LOCUS       NM_002364               1607 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MAGE family member B2 (MAGEB2), mRNA.
ACCESSION   NM_002364 XM_002346292
VERSION     NM_002364.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Cui,J., Chen,Y., Ou,Y., Liu,G., Wen,Q., Zhu,W., Liang,L., Chen,Z.,
            Yang,H., Wang,L. and Wei,M.
  TITLE     Cancer germline antigen gene MAGEB2 promotes cell invasion and
            correlates with immune microenvironment and immunotherapeutic
            efficiency in laryngeal cancer
  JOURNAL   Clin Immunol 240, 109045 (2022)
   PUBMED   35618211
  REMARK    GeneRIF: Cancer germline antigen gene MAGEB2 promotes cell invasion
            and correlates with immune microenvironment and immunotherapeutic
            efficiency in laryngeal cancer.
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Ladelfa,M.F., Peche,L.Y., Amato,G.E., Escalada,M.C., Zampieri,S.,
            Pascucci,F.A., Benevento,A.F., Do Porto,D.F., Dardis,A.,
            Schneider,C. and Monte,M.
  TITLE     Expression of the tumor-expressed protein MageB2 enhances rRNA
            transcription
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (7), 119015 (2021)
   PUBMED   33741433
  REMARK    GeneRIF: Expression of the tumor-expressed protein MageB2 enhances
            rRNA transcription.
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Nobeyama,Y. and Nakagawa,H.
  TITLE     Aberrant demethylation and expression of MAGEB2 in a subset of
            malignant peripheral nerve sheath tumors from neurofibromatosis
            type 1
  JOURNAL   J Dermatol Sci 81 (2), 118-123 (2016)
   PUBMED   26642794
  REMARK    GeneRIF: MAGEB2 can be aberrantly demethylated and expressed in
            malignant peripheral nerve sheath tumors. Conversely, the gene may
            not be demethylated in any types of neurofibroma, suggesting that
            the demethylation does not occur before malignant transformation.
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Park,J.H. and Lee,S.W.
  TITLE     Hypertonicity induction of melanoma antigen, a tumor-associated
            antigen
  JOURNAL   Mol Cells 13 (2), 288-295 (2002)
   PUBMED   12018852
  REMARK    GeneRIF: Results show that hypertonic culture medium differentially
            induces the expression of melanoma antigens B1 and B2 (MAGE-B1,
            -B2) in different human tumor cell lines.
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   McCurdy,D.K., Tai,L.Q., Nguyen,J., Wang,Z., Yang,H.M., Udar,N.,
            Naiem,F., Concannon,P. and Gatti,R.A.
  TITLE     MAGE Xp-2: a member of the MAGE gene family isolated from an
            expression library using systemic lupus erythematosus sera
  JOURNAL   Mol Genet Metab 63 (1), 3-13 (1998)
   PUBMED   9538511
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Lurquin,C., De Smet,C., Brasseur,F., Muscatelli,F., Martelange,V.,
            De Plaen,E., Brasseur,R., Monaco,A.P. and Boon,T.
  TITLE     Two members of the human MAGEB gene family located in Xp21.3 are
            expressed in tumors of various histological origins
  JOURNAL   Genomics 46 (3), 397-408 (1997)
   PUBMED   9441743
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Dabovic,B., Zanaria,E., Bardoni,B., Lisa,A., Bordignon,C.,
            Russo,V., Matessi,C., Traversari,C. and Camerino,G.
  TITLE     A family of rapidly evolving genes from the sex reversal critical
            region in Xp21
  JOURNAL   Mamm Genome 6 (9), 571-580 (1995)
   PUBMED   8535061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005185.1 and AK223081.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002364.4.
            
            Summary: This gene is a member of the MAGEB gene family. The
            members of this family have their entire coding sequences located
            in the last exon, and the encoded proteins show 50 to 68% sequence
            identity to each other. The promoters and first exons of the MAGEB
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. This gene is localized in the
            DSS (dosage-sensitive sex reversal) critical region. It is
            expressed in testis and placenta, and in a significant fraction of
            tumors of various histological types. The MAGEB genes are clustered
            on chromosome Xp22-p21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026071.2, SRR5189661.72326.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378988.5/ ENSP00000368273.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC005185.1         33734-33826
            94-1594             AC005185.1         36747-38247
            1595-1607           AK223081.1         1582-1594
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..1607
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /note="MAGE family member B2"
                     /db_xref="GeneID:4113"
                     /db_xref="HGNC:HGNC:6809"
                     /db_xref="MIM:300098"
     exon            1..93
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1607
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1058
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /note="cancer/testis antigen family 3, member 2; DSS/AHC
                     critical interval MAGE superfamily 6; MAGE-B2 antigen;
                     MAGE XP-2 antigen; melanoma antigen family B, 2;
                     cancer/testis antigen 3.2; melanoma antigen family B2"
                     /codon_start=1
                     /product="melanoma-associated antigen B2"
                     /protein_id="NP_002355.2"
                     /db_xref="CCDS:CCDS14219.1"
                     /db_xref="GeneID:4113"
                     /db_xref="HGNC:HGNC:6809"
                     /db_xref="MIM:300098"
                     /translation="MPRGQKSKLRAREKRRKARDETRGLNVPQVTEAEEEEAPCCSSS
                     VSGGAASSSPAAGIPQEPQRAPTTAAAAAAGVSSTKSKKGAKSHQGEKNASSSQASTS
                     TKSPSEDPLTRKSGSLVQFLLYKYKIKKSVTKGEMLKIVGKRFREHFPEILKKASEGL
                     SVVFGLELNKVNPNGHTYTFIDKVDLTDEESLLSSWDFPRRKLLMPLLGVIFLNGNSA
                     TEEEIWEFLNMLGVYDGEEHSVFGEPWKLITKDLVQEKYLEYKQVPSSDPPRFQFLWG
                     PRAYAETSKMKVLEFLAKVNGTTPCAFPTHYEEALKDEEKAGV"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1607
                     /gene="MAGEB2"
                     /gene_synonym="CT3.2; DAM6; MAGE-XP-2"
                     /note="major polyA site"
ORIGIN      
        1 acttccgctt tggaggcgag gacccgagcg agtgtagggg gtgcggcgtc tggtcagcca
       61 ggggtgaatt ctcaggactg gtcggcagtc aagccatcat gcctcgtggt cagaagagta
      121 agctccgtgc ccgtgagaaa cgccgcaagg cccgagatga gacccggggt ctcaatgttc
      181 ctcaggtcac tgaagcagag gaagaagagg ccccctgctg ttcctcttct gtttctgggg
      241 gtgctgcttc aagctctcct gctgctggca ttccccagga gcctcagaga gccccaacca
      301 ctgccgctgc tgcggctgcg ggtgtttcat ccacaaaatc taaaaaaggt gccaagagcc
      361 accaaggtga gaaaaatgca agttcctccc aggcctcaac atccactaag agcccaagcg
      421 aagatcctct aaccaggaag tcagggtcgt tggtgcagtt cctgttgtac aagtataaaa
      481 taaaaaagtc cgttacaaag ggagaaatgc tgaaaattgt tggcaaaagg ttcagggagc
      541 acttccctga gatcctcaag aaagcctctg agggcctcag tgttgtcttt ggccttgagc
      601 tgaataaagt caaccccaac ggccacactt acaccttcat cgacaaggta gacctcactg
      661 atgaggaatc cctgctcagt tcctgggact ttcccaggag aaagcttctg atgcctctcc
      721 tgggtgtgat cttcttaaat ggcaactcag ctactgagga agagatctgg gaattcctga
      781 atatgttggg agtctatgat ggagaggagc actcagtctt tggggaaccc tggaagctca
      841 tcaccaaaga tctggtgcag gaaaaatatc tggagtacaa gcaggtgccc agcagtgatc
      901 ccccacgctt tcaattcctg tggggtccga gagcctatgc tgaaaccagc aagatgaaag
      961 tcctggagtt tttggccaag gtaaatggta ccaccccctg tgccttccca acccattacg
     1021 aagaagcttt gaaagatgaa gagaaagccg gagtctgagc cagagttgta gccaggcctt
     1081 gcactactgc catagccaat caatctccca aagccaagtt tacctgctgt tctcaccccc
     1141 aatgaggtct taggcagatt ctttactttg taattcaaaa ggcctgttaa cctttgttct
     1201 tgttatgcat gaataacttg ttgacttttt ttttttctct ttttcaacta gtgtttcaac
     1261 aggtttattt agattcagaa tgtaaattta caaatgatat agatcaccct gttattgctg
     1321 tttttcaggg acagtagaaa gtgttttgtt ttttgagtga aacaacttat taataaaaat
     1381 ccttaaatca cttttgtaat ccaggacaag aaaatgtggc attagagtag aaatatcttt
     1441 ggaaatgtga aagaccccat agtgaaatat ttgggatcag aagccagagg tgtaaaagtg
     1501 gtcaattctt ggtttacttc atttaatctt tcttttcata aagatacata cctggatttg
     1561 tttatgttat tcaagaatgt gtgagaaatt aaaccatagt tagttaa
//
