LOCUS       NM_001370158            1719 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MAGE family member B16 (MAGEB16), transcript variant
            1, mRNA.
ACCESSION   NM_001370158 XM_011545453
VERSION     NM_001370158.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Liu,Y., Wang,M., Jiang,S., Lu,Y., Tao,D., Yang,Y., Ma,Y. and
            Zhang,S.
  TITLE     Demethylation of CpG islands in the 5' upstream regions mediates
            the expression of the human testis-specific gene MAGEB16 and its
            mouse homolog Mageb16
  JOURNAL   BMB Rep 47 (2), 86-91 (2014)
   PUBMED   24219866
  REMARK    GeneRIF: The testis-specific expression of MAGEB16 and Mageb16 is
            regulated by the methylation status of their promoter regions.
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161722.9.
            
            On May 2, 2019 this sequence version replaced XM_011545453.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.257867.1,
                                           SRR5189667.398657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399988.6/ ENSP00000382870.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL161722.9         37640-37716         c
            78-1719             AL161722.9         32286-33927         c
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.1"
     gene            1..1719
                     /gene="MAGEB16"
                     /note="MAGE family member B16"
                     /db_xref="GeneID:139604"
                     /db_xref="HGNC:HGNC:21188"
                     /db_xref="MIM:300762"
     exon            1..77
                     /gene="MAGEB16"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1719
                     /gene="MAGEB16"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1118
                     /gene="MAGEB16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanoma antigen family B, 16 (pseudogene);
                     melanoma-associated antigen B16; MAGE-B16 antigen;
                     melanoma antigen family B16"
                     /codon_start=1
                     /product="melanoma-associated antigen B16 isoform 1"
                     /protein_id="NP_001357087.1"
                     /db_xref="CCDS:CCDS43927.1"
                     /db_xref="GeneID:139604"
                     /db_xref="HGNC:HGNC:21188"
                     /db_xref="MIM:300762"
                     /translation="MSQDQESPRCTHDQHLQTFSETQSLEVAQVSKALEKTLLSSSHP
                     LVPGKLKEAPAAKAESPLEVPQSFCSSSIAVTTTSSSESDEASSNQEEEDSPSSSEDT
                     SDPRNVPADALDQKVAFLVNFMLHKCQMKKPITKADMLKIIIKDDESHFSEILLRASE
                     HLEMIFGLDVVEVDPTTHCYGLFIKLGLTYDGMLSGEKGVPKTGLLIIVLGVIFMKGN
                     RATEEEVWEVLNLTGVYSGKKHFIFGEPRMLITKDFVKEKYLEYQQVANSDPARYEFL
                     WGPRAKAETSKMKVLEFVAKVHGSYPHSFPSQYAEALKEEEERARARI"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB16"
                     /note="hexamer: AATAAA"
     polyA_site      1719
                     /gene="MAGEB16"
                     /note="major polyA site"
ORIGIN      
        1 tgtgacgacc ttatctgagg aaggtgcacc ctagtcatca gaggaacgag tcgctgcagg
       61 cactgtcagg tgtcgaggca gtgattcttc attgcctgcc ctcctgtcca cactcctgcc
      121 tactgccacc cacaagggtc atcatgtctc aggatcagga gagtccacga tgcacacatg
      181 atcagcacct tcagaccttc agtgagaccc agagcctgga ggttgcacag gtctccaagg
      241 ctctggagaa gaccctcctc tcctcctccc atcctctagt gcctggcaaa ctgaaggaag
      301 ctcctgctgc taaggcagag agtcctcttg aggttcctca gagtttctgc tcctcttcca
      361 ttgccgtcac aaccacctca tcaagtgaat ctgatgaggc ttccagcaat caagaagagg
      421 aagatagtcc aagctcctca gaggatacat cagaccccag gaatgtgccc gcagatgctc
      481 tcgaccagaa agtggctttt ttggtgaatt tcatgctgca caagtgtcag atgaaaaagc
      541 caataacaaa ggcagatatg ttgaagatta tcatcaaaga tgatgagagc cacttctctg
      601 agatcctcct gagagcttct gagcacctag agatgatatt tggccttgat gtggtggagg
      661 tggaccccac cacccattgc tatggcctct tcatcaaact gggcctcacc tatgatggga
      721 tgctgagtgg tgaaaagggt gtgcccaaga ctggcctcct gataattgtc ctgggtgtga
      781 tcttcatgaa gggcaaccgt gccactgaag aggaagtctg ggaagtgctg aatttgacgg
      841 gagtatattc tgggaagaag cacttcatct ttggagagcc cagaatgctc atcaccaaag
      901 attttgtgaa ggagaagtac ctggagtacc agcaggtggc caacagtgat cctgcacgat
      961 atgaattcct gtggggccca agagccaaag ctgaaaccag caagatgaaa gtcctggagt
     1021 ttgtggccaa agttcatggg tcttacccac attctttccc atctcagtat gcggaagctc
     1081 tgaaagagga agaagagaga gctagagcca gaatttgagt cagggctgac tccatttcca
     1141 cagccactgt gagttccagt gctatgtctg gtagcttctc ccatacctag tgaagacaag
     1201 gatagatgtt ttatgtaaca tttgcagaag gcagttagtg ttcaaggatg caggtccagg
     1261 gtggggctgg aggaaaaata gtatatatca tctatatccc tattttgtat gtgtaacttg
     1321 acagtttatt cttttatttt ttaatggcta tattattcag atgatgtttc ttttaataga
     1381 agtttaggta gtttccagat ctcttaagtt ttgaataata ttggtcatcc atttaatgtt
     1441 tttcatgagg tttagtggca tatgttttgc tgattttgta aaacagattg ggaaaccatc
     1501 tatattgtgt tctgatatag gatgacatga cattactaag aactctgctt ttaaatatcc
     1561 gtttaatgtt ttgcatgcag tttagtagca aaggttttgt taattttgta aaacagatta
     1621 gaaaaccatc catctatatt gtgttctagt atagcatgac atgacattgc taagaacttt
     1681 gctttaaaat atttggaata aaaaatagat aaaagatga
//
