LOCUS       NM_005365               1814 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens MAGE family member A9 (MAGEA9), mRNA.
ACCESSION   NM_005365
VERSION     NM_005365.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Yu,L., Shao,X., Huo,L. and Zhang,T.
  TITLE     Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung
            Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation
            and Migration by Regulating miR-143-3p and MAGE Family Member A9
            (MAGEA9) in Oral Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 26, e924187 (2020)
   PUBMED   32879299
  REMARK    GeneRIF: Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung
            Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation
            and Migration by Regulating miR-143-3p and MAGE Family Member A9
            (MAGEA9) in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Wei,Y., Wang,Y., Gong,J., Rao,L., Wu,Z., Nie,T., Shi,D. and
            Zhang,L.
  TITLE     High expression of MAGE-A9 contributes to stemness and malignancy
            of human hepatocellular carcinoma
  JOURNAL   Int J Oncol 52 (1), 219-230 (2018)
   PUBMED   29138811
  REMARK    GeneRIF: MAGE-A9 overexpression promoted cell proliferation, colony
            formation, migration, chemoresistance, and tumorigenicity in the
            context of EpCAM+ HCC cells, whereas MAGE-A9 knockdown
            significantly inhibited anchorage-dependent and spheroid colony
            formation and in vivo tumorigenicity.
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Shen,Y., Xu,J., Yang,X., Liu,Y., Ma,Y., Yang,D., Dong,Q. and
            Yang,Y.
  TITLE     Evidence for the involvement of the proximal copy of the MAGEA9
            gene in Xq28-linked CNV67 specific to spermatogenic failure
  JOURNAL   Biol Reprod 96 (3), 610-616 (2017)
   PUBMED   28339631
  REMARK    GeneRIF: potential X-linked candidate for the CNV67-related
            spermatogenic failure phenotype
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Oehlrich,N., Devitt,G., Linnebacher,M., Schwitalle,Y.,
            Grosskinski,S., Stevanovic,S. and Zoller,M.
  TITLE     Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic
            T-lymphocyte lines for transfer in patients with renal cell
            carcinoma
  JOURNAL   Int J Cancer 117 (2), 256-264 (2005)
   PUBMED   15900605
  REMARK    GeneRIF: May provide suitable targets for immunotherapy of renal
            cell carcinoma.
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Serrano,A., Lethe,B., Delroisse,J.M., Lurquin,C., De Plaen,E.,
            Brasseur,F., Rimoldi,D. and Boon,T.
  TITLE     Quantitative evaluation of the expression of MAGE genes in tumors
            by limiting dilution of cDNA libraries
  JOURNAL   Int J Cancer 83 (5), 664-669 (1999)
   PUBMED   10521804
REFERENCE   8  (bases 1 to 1814)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   9  (bases 1 to 1814)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   10 (bases 1 to 1814)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244098.2 and BC002351.2.
            
            On Aug 14, 2020 this sequence version replaced NM_005365.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002351.2, SRR5189667.401364.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243314.5/ ENSP00000243314.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC244098.2         61610-61616         c
            8-1814              BC002351.2         1-1807
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1814
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /note="MAGE family member A9"
                     /db_xref="GeneID:4108"
                     /db_xref="HGNC:HGNC:6807"
                     /db_xref="MIM:300342"
     exon            1..66
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /inference="alignment:Splign:2.1.0"
     exon            67..153
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /inference="alignment:Splign:2.1.0"
     exon            154..222
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /inference="alignment:Splign:2.1.0"
     exon            223..1814
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1235
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /note="cancer/testis antigen family 1, member 9; MAGE-9
                     antigen; cancer/testis antigen 1.9; melanoma antigen
                     family A, 9; melanoma antigen family A9"
                     /codon_start=1
                     /product="melanoma-associated antigen 9"
                     /protein_id="NP_005356.1"
                     /db_xref="CCDS:CCDS14691.1"
                     /db_xref="GeneID:4108"
                     /db_xref="HGNC:HGNC:6807"
                     /db_xref="MIM:300342"
                     /translation="MSLEQRSPHCKPDEDLEAQGEDLGLMGAQEPTGEEEETTSSSDS
                     KEEEVSAAGSSSPPQSPQGGASSSISVYYTLWSQFDEGSSSQEEEEPSSSVDPAQLEF
                     MFQEALKLKVAELVHFLLHKYRVKEPVTKAEMLESVIKNYKRYFPVIFGKASEFMQVI
                     FGTDVKEVDPAGHSYILVTALGLSCDSMLGDGHSMPKAALLIIVLGVILTKDNCAPEE
                     VIWEALSVMGVYVGKEHMFYGEPRKLLTQDWVQENYLEYRQVPGSDPAHYEFLWGSKA
                     HAETSYEKVINYLVMLNAREPICYPSLYEEVLGEEQEGV"
ORIGIN      
        1 gtgcgcactg ggggtcagag agaagggaga ggcctccttc tgaggggcgg cttgataccg
       61 gtggaggagc tccaggaagc aggcaggcct tggtctgaga cagtgtcctc aggtcgcaga
      121 gcagaggaga cccaggcagt gtcagcagtg aaggttctcg ggacaggcta accaggagga
      181 caggagcccc aagaggcccc agagcagcac tgacgaagac ctgcctgtgg gtctccatcg
      241 cccagctcct gcccacgctc ctgactgctg ccctgaccag agtcatcatg tctctcgagc
      301 agaggagtcc gcactgcaag cctgatgaag accttgaagc ccaaggagag gacttgggcc
      361 tgatgggtgc acaggaaccc acaggcgagg aggaggagac tacctcctcc tctgacagca
      421 aggaggagga ggtgtctgct gctgggtcat caagtcctcc ccagagtcct cagggaggcg
      481 cttcctcctc catttccgtc tactacactt tatggagcca attcgatgag ggctccagca
      541 gtcaagaaga ggaagagcca agctcctcgg tcgacccagc tcagctggag ttcatgttcc
      601 aagaagcact gaaattgaag gtggctgagt tggttcattt cctgctccac aaatatcgag
      661 tcaaggagcc ggtcacaaag gcagaaatgc tggagagcgt catcaaaaat tacaagcgct
      721 actttcctgt gatcttcggc aaagcctccg agttcatgca ggtgatcttt ggcactgatg
      781 tgaaggaggt ggaccccgcc ggccactcct acatccttgt cactgctctt ggcctctcgt
      841 gcgatagcat gctgggtgat ggtcatagca tgcccaaggc cgccctcctg atcattgtcc
      901 tgggtgtgat cctaaccaaa gacaactgcg cccctgaaga ggttatctgg gaagcgttga
      961 gtgtgatggg ggtgtatgtt gggaaggagc acatgttcta cggggagccc aggaagctgc
     1021 tcacccaaga ttgggtgcag gaaaactacc tggagtaccg gcaggtgccc ggcagtgatc
     1081 ctgcgcacta cgagttcctg tggggttcca aggcccacgc tgaaaccagc tatgagaagg
     1141 tcataaatta tttggtcatg ctcaatgcaa gagagcccat ctgctaccca tccctttatg
     1201 aagaggtttt gggagaggag caagagggag tctgagcacc agccgcagcc ggggccaaag
     1261 tttgtggggt cagggcccca tccagcagct gccctgcccc atgtgacatg aggcccattc
     1321 ttcgctctgt gtttgaagag agcaatcagt gttctcagtg gcagtgggtg gaagtgagca
     1381 cactgtatgt catctctggg ttccttgtct attgggtgat ttggagattt atccttgctc
     1441 ccttttggaa ttgttcaaat gttcttttaa tggtcagttt aatgaacttc accatcgaag
     1501 ttaatgaatg acagtagtca cacatattgc tgtttatgtt atttaggagt aagattcttg
     1561 cttttgagtc acatggggaa atccctgtta ttttgtgaat tgggacaaga taacatagca
     1621 gaggaattaa taattttttt gaaacttgaa cttagcagca aaatagagct cataaagaaa
     1681 tagtgaaatg aaaatgtagt taattcttgc cttatacctc tttctctctc ctgtaaaatt
     1741 aaaacatata catgtatacc tggatttgct tggcttcttt gagcatgtaa gagaaataaa
     1801 aattgaaaga ataa
//
