LOCUS       NM_002365               2087 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens MAGE family member B3 (MAGEB3), transcript variant 1,
            mRNA.
ACCESSION   NM_002365
VERSION     NM_002365.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Lurquin,C., De Smet,C., Brasseur,F., Muscatelli,F., Martelange,V.,
            De Plaen,E., Brasseur,R., Monaco,A.P. and Boon,T.
  TITLE     Two members of the human MAGEB gene family located in Xp21.3 are
            expressed in tumors of various histological origins
  JOURNAL   Genomics 46 (3), 397-408 (1997)
   PUBMED   9441743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005185.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 14, 2020 this sequence version replaced NM_002365.4.
            
            Summary: This gene is a MAGE-B subfamily member of the MAGE gene
            family. MAGE family member proteins direct the expression of tumor
            antigens recognized on a human melanoma by autologous cytolytic T
            lymphocytes. There are two known clusters of MAGE genes on
            chromosome X. The members of the MAGE-A subfamily are located in
            the Xq28 region, while the members of the MAGE-B subfamily are
            clustered in the Xp21 region. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057441.1, SRR14038192.2866106.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361644.4/ ENSP00000355198.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC005185.1         48828-48988
            162-263             AC005185.1         49688-49789
            264-353             AC005185.1         50998-51087
            354-455             AC005185.1         51433-51534
            456-2087            AC005185.1         54035-55666
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..2087
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /note="MAGE family member B3"
                     /db_xref="GeneID:4114"
                     /db_xref="HGNC:HGNC:6810"
                     /db_xref="MIM:300152"
     exon            1..161
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /inference="alignment:Splign:2.1.0"
     exon            162..263
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /inference="alignment:Splign:2.1.0"
     exon            264..353
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /inference="alignment:Splign:2.1.0"
     exon            354..455
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..2087
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..1557
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /note="cancer/testis antigen family 3, member 5; MAGE-B3
                     antigen; melanoma antigen family B, 3; melanoma antigen
                     family B3"
                     /codon_start=1
                     /product="melanoma-associated antigen B3"
                     /protein_id="NP_002356.2"
                     /db_xref="CCDS:CCDS14220.1"
                     /db_xref="GeneID:4114"
                     /db_xref="HGNC:HGNC:6810"
                     /db_xref="MIM:300152"
                     /translation="MPRGQKSTLHAREKRQQTRGQTQDHQGAQITATNKKKVSFSSPL
                     ILGATIQKKSAGRSRSALKKPQRALSTTTSVDVSYKKSYKGANSKIEKKQSFSQGLSS
                     TVQSRTDPLIMKTNMLVQFLMEMYKMKKPIMKADMLKIVQKSHKNCFPEILKKASFNM
                     EVVFGVDLKKVDSTKDSYVLVSKMDLPNNGTVTRGRGFPKTGLLLNLLGVIFMKGNCA
                     TEEKIWEFLNKMRIYDGKKHFIFGEPRKLITQDLVKLKYLEYRQVPNSNPARYEFLWG
                     PRAHAETSKMKVLEFWAKVNKTVPSAFQFWYEEALRDEEERVQAAAMLNDGSSAMGRK
                     CSKAKASSSSHA"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /note="hexamer: AATAAA"
     polyA_site      2087
                     /gene="MAGEB3"
                     /gene_synonym="CT3.5"
                     /note="major polyA site"
ORIGIN      
        1 aacccgactc cgctgtctgc cctcacagga cccaaacatc cctggcctaa tgtggctcat
       61 caaaacttca gcctagatct cggaggacct tgatctgagc aggattcatg gcatggaatg
      121 tggagtccca ggactggcca gcagcgaagt gaggttcttg agcagggctc tggctcacgc
      181 ttgtaatccc aacattttgg gaggacgaag ccagcctcat cgcttaagca caggagttcg
      241 aggactggga ggtggaggtt gtggcagggc tgtggctcac gcttgtaatc ccaacatttt
      301 gggcggagga agccagcctc atcgcttaag cacaggagtt cgcggactgg gaggcagggc
      361 tctggctcac gcttgtaatc ccaacatttt gggaggacga agccagcctc atcgcttaag
      421 cacaggagtt cgaggactgg gaggtggagg ttgtggtgcc tgtatcacct gcccttctgc
      481 tgacactcct gcctgctgtt cctgactaca gccatcatgc ctcggggtca gaagagtacg
      541 ctccatgcac gtgagaaacg ccagcagacc cggggtcaga cccaggatca ccagggtgct
      601 cagatcactg caactaacaa gaaaaaagta tccttttcat cccctcttat tttgggggct
      661 actatccaga aaaagtctgc tggtaggtca cgtagtgctc tcaagaagcc tcagagagca
      721 ctatccacca ctacatctgt agatgtttct tacaaaaagt catacaaggg agccaacagc
      781 aaaattgaga aaaagcaaag cttctctcag ggtctatcct ccactgtgca gtctcgcaca
      841 gaccctctaa tcatgaagac aaatatgttg gtgcagttcc tgatggaaat gtacaagatg
      901 aaaaagccca ttatgaaagc agatatgcta aaaattgtcc aaaaaagcca taagaattgc
      961 ttccctgaga tccttaaaaa agcttctttc aacatggagg tggtatttgg tgttgattta
     1021 aagaaagttg attctaccaa ggactcctat gtccttgtca gcaaaatgga tctccccaac
     1081 aatgggacag tgactcgtgg gaggggattt cccaagacag gtctcctgct gaatctcctg
     1141 ggcgtgatct tcatgaaggg caactgtgcc actgaggaga agatctggga attcctgaat
     1201 aagatgagaa tatatgatgg gaagaaacac ttcatatttg gggagcccag aaagctcatc
     1261 acccaagatt tggtgaagct taaatacctg gagtaccgac aagtgcccaa cagtaatcct
     1321 gcacgctatg aattcctgtg gggtccaaga gcccatgctg aaaccagcaa gatgaaggtc
     1381 ctggagtttt gggccaaggt caataaaact gtccccagtg cgttccagtt ctggtatgaa
     1441 gaggctttga gagatgagga agaaagagtc caagctgcag ctatgctcaa tgatggcagt
     1501 agtgccatgg gcagaaagtg ttccaaggcc aaggctagca gctcttccca cgcctagtga
     1561 agttgaagca aattttgcat tttgtggtta aagagggcag tcactgttcc aaggagtgaa
     1621 ggactgggtg ttactggagg gaacacactg tataatacct tttgtttctg ttctaaatgg
     1681 ataatttgaa gttttatctg tattttgggg catatttttc aaatgttcct tttatttaac
     1741 attgtaatct aagtttagga ttgatactgg tcacatttgt tgtttaagag taaaaatttt
     1801 gctgttttgt aaaacagatt gagaaaaatt cgatcttatt tagtgatctg ttgcaagata
     1861 acttggaatt agaataagca tttccttgaa aatgtttaaa aaaaaaaagt cagcagtaaa
     1921 atgtatggca ttaagaaata gagaaagagt gtaagatggt caatatttgg tttcctaaat
     1981 gcttttactc tgtgctttaa gaaaatgaaa gataaataac catatatgtc tggcttactt
     2041 aagaatgtag aattaaatca taataaatta gacctcatgc tgacaca
//
