LOCUS       NM_005366               1902 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MAGE family member A11 (MAGEA11), transcript variant
            1, mRNA.
ACCESSION   NM_005366
VERSION     NM_005366.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Farhadi,L., Soleimani,F., Fakhari,S. and Jalili,A.
  TITLE     The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced
            Apoptosis in the in vitro Model of Prostate Cancer
  JOURNAL   Gulf J Oncolog 1 (41), 7-16 (2023)
   PUBMED   36804154
  REMARK    GeneRIF: The Disruption of Mage-11 Gene via CRISPR/Cas9 Method
            Induced Apoptosis in the in vitro Model of Prostate Cancer.
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Aghamajidi,A., Ousati Ashtiani,Z., Mohsenzadegan,M., Tajik,N.,
            Ghafoori Yazdi,M., Sharifi,L. and Nowroozi,M.R.
  TITLE     Molecular Characteristics of Bladder Tumor: Increased Gene
            Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and
            MicroRNA-125b
  JOURNAL   Iran J Allergy Asthma Immunol 21 (5), 561-573 (2022)
   PUBMED   36341564
  REMARK    GeneRIF: Molecular Characteristics of Bladder Tumor: Increased Gene
            Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and
            MicroRNA-125b.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Mohsenzadegan,M., Razmi,M., Vafaei,S., Abolhasani,M., Madjd,Z.,
            Saeednejad Zanjani,L. and Sharifi,L.
  TITLE     Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is
            associated with tumor aggressiveness in patients with bladder
            cancer
  JOURNAL   Sci Rep 12 (1), 599 (2022)
   PUBMED   35022469
  REMARK    GeneRIF: Co-expression of cancer-testis antigens of MAGE-A6 and
            MAGE-A11 is associated with tumor aggressiveness in patients with
            bladder cancer.
            Erratum:[Sci Rep. 2022 Feb 7;12(1):2330. doi:
            10.1038/s41598-022-06282-9.. PMID: 35132168]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Yang,S.W., Huang,X., Lin,W., Min,J., Miller,D.J., Mayasundari,A.,
            Rodrigues,P., Griffith,E.C., Gee,C.T., Li,L., Li,W., Lee,R.E.,
            Rankovic,Z., Chen,T. and Potts,P.R.
  TITLE     Structural basis for substrate recognition and chemical inhibition
            of oncogenic MAGE ubiquitin ligases
  JOURNAL   Nat Commun 11 (1), 4931 (2020)
   PUBMED   33004795
  REMARK    GeneRIF: Structural basis for substrate recognition and chemical
            inhibition of oncogenic MAGE ubiquitin ligases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Bai,S., He,B. and Wilson,E.M.
  TITLE     Melanoma antigen gene protein MAGE-11 regulates androgen receptor
            function by modulating the interdomain interaction
  JOURNAL   Mol Cell Biol 25 (4), 1238-1257 (2005)
   PUBMED   15684378
  REMARK    GeneRIF: MAGE-11 is a unique AR coregulator that increases AR
            activity by modulating the AR interdomain interaction.
            Erratum:[Mol Cell Biol. 2005 May;25(10):4333]
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Serrano,A., Lethe,B., Delroisse,J.M., Lurquin,C., De Plaen,E.,
            Brasseur,F., Rimoldi,D. and Boon,T.
  TITLE     Quantitative evaluation of the expression of MAGE genes in tumors
            by limiting dilution of cDNA libraries
  JOURNAL   Int J Cancer 83 (5), 664-669 (1999)
   PUBMED   10521804
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   Jurk,M., Kremmer,E., Schwarz,U., Forster,R. and Winnacker,E.L.
  TITLE     MAGE-11 protein is highly conserved in higher organisms and located
            predominantly in the nucleus
  JOURNAL   Int J Cancer 75 (5), 762-766 (1998)
   PUBMED   9495246
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244098.2, BQ212898.1,
            BC004479.2 and AI691089.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005366.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB037612.1, SRR5189667.221873.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355220.6/ ENSP00000347358.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC244098.2         131469-131486       c
            19-723              BQ212898.1         1-705
            724-1882            BC004479.2         642-1800
            1883-1902           AI691089.1         9-28                c
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1902
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /note="MAGE family member A11"
                     /db_xref="GeneID:4110"
                     /db_xref="HGNC:HGNC:6798"
                     /db_xref="MIM:300344"
     exon            1..103
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /inference="alignment:Splign:2.1.0"
     exon            104..216
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1410
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /note="isoform a is encoded by transcript variant 1;
                     cancer/testis antigen family 1, member 11; MAGE-11
                     antigen; melanoma-associated antigen 11; melanoma antigen
                     family A, 11; cancer/testis antigen 1.11; melanoma antigen
                     family A11"
                     /codon_start=1
                     /product="melanoma-associated antigen 11 isoform a"
                     /protein_id="NP_005357.2"
                     /db_xref="CCDS:CCDS48180.1"
                     /db_xref="GeneID:4110"
                     /db_xref="HGNC:HGNC:6798"
                     /db_xref="MIM:300344"
                     /translation="METQFRRGGLGCSPASIKRKKKREDSGDFGLQVSTMFSEDDFQS
                     TERAPYGPQLQWSQDLPRVQVFREQANLEDRSPRRTQRITGGEQVLWGPITQIFPTVR
                     PADLTRVIMPLEQRSQHCKPEEGLQAQEEDLGLVGAQALQAEEQEAAFFSSTLNVGTL
                     EELPAAESPSPPQSPQEESFSPTAMDAIFGSLSDEGSGSQEKEGPSTSPDLIDPESFS
                     QDILHDKIIDLVHLLLRKYRVKGLITKAEMLGSVIKNYEDYFPEIFREASVCMQLLFG
                     IDVKEVDPTSHSYVLVTSLNLSYDGIQCNEQSMPKSGLLIIVLGVIFMEGNCIPEEVM
                     WEVLSIMGVYAGREHFLFGEPKRLLTQNWVQEKYLVYRQVPGTDPACYEFLWGPRAHA
                     ETSKMKVLEYIANANGRDPTSYPSLYEDALREEGEGV"
     exon            217..312
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /inference="alignment:Splign:2.1.0"
     exon            313..386
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1902
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="MAGEA11"
                     /gene_synonym="CT1.11; MAGE-11; MAGE11; MAGEA-11"
                     /note="major polyA site"
ORIGIN      
        1 attggcttcc gcctctggga tctgagagaa gcgaaagcgt ctttctgagg ggtgtcttga
       61 gagtggcaga gggcagcggg tccaggctcc atgaggaggc aagccttggg aatctgaggg
      121 atggagactc agttccgcag agggggtctg gggtgcagcc ctgccagcat caagaggaag
      181 aagaagaggg aggactcagg agactttgga ctccaggtga gcactatgtt ctcagaggac
      241 gacttccagt caacagaaag agccccatat ggtccacaac tacagtggtc ccaggatctg
      301 ccaagagtcc aggtttttag agaacaggcc aacctggagg acaggagtcc caggagaacc
      361 cagaggatca ctggaggaga acaagtgctg tggggcccca tcacccagat atttcccaca
      421 gttcggcctg ctgacctaac cagagtcatc atgcctcttg agcaaagaag tcagcactgc
      481 aagcctgagg aaggccttca ggcccaagaa gaagacctgg gcctggtggg tgcacaggct
      541 ctccaagctg aggagcagga ggctgccttc ttctcctcta ctctgaatgt gggcactcta
      601 gaggagttgc ctgctgctga gtcaccaagt cctccccaga gtcctcagga agagtccttc
      661 tctcccactg ccatggatgc catctttggg agcctatctg atgagggctc tggcagccaa
      721 gaaaaggagg ggccaagtac ctcgcctgac ctgatagacc ctgagtcctt ttcccaagat
      781 atactacatg acaagataat tgatttggtt catttattgc tccgcaagta tcgagtcaag
      841 gggctgatca caaaggcaga aatgctgggg agtgtcatca aaaattatga ggactacttt
      901 cctgagatat ttagggaagc ctctgtatgc atgcaactgc tctttggcat tgatgtgaag
      961 gaagtggacc ccactagcca ctcctatgtc cttgtcacct ccctcaacct ctcttatgat
     1021 ggcatacagt gtaatgagca gagcatgccc aagtctggcc tcctgataat agtcctgggt
     1081 gtaatcttca tggaggggaa ctgcatccct gaagaggtta tgtgggaagt cctgagcatt
     1141 atgggggtgt atgctggaag ggagcacttc ctctttgggg agcccaagag gctccttacc
     1201 caaaattggg tgcaggaaaa gtacctggtg taccggcagg tgcccggcac tgatcctgca
     1261 tgctatgagt tcctgtgggg tccaagggcc cacgctgaga ccagcaagat gaaagttctt
     1321 gagtacatag ccaatgccaa tgggagggat cccacttctt acccatccct gtatgaagat
     1381 gctttgagag aggagggaga gggagtctga gcatgagatg caaccagggc cagcgggcag
     1441 ggaaatgggc caatgcatgc ttcagggcca cacccagcag tttccctgtc ctgtgtgaaa
     1501 tcaggcccat tcttccctct gtgtttgatg agagaagtca gtgttctcag tagtagaagg
     1561 cacagtgaat ggaagggaac acattgtata ctgcctttag gtttctcttc catcgggtga
     1621 cttggagatt tctttttgtt tccctttggt aattttcaaa tattgttcct gtaataaaag
     1681 ttttagttag cttcaacatc taagtgtatg gatgatactg accacacatg ttgttttgct
     1741 tatccatttc aagtgcaagt gtttgccatt ttgtaaaaca ttttgggaaa tcttccatct
     1801 tgctgtgatt tgcaataggt attttcttgg agaatgtaag aacttaacaa taaagctgaa
     1861 ctggtgttgt gaaacagaga aataaaagga gaaggtcatt aa
//
