LOCUS       NP_005356                315 aa            linear   PRI 30-APR-2025
DEFINITION  melanoma-associated antigen 9 [Homo sapiens].
ACCESSION   NP_005356
VERSION     NP_005356.1
DBSOURCE    REFSEQ: accession NM_005365.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 315)
  AUTHORS   Yu,L., Shao,X., Huo,L. and Zhang,T.
  TITLE     Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung
            Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation
            and Migration by Regulating miR-143-3p and MAGE Family Member A9
            (MAGEA9) in Oral Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 26, e924187 (2020)
   PUBMED   32879299
  REMARK    GeneRIF: Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung
            Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation
            and Migration by Regulating miR-143-3p and MAGE Family Member A9
            (MAGEA9) in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 315)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 315)
  AUTHORS   Wei,Y., Wang,Y., Gong,J., Rao,L., Wu,Z., Nie,T., Shi,D. and
            Zhang,L.
  TITLE     High expression of MAGE-A9 contributes to stemness and malignancy
            of human hepatocellular carcinoma
  JOURNAL   Int J Oncol 52 (1), 219-230 (2018)
   PUBMED   29138811
  REMARK    GeneRIF: MAGE-A9 overexpression promoted cell proliferation, colony
            formation, migration, chemoresistance, and tumorigenicity in the
            context of EpCAM+ HCC cells, whereas MAGE-A9 knockdown
            significantly inhibited anchorage-dependent and spheroid colony
            formation and in vivo tumorigenicity.
REFERENCE   5  (residues 1 to 315)
  AUTHORS   Shen,Y., Xu,J., Yang,X., Liu,Y., Ma,Y., Yang,D., Dong,Q. and
            Yang,Y.
  TITLE     Evidence for the involvement of the proximal copy of the MAGEA9
            gene in Xq28-linked CNV67 specific to spermatogenic failure
  JOURNAL   Biol Reprod 96 (3), 610-616 (2017)
   PUBMED   28339631
  REMARK    GeneRIF: potential X-linked candidate for the CNV67-related
            spermatogenic failure phenotype
REFERENCE   6  (residues 1 to 315)
  AUTHORS   Oehlrich,N., Devitt,G., Linnebacher,M., Schwitalle,Y.,
            Grosskinski,S., Stevanovic,S. and Zoller,M.
  TITLE     Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic
            T-lymphocyte lines for transfer in patients with renal cell
            carcinoma
  JOURNAL   Int J Cancer 117 (2), 256-264 (2005)
   PUBMED   15900605
  REMARK    GeneRIF: May provide suitable targets for immunotherapy of renal
            cell carcinoma.
REFERENCE   7  (residues 1 to 315)
  AUTHORS   Serrano,A., Lethe,B., Delroisse,J.M., Lurquin,C., De Plaen,E.,
            Brasseur,F., Rimoldi,D. and Boon,T.
  TITLE     Quantitative evaluation of the expression of MAGE genes in tumors
            by limiting dilution of cDNA libraries
  JOURNAL   Int J Cancer 83 (5), 664-669 (1999)
   PUBMED   10521804
REFERENCE   8  (residues 1 to 315)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   9  (residues 1 to 315)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   10 (residues 1 to 315)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244098.2 and BC002351.2.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002351.2, SRR5189667.401364.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243314.5/ ENSP00000243314.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     Protein         1..315
                     /product="melanoma-associated antigen 9"
                     /note="cancer/testis antigen family 1, member 9; MAGE-9
                     antigen; cancer/testis antigen 1.9; melanoma antigen
                     family A, 9; melanoma antigen family A9"
                     /calculated_mol_wt=34957
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P43362.1)"
     Region          5..80
                     /region_name="MAGE_N"
                     /note="Melanoma associated antigen family N terminal;
                     pfam12440"
                     /db_xref="CDD:463582"
     Region          128..279
                     /region_name="MAGE"
                     /note="MAGE homology domain; pfam01454"
                     /db_xref="CDD:426270"
     CDS             1..315
                     /gene="MAGEA9"
                     /gene_synonym="CT1.9; MAGE9"
                     /coded_by="NM_005365.5:288..1235"
                     /db_xref="CCDS:CCDS14691.1"
                     /db_xref="GeneID:4108"
                     /db_xref="HGNC:HGNC:6807"
                     /db_xref="MIM:300342"
ORIGIN      
        1 msleqrsphc kpdedleaqg edlglmgaqe ptgeeeetts ssdskeeevs aagsssppqs
       61 pqggasssis vyytlwsqfd egsssqeeee psssvdpaql efmfqealkl kvaelvhfll
      121 hkyrvkepvt kaemlesvik nykryfpvif gkasefmqvi fgtdvkevdp aghsyilvta
      181 lglscdsmlg dghsmpkaal liivlgvilt kdncapeevi wealsvmgvy vgkehmfyge
      241 prklltqdwv qenyleyrqv pgsdpahyef lwgskahaet syekvinylv mlnarepicy
      301 pslyeevlge eqegv
//
