LOCUS       NM_005362               1682 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAGE family member A3 (MAGEA3), mRNA.
ACCESSION   NM_005362
VERSION     NM_005362.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Yu,Q.Y., Wang,Z.W., Zhou,M.Y., Li,S.F. and Liao,X.H.
  TITLE     MAGE-A3 regulates tumor stemness in gastric cancer through the
            PI3K/AKT pathway
  JOURNAL   Aging (Albany NY) 14 (23), 9579-9598 (2022)
   PUBMED   36367777
  REMARK    GeneRIF: MAGE-A3 regulates tumor stemness in gastric cancer through
            the PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Craig,A.J., Garcia-Lezana,T., Ruiz de Galarreta,M.,
            Villacorta-Martin,C., Kozlova,E.G., Martins-Filho,S.N., von
            Felden,J., Ahsen,M.E., Bresnahan,E., Hernandez-Meza,G., Labgaa,I.,
            D'Avola,D., Schwartz,M., Llovet,J.M., Sia,D., Thung,S., Losic,B.,
            Lujambio,A. and Villanueva,A.
  TITLE     Transcriptomic characterization of cancer-testis antigens
            identifies MAGEA3 as a driver of tumor progression in
            hepatocellular carcinoma
  JOURNAL   PLoS Genet 17 (6), e1009589 (2021)
   PUBMED   34166362
  REMARK    GeneRIF: Transcriptomic characterization of cancer-testis antigens
            identifies MAGEA3 as a driver of tumor progression in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Khalvandi,A., Abolhasani,M., Madjd,Z., Shekarabi,M.,
            Kourosh-Arami,M. and Mohsenzadegan,M.
  TITLE     Nuclear overexpression levels of MAGE-A3 predict poor prognosis in
            patients with prostate cancer
  JOURNAL   APMIS 129 (6), 291-303 (2021)
   PUBMED   33743542
  REMARK    GeneRIF: Nuclear overexpression levels of MAGE-A3 predict poor
            prognosis in patients with prostate cancer.
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Das,B. and Senapati,S.
  TITLE     Immunological and functional aspects of MAGEA3 cancer/testis
            antigen
  JOURNAL   Adv Protein Chem Struct Biol 125, 121-147 (2021)
   PUBMED   33931137
  REMARK    GeneRIF: Immunological and functional aspects of MAGEA3
            cancer/testis antigen.
            Review article
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Brasseur,F., Rimoldi,D., Lienard,D., Lethe,B., Carrel,S.,
            Arienti,F., Suter,L., Vanwijck,R., Bourlond,A., Humblet,Y. et al.
  TITLE     Expression of MAGE genes in primary and metastatic cutaneous
            melanoma
  JOURNAL   Int J Cancer 63 (3), 375-380 (1995)
   PUBMED   7591235
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Kocher,T., Schultz-Thater,E., Gudat,F., Schaefer,C., Casorati,G.,
            Juretic,A., Willimann,T., Harder,F., Heberer,M. and Spagnoli,G.C.
  TITLE     Identification and intracellular location of MAGE-3 gene product
  JOURNAL   Cancer Res 55 (11), 2236-2239 (1995)
   PUBMED   7757970
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Ding,M., Beck,R.J., Keller,C.J. and Fenton,R.G.
  TITLE     Cloning and analysis of MAGE-1-related genes
  JOURNAL   Biochem Biophys Res Commun 202 (1), 549-555 (1994)
   PUBMED   8037761
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   van der Bruggen,P., Traversari,C., Chomez,P., Lurquin,C., De
            Plaen,E., Van den Eynde,B., Knuth,A. and Boon,T.
  TITLE     A gene encoding an antigen recognized by cytolytic T lymphocytes on
            a human melanoma
  JOURNAL   Science 254 (5038), 1643-1647 (1991)
   PUBMED   1840703
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244102.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_005362.3.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.52621.1, BC005963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370278.4/ ENSP00000359301.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC244102.3         113354-113389
            37-102              AC244102.3         115182-115247
            103-1682            AC244102.3         115328-116907
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1682
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /note="MAGE family member A3"
                     /db_xref="GeneID:4102"
                     /db_xref="HGNC:HGNC:6801"
                     /db_xref="MIM:300174"
     exon            1..36
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /inference="alignment:Splign:2.1.0"
     exon            37..102
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /inference="alignment:Splign:2.1.0"
     exon            103..1682
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1112
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /note="cancer/testis antigen family 1, member 3; antigen
                     MZ2-D; MAGE-3 antigen; melanoma antigen family A, 3;
                     cancer/testis antigen 1.3; melanoma antigen family A3"
                     /codon_start=1
                     /product="melanoma-associated antigen 3"
                     /protein_id="NP_005353.1"
                     /db_xref="CCDS:CCDS76045.1"
                     /db_xref="GeneID:4102"
                     /db_xref="HGNC:HGNC:6801"
                     /db_xref="MIM:300174"
                     /translation="MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSST
                     LVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLE
                     SEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQL
                     VFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPE
                     EKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPR
                     ALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /note="hexamer: AATAAA"
     polyA_site      1682
                     /gene="MAGEA3"
                     /gene_synonym="CT1.3; HIP8; HYPD; MAGE3; MAGEA6"
                     /note="major polyA site"
ORIGIN      
        1 ggagggaagc cggcccaggc tcggtgagga ggcaaggttc tgaggggaca ggctgacctg
       61 gaggaccaga ggcccccgga ggagcactga aggagaagat ctgccagtgg gtctccattg
      121 cccagctcct gcccacactc ccgcctgttg ccctgaccag agtcatcatg cctcttgagc
      181 agaggagtca gcactgcaag cctgaagaag gccttgaggc ccgaggagag gccctgggcc
      241 tggtgggtgc gcaggctcct gctactgagg agcaggaggc tgcctcctcc tcttctactc
      301 tagttgaagt caccctgggg gaggtgcctg ctgccgagtc accagatcct ccccagagtc
      361 ctcagggagc ctccagcctc cccactacca tgaactaccc tctctggagc caatcctatg
      421 aggactccag caaccaagaa gaggaggggc caagcacctt ccctgacctg gagtccgagt
      481 tccaagcagc actcagtagg aaggtggccg agttggttca ttttctgctc ctcaagtatc
      541 gagccaggga gccggtcaca aaggcagaaa tgctggggag tgtcgtcgga aattggcagt
      601 atttctttcc tgtgatcttc agcaaagctt ccagttcctt gcagctggtc tttggcatcg
      661 agctgatgga agtggacccc atcggccact tgtacatctt tgccacctgc ctgggcctct
      721 cctacgatgg cctgctgggt gacaatcaga tcatgcccaa ggcaggcctc ctgataatcg
      781 tcctggccat aatcgcaaga gagggcgact gtgcccctga ggagaaaatc tgggaggagc
      841 tgagtgtgtt agaggtgttt gaggggaggg aagacagtat cttgggggat cccaagaagc
      901 tgctcaccca acatttcgtg caggaaaact acctggagta ccggcaggtc cccggcagtg
      961 atcctgcatg ttatgaattc ctgtggggtc caagggccct cgttgaaacc agctatgtga
     1021 aagtcctgca ccatatggta aagatcagtg gaggacctca catttcctac ccacccctgc
     1081 atgagtgggt tttgagagag ggggaagagt gagtctgagc acgagttgca gccagggcca
     1141 gtgggagggg gtctgggcca gtgcaccttc cggggccgca tcccttagtt tccactgcct
     1201 cctgtgacgt gaggcccatt cttcactctt tgaagcgagc agtcagcatt cttagtagtg
     1261 ggtttctgtt ctgttggatg actttgagat tattctttgt ttcctgttgg agttgttcaa
     1321 atgttccttt taacggatgg ttgaatgagc gtcagcatcc aggtttatga atgacagtag
     1381 tcacacatag tgctgtttat atagtttagg agtaagagtc ttgtttttta ctcaaattgg
     1441 gaaatccatt ccattttgtg aattgtgaca taataatagc agtggtaaaa gtatttgctt
     1501 aaaattgtga gcgaattagc aataacatac atgagataac tcaagaaatc aaaagatagt
     1561 tgattcttgc cttgtacctc aatctattct gtaaaattaa acaaatatgc aaaccaggat
     1621 ttccttgact tctttgagaa tgcaagcgaa attaaatctg aataaataat tcttcctctt
     1681 ca
//
