LOCUS       NM_002367               2188 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAGE family member B4 (MAGEB4), mRNA.
ACCESSION   NM_002367
VERSION     NM_002367.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Afsharpad,M., Nowroozi,M.R., Mobasheri,M.B., Ayati,M.,
            Nekoohesh,L., Saffari,M., Zendehdel,K. and Modarressi,M.H.
  TITLE     Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for
            Transitional Cell Carcinoma of Bladder
  JOURNAL   Pathol Oncol Res 25 (1), 191-199 (2019)
   PUBMED   29058301
  REMARK    GeneRIF: High MAGEB4 expression is associated with Transitional
            Cell Carcinoma of Bladder.
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 2188)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2188)
  AUTHORS   Okutman,O., Muller,J., Skory,V., Garnier,J.M., Gaucherot,A.,
            Baert,Y., Lamour,V., Serdarogullari,M., Gultomruk,M., Ropke,A.,
            Kliesch,S., Herbepin,V., Aknin,I., Benkhalifa,M., Teletin,M.,
            Bakircioglu,E., Goossens,E., Charlet-Berguerand,N., Bahceci,M.,
            Tuttelmann,F. and Viville,S.
  TITLE     A no-stop mutation in MAGEB4 is a possible cause of rare X-linked
            azoospermia and oligozoospermia in a consanguineous Turkish family
  JOURNAL   J Assist Reprod Genet 34 (5), 683-694 (2017)
   PUBMED   28401488
  REMARK    GeneRIF: The whole exome analysis of a consanguineous Turkish
            family revealed MAGEB4 as a possible new X-linked cause of
            inherited male infertility. This study provides the first clue to
            the physiological function of a MAGE protein.
REFERENCE   7  (bases 1 to 2188)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 2188)
  AUTHORS   Lurquin,C., De Smet,C., Brasseur,F., Muscatelli,F., Martelange,V.,
            De Plaen,E., Brasseur,R., Monaco,A.P. and Boon,T.
  TITLE     Two members of the human MAGEB gene family located in Xp21.3 are
            expressed in tumors of various histological origins
  JOURNAL   Genomics 46 (3), 397-408 (1997)
   PUBMED   9441743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313769.1 and BC032852.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002367.3.
            
            Summary: This gene is a member of the MAGEB gene family. The
            members of this family have their entire coding sequences located
            in the last exon, and the encoded proteins show 50 to 68% sequence
            identity to each other. The promoters and first exons of the MAGEB
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEB genes are clustered
            on chromosome Xp22-p21. This gene sequence ends in the first intron
            of MAGEB1, another family member. This gene is expressed in testis.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK313769.1, BC032852.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378982.4/ ENSP00000368266.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-978               AK313769.1         1-978
            979-1041            BC032852.2         927-989
            1042-1177           AK313769.1         1042-1177
            1178-2188           BC032852.2         1126-2136
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..2188
                     /gene="MAGEB4"
                     /gene_synonym="CT3.6"
                     /note="MAGE family member B4"
                     /db_xref="GeneID:4115"
                     /db_xref="HGNC:HGNC:6811"
                     /db_xref="MIM:300153"
     exon            1..2188
                     /gene="MAGEB4"
                     /gene_synonym="CT3.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1177
                     /gene="MAGEB4"
                     /gene_synonym="CT3.6"
                     /note="cancer/testis antigen family 3, member 6; MAGE-B4
                     antigen; melanoma antigen family B, 4; melanoma antigen
                     family B4"
                     /codon_start=1
                     /product="melanoma-associated antigen B4"
                     /protein_id="NP_002358.1"
                     /db_xref="CCDS:CCDS14221.1"
                     /db_xref="GeneID:4115"
                     /db_xref="HGNC:HGNC:6811"
                     /db_xref="MIM:300153"
                     /translation="MPRGQKSKLRAREKRQRTRGQTQDLKVGQPTAAEKEESPSSSSS
                     VLRDTASSSLAFGIPQEPQREPPTTSAAAAMSCTGSDKGDESQDEENASSSQASTSTE
                     RSLKDSLTRKTKMLVQFLLYKYKMKEPTTKAEMLKIISKKYKEHFPEIFRKVSQRTEL
                     VFGLALKEVNPTTHSYILVSMLGPNDGNQSSAWTLPRNGLLMPLLSVIFLNGNCAREE
                     EIWEFLNMLGIYDGKRHLIFGEPRKLITQDLVQEKYLEYQQVPNSDPPRYQFLWGPRA
                     HAETSKMKVLEFLAKVNDTTPNNFPLLYEEALRDEEERAGARPRVAARRGTTAMTSAY
                     SRATSSSSSQPM"
ORIGIN      
        1 agaggcggct tctgaaaagc caaggtagta tctgcctgct gaaggtgttc tcaggatttc
       61 atttgctctt ctccaggaac cacatcacct gcccttctgc ctacactcct gcctgctgtg
      121 cctaaccaca gccatcatgc ctcggggtca gaagagtaag ctccgtgccc gtgagaaacg
      181 ccagcggacc cgtggtcaga cccaggatct caaggttggt cagcctactg cagcagagaa
      241 agaagagtct ccttcctctt cctcatctgt tttgagggat actgcctcca gctcccttgc
      301 ttttggcatt ccccaggagc ctcagagaga gccacccacc acctctgctg ctgcagctat
      361 gtcatgcact ggatctgata aaggcgacga gagccaagat gaggaaaatg caagttcctc
      421 ccaggcctca acatccactg agagatcact caaagattct ctaaccagga agacgaagat
      481 gttagtgcag ttcctgctgt acaagtataa aatgaaagag cccactacaa aggcagaaat
      541 gctgaagatc atcagcaaaa agtacaagga gcacttccct gagatcttca ggaaagtctc
      601 tcagcgcacg gagctggtct ttggccttgc cttgaaggag gtcaacccca ccactcactc
      661 ctacatcctc gtcagcatgc taggccccaa cgatggaaac cagagcagtg cctggaccct
      721 tccaaggaat gggcttctga tgcctctact gagtgtgatc ttcttaaatg gcaactgtgc
      781 ccgtgaagag gaaatctggg aattcctgaa tatgctgggg atctatgatg gaaagaggca
      841 ccttatcttt ggggaacccc gaaagctcat cacccaagat ctggtacagg aaaaatatct
      901 ggaataccag caggtgccca acagtgatcc cccacgctat caattcctgt ggggtccaag
      961 agctcatgca gaaaccagca agatgaaagt cctggagttt ttggccaagg tgaatgacac
     1021 cacccccaat aacttcccac tgctttatga agaggctttg agagatgaag aagagagagc
     1081 tggagcccgg cccagagttg cagccaggcg tggcactaca gccatgacta gtgcgtattc
     1141 cagggccaca tccagtagct cttcccaacc catgtgagat ctaaggcaaa ttgttcactt
     1201 tgtggttgaa agacctgctg ctttctctgt tcctgtgatg catgaataac tcattgattt
     1261 atctctttgt tgtattttcc atgatgtttc ttaaaataga aagtttattt agattcagaa
     1321 tataaattta gaaatggcat gcatcacaca tttattgctg tttatcaggt tggtttagtg
     1381 ataataattt tgtttttgaa atacaaatag aaaatcctga aataattttt gtgatacaga
     1441 gcaaaataac acggcatggg agtaaggtta tccttagaaa tttaaaataa ctccacagta
     1501 aaataggtag aatctgaaga tagaaaggga agaaaagtaa aagttgcttt attcgtggtt
     1561 tgtcttactc agttcagtct ttttttgctc ataaatttaa aagttacata cctggtttgc
     1621 ttagattatt caagaatgtg gaggcctggg ccaaggtcaa tgacagtgtc tccattgtct
     1681 tccctccatt aagagaagac tttaagagat gagggagaga gagccagaga cagtgttgca
     1741 actgggcctg gcatgtttca gtgtggtgtc cagcagtgtc tcccactcct tgtgaagtct
     1801 gaggtatatt ctttactttt gattaagaaa acacttaacc ttctaattaa tggagagcca
     1861 aaggggagtt ggtgggaaca ccatgtataa catatttgta tgtaaaatga tttatctttt
     1921 ctttttcctg tttttcagtg ttcttttttt aaattgtaga tttatttagt ttcagaatct
     1981 aagtttatga atggcatgaa tcactcattt attaaaatat atcaggttgg agagtgagaa
     2041 tttttgcatt atgtaaaaca atttaaaaat cttttaagtc tttttctgtg atctagaaca
     2101 agataatatg gcattggaat atggaatttg tgaaaaggaa attaccttgc aataaagttg
     2161 gtgggaccag gaagtagaga aaaaaaaa
//
