LOCUS       NM_001166387            1792 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MAGE family member A12 (MAGEA12), transcript variant
            2, mRNA.
ACCESSION   NM_001166387
VERSION     NM_001166387.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Shang,Y., Jiang,Y.L., Ye,L.J., Chen,L.N. and Ke,Y.
  TITLE     Resveratrol acts via melanoma-associated antigen A12
            (MAGEA12)/protein kinase B (Akt) signaling to inhibit the
            proliferation of oral squamous cell carcinoma cells
  JOURNAL   Bioengineered 12 (1), 2253-2262 (2021)
   PUBMED   34085601
  REMARK    GeneRIF: Resveratrol acts via melanoma-associated antigen A12
            (MAGEA12)/protein kinase B (Akt) signaling to inhibit the
            proliferation of oral squamous cell carcinoma cells.
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Zhao,G., Bae,J.Y., Zheng,Z., Park,H.S., Chung,K.Y., Roh,M.R. and
            Jin,Z.
  TITLE     Overexpression and Implications of Melanoma-associated Antigen A12
            in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma
  JOURNAL   Anticancer Res 39 (4), 1849-1857 (2019)
   PUBMED   30952725
  REMARK    GeneRIF: MAGEA12-mediated down-regulation of p21 may be involved in
            cutaneous squamous cell carcinoma pathogenesis and MAGEA12 may
            serve as a molecular biomarker in cSCC.
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Wu,J., Wang,J. and Shen,W.
  TITLE     Identification of MAGEA12 as a prognostic outlier gene in gastric
            cancers
  JOURNAL   Neoplasma 64 (2), 238-243 (2017)
   PUBMED   28043151
  REMARK    GeneRIF: over-expression of MAGEA12 in a subset of gastric cancers
            was associated with later stage and reduced survival
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Heidecker,L., Brasseur,F., Probst-Kepper,M., Gueguen,M., Boon,T.
            and Van den Eynde,B.J.
  TITLE     Cytolytic T lymphocytes raised against a human bladder carcinoma
            recognize an antigen encoded by gene MAGE-A12
  JOURNAL   J Immunol 164 (11), 6041-6045 (2000)
   PUBMED   10820289
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Gibbs,P., Hutchins,A.M., Dorian,K.T., Vaughan,H.A., Davis,I.D.,
            Silvapulle,M. and Cebon,J.S.
  TITLE     MAGE-12 and MAGE-6 are frequently expressed in malignant melanoma
  JOURNAL   Melanoma Res 10 (3), 259-264 (2000)
   PUBMED   10890380
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Ding,M., Beck,R.J., Keller,C.J. and Fenton,R.G.
  TITLE     Cloning and analysis of MAGE-1-related genes
  JOURNAL   Biochem Biophys Res Commun 202 (1), 549-555 (1994)
   PUBMED   8037761
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244102.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001166387.3.
            
            Summary: This gene is closely related to several other genes
            clustered on chromosome X. These genes may be overexpressed in
            tumors. Multiple alternatively spliced variants encoding the same
            protein have been identified. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.54033.1,
                                           SRR5189661.114417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393869.8/ ENSP00000377447.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC244102.3         148317-148419
            104-209             AC244102.3         149708-149813
            210-1792            AC244102.3         150647-152229
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1792
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /note="MAGE family member A12"
                     /db_xref="GeneID:4111"
                     /db_xref="HGNC:HGNC:6799"
                     /db_xref="MIM:300177"
     exon            1..103
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /inference="alignment:Splign:2.1.0"
     exon            104..209
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /inference="alignment:Splign:2.1.0"
     exon            210..1792
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1229
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /note="cancer/testis antigen family 1, member 12;
                     cancer/testis antigen 1.12; MAGE12F antigen; melanoma
                     antigen family A, 12; melanoma antigen family A12"
                     /codon_start=1
                     /product="melanoma-associated antigen 12"
                     /protein_id="NP_001159859.1"
                     /db_xref="CCDS:CCDS76048.1"
                     /db_xref="GeneID:4111"
                     /db_xref="HGNC:HGNC:6799"
                     /db_xref="MIM:300177"
                     /translation="MPLEQRSQHCKPEEGLEAQGEALGLVGAQAPATEEQETASSSST
                     LVEVTLREVPAAESPSPPHSPQGASTLPTTINYTLWSQSDEGSSNEEQEGPSTFPDLE
                     TSFQVALSRKMAELVHFLLLKYRAREPFTKAEMLGSVIRNFQDFFPVIFSKASEYLQL
                     VFGIEVVEVVRIGHLYILVTCLGLSYDGLLGDNQIVPKTGLLIIVLAIIAKEGDCAPE
                     EKIWEELSVLEASDGREDSVFAHPRKLLTQDLVQENYLEYRQVPGSDPACYEFLWGPR
                     ALVETSYVKVLHHLLKISGGPHISYPPLHEWAFREGEE"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /note="hexamer: ATTAAA"
     polyA_site      1792
                     /gene="MAGEA12"
                     /gene_synonym="CT1.12; MAGE12"
                     /note="major polyA site"
ORIGIN      
        1 actgacttgc gcgttggagg tcagagaaca gcgagattct cgccctgagc aacggcctga
       61 cgtcggtgga gggaagcagg cgcaggctcc gtgaggaggc aagatctcag ggagttgagg
      121 accttttctt cagagggtga ctcaggtcaa cacaggggcc cccatgtagt cgacagacac
      181 agtggtccta agatctacca agcatccagg ttctgaggag acaggccccg gagcagcact
      241 agctcctgcc cacactccta cctgctgccc tgaccagagt catcatgcca cttgagcaga
      301 ggagtcagca ctgcaagcct gaggaaggcc ttgaggccca aggagaggcc ctgggcttgg
      361 tgggtgcgca ggctcctgct actgaggagc aggagactgc ctcctcctcc tctactctag
      421 tggaagtcac cctgcgggag gtgcctgctg ccgagtcacc aagtcctccc cacagtcctc
      481 agggagcctc caccctcccc actaccatca actatactct ctggagtcaa tccgatgagg
      541 gctccagcaa cgaagaacag gaagggccaa gcacctttcc tgacctggag acgagcttcc
      601 aagtagcact cagtaggaag atggctgagt tggttcattt tctgctcctc aagtatcgag
      661 ccagggagcc attcacaaag gcagaaatgc tggggagtgt catcagaaat ttccaggact
      721 tctttcctgt gatcttcagc aaagcctccg agtacttgca gctggtcttt ggcatcgagg
      781 tggtggaagt ggtccgcatc ggccacttgt acatccttgt cacctgcctg ggcctctcct
      841 acgatggcct gctgggcgac aatcagatcg tgcccaagac aggcctcctg ataatcgtcc
      901 tggccataat cgcaaaagag ggcgactgtg cccctgagga gaaaatctgg gaggagctga
      961 gtgtgttgga ggcatctgat gggagggagg acagtgtctt tgcgcatccc aggaagctgc
     1021 tcacccaaga tttggtgcag gaaaactacc tggagtaccg gcaggtcccc ggcagtgatc
     1081 ctgcatgcta cgagttcctg tggggtccaa gggccctcgt tgaaaccagc tatgtgaaag
     1141 tcctgcacca tttgctaaag atcagtggag gacctcacat ttcctaccca cccctgcatg
     1201 aatgggcttt tagagagggg gaagagtgag tctgagcacg agttgcagcc agggccagtg
     1261 ggagggggtc tgggccagtg caccttccaa ggccccatcc attagtttcc actgcctcgt
     1321 gtgacatgag gcccattctt cactctttga agagagcagt cagtattgtt agtagtgagt
     1381 ttctgttcta ttggatgact ttgagattta tctttgtttc ctgttggaat tgttcaaatg
     1441 ttccttttaa cggatggttg aatgaacttc agcatccaag tttatgaatg acagtagtca
     1501 cacatagtgc tgtttatata gtttaggagt aagagtgttg ttttttattc agattgggaa
     1561 atccattcca ttttgtgaat tgtgacaaat aacagcagtg gaaaaagtat gtgcttagaa
     1621 ttgtgaaaga attagcagta aaatacatga gataaagacc tcaagaagtt aaaagatact
     1681 taattcttgc cttatacctc actctattct gtaaatttga aaaaaaagca tggatacctg
     1741 gatatccttg gcttctttga gaatttaaga gaaattaaat ctgaataaat aa
//
