LOCUS       NM_005364               1781 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens MAGE family member A8 (MAGEA8), transcript variant 3,
            mRNA.
ACCESSION   NM_005364
VERSION     NM_005364.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Serrano,A., Lethe,B., Delroisse,J.M., Lurquin,C., De Plaen,E.,
            Brasseur,F., Rimoldi,D. and Boon,T.
  TITLE     Quantitative evaluation of the expression of MAGE genes in tumors
            by limiting dilution of cDNA libraries
  JOURNAL   Int J Cancer 83 (5), 664-669 (1999)
   PUBMED   10521804
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313943.1 and BC002455.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005364.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.352954.1,
                                           SRR5189667.124238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286482.6/ ENSP00000286482.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK313943.1         43-54
            13-1781             BC002455.2         1-1769
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1781
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /note="MAGE family member A8"
                     /db_xref="GeneID:4107"
                     /db_xref="HGNC:HGNC:6806"
                     /db_xref="MIM:300341"
     exon            1..103
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /inference="alignment:Splign:2.1.0"
     exon            104..165
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /inference="alignment:Splign:2.1.0"
     exon            166..1781
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1185
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /note="cancer/testis antigen family 1, member 8; melanoma
                     antigen family A, 8; MAGE-8 antigen; cancer/testis antigen
                     1.8; melanoma antigen family A8"
                     /codon_start=1
                     /product="melanoma-associated antigen 8"
                     /protein_id="NP_005355.2"
                     /db_xref="CCDS:CCDS14692.1"
                     /db_xref="GeneID:4107"
                     /db_xref="HGNC:HGNC:6806"
                     /db_xref="MIM:300341"
                     /translation="MLLGQKSQRYKAEEGLQAQGEAPGLMDVQIPTAEEQKAASSSST
                     LIMGTLEEVTDSGSPSPPQSPEGASSSLTVTDSTLWSQSDEGSSSNEEEGPSTSPDPA
                     HLESLFREALDEKVAELVRFLLRKYQIKEPVTKAEMLESVIKNYKNHFPDIFSKASEC
                     MQVIFGIDVKEVDPAGHSYILVTCLGLSYDGLLGDDQSTPKTGLLIIVLGMILMEGSR
                     APEEAIWEALSVMGLYDGREHSVYWKLRKLLTQEWVQENYLEYRQAPGSDPVRYEFLW
                     GPRALAETSYVKVLEHVVRVNARVRISYPSLHEEALGEEKGV"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /note="hexamer: ATTAAA"
     polyA_site      1781
                     /gene="MAGEA8"
                     /gene_synonym="CT1.8; MAGE8"
                     /note="major polyA site"
ORIGIN      
        1 actgacgtgg ccgcggggat cagagagaag cgagggcctg gttctgaggg gtcggcttga
       61 gatcggctga gggaagcggg ctcagggtct gtgaggaggc aaggttcgca gagaacaggc
      121 cagccaggag gtcaggaggc cccagagaag cactgaagaa gacctgcctg tgggtctcaa
      181 ttgcccagct ccggcccaca ctctcctgct gccctgacct gagtcatcat gcttcttggg
      241 cagaagagtc agcgctacaa ggctgaggaa ggccttcagg cccaaggaga ggcaccaggg
      301 cttatggatg tgcagattcc cacagctgag gagcagaagg ctgcatcctc ctcctctact
      361 ctgatcatgg gaacccttga ggaggtgact gattctgggt caccaagtcc tccccagagt
      421 cctgagggtg cctcctcttc cctgactgtc accgacagca ctctgtggag ccaatccgat
      481 gagggttcca gcagcaatga agaggagggg ccaagcacct ccccggaccc agctcacctg
      541 gagtccctgt tccgggaagc acttgatgag aaagtggctg agttagttcg tttcctgctc
      601 cgcaaatatc aaattaagga gccggtcaca aaggcagaaa tgcttgagag tgtcatcaaa
      661 aattacaaga accactttcc tgatatcttc agcaaagcct ctgagtgcat gcaggtgatc
      721 tttggcattg atgtgaagga agtggaccct gccggccact cctacatcct tgtcacctgc
      781 ctgggcctct cctatgatgg cctgctgggt gatgatcaga gtacgcccaa gaccggcctc
      841 ctgataatcg tcctgggcat gatcttaatg gagggcagcc gcgccccgga ggaggcaatc
      901 tgggaagcgt tgagtgtgat ggggctgtat gatgggaggg agcacagtgt ctattggaag
      961 ctcaggaagc tgctcaccca agagtgggtg caggagaact acctggagta ccgccaggcg
     1021 cccggcagtg atcctgtgcg ctacgagttc ctgtggggtc caagggccct tgctgaaacc
     1081 agctatgtga aagtcctgga gcatgtggtc agggtcaatg caagagttcg catttcctac
     1141 ccatccctgc atgaagaggc tttgggagag gagaaaggag tttgagcagg agttgcagct
     1201 agggccagtg gggcaggttg tgggagggcc tgggccagtg cacgttccag ggccacatcc
     1261 accactttcc ctgctctgtt acatgaggcc cattcttcac tctgtgtttg aagagagcag
     1321 tcacagttct cagtagtggg gagcatgttg ggtgtgaggg aacacagtgt ggaccatctc
     1381 tcagttcctg ttctattggg cgatttggag gtttatcttt gtttcctttt ggaattgttc
     1441 caatgttcct tctaatggat ggtgtaatga acttcaacat tcattttatg tatgacagta
     1501 gacagactta ctgcttttta tatagtttag gagtaagagt cttgcttttc atttatactg
     1561 ggaaacccat gttatttctt gaattcagac actacaagag cagaggatta aggttttttt
     1621 agaaatgtga aacaacatag cagtaaaata catgagataa agacataaag aaattaaaca
     1681 atagttaatt cttgccttac ctgtacctct tagtgtaccc tatgtacctg aatttgcttg
     1741 gcttctttga gaatgaaatt gaattaaata tgaataaata a
//
