LOCUS       NP_001074259             315 aa            linear   PRI 28-APR-2025
DEFINITION  melanoma-associated antigen 9 [Homo sapiens].
ACCESSION   NP_001074259 XP_001126443 XP_001126454
VERSION     NP_001074259.1
DBSOURCE    REFSEQ: accession NM_001080790.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 315)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 315)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   4  (residues 1 to 315)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   5  (residues 1 to 315)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB015621.1 and AC016940.7.
            
            On or before Jan 28, 2007 this sequence version replaced
            XP_001126454.1, XP_001126443.1.
            
            Summary: MAGEA9B is a duplication of the MAGEA9 gene (MIM 300342)
            on chromosome Xq28. The 2 copies are separated by about 194 kb
            (Hartz, 2009).[supplied by OMIM, Mar 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292272.1, BE793498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595065.6/ ENSP00000471017.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     Protein         1..315
                     /product="melanoma-associated antigen 9"
                     /note="CT1.9; MAGE-9 antigen; cancer/testis antigen 1.9;
                     melanoma antigen family A, 9B; melanoma antigen family
                     A9B"
                     /calculated_mol_wt=34957
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P43362.1)"
     Region          5..80
                     /region_name="MAGE_N"
                     /note="Melanoma associated antigen family N terminal;
                     pfam12440"
                     /db_xref="CDD:463582"
     Region          128..279
                     /region_name="MAGE"
                     /note="MAGE homology domain; pfam01454"
                     /db_xref="CDD:426270"
     CDS             1..315
                     /gene="MAGEA9B"
                     /coded_by="NM_001080790.1:288..1235"
                     /db_xref="CCDS:CCDS35423.1"
                     /db_xref="GeneID:728269"
                     /db_xref="HGNC:HGNC:31909"
                     /db_xref="MIM:300764"
ORIGIN      
        1 msleqrsphc kpdedleaqg edlglmgaqe ptgeeeetts ssdskeeevs aagsssppqs
       61 pqggasssis vyytlwsqfd egsssqeeee psssvdpaql efmfqealkl kvaelvhfll
      121 hkyrvkepvt kaemlesvik nykryfpvif gkasefmqvi fgtdvkevdp aghsyilvta
      181 lglscdsmlg dghsmpkaal liivlgvilt kdncapeevi wealsvmgvy vgkehmfyge
      241 prklltqdwv qenyleyrqv pgsdpahyef lwgskahaet syekvinylv mlnarepicy
      301 pslyeevlge eqegv
//
