LOCUS       NM_173699               1812 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MAGE family member B18 (MAGEB18), mRNA.
ACCESSION   NM_173699
VERSION     NM_173699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Doyle,J.M., Gao,J., Wang,J., Yang,M. and Potts,P.R.
  TITLE     MAGE-RING protein complexes comprise a family of E3 ubiquitin
            ligases
  JOURNAL   Mol Cell 39 (6), 963-974 (2010)
   PUBMED   20864041
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129850.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_173699.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029525.1, AK057361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325250.2/ ENSP00000314543.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC129850.7         27523-27647         c
            126-1255            AC129850.7         25937-27066         c
            1256-1812           AC129850.7         25254-25810         c
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.3"
     gene            1..1812
                     /gene="MAGEB18"
                     /note="MAGE family member B18"
                     /db_xref="GeneID:286514"
                     /db_xref="HGNC:HGNC:28515"
                     /db_xref="MIM:301064"
     exon            1..125
                     /gene="MAGEB18"
                     /inference="alignment:Splign:2.1.0"
     exon            126..1255
                     /gene="MAGEB18"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1219
                     /gene="MAGEB18"
                     /note="MAGE-B18 antigen; melanoma antigen family B, 18;
                     melanoma antigen family B18"
                     /codon_start=1
                     /product="melanoma-associated antigen B18"
                     /protein_id="NP_775970.2"
                     /db_xref="CCDS:CCDS14216.1"
                     /db_xref="GeneID:286514"
                     /db_xref="HGNC:HGNC:28515"
                     /db_xref="MIM:301064"
                     /translation="MPRGQKSKLRAREKRHQARCENQDLGATQATVAEGESPSPAYLL
                     FGDRPQNLPAAETPSIPEALQGAPSTTNAIAPVSCSSNEGASSQDEKSLGSSREAEGW
                     KEDPLNKKVVSLVHFLLQKYETKEPITKGDMIKFVIRKDKCHFNEILKRASEHMELAL
                     GVDLKEVDPIRHYYAFFSKLDLTYDETTSDEEKIPKTGLLMIALGVIFLNGNRAPEEA
                     VWEIMNMMGVYADRKHFLYGDPRKVMTKDLVQLKYLEYQQVPNSDPPRYEFLWGPRAH
                     AETSKMKVLEFVAKIHDTVPSAFPSCYEEALRDEEQRTQARAAARAHTAAMANARSRT
                     TSSSFSHAK"
     exon            1256..1812
                     /gene="MAGEB18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB18"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="MAGEB18"
                     /note="major polyA site"
ORIGIN      
        1 aaagtgggcg tggccggaca tgtttctctt gacctatctt ccacatcatc aagctgttac
       61 gggcgaaacc ttggtctgaa acatgcggcc agagaaataa atctcaggat ccggcaggtg
      121 tcaaaggtgc cctcttcatc aattcaactg cctgcactat tgtctgtagt ccctgacaag
      181 agtaattatg cctcgaggtc agaagagtaa gctccgtgcc cgtgagaaac gccaccaggc
      241 tcgttgtgag aatcaggatc tgggagctac gcaggccact gtggcagaag gagagtcacc
      301 ctcccctgcc tatcttctct ttggtgacag accccagaat ttgcctgctg ctgagacacc
      361 tagcatccct gaagcgcttc agggagcccc atccaccacc aatgctattg cacctgtttc
      421 atgcagttca aatgaaggtg ccagcagcca agatgagaaa agtctaggtt cctcaaggga
      481 agctgagggc tggaaagaag atcctttaaa caagaaagta gtgtcgctgg tgcatttctt
      541 gcttcagaag tatgaaacga aagagccaat tacaaaggga gatatgataa agtttgttat
      601 caggaaggat aagtgtcact tcaatgagat cctcaagaga gcctctgagc acatggagct
      661 ggcacttggt gttgatttga aggaagtgga tcccatcagg cactactatg cctttttcag
      721 caaattagac ctcacctatg atgaaacaac cagtgatgaa gaaaaaattc ccaagactgg
      781 cctcctgatg attgcactgg gtgtgatctt tctgaatggc aaccgtgccc cagaagaggc
      841 agtctgggaa attatgaata tgatgggtgt atatgccgat aggaagcact tcctctatgg
      901 ggatcccagg aaggtcatga ccaaagattt ggtgcagcta aagtacctgg agtaccagca
      961 agtgcccaac agtgatcctc cacgctatga attcctgtgg ggtccaagag ctcacgctga
     1021 aactagcaag atgaaagtcc tggagtttgt agccaagata catgataccg tccctagtgc
     1081 cttcccatcc tgctatgaag aggctttgag ggatgaggaa cagagaaccc aagccagagc
     1141 tgcagccagg gctcatactg ctgccatggc aaatgcacgt tccagaacca cgtctagcag
     1201 cttctcccat gctaagtgaa atctgaggct tgttcttcac tttttggtcg aaaaggttac
     1261 atttcaaatg ttcaagtctg aagattgttt tctttgtgga agagaagagc agtcaacatt
     1321 ctaagtagtg aatggccaga gtgcgtctgg agggaacaca gcatatatca ttttgtgtta
     1381 atagtctata gtaactcgga gttgtatctt tttctttctt ttttttttgg tgttatattt
     1441 caaatgttgt tgcttataat agaagtttta gataacttca gaatctatat ttattaatga
     1501 ctttggttac acacgtattg ctatttaaga gtaggagttt tattgttctg taaaacaaat
     1561 tgggaaacct tctttcatat ttaatgagcc agaacaagga aacacagtat tggaataggt
     1621 atttccttaa aaaatgtgag atgatttagc agtaaaattt tggagatcaa aacataggtg
     1681 agaaaaagta aacttttcag ttcttggttt tctttttcca ttttagtctg ttatataaaa
     1741 ataaaagtca tacctggatt ggcttagctt actgaagaag gtaggaagaa ataaaatgtt
     1801 tatgaaccag ca
//
