LOCUS       NM_001011548            1724 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAGE family member A4 (MAGEA4), transcript variant 1,
            mRNA.
ACCESSION   NM_001011548
VERSION     NM_001011548.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Hashimoto,K., Nishimura,S., Shinyashiki,Y., Ito,T., Kakinoki,R. and
            Akagi,M.
  TITLE     Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid
            tumors
  JOURNAL   Medicine (Baltimore) 102 (22), e33908 (2023)
   PUBMED   37266606
  REMARK    GeneRIF: Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of
            desmoid tumors.
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Cai,R., Zhao,F., Zhou,H., Wang,Z., Lin,D., Huang,L., Xie,W.,
            Chen,J., Zhou,L., Zhang,N. and Huang,C.
  TITLE     A tumor-associated autoantibody panel for the detection of
            non-small cell lung cancer
  JOURNAL   Front Oncol 12, 1056572 (2022)
   PUBMED   36531074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Hashimoto,K., Nishimura,S., Ito,T., Oka,N., Kakinoki,R. and
            Akagi,M.
  TITLE     Clinicopathological assessment of cancer/testis antigens NY-ESO-1
            and MAGE-A4 in osteosarcoma
  JOURNAL   Eur J Histochem 66 (3), 3377 (2022)
   PUBMED   35736245
  REMARK    GeneRIF: Clinicopathological assessment of cancer/testis antigens
            NYESO1 and MAGEA4 in osteosarcoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Ishihara,M., Kageyama,S., Miyahara,Y., Ishikawa,T., Ueda,S.,
            Soga,N., Naota,H., Mukai,K., Harada,N., Ikeda,H. and Shiku,H.
  TITLE     MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression
            relationships in solid tumours
  JOURNAL   BMC Cancer 20 (1), 606 (2020)
   PUBMED   32600281
  REMARK    GeneRIF: MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and
            co-expression relationships in solid tumours.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Brasseur,F., Rimoldi,D., Lienard,D., Lethe,B., Carrel,S.,
            Arienti,F., Suter,L., Vanwijck,R., Bourlond,A., Humblet,Y. et al.
  TITLE     Expression of MAGE genes in primary and metastatic cutaneous
            melanoma
  JOURNAL   Int J Cancer 63 (3), 375-380 (1995)
   PUBMED   7591235
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Imai,Y., Shichijo,S., Yamada,A., Katayama,T., Yano,H. and Itoh,K.
  TITLE     Sequence analysis of the MAGE gene family encoding human
            tumor-rejection antigens
  JOURNAL   Gene 160 (2), 287-290 (1995)
   PUBMED   7642112
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Ding,M., Beck,R.J., Keller,C.J. and Fenton,R.G.
  TITLE     Cloning and analysis of MAGE-1-related genes
  JOURNAL   Biochem Biophys Res Commun 202 (1), 549-555 (1994)
   PUBMED   8037761
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX479311.1 and AF274855.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. Several
            variants encoding the same protein have been found for this gene.
            [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 5. All twelve variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX479311.1, DA912058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276344.6/ ENSP00000276344.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BX479311.1         1-153
            154-1724            AF274855.3         119938-121508
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1724
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /note="MAGE family member A4"
                     /db_xref="GeneID:4103"
                     /db_xref="HGNC:HGNC:6802"
                     /db_xref="MIM:300175"
     exon            1..81
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /inference="alignment:Splign:2.1.0"
     exon            82..153
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1724
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1172
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /note="cancer/testis antigen family 1, member 4; MAGE-4
                     antigen; MAGE-41 antigen; MAGE-X2 antigen; cancer/testis
                     antigen 1.4; melanoma antigen family A, 4; melanoma
                     antigen family A4"
                     /codon_start=1
                     /product="melanoma-associated antigen 4"
                     /protein_id="NP_001011548.1"
                     /db_xref="CCDS:CCDS14702.1"
                     /db_xref="GeneID:4103"
                     /db_xref="HGNC:HGNC:6802"
                     /db_xref="MIM:300175"
                     /translation="MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSS
                     PLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDA
                     ESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLK
                     MIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSAS
                     EEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGP
                     RALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /note="hexamer: AATAAA"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /note="hexamer: AATAAT"
     polyA_site      1711
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
     polyA_site      1724
                     /gene="MAGEA4"
                     /gene_synonym="CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A;
                     MAGE4B"
                     /note="major polyA site"
ORIGIN      
        1 agagacaagc gagcttctgc gtctgactcg cagcttgaga ctggcggagg gaagcccgcc
       61 caggctctat aaggagacaa ggttctgagc agacaggcca accggaggac aggattccct
      121 ggaggccaca gaggagcacc aaggagaaga tctgcctgtg ggtccccatt gcccagcttt
      181 tgcctgcact cttgcctgct gccctgacca gagtcatcat gtcttctgag cagaagagtc
      241 agcactgcaa gcctgaggaa ggcgttgagg cccaagaaga ggccctgggc ctggtgggtg
      301 cacaggctcc tactactgag gagcaggagg ctgctgtctc ctcctcctct cctctggtcc
      361 ctggcaccct ggaggaagtg cctgctgctg agtcagcagg tcctccccag agtcctcagg
      421 gagcctctgc cttacccact accatcagct tcacttgctg gaggcaaccc aatgagggtt
      481 ccagcagcca agaagaggag gggccaagca cctcgcctga cgcagagtcc ttgttccgag
      541 aagcactcag taacaaggtg gatgagttgg ctcattttct gctccgcaag tatcgagcca
      601 aggagctggt cacaaaggca gaaatgctgg agagagtcat caaaaattac aagcgctgct
      661 ttcctgtgat cttcggcaaa gcctccgagt ccctgaagat gatctttggc attgacgtga
      721 aggaagtgga ccccgccagc aacacctaca cccttgtcac ctgcctgggc ctttcctatg
      781 atggcctgct gggtaataat cagatctttc ccaagacagg ccttctgata atcgtcctgg
      841 gcacaattgc aatggagggc gacagcgcct ctgaggagga aatctgggag gagctgggtg
      901 tgatgggggt gtatgatggg agggagcaca ctgtctatgg ggagcccagg aaactgctca
      961 cccaagattg ggtgcaggaa aactacctgg agtaccggca ggtacccggc agtaatcctg
     1021 cgcgctatga gttcctgtgg ggtccaaggg ctctggctga aaccagctat gtgaaagtcc
     1081 tggagcatgt ggtcagggtc aatgcaagag ttcgcattgc ctacccatcc ctgcgtgaag
     1141 cagctttgtt agaggaggaa gagggagtct gagcatgagt tgcagccagg gctgtgggga
     1201 aggggcaggg ctgggccagt gcatctaaca gccctgtgca gcagcttccc ttgcctcgtg
     1261 taacatgagg cccattcttc actctgtttg aagaaaatag tcagtgttct tagtagtggg
     1321 tttctatttt gttggatgac ttggagattt atctctgttt ccttttacaa ttgttgaaat
     1381 gttcctttta atggatggtt gaattaactt cagcatccaa gtttatgaat cgtagttaac
     1441 gtatattgct gttaatatag tttaggagta agagtcttgt tttttattca gattgggaaa
     1501 tccgttctat tttgtgaatt tgggacataa taacagcagt ggagtaagta tttagaagtg
     1561 tgaattcacc gtgaaatagg tgagataaat taaaagatac ttaattcccg ccttatgcct
     1621 cagtctattc tgtaaaattt aaaaaatata tatgcatacc tggatttcct tggcttcgtg
     1681 aatgtaagag aaattaaatc tgaataaata attctttctg ttaa
//
