LOCUS       NM_001080790            1814 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAGE family member A9B (MAGEA9B), mRNA.
ACCESSION   NM_001080790 XM_001126443 XM_001126454
VERSION     NM_001080790.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB015621.1 and AC016940.7.
            
            On or before Jan 28, 2007 this sequence version replaced
            XM_001126454.1, XM_001126443.1.
            
            Summary: MAGEA9B is a duplication of the MAGEA9 gene (MIM 300342)
            on chromosome Xq28. The 2 copies are separated by about 194 kb
            (Hartz, 2009).[supplied by OMIM, Mar 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292272.1, BE793498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595065.6/ ENSP00000471017.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               DB015621.1         1-472
            473-1814            AC016940.7         76213-77554
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1814
                     /gene="MAGEA9B"
                     /note="MAGE family member A9B"
                     /db_xref="GeneID:728269"
                     /db_xref="HGNC:HGNC:31909"
                     /db_xref="MIM:300764"
     exon            1..66
                     /gene="MAGEA9B"
                     /inference="alignment:Splign:2.1.0"
     exon            67..153
                     /gene="MAGEA9B"
                     /inference="alignment:Splign:2.1.0"
     exon            154..222
                     /gene="MAGEA9B"
                     /inference="alignment:Splign:2.1.0"
     exon            223..1814
                     /gene="MAGEA9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1235
                     /gene="MAGEA9B"
                     /note="CT1.9; MAGE-9 antigen; cancer/testis antigen 1.9;
                     melanoma antigen family A, 9B; melanoma antigen family
                     A9B"
                     /codon_start=1
                     /product="melanoma-associated antigen 9"
                     /protein_id="NP_001074259.1"
                     /db_xref="CCDS:CCDS35423.1"
                     /db_xref="GeneID:728269"
                     /db_xref="HGNC:HGNC:31909"
                     /db_xref="MIM:300764"
                     /translation="MSLEQRSPHCKPDEDLEAQGEDLGLMGAQEPTGEEEETTSSSDS
                     KEEEVSAAGSSSPPQSPQGGASSSISVYYTLWSQFDEGSSSQEEEEPSSSVDPAQLEF
                     MFQEALKLKVAELVHFLLHKYRVKEPVTKAEMLESVIKNYKRYFPVIFGKASEFMQVI
                     FGTDVKEVDPAGHSYILVTALGLSCDSMLGDGHSMPKAALLIIVLGVILTKDNCAPEE
                     VIWEALSVMGVYVGKEHMFYGEPRKLLTQDWVQENYLEYRQVPGSDPAHYEFLWGSKA
                     HAETSYEKVINYLVMLNAREPICYPSLYEEVLGEEQEGV"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA9B"
                     /note="hexamer: AATAAA"
     polyA_site      1814
                     /gene="MAGEA9B"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcactg ggggtcagag agaagggaga ggcctccttc tgaggggcgg cttgataccg
       61 gtggaggagc tccaggaagc aggcaggcct tggtctgaga cagtgtcctc aggtcgcaga
      121 gcagaggaga cccaggcagt gtcagcagtg aaggttctcg ggacaggcta accaggagga
      181 caggagcccc aagaggcccc agagcagcac tgacgaagac ctgcctgtgg gtctccatcg
      241 cccagctcct gcccacgctc ctgactgctg ccctgaccag agtcatcatg tctctcgagc
      301 agaggagtcc gcactgcaag cctgatgaag accttgaagc ccaaggagag gacttgggcc
      361 tgatgggtgc acaggaaccc acaggcgagg aggaggagac tacctcctcc tctgacagca
      421 aggaggagga ggtgtctgct gctgggtcat caagtcctcc ccagagtcct cagggaggcg
      481 cttcctcctc catttccgtc tactacactt tatggagcca attcgatgag ggctccagca
      541 gtcaagaaga ggaagagcca agctcctcgg tcgacccagc tcagctggag ttcatgttcc
      601 aagaagcact gaaattgaag gtggctgagt tggttcattt cctgctccac aaatatcgag
      661 tcaaggagcc ggtcacaaag gcagaaatgc tggagagcgt catcaaaaat tacaagcgct
      721 actttcctgt gatcttcggc aaagcctccg agttcatgca ggtgatcttt ggcactgatg
      781 tgaaggaggt ggaccccgcc ggccactcct acatccttgt cactgctctt ggcctctcgt
      841 gcgatagcat gctgggtgat ggtcatagca tgcccaaggc cgccctcctg atcattgtcc
      901 tgggtgtgat cctaaccaaa gacaactgcg cccctgaaga ggttatctgg gaagcgttga
      961 gtgtgatggg ggtgtatgtt gggaaggagc acatgttcta cggggagccc aggaagctgc
     1021 tcacccaaga ttgggtgcag gaaaactacc tggagtaccg gcaggtgccc ggcagtgatc
     1081 ctgcgcacta cgagttcctg tggggttcca aggcccacgc tgaaaccagc tatgagaagg
     1141 tcataaatta tttggtcatg ctcaatgcaa gagagcccat ctgctaccca tccctttatg
     1201 aagaggtttt gggagaggag caagagggag tctgagcacc agccgcagcc ggggccaaag
     1261 tttgtggggt cagggcccca tccagcagct gccctgcccc atgtgacatg aggcccattc
     1321 ttggctctgt gtttgaagag agcaatcagt gttctcagtg gcagtgggtg gaagtgagca
     1381 cactgtatgt catctctggg ttccttgtct attgggtgat ttggagattt atccttgctc
     1441 ccttttggaa ttgttcaaat gttcttttaa tggtcagttt aatgaacttc accatcgaag
     1501 ttaatgaatg acagtagtca cacatattgc tgtttatgtt atttaggagt aagattcttg
     1561 cttttgagtc acatggggaa atccctgtta ttttgtgaat tgggacaaga taacatagca
     1621 gaggaattaa taattttttt gaaacttgaa cttagcagca aaatagagct cataaagaaa
     1681 tagtgaaatg aaaatgtagt taattcttgc cttatacctc tttctctctc ctgtaaaatt
     1741 aaaatatata catgtatacc tggatttgct tggcttcttt gagcatgtaa gagaaataaa
     1801 aattgaaaga ataa
//
