LOCUS       NM_001386132            1886 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MAGE family member A2B (MAGEA2B), transcript variant
            7, mRNA.
ACCESSION   NM_001386132 XM_017029406
VERSION     NM_001386132.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Gaugler,B., Van den Eynde,B., van der Bruggen,P., Romero,P.,
            Gaforio,J.J., De Plaen,E., Lethe,B., Brasseur,F. and Boon,T.
  TITLE     Human gene MAGE-3 codes for an antigen recognized on a melanoma by
            autologous cytolytic T lymphocytes
  JOURNAL   J Exp Med 179 (3), 921-930 (1994)
   PUBMED   8113684
REFERENCE   8  (bases 1 to 1886)
  AUTHORS   De Smet,C., Lurquin,C., van der Bruggen,P., De Plaen,E.,
            Brasseur,F. and Boon,T.
  TITLE     Sequence and expression pattern of the human MAGE2 gene
  JOURNAL   Immunogenetics 39 (2), 121-129 (1994)
   PUBMED   8276455
REFERENCE   9  (bases 1 to 1886)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
REFERENCE   10 (bases 1 to 1886)
  AUTHORS   van der Bruggen,P., Traversari,C., Chomez,P., Lurquin,C., De
            Plaen,E., Van den Eynde,B., Knuth,A. and Boon,T.
  TITLE     A gene encoding an antigen recognized by cytolytic T lymphocytes on
            a human melanoma
  JOURNAL   Science 254 (5038), 1643-1647 (1991)
   PUBMED   1840703
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244102.3.
            
            On Aug 10, 2020 this sequence version replaced XM_017029406.2.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. This gene has
            two identical copies at different loci. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.34019.1,
                                           SRR11853561.29909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682532.1/ ENSP00000507594.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC244102.3         129188-129242
            56-134              AC244102.3         129639-129717
            135-254             AC244102.3         130517-130636
            255-320             AC244102.3         131456-131521
            321-1886            AC244102.3         131602-133167
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1886
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /note="MAGE family member A2B"
                     /db_xref="GeneID:266740"
                     /db_xref="HGNC:HGNC:19340"
                     /db_xref="MIM:300549"
     exon            1..55
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            56..134
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            135..254
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..320
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1886
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1330
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /note="melanoma antigen, family A, 2, copy b; melanoma
                     antigen 2; MAGE-2 antigen; cancer/testis antigen 1.2;
                     melanoma antigen family A, 2B; melanoma antigen family
                     A2B"
                     /codon_start=1
                     /product="melanoma-associated antigen 2"
                     /protein_id="NP_001373061.1"
                     /db_xref="CCDS:CCDS76046.1"
                     /db_xref="GeneID:266740"
                     /db_xref="HGNC:HGNC:19340"
                     /db_xref="MIM:300549"
                     /translation="MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSST
                     LVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLE
                     SEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQL
                     VFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPE
                     EKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPR
                     ALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
                     /note="hexamer: ATTAAA"
     polyA_site      1876
                     /gene="MAGEA2B"
                     /gene_synonym="CT1.2; MAGE2"
ORIGIN      
        1 gcaacggcct gacgtcggcg gagggaagca ggcgcaggct ccgtgaggag gcaagaatcc
       61 gggctttgcc cctgcaatca acccacggaa gctccgggaa tggcggccaa gcacgcggat
      121 cctgacgttc acatatctca gggagttgat gaccttgttt tcagaaggtg actcaggtca
      181 acacaggggc ccccatctgg tcgacagatg cagtggttct aggatctgcc aagcatccag
      241 gtggagagcc tgaggttctg agggggacag gctgacaagt aggacccgag gcactggagg
      301 agcattgaag gagaagatct gcctgtgggt cttcattgcc cagctcctgc ccgcactcct
      361 gcctgctgcc ctgaccagag tcatcatgcc tcttgagcag aggagtcagc actgcaagcc
      421 tgaagaaggc cttgaggccc gaggagaggc cctgggcctg gtgggtgcgc aggctcctgc
      481 tactgaggag cagcagaccg cttcttcctc ttctactcta gtggaagtta ccctggggga
      541 ggtgcctgct gccgactcac cgagtcctcc ccacagtcct cagggagcct ccagcttctc
      601 gactaccatc aactacactc tttggagaca atccgatgag ggctccagca accaagaaga
      661 ggaggggcca agaatgtttc ccgacctgga gtccgagttc caagcagcaa tcagtaggaa
      721 gatggttgag ttggttcatt ttctgctcct caagtatcga gccagggagc cggtcacaaa
      781 ggcagaaatg ctggagagtg tcctcagaaa ttgccaggac ttctttcccg tgatcttcag
      841 caaagcctcc gagtacttgc agctggtctt tggcatcgag gtggtggaag tggtccccat
      901 cagccacttg tacatccttg tcacctgcct gggcctctcc tacgatggcc tgctgggcga
      961 caatcaggtc atgcccaaga caggcctcct gataatcgtc ctggccataa tcgcaataga
     1021 gggcgactgt gcccctgagg agaaaatctg ggaggagctg agtatgttgg aggtgtttga
     1081 ggggagggag gacagtgtct tcgcacatcc caggaagctg ctcatgcaag atctggtgca
     1141 ggaaaactac ctggagtacc ggcaggtgcc cggcagtgat cctgcatgct acgagttcct
     1201 gtggggtcca agggccctca ttgaaaccag ctatgtgaaa gtcctgcacc atacactaaa
     1261 gatcggtgga gaacctcaca tttcctaccc acccctgcat gaacgggctt tgagagaggg
     1321 agaagagtga gtctcagcac atgttgcagc cagggccagt gggagggggt ctgggccagt
     1381 gcaccttcca gggccccatc cattagcttc cactgcctcg tgtgatatga ggcccattcc
     1441 tgcctctttg aagagagcag tcagcattct tagcagtgag tttctgttct gttggatgac
     1501 tttgagattt atctttgttt cctgttggaa ttgttcaaat gttcctttta acaaatggtt
     1561 ggatgaactt cagcatccaa gtttatgaat gacagtagtc acacatagtg ctgtttatat
     1621 agtttagggg taagagtcct gttttttatt cagattggga aatccattcc attttgtgag
     1681 ttgtcacata ataacagcag tggaatatgt atttgcctat attgtgaacg aattagcagt
     1741 aaaatacatg atacaaggaa ctcaaaagat agttaattct tgccttatac ctcagtctat
     1801 tatgtaaaat taaaaatatg tgtatgtttt tgcttctttg agaatgcaaa agaaattaaa
     1861 tctgaataaa taattcttcc tgttca
//
