LOCUS       NM_005363               1682 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens MAGE family member A6 (MAGEA6), transcript variant 1,
            mRNA.
ACCESSION   NM_005363
VERSION     NM_005363.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Zhou,J., Fan,Q., Li,J., Wu,J., Huang,J., Zhang,Y. and He,X.
  TITLE     Knockdown of MAGE-A6 enhanced the irradiation sensitivity of
            non-small cell lung cancer cells by activating the AMPK pathway
  JOURNAL   Environ Toxicol 37 (7), 1711-1722 (2022)
   PUBMED   35285568
  REMARK    GeneRIF: Knockdown of MAGE-A6 enhanced the irradiation sensitivity
            of non-small cell lung cancer cells by activating the AMPK pathway.
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Mohsenzadegan,M., Razmi,M., Vafaei,S., Abolhasani,M., Madjd,Z.,
            Saeednejad Zanjani,L. and Sharifi,L.
  TITLE     Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is
            associated with tumor aggressiveness in patients with bladder
            cancer
  JOURNAL   Sci Rep 12 (1), 599 (2022)
   PUBMED   35022469
  REMARK    GeneRIF: Co-expression of cancer-testis antigens of MAGE-A6 and
            MAGE-A11 is associated with tumor aggressiveness in patients with
            bladder cancer.
            Erratum:[Sci Rep. 2022 Feb 7;12(1):2330. doi:
            10.1038/s41598-022-06282-9.. PMID: 35132168]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Tsang,Y.H., Wang,Y., Kong,K., Grzeskowiak,C., Zagorodna,O.,
            Dogruluk,T., Lu,H., Villafane,N., Bhavana,V.H., Moreno,D.,
            Elsea,S.H., Liang,H., Mills,G.B. and Scott,K.L.
  TITLE     Differential expression of MAGEA6 toggles autophagy to promote
            pancreatic cancer progression
  JOURNAL   Elife 9, e48963 (2020)
   PUBMED   32270762
  REMARK    GeneRIF: Differential expression of MAGEA6 toggles autophagy to
            promote pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Tatsumi,T., Kierstead,L.S., Ranieri,E., Gesualdo,L., Schena,F.P.,
            Finke,J.H., Bukowski,R.M., Mueller-Berghaus,J., Kirkwood,J.M.,
            Kwok,W.W. and Storkus,W.J.
  TITLE     Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell
            responses against MAGE-6 in HLA-DRB10401(+) patients with renal
            cell carcinoma or melanoma
  JOURNAL   J Exp Med 196 (5), 619-628 (2002)
   PUBMED   12208877
  REMARK    GeneRIF: Disease-associated bias in T helper type 1 (Th1)/Th2
            CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients
            with renal cell carcinoma or melanoma.
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Imai,Y., Shichijo,S., Yamada,A., Katayama,T., Yano,H. and Itoh,K.
  TITLE     Sequence analysis of the MAGE gene family encoding human
            tumor-rejection antigens
  JOURNAL   Gene 160 (2), 287-290 (1995)
   PUBMED   7642112
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Ding,M., Beck,R.J., Keller,C.J. and Fenton,R.G.
  TITLE     Cloning and analysis of MAGE-1-related genes
  JOURNAL   Biochem Biophys Res Commun 202 (1), 549-555 (1994)
   PUBMED   8037761
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244102.3.
            
            On Jan 5, 2021 this sequence version replaced NM_005363.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289437.1, SRR11853567.32398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329342.10/ ENSP00000329199.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC244102.3         184214-184249       c
            37-102              AC244102.3         182356-182421       c
            103-1682            AC244102.3         180696-182275       c
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1682
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /note="MAGE family member A6"
                     /db_xref="GeneID:4105"
                     /db_xref="HGNC:HGNC:6804"
                     /db_xref="MIM:300176"
     exon            1..36
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /inference="alignment:Splign:2.1.0"
     exon            37..102
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /inference="alignment:Splign:2.1.0"
     exon            103..1682
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1112
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /note="cancer/testis antigen family 1, member 6; MAGE-6
                     antigen; MAGE3B antigen; cancer/testis antigen 1.6;
                     melanoma antigen family A, 6; melanoma antigen family A6"
                     /codon_start=1
                     /product="melanoma-associated antigen 6"
                     /protein_id="NP_005354.1"
                     /db_xref="CCDS:CCDS76050.1"
                     /db_xref="GeneID:4105"
                     /db_xref="HGNC:HGNC:6804"
                     /db_xref="MIM:300176"
                     /translation="MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSST
                     LVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLE
                     SEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQL
                     VFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPE
                     EKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPR
                     ALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /note="hexamer: AATAAA"
     polyA_site      1682
                     /gene="MAGEA6"
                     /gene_synonym="CT1.6; MAGE-3b; MAGE3B; MAGE6"
                     /note="major polyA site"
ORIGIN      
        1 ggagggaagc cggcccaggc tcggtgagga ggcaaggttc tgaggggaca ggctgacgtg
       61 gaggaacaga ggcccccgga ggagcactga aggagaagat ctgccagtgg gtctccattg
      121 cccagctcct gcccacactc ccgcctgttg ccctgaccag agtcatcatg cctcttgagc
      181 agaggagtca gcactgcaag cctgaagaag gccttgaggc ccgaggagag gccctgggcc
      241 tggtgggtgc gcaggctcct gctactgagg agcaggaggc tgcctcctcc tcttctactc
      301 tagttgaagt caccctgggg gaggtgcctg ctgccgagtc accagatcct ccccagagtc
      361 ctcagggagc ctccagcctc cccactacca tgaactaccc tctctggagc caatcctatg
      421 aggactccag caaccaagaa gaggaggggc caagcacctt ccctgacctg gagtctgagt
      481 tccaagcagc actcagtagg aaggtggcca agttggttca ttttctgctc ctcaagtatc
      541 gagccaggga gccggtcaca aaggcagaaa tgctggggag tgtcgtcgga aattggcagt
      601 acttctttcc tgtgatcttc agcaaagctt ccgattcctt gcagctggtc tttggcatcg
      661 agctgatgga agtggacccc atcggccacg tgtacatctt tgccacctgc ctgggcctct
      721 cctacgatgg cctgctgggt gacaatcaga tcatgcccaa gacaggcttc ctgataatca
      781 tcctggccat aatcgcaaaa gagggcgact gtgcccctga ggagaaaatc tgggaggagc
      841 tgagtgtgtt agaggtgttt gaggggaggg aagacagtat cttcggggat cccaagaagc
      901 tgctcaccca atatttcgtg caggaaaact acctggagta ccggcaggtc cccggcagtg
      961 atcctgcatg ctatgagttc ctgtggggtc caagggccct cattgaaacc agctatgtga
     1021 aagtcctgca ccatatggta aagatcagtg gaggacctcg catttcctac ccactcctgc
     1081 atgagtgggc tttgagagag ggggaagagt gagtctgagc acgagttgca gccagggcca
     1141 gtgggagggg gtttgggcca gtgcaccttc cggggcccca tcccttagtt tccactgcct
     1201 cctgtgacgt gaggcccatt cttcactctt tgaagcgagc agtcagcatt cttagtagtg
     1261 ggtttctgtt ctgttggatg actttgagat tattctttgt ttcctgttgg agttgttcaa
     1321 atgttccttt taacggatgg ttgaatgagc gtcagcatcc aggtttatga atgacagtag
     1381 tcacacatag tgctgtttat atagtttagg agtaagagtc ttgtttttta ttcagattgg
     1441 gaaatccatt ccattttgtg aattgtgaca taataatagc agtggtaaaa gtatttgctt
     1501 aaaattgtga gcgaattagc aataacatac atgagataac tcaagaaatc aaaagatagt
     1561 tgattcttgc cttgtacctc aatctattct gtaaaattaa acaaatatgc aaaccaggat
     1621 ttccttgact tctttgagaa tgcaagcgaa attaaatctg aataaataat tcttcctctt
     1681 ca
//
