LOCUS       NM_005462               4256 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens MAGE family member C1 (MAGEC1), mRNA.
ACCESSION   NM_005462 XM_936930
VERSION     NM_005462.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4256)
  AUTHORS   Lin,X., Huo,J., Su,H., Xu,Y. and Zhang,F.
  TITLE     The Association of Melanoma-Associated Antigen-C Gene With
            Clinicopathological Characteristics and Prognosis in Breast Cancer:
            A Systematic Review and Meta-Analysis
  JOURNAL   Clin Breast Cancer 24 (1), 7-16 (2024)
   PUBMED   37872029
  REMARK    GeneRIF: The Association of Melanoma-Associated Antigen-C Gene With
            Clinicopathological Characteristics and Prognosis in Breast Cancer:
            A Systematic Review and Meta-Analysis.
            Review article
REFERENCE   2  (bases 1 to 4256)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   3  (bases 1 to 4256)
  AUTHORS   Xu,P., Zhang,L., Wang,X., Zhou,D., Ouyang,J. and Chen,B.
  TITLE     Expression of MAGE-C1/CT7 provides prognostic information in
            multiple myeloma
  JOURNAL   Leuk Lymphoma 58 (1), 244-246 (2017)
   PUBMED   27248683
  REMARK    GeneRIF: Results suggest that melanoma antigen, family C, 1 protein
            (MAGE-C1/CT7) expression is associated with inferior outcome of
            patients with multiple myeloma (MM) from a Chinese population.
REFERENCE   4  (bases 1 to 4256)
  AUTHORS   Hilal,N.R., Novikov,D.V., Novikov,V.V. and Karaulov,A.V.
  TITLE     [Cancer-testis genes in colon cancer]
  JOURNAL   Ter Arkh 89 (5), 113-117 (2017)
   PUBMED   28631709
  REMARK    GeneRIF: In patients with Colon cancer, the expression of MAGE-C1
            gene was related to a favorable prognosis.
            Review article
REFERENCE   5  (bases 1 to 4256)
  AUTHORS   Hou,S., Sang,M., Zhao,L., Hou,R. and Shan,B.
  TITLE     The expression of MAGE-C1 and MAGE-C2 in breast cancer and their
            clinical significance
  JOURNAL   Am J Surg 211 (1), 142-151 (2016)
   PUBMED   26321295
  REMARK    GeneRIF: MAGE-C1 and MAGE-C2 expressions were positively associated
            with high tumor grade and reduced recurrence-free survival in
            breast cancer.
REFERENCE   6  (bases 1 to 4256)
  AUTHORS   Cho,H.J., Caballero,O.L., Gnjatic,S., Andrade,V.C., Colleoni,G.W.,
            Vettore,A.L., Outtz,H.H., Fortunato,S., Altorki,N., Ferrera,C.A.,
            Chua,R., Jungbluth,A.A., Chen,Y.T., Old,L.J. and Simpson,A.J.
  TITLE     Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7)
            and NY-ESO-1 (CT6)
  JOURNAL   Cancer Immun 6, 12 (2006)
   PUBMED   17137291
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4256)
  AUTHORS   Jungbluth,A.A., Chen,Y.T., Busam,K.J., Coplan,K., Kolb,D.,
            Iversen,K., Williamson,B., Van Landeghem,F.K., Stockert,E. and
            Old,L.J.
  TITLE     CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues
  JOURNAL   Int J Cancer 99 (6), 839-845 (2002)
   PUBMED   12115486
  REMARK    GeneRIF: Overexpression of MAGE-C1 is associated with mammary gland
            and ovary, non small cell lung carcinoma and metastatic melanoma
REFERENCE   8  (bases 1 to 4256)
  AUTHORS   Lim,S.H., Bumm,K., Chiriva-Internati,M., Xue,Y. and Wang,Z.
  TITLE     MAGE-C1 (CT7) gene expression in multiple myeloma: relationship to
            sperm protein 17
  JOURNAL   Eur J Haematol 67 (5-6), 332-334 (2001)
   PUBMED   11872084
  REMARK    GeneRIF: MAGE-C1 is cancer-testis antigen suitable for immune
            targeting in multiple myeloma.
            Erratum:[Eur J Haematol. 2005 Mar;74(3):275. Chiriva-Intemati, M
            [corrected to Chiriva-Internati, M]]
REFERENCE   9  (bases 1 to 4256)
  AUTHORS   Chen,Y.T., Gure,A.O., Tsang,S., Stockert,E., Jager,E., Knuth,A. and
            Old,L.J.
  TITLE     Identification of multiple cancer/testis antigens by allogeneic
            antibody screening of a melanoma cell line library
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6919-6923 (1998)
   PUBMED   9618514
REFERENCE   10 (bases 1 to 4256)
  AUTHORS   Lucas,S., De Smet,C., Arden,K.C., Viars,C.S., Lethe,B., Lurquin,C.
            and Boon,T.
  TITLE     Identification of a new MAGE gene with tumor-specific expression by
            representational difference analysis
  JOURNAL   Cancer Res 58 (4), 743-752 (1998)
   PUBMED   9485030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF056334.1, AL022152.1 and
            BQ772869.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005462.4.
            
            Summary: This gene is a member of the melanoma antigen gene (MAGE)
            family. The proteins of this family are tumor-specific antigens
            that can be recognized by autologous cytolytic T lymphocytes. This
            protein contains a large number of unique short repetitive
            sequences in front of the MAGE-homologous sequence, and therefore
            is about 800 aa longer than the other MAGE proteins. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF056334.1, DB099371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285879.5/ ENSP00000285879.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-737               AF056334.1         1-737
            738-1417            AL022152.1         12964-13643
            1418-4228           AF056334.1         1418-4228
            4229-4256           BQ772869.1         44-71               c
FEATURES             Location/Qualifiers
     source          1..4256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.2"
     gene            1..4256
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="MAGE family member C1"
                     /db_xref="GeneID:9947"
                     /db_xref="HGNC:HGNC:6812"
                     /db_xref="MIM:300223"
     exon            1..85
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..183
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..290
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..3715
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="cancer/testis antigen family 7, member 1;
                     cancer/testis antigen 7.1; MAGE-C1 antigen; melanoma
                     antigen family C, 1; melanoma antigen family C1"
                     /codon_start=1
                     /product="melanoma-associated antigen C1"
                     /protein_id="NP_005453.2"
                     /db_xref="CCDS:CCDS35417.1"
                     /db_xref="GeneID:9947"
                     /db_xref="HGNC:HGNC:6812"
                     /db_xref="MIM:300223"
                     /translation="MGDKDMPTAGMPSLLQSSSESPQSCPEGEDSQSPLQIPQSSPES
                     DDTLYPLQSPQSRSEGEDSSDPLQRPPEGKDSQSPLQIPQSSPEGDDTQSPLQNSQSS
                     PEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESTQSPFEGFPQ
                     SVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIPVSRSFSSTLLSIFQSSP
                     ERTQSTFEGFAQSPLQIPVSPSSSSTLLSLFQSFSERTQSTFEGFAQSSLQIPVSPSF
                     SSTLVSLFQSSPERTQSTFEGFPQSPLQIPVSSSSSSTLLSLFQSSPERTHSTFEGFP
                     QSLLQIPMTSSFSSTLLSIFQSSPESAQSTFEGFPQSPLQIPGSPSFSSTLLSLFQSS
                     PERTHSTFEGFPQSPLQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSS
                     FSYTLLSLFQSSPERTHSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEG
                     FPQSPLQIPQSPPEGENTHSPLQIVPSLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQ
                     SPPQGEDSLSPHYFPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQSPLQGEEFQSS
                     LQSPVSICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHSQSPLQSPESA
                     PEGEDSLSPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSL
                     QSPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESP
                     QSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPVI
                     SFSSSTSLSPFSEESSSPVDEYTSSSDTLLESDSLTDSESLIESEPLFTYTLDEKVDE
                     LARFLLLKYQVKQPITKAEMLTNVISRYTGYFPVIFRKAREFIEILFGISLREVDPDD
                     SYVFVNTLDLTSEGCLSDEQGMSQNRLLILILSIIFIKGTYASEEVIWDVLSGIGVRA
                     GREHFAFGEPRELLTKVWVQEHYLEYREVPNSSPPRYEFLWGPRAHSEVIKRKVVEFL
                     AMLKNTVPITFPSSYKDALKDVEERAQAIIDTTDDSTATESASSSVMSPSFSSE"
     exon            291..4256
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4123..4128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="hexamer: AATAAA"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="hexamer: AGTAAA"
     polyA_site      4143
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="major polyA site"
     polyA_site      4159
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
     regulatory      4250..4255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
                     /note="hexamer: AATAAA"
     polyA_site      4256
                     /gene="MAGEC1"
                     /gene_synonym="CT7; CT7.1"
ORIGIN      
        1 gtctgaagga cctgaggcat tttgtgacga ggatcgtctc aggtcagcgg agggaggaga
       61 cttatagacc tatccagtct tcaaggtgct ccagaaagca ggagttgaag acctgggtgt
      121 gagggacaca tacatcctaa aagcaccaca gcagaggagg cccaggcagt gccaggagtc
      181 aaggttccca gaagacaaac cccctaggaa gacaggcgac ctgtgaggcc ctagagcacc
      241 accttaagag aagaagagct gtaagccggc ctttgtcaga gccatcatgg gggacaagga
      301 tatgcctact gctgggatgc cgagtcttct ccagagttcc tctgagagtc ctcagagttg
      361 tcctgagggg gaggactccc agtctcctct ccagattccc cagagttctc ctgagagcga
      421 cgacaccctg tatcctctcc agagtcctca gagtcgttct gagggggagg actcctcgga
      481 tcctctccag agacctcctg aggggaagga ctcccagtct cctctccaga ttccccagag
      541 ttctcctgag ggcgacgaca cccagtctcc tctccagaat tctcagagtt ctcctgaggg
      601 gaaggactcc ctgtctcctc tagagatttc tcagagccct cctgagggtg aggatgtcca
      661 gtctcctctg cagaatcctg cgagttcctt cttctcctct gctttattga gtattttcca
      721 gagttcccct gagagtactc aaagtccttt tgagggtttt ccccagtctg ttctccagat
      781 tcctgtgagc gccgcctcct cctccacttt agtgagtatt ttccagagtt cccctgagag
      841 tactcaaagt ccttttgagg gttttcccca gtctccactc cagattcctg tgagccgctc
      901 cttctcctcc actttattga gtattttcca gagttcccct gagagaactc agagtacttt
      961 tgagggtttt gcccagtctc ctctccagat tcctgtgagc ccctcctcct cctccacttt
     1021 actgagtctt ttccagagtt tctctgagag aactcagagt acttttgagg gttttgccca
     1081 gtcttctctc cagattcctg tgagcccctc cttctcctcc actttagtga gtcttttcca
     1141 gagttcccct gagagaactc agagtacttt tgagggtttt ccccagtctc ctctccagat
     1201 tcctgtgagc tcctcctcct cctccacttt attgagtctt ttccagagtt cccctgagag
     1261 aactcacagt acttttgagg gttttcccca gtctcttctc cagattccta tgacctcctc
     1321 cttctcctct actttattga gtattttcca gagttctcct gagagtgctc aaagtacttt
     1381 tgagggtttt ccccagtctc ctctccagat tcctgggagc ccctccttct cctccacttt
     1441 actgagtctt ttccagagtt cccctgagag aactcacagt acttttgagg gttttcccca
     1501 gtctcctctc cagattccta tgacctcctc cttctcctct actttattga gtattttaca
     1561 gagttctcct gagagtgctc aaagtgcttt tgagggtttt ccccagtctc ctctccagat
     1621 tcctgtgagc tcctctttct cctacacttt attgagtctt ttccagagtt cccctgagag
     1681 aactcacagt acttttgagg gttttcccca gtctcctctc cagattcctg tgagctcctc
     1741 ctcctcctcc tccactttat tgagtctttt ccagagttcc cctgagtgta ctcaaagtac
     1801 ttttgagggt tttccccagt ctcctctcca gattcctcag agtcctcctg aaggggagaa
     1861 tacccattct cctctccaga ttgttccaag tcttcctgag tgggaggact ccctgtctcc
     1921 tcactacttt cctcagagcc ctcctcaggg ggaggactcc ctatctcctc actactttcc
     1981 tcagagccct cctcaggggg aggactccct gtctcctcac tactttcctc agagccctca
     2041 gggggaggac tccctgtctc ctcactactt tcctcagagc cctcctcagg gggaggactc
     2101 catgtctcct ctctactttc ctcagagtcc tcttcagggg gaggaattcc agtcttctct
     2161 ccagagccct gtgagcatct gctcctcctc cactccatcc agtcttcccc agagtttccc
     2221 tgagagttct cagagtcctc ctgaggggcc tgtccagtct cctctccata gtcctcagag
     2281 ccctcctgag gggatgcact cccaatctcc tctccagagt cctgagagtg ctcctgaggg
     2341 ggaggattcc ctgtctcctc tccaaattcc tcagagtcct cttgagggag aggactccct
     2401 gtcttctctc cattttcctc agagtcctcc tgagtgggag gactccctct ctcctctcca
     2461 ctttcctcag tttcctcctc agggggagga cttccagtct tctctccaga gtcctgtgag
     2521 tatctgctcc tcctccactt ctttgagtct tccccagagt ttccctgaga gtcctcagag
     2581 tcctcctgag gggcctgctc agtctcctct ccagagacct gtcagctcct tcttctccta
     2641 cactttagcg agtcttctcc aaagttccca tgagagtcct cagagtcctc ctgaggggcc
     2701 tgcccagtct cctctccaga gtcctgtgag ctccttcccc tcctccactt catcgagtct
     2761 ttcccagagt tctcctgtga gctccttccc ctcctccact tcatcgagtc tttccaagag
     2821 ttcccctgag agtcctctcc agagtcctgt gatctccttc tcctcctcca cttcattgag
     2881 cccattcagt gaagagtcca gcagcccagt agatgaatat acaagttcct cagacacctt
     2941 gctagagagt gattccttga cagacagcga gtccttgata gagagcgagc ccttgttcac
     3001 ttatacactg gatgaaaagg tggacgagtt ggcgcggttt cttctcctca aatatcaagt
     3061 gaagcagcct atcacaaagg cagagatgct gacgaatgtc atcagcaggt acacgggcta
     3121 ctttcctgtg atcttcagga aagcccgtga gttcatagag atactttttg gcatttccct
     3181 gagagaagtg gaccctgatg actcctatgt ctttgtaaac acattagacc tcacctctga
     3241 ggggtgtctg agtgatgagc agggcatgtc ccagaaccgc ctcctgattc ttattctgag
     3301 tatcatcttc ataaagggca cctatgcctc tgaggaggtc atctgggatg tgctgagtgg
     3361 aataggggtg cgtgctggga gggagcactt tgcctttggg gagcccaggg agctcctcac
     3421 taaagtttgg gtgcaggaac attacctaga gtaccgggag gtgcccaact cttctcctcc
     3481 tcgttacgaa ttcctgtggg gtccaagagc tcattcagaa gtcattaaga ggaaagtagt
     3541 agagtttttg gccatgctaa agaataccgt ccctattacc tttccatcct cttacaagga
     3601 tgctttgaaa gatgtggaag agagagccca ggccataatt gacaccacag atgattcgac
     3661 tgccacagaa agtgcaagct ccagtgtcat gtcccccagc ttctcttctg agtgaagtct
     3721 agggcagatt cttccctctg agtttgaagg gggcagtcga gtttctacgt ggtggagggc
     3781 ctggttgagg ctggagagaa cacagtgcta tttgcatttc tgttccatat gggtagttat
     3841 ggggtttacc tgttttactt ttgggtattt ttcaaatgct tttcctatta ataacaggtt
     3901 taaatagctt cagaatccta gtttatgcac atgagtcgca catgtattgc tgtttttctg
     3961 gtttaagagt aacagtttga tattttgtaa aaacaaaaac acacccaaac acaccacatt
     4021 gggaaaacct tctgcctcat tttgtgatgt gtcacaggtt aatgtggtgt tactgtagga
     4081 attttcttga aactgtgaag gaactctgca gttaaatagt ggaataaagt aaaggattgt
     4141 taatgtttgc atttcctcag gtcctttagt ctgttgttct tgaaaactaa agatacatac
     4201 ctggtttgct tggcttacgt aagaaagtag aagaaagtaa actgtaataa ataaaa
//
