneRIF: CT10 and PRAME are expressed in a subset of HGUC and CTA
            and MHC I expression correlate with a number of important immune
            parameters
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J Immunol 169 (2), 1102-1109 (2002)
   PUBMED   12097419
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Kawano,Y., Sasaki,M., Nakahira,K., Yoshimine,T., Shimizu,K.,
            Wada,H. and Ikenaka,K.
  TITLE     Structural characterization and chromosomal localization of the
            MAGE-E1 gene
  JOURNAL   Gene 277 (1-2), 129-137 (2001)
   PUBMED   11602350
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Sasaki,M., Nakahira,K., Kawano,Y., Katakura,H., Yoshimine,T.,
            Shimizu,K., Kim,S.U. and Ikenaka,K.
  TITLE     MAGE-E1, a new member of the melanoma-associated antigen gene
            family and its expression in human glioma
  JOURNAL   Cancer Res 61 (12), 4809-4814 (2001)
   PUBMED   11406556
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Lucas,S., De Plaen,E. and Boon,T.
  TITLE     MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the
            MAGE family with tumor-specific expression
  JOURNAL   Int J Cancer 87 (1), 55-60 (2000)
   PUBMED   10861452
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Gure,A.O., Stockert,E., Arden,K.C., Boyer,A.D., Viars,C.S.,
            Scanlan,M.J., Old,L.J. and Chen,Y.T.
  TITLE     CT10: a new cancer-testis (CT) antigen homologous to CT7 and the
            MAGE family, identified by representational-difference analysis
  JOURNAL   Int J Cancer 85 (5), 726-732 (2000)
   PUBMED   10699956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013318.1, AF116194.1,
            BC005891.2, BP370466.1 and BM548987.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016249.3.
            
            Summary: This gene is a member of the MAGEC gene family. It is not
            expressed in normal tissues, except for testis, and is expressed in
            tumors of various histological types. This gene and the other MAGEC
            genes are clustered on chromosome Xq26-q27. [provided by RefSeq,
            Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP283302.1, BC013318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247452.4/ ENSP00000354660.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BC013318.1         5-41
            38-913              AF116194.1         21-896
            914-1256            BC005891.2         645-987
            1257-1268           BP370466.1         521-532
            1269-1991           BC013318.1         1273-1995
            1992-1994           BM548987.1         448-450
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.2"
     gene            1..1994
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /note="MAGE family member C2"
                     /db_xref="GeneID:51438"
                     /db_xref="HGNC:HGNC:13574"
                     /db_xref="MIM:300468"
     exon            1..188
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..282
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..1994
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1470
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /note="melanoma antigen, family E, 1, cancer/testis
                     specific; cancer/testis antigen 10; hepatocellular cancer
                     antigen 587; MAGE-C2 antigen; melanoma antigen family C,
                     2; MAGE-E1 antigen; hepatocellular carcinoma-associated
                     antigen 587; melanoma antigen family C2"
                     /codon_start=1
                     /product="melanoma-associated antigen C2"
                     /protein_id="NP_057333.1"
                     /db_xref="CCDS:CCDS14678.1"
                     /db_xref="GeneID:51438"
                     /db_xref="HGNC:HGNC:13574"
                     /db_xref="MIM:300468"
                     /translation="MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASS
                     TLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSS
                     CCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEE
                     PVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEG
                     SDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTK
                     VWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYK
                     DALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /note="hexamer: AATAAA"
     polyA_site      1994
                     /gene="MAGEC2"
                     /gene_synonym="CT10; HCA587; MAGEE1"
                     /note="major polyA site"
ORIGIN      
        1 gctttcccga cggccatctt gggaatctga cggatcgaag gcatttgtga ggaggcgcga
       61 atcaagttag cggggggaag agtcttagac ctggccagtc ctcagggtga gggccctgag
      121 gaagaactga gggacctccc accatagaga gaagaaaccc cggcctgtac tgcgctgccg
      181 tgagactggt gctccaggaa ccaggtggtg acgaactggg tgtgaggcac acagcctaaa
      241 gtcagcacag cagaggaggc ccaggcagtg ccaggagtca aggcctgttg gatctcatca
      301 tccatatccc tgttgatacg tttacctgct gctcctgaag aagtcgtcat gcctcccgtt
      361 ccaggcgttc cattccgcaa cgttgacaac gactccccga cctcagttga gttagaagac
      421 tgggtagatg cacagcatcc cacagatgag gaagaggagg aagcctcctc cgcctcttcc
      481 actttgtact tagtattttc cccctcttct ttctccacat cctcttctct gattcttggt
      541 ggtcctgagg aggaggaggt gccctctggt gtgataccaa atcttaccga gagcattccc
      601 agtagtcctc cacagggtcc tccacagggt ccttcccaga gtcctctgag ctcctgctgc
      661 tcctcttttt catggagctc attcagtgag gagtccagca gccagaaagg ggaggataca
      721 ggcacctgtc agggcctgcc agacagtgag tcctctttca catatacact agatgaaaag
      781 gtggccgagt tagtggagtt cctgctcctc aaatacgaag cagaggagcc tgtaacagag
      841 gcagagatgc tgatgattgt catcaagtac aaagattact ttcctgtgat actcaagaga
      901 gcccgtgagt tcatggagct tctttttggc cttgccctga tagaagtggg ccctgaccac
      961 ttctgtgtgt ttgcaaacac agtaggcctc accgatgagg gtagtgatga tgagggcatg
     1021 cccgagaaca gcctcctgat tattattctg agtgtgatct tcataaaggg caactgtgcc
     1081 tctgaggagg tcatctggga agtgctgaat gcagtagggg tatatgctgg gagggagcac
     1141 ttcgtctatg gggagcctag ggagctcctc actaaagttt gggtgcaggg acattacctg
     1201 gagtatcggg aggtgcccca cagttctcct ccatattatg aattcctgtg gggtccgaga
     1261 gcccattcag aaagcatcaa gaagaaagta ctagagtttt tagccaagct gaacaacact
     1321 gttcctagtt cctttccatc ctggtacaag gatgctttga aagatgtgga agagagagtc
     1381 caggccacaa ttgataccgc agatgatgcc actgtcatgg ccagtgaaag cctcagtgtc
     1441 atgtccagca acgtctcctt ttctgagtga agtctaggat agtttcttcc ccttgtgttt
     1501 gaacagggca gtttaggttc taggtagtgg agggccaggt ggggctcgag gaacgtagtg
     1561 ttctttgcat ttctgtccca tatgggtgat gtagagattt acctgttttt cagtattttc
     1621 taaatgcttt tcctttgaat agcaggtagt tagcttcaga gtgttaattt atgaatatta
     1681 gtcgcacatg tattgctctt tatctggttt aagagtaaca gtttgatatt ttgttaaaaa
     1741 aatggaaata ccttctccct tattttgtga tctgtaacag ggtagtgtgg tattgtaata
     1801 ggcatttttt ttttttttta caatgtgcaa taactcagca gttaaatagt ggaacaaaat
     1861 tgaagggtgg tcagtagttt catttccttg tcctgcttat tcttttgttc ttgaaaatta
     1921 tatatacctg gctttgctta gcttgttgaa gaaagtagca gaaattaaat cttaataaaa
     1981 gaaagcccca ctga
//
