LOCUS       NM_173523               1949 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens MAGE family member B6 (MAGEB6), mRNA.
ACCESSION   NM_173523
VERSION     NM_173523.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Lucas,S., De Plaen,E. and Boon,T.
  TITLE     MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the
            MAGE family with tumor-specific expression
  JOURNAL   Int J Cancer 87 (1), 55-60 (2000)
   PUBMED   10861452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005297.1.
            
            On Mar 28, 2003 this sequence version replaced NM_173523.1.
            
            Summary: This gene is a member of the MAGEB gene family. The
            members of this family have their entire coding sequences located
            in the last exon, and the encoded proteins show 50 to 68% sequence
            identity to each other. The promoters and first exons of the MAGEB
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. This gene is expressed in
            testis, and in a significant fraction of tumors of various
            histological types. The MAGEB genes are clustered on chromosome
            Xp22-p21. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097561.1, BC067286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379034.1/ ENSP00000368320.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC005297.1         148960-149047       c
            89-1949             AC005297.1         145841-147701       c
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.3"
     gene            1..1949
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /note="MAGE family member B6"
                     /db_xref="GeneID:158809"
                     /db_xref="HGNC:HGNC:23796"
                     /db_xref="MIM:300467"
     exon            1..88
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /inference="alignment:Splign:2.1.0"
     exon            89..1949
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1373
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /note="cancer/testis antigen family 3, member 4; MAGE-B6
                     antigen; cancer/testis antigen 3.4; melanoma antigen
                     family B, 6; melanoma antigen family B6"
                     /codon_start=1
                     /product="melanoma-associated antigen B6"
                     /protein_id="NP_775794.2"
                     /db_xref="CCDS:CCDS14217.1"
                     /db_xref="GeneID:158809"
                     /db_xref="HGNC:HGNC:23796"
                     /db_xref="MIM:300467"
                     /translation="MPRGHKSKLRTCEKRQETNGQPQGLTGPQATAEKQEESHSSSSS
                     SRACLGDCRRSSDASIPQESQGVSPTGSPDAVVSYSKSDVAANGQDEKSPSTSRDASV
                     PQESQGASPTGSPDAGVSGSKYDVAANGQDEKSPSTSHDVSVPQESQGASPTGSPDAG
                     VSGSKYDVAAEGEDEESVSASQKAIIFKRLSKDAVKKKACTLAQFLQKKFEKKESILK
                     ADMLKCVRREYKPYFPQILNRTSQHLVVAFGVELKEMDSSGESYTLVSKLGLPSEGIL
                     SGDNALPKSGLLMSLLVVIFMNGNCATEEEVWEFLGLLGIYDGILHSIYGDARKIITE
                     DLVQDKYVVYRQVCNSDPPCYEFLWGPRAYAETTKMRVLRVLADSSNTSPGLYPHLYE
                     DALIDEVERALRLRA"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /note="hexamer: AATAAA"
     polyA_site      1949
                     /gene="MAGEB6"
                     /gene_synonym="CT3.4; MAGE-B6; MAGEB6A"
                     /note="major polyA site"
ORIGIN      
        1 aataaagggg tctgagccgg tcgcctgagc ctgaaaagtg ctgtcacgtc agcggaagga
       61 ggcgtcccag atcttctcag ctgtcttggt gccagccttc ctagtcttcc tacccacact
      121 cctacctgct gtcacaggcc acagccatca tgcctcgggg tcacaagagt aagctccgta
      181 cctgtgagaa acgccaagag accaatggtc agccacaggg tctcacgggt ccccaggcca
      241 ctgcagagaa gcaggaagag tcccactctt cctcatcctc ttctcgcgct tgtctgggtg
      301 attgtcgtag gtcttctgat gcctccattc ctcaggagtc tcagggagtg tcacccactg
      361 ggtctcctga tgcagttgtt tcatattcaa aatccgatgt ggctgccaac ggccaagatg
      421 agaaaagtcc aagcacctcc cgtgatgcct ccgttcctca ggagtctcag ggagcttcac
      481 ccactggctc tcctgatgca ggtgtttcag gctcaaaata tgatgtggct gccaacggcc
      541 aagatgagaa aagtccaagc acttcccatg atgtctccgt tcctcaggag tctcagggag
      601 cttcacccac tggctcgcct gatgcaggtg tttcaggctc aaaatatgat gtggctgccg
      661 agggtgaaga tgaggaaagt gtaagcgcct cacagaaagc catcattttt aagcgcttaa
      721 gcaaagatgc tgtaaagaag aaggcgtgca cgttggcgca attcctgcag aagaagtttg
      781 agaagaaaga gtccattttg aaggcagaca tgctgaagtg tgtccgcaga gagtacaagc
      841 cctacttccc tcagatcctc aacagaacct cccaacattt ggtggtggcc tttggcgttg
      901 aattgaaaga aatggattcc agcggcgagt cctacaccct tgtcagcaag ctaggcctcc
      961 ccagtgaagg aattctgagt ggtgataatg cgctgccgaa gtcgggtctc ctgatgtcgc
     1021 tcctggttgt gatcttcatg aacggcaact gtgccactga agaggaggtc tgggagttcc
     1081 tgggtctgtt ggggatatat gatgggatcc tgcattcaat ctatggggat gctcggaaga
     1141 tcattactga agatttggtg caagataagt acgtggttta ccggcaggtg tgcaacagtg
     1201 atcctccatg ctatgagttc ctgtggggtc cacgagccta tgctgaaacc accaagatga
     1261 gagtcctgcg tgttttggcc gacagcagta acaccagtcc cggtttatac ccacatctgt
     1321 atgaagacgc tttgatagat gaggtagaga gagcattgag actgagagct taaggcaggg
     1381 ctggcactat ttccttggcc agggtacctt atggggccat atcctacaga tcctcccatt
     1441 tctagggagg tctgaagtag aattttcact ttatgttaga agagagtagt gagctttcta
     1501 agtagtgcag tatagtagag gctggaggga acaagatatg tatctttctt ttgttacaca
     1561 tgagtaactt gcagatttat gttttatctc tgtcagttat caacattgtt cctgttaagt
     1621 gaaggtttat tttgcttcag attatacaat tatcaataac atagctctca cattcatggc
     1681 tgtttaacca atctgaaagt tacggtttgg gaattaataa aacaaagtca tacaacacat
     1741 tttctttgta attgagaact agataacatg gtaacagaga attgattttc atatgaatct
     1801 taactccaca gtaaaatagt tgacatcata atatgaagag aaagaaaagg aaaaacagaa
     1861 atgtaaaagt tgtttaattc ttggtttgcc taattcgttt tcctatttct tttcatacaa
     1921 ataaaggata cctggattta tttaggtta
//
