LOCUS       NM_177404               1718 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MAGE family member B1 (MAGEB1), transcript variant 2,
            mRNA.
ACCESSION   NM_177404
VERSION     NM_177404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Park,J.H. and Lee,S.W.
  TITLE     Hypertonicity induction of melanoma antigen, a tumor-associated
            antigen
  JOURNAL   Mol Cells 13 (2), 288-295 (2002)
   PUBMED   12018852
  REMARK    GeneRIF: Results show that hypertonic culture medium differentially
            induces the expression of melanoma antigens B1 and B2 (MAGE-B1,
            -B2) in different human tumor cell lines.
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Lurquin,C., De Smet,C., Brasseur,F., Muscatelli,F., Martelange,V.,
            De Plaen,E., Brasseur,R., Monaco,A.P. and Boon,T.
  TITLE     Two members of the human MAGEB gene family located in Xp21.3 are
            expressed in tumors of various histological origins
  JOURNAL   Genomics 46 (3), 397-408 (1997)
   PUBMED   9441743
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Dabovic,B., Zanaria,E., Bardoni,B., Lisa,A., Bordignon,C.,
            Russo,V., Matessi,C., Traversari,C. and Camerino,G.
  TITLE     A family of rapidly evolving genes from the sex reversal critical
            region in Xp21
  JOURNAL   Mamm Genome 6 (9), 571-580 (1995)
   PUBMED   8535061
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Muscatelli,F., Walker,A.P., De Plaen,E., Stafford,A.N. and
            Monaco,A.P.
  TITLE     Isolation and characterization of a MAGE gene family in the Xp21.3
            region
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 4987-4991 (1995)
   PUBMED   7761436
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005185.1 and BU166425.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_177404.2.
            
            Summary: This gene is a member of the MAGEB gene family. The
            members of this family have their entire coding sequences located
            in the last exon, and the encoded proteins show 50 to 68% sequence
            identity to each other. The promoters and first exons of the MAGEB
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. This gene is localized in the
            DSS (dosage-sensitive sex reversal) critical region, and expressed
            in testis and in a significant fraction of tumors of various
            histological types. This gene and other MAGEB members are clustered
            on chromosome Xp22-p21. Multiple alternatively spliced transcript
            variants encoding the same protein have been found for this gene,
            however, the full length nature of some variants has not been
            defined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks three 5' exons but has
            an alternate 5' exon, as compared to variant 1. Variants 1, 2 and 3
            all have the same last exon and encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.53423.1, BC013772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397548.4/ ENSP00000380681.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC005185.1         65317-65324
            9-801               BU166425.1         1-793
            802-1718            AC005185.1         69295-70211
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..1718
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /note="MAGE family member B1"
                     /db_xref="GeneID:4112"
                     /db_xref="HGNC:HGNC:6808"
                     /db_xref="MIM:300097"
     exon            1..111
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..1718
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1215
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /note="cancer/testis antigen family 3, member 1; DSS/AHC
                     critical interval MAGE superfamily 10; MAGE-XP antigen;
                     cancer/testis antigen 3.1; MAGE-B1 antigen; melanoma
                     antigen family B, 1; melanoma antigen family B1"
                     /codon_start=1
                     /product="melanoma-associated antigen B1"
                     /protein_id="NP_796379.1"
                     /db_xref="CCDS:CCDS14222.1"
                     /db_xref="GeneID:4112"
                     /db_xref="HGNC:HGNC:6808"
                     /db_xref="MIM:300097"
                     /translation="MPRGQKSKLRAREKRRKAREETQGLKVAHATAAEKEECPSSSPV
                     LGDTPTSSPAAGIPQKPQGAPPTTTAAAAVSCTESDEGAKCQGEENASFSQATTSTES
                     SVKDPVAWEAGMLMHFILRKYKMREPIMKADMLKVVDEKYKDHFTEILNGASRRLELV
                     FGLDLKEDNPSGHTYTLVSKLNLTNDGNLSNDWDFPRNGLLMPLLGVIFLKGNSATEE
                     EIWKFMNVLGAYDGEEHLIYGEPRKFITQDLVQEKYLKYEQVPNSDPPRYQFLWGPRA
                     YAETTKMKVLEFLAKMNGATPRDFPSHYEEALRDEEERAQVRSSVRARRRTTATTFRA
                     RSRAPFSRSSHPM"
     regulatory      1698..1703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /note="hexamer: AATAAA"
     polyA_site      1718
                     /gene="MAGEB1"
                     /gene_synonym="CT3.1; DAM10; MAGE-Xp; MAGEL1"
                     /note="major polyA site"
ORIGIN      
        1 atcctgactt ccgctttgaa ggcgaggacc ccagcgagcg taagggcgca gtgtccgcct
       61 ggcggatttg ggtcagcagg cggaagtcgt cccaggctgc tagatactaa ggtgccacat
      121 ctcctgcctt tctgctcact ttcctgcctg ttttgcctga ccacagccat catgcctcgg
      181 ggtcagaaga gtaagctccg tgctcgtgag aaacgccgca aggcgcgaga ggagacccag
      241 ggtctcaagg ttgctcacgc cactgcagca gagaaagagg agtgcccctc ctcctctcct
      301 gttttagggg atactcccac aagctcccct gctgctggca ttccccagaa gcctcaggga
      361 gctccaccca ccaccactgc tgctgcagct gtgtcatgta ccgaatctga cgaaggtgcc
      421 aaatgccaag gtgaggaaaa tgcaagtttc tcccaggcca caacatccac tgagagctca
      481 gtcaaagatc ctgtagcctg ggaggcagga atgctgatgc acttcattct acgtaagtat
      541 aaaatgagag agcccattat gaaggcagat atgctgaagg ttgttgatga aaagtacaag
      601 gatcacttca ctgagatcct caatggagcc tctcgccgct tggagctcgt ctttggcctt
      661 gatttgaagg aagacaaccc tagtggccac acctacaccc tcgtcagtaa gctaaacctc
      721 accaatgatg gaaacctgag caatgattgg gactttccca ggaatgggct tctgatgcct
      781 ctcctgggtg tgatcttctt aaagggcaac tctgccaccg aggaagagat ctggaaattc
      841 atgaatgtgt tgggagccta tgatggagag gagcacttaa tctatgggga accccgtaag
      901 ttcatcaccc aagatctggt gcaggaaaaa tatctgaagt acgagcaggt gcccaacagt
      961 gatcccccac gctatcaatt cctatggggt ccgagagcct atgctgaaac caccaagatg
     1021 aaagtcctcg agtttttggc caagatgaat ggtgccactc cccgtgactt cccatcccat
     1081 tatgaagagg ctttgagaga tgaggaagag agagcccaag tccgatccag tgttagagcc
     1141 aggcgtcgca ctactgccac gacttttaga gcgcgttcta gagccccatt cagcaggtcc
     1201 tcccacccca tgtgagaact caggcagatt gttcactttg tttttgtggc aagatgccaa
     1261 ccttttgaag tagtgagcag ccaagatatg gctagagaga tcatcatata tatctccttt
     1321 gtgttcctgt taaacattag tatctttcaa gtgtttttct tttaatagaa tgtttattta
     1381 gagttgggat ctatgtctat gagcgacatg gatcacacat ttattggtgc tgccagcttt
     1441 aagcatatga gttttgatat tctatatttt tcaaatcctt gaatcttttt tgggttgaag
     1501 aagaagaaag catagcttta gaatagagat tttctcagaa atgtgtgaaa gaacctcaca
     1561 caacataatt ggagtcttaa aatagaggaa gagtaagcaa agcatgtcaa gtttttgttt
     1621 tctgcattca gttttgtttt tgtaaaatcc aaagatacat acctggttgt ttttagcctt
     1681 ttcaagaatg cagataaaat aaatagtaat aaattata
//
