LOCUS       NM_021048               2652 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MAGE family member A10 (MAGEA10), transcript variant
            2, mRNA.
ACCESSION   NM_021048
VERSION     NM_021048.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2652)
  AUTHORS   Mastutik,G., Rahniayu,A., Marhana,I.A., Amin,M., Ruslan,S.E.N. and
            Trianto,H.F.
  TITLE     Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and
            Bronchoalveolar Lavage Specimens from Patients with the Central
            Lung Tumor
  JOURNAL   Asian Pac J Cancer Prev 25 (1), 159-167 (2024)
   PUBMED   38285780
  REMARK    GeneRIF: Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy
            and Bronchoalveolar Lavage Specimens from Patients with the Central
            Lung Tumor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2652)
  AUTHORS   Samel,A., Vaartnou,F., Verk,L., Kurg,K., Mutso,M. and Kurg,R.
  TITLE     How the Intrinsically Disordered N-Terminus of Cancer/Testis
            Antigen MAGEA10 Is Responsible for Its Expression, Nuclear
            Localisation and Aberrant Migration
  JOURNAL   Biomolecules 13 (12), 1704 (2023)
   PUBMED   38136576
  REMARK    GeneRIF: How the Intrinsically Disordered N-Terminus of
            Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression,
            Nuclear Localisation and Aberrant Migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2652)
  AUTHORS   Fujiya,K., Terashima,M., Ohshima,K., Aizawa,D., Sugino,T.,
            Serizawa,M., Nakamura,K., Nagashima,T., Hatakeyama,K., Urakami,K.,
            Akiyama,Y., Tsubosa,Y., Kitagawa,Y. and Yamaguchi,K.
  TITLE     MAGEA10 expression is a predictive marker of early hepatic
            recurrence after curative gastrectomy for gastric and
            gastroesophageal junction cancer
  JOURNAL   Gastric Cancer 24 (2), 341-351 (2021)
   PUBMED   32965606
  REMARK    GeneRIF: MAGEA10 expression is a predictive marker of early hepatic
            recurrence after curative gastrectomy for gastric and
            gastroesophageal junction cancer.
REFERENCE   4  (bases 1 to 2652)
  AUTHORS   Su,C., Xu,Y., Li,X., Ren,S., Zhao,C., Hou,L., Ye,Z. and Zhou,C.
  TITLE     Predictive and prognostic effect of CD133 and cancer-testis
            antigens in stage Ib-IIIA non-small cell lung cancer
  JOURNAL   Int J Clin Exp Pathol 8 (5), 5509-5518 (2015)
   PUBMED   26191258
  REMARK    GeneRIF: CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely
            expressed in patients with squamous cell carcinoma of the lung and
            when CTAs combined with CD133, they can be better prognostic
            factors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2652)
  AUTHORS   Schultz-Thater,E., Piscuoglio,S., Iezzi,G., Le Magnen,C., Zajac,P.,
            Carafa,V., Terracciano,L., Tornillo,L. and Spagnoli,G.C.
  TITLE     MAGE-A10 is a nuclear protein frequently expressed in high
            percentages of tumor cells in lung, skin and urothelial
            malignancies
  JOURNAL   Int J Cancer 129 (5), 1137-1148 (2011)
   PUBMED   21710496
  REMARK    GeneRIF: High MAGE-A10 is associated with lung, skin and urothelial
            malignancies.
REFERENCE   6  (bases 1 to 2652)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 2652)
  AUTHORS   Lin,J., Lin,L., Thomas,D.G., Greenson,J.K., Giordano,T.J.,
            Robinson,G.S., Barve,R.A., Weishaar,F.A., Taylor,J.M.,
            Orringer,M.B. and Beer,D.G.
  TITLE     Melanoma-associated antigens in esophageal adenocarcinoma:
            identification of novel MAGE-A10 splice variants
  JOURNAL   Clin Cancer Res 10 (17), 5708-5716 (2004)
   PUBMED   15355897
  REMARK    GeneRIF: This is the first report of these MAGE-A10 alternative
            splice sequences, and characterization of MAGE-A expression
REFERENCE   8  (bases 1 to 2652)
  AUTHORS   Rimoldi,D., Salvi,S., Reed,D., Coulie,P., Jongeneel,V.C., De
            Plaen,E., Brasseur,F., Rodriguez,A.M., Boon,T. and Cerottini,J.C.
  TITLE     cDNA and protein characterization of human MAGE-10
  JOURNAL   Int J Cancer 82 (6), 901-907 (1999)
   PUBMED   10446460
REFERENCE   9  (bases 1 to 2652)
  AUTHORS   Rogner,U.C., Wilke,K., Steck,E., Korn,B. and Poustka,A.
  TITLE     The melanoma antigen gene (MAGE) family is clustered in the
            chromosomal band Xq28
  JOURNAL   Genomics 29 (3), 725-731 (1995)
   PUBMED   8575766
REFERENCE   10 (bases 1 to 2652)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116666.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021048.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. Alternative
            splicing results in multiple transcript variants. Read-through
            transcription also exists between this gene and the downstream
            melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004105.2, AK314161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370323.9/ ENSP00000359347.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC116666.2         73021-73123         c
            104-202             AC116666.2         71417-71515         c
            203-276             AC116666.2         70307-70380         c
            277-2652            AC116666.2         67856-70231         c
FEATURES             Location/Qualifiers
     source          1..2652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2652
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /note="MAGE family member A10"
                     /db_xref="GeneID:4109"
                     /db_xref="HGNC:HGNC:6797"
                     /db_xref="MIM:300343"
     exon            1..103
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /inference="alignment:Splign:2.1.0"
     exon            104..202
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /inference="alignment:Splign:2.1.0"
     exon            203..276
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /inference="alignment:Splign:2.1.0"
     exon            277..2652
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1451
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /note="cancer/testis antigen family 1, member 10; MAGE-10
                     antigen; cancer/testis antigen 1.10; melanoma antigen
                     family A, 10; melanoma antigen family A10"
                     /codon_start=1
                     /product="melanoma-associated antigen 10"
                     /protein_id="NP_066386.3"
                     /db_xref="CCDS:CCDS14705.1"
                     /db_xref="GeneID:4109"
                     /db_xref="HGNC:HGNC:6797"
                     /db_xref="MIM:300343"
                     /translation="MPRAPKRQRCMPEEDLQSQSETQGLEGAQAPLAVEEDASSSTST
                     SSSFPSSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASLPL
                     DQSDEGSSSQKEESPSTLQVLPDSESLPRSEIDEKVTDLVQFLLFKYQMKEPITKAEI
                     LESVIRNYEDHFPLLFSEASECMLLVFGIDVKEVDPTGHSFVLVTSLGLTYDGMLSDV
                     QSMPKTGILILILSIVFIEGYCTPEEVIWEALNMMGLYDGMEHLIYGEPRKLLTQDWV
                     QENYLEYRQVPGSDPARYEFLWGPRAHAEIRKMSLLKFLAKVNGSDPRSFPLWYEEAL
                     KDEEERAQDRIATTDDTTAMASASSSATGSFSYPE"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /note="hexamer: ATTAAA"
     polyA_site      2652
                     /gene="MAGEA10"
                     /gene_synonym="CT1.10; MAGE10"
                     /note="major polyA site"
ORIGIN      
        1 ctaacttacg cctcggggat cagagagaag cgaggttctc gttctgaggg acaggcttga
       61 gatcggctga agagagcggg cccaggctct gtgaggaggc aagggaggtg agaaccttgc
      121 tctcagaggg tgactcaagt caacacaggg aacccctctt ttctacagac acagtgggtc
      181 gcaggatctg acaagagtcc aggttctcag gggacaggga gagcaagagg tcaagagctg
      241 tgggacacca cagagcagca ctgaaggaga agacctgcct gtgggtcccc atcgcccaag
      301 tcctgcccac actcccacct gctaccctga tcagagtcat catgcctcga gctccaaagc
      361 gtcagcgctg catgcctgaa gaagatcttc aatcccaaag tgagacacag ggcctcgagg
      421 gtgcacaggc tcccctggct gtggaggagg atgcttcatc atccacttcc accagctcct
      481 cttttccatc ctcttttccc tcctcctcct cttcctcctc ctcctcctgc tatcctctaa
      541 taccaagcac cccagaggag gtttctgctg atgatgagac accaaatcct ccccagagtg
      601 ctcagatagc ctgctcctcc ccctcggtcg ttgcttccct tccattagat caatctgatg
      661 agggctccag cagccaaaag gaggagagtc caagcaccct acaggtcctg ccagacagtg
      721 agtctttacc cagaagtgag atagatgaaa aggtgactga tttggtgcag tttctgctct
      781 tcaagtatca aatgaaggag ccgatcacaa aggcagaaat actggagagt gtcataagaa
      841 attatgaaga ccacttccct ttgttgttta gtgaagcctc cgagtgcatg ctgctggtct
      901 ttggcattga tgtaaaggaa gtggatccca ctggccactc ctttgtcctt gtcacctccc
      961 tgggcctcac ctatgatggg atgctgagtg atgtccagag catgcccaag actggcattc
     1021 tcatacttat cctaagcata gtcttcatag agggctactg cacccctgag gaggtcatct
     1081 gggaagcact gaatatgatg gggctgtatg atgggatgga gcacctcatt tatggggagc
     1141 ccaggaagct gctcacccaa gattgggtgc aggaaaacta cctggagtac cggcaggtgc
     1201 ctggcagtga tcctgcacgg tatgagtttc tgtggggtcc aagggctcat gctgaaatta
     1261 ggaagatgag tctcctgaaa tttttggcca aggtaaatgg gagtgatcca agatccttcc
     1321 cactgtggta tgaggaggct ttgaaagatg aggaagagag agcccaggac agaattgcca
     1381 ccacagatga tactactgcc atggccagtg caagttctag cgctacaggt agcttctcct
     1441 accctgaata aagtaagaca gattcttcac tgtgttttaa aaggcaagtc aaataccaca
     1501 tgattttact catatgtgga atctaaaaaa aaaaaaaaaa aaagttggta tcatggaagt
     1561 agagagtaga gcagtagtta cattacaatt aaataggagg aataagttct agtgttctat
     1621 tgcacagtag gatgactata gttaacatta agatattgta tattacaaaa cagctagaag
     1681 gaaggctttt caatattgtc accaaaaaga aatgataaat gcatgaggtg atggatacac
     1741 tacctgattt gatcattata ctacatatac atgaatcaga acatcaaatt gtacctcata
     1801 aatatctaca attacatgtc agtttttgtt tatgtttttg ttttttttta atttatgaaa
     1861 acaaatgaga atggaaatca atgatgtatg tggtggaggg ccaggctgag gctgaggaaa
     1921 atacagtgca taacatcttt gtcttactgt tttctttgga taacctgggg acttcttttc
     1981 ttttcttctt ggtattttat tttctttttc ttcttcttct tttttttttt ttaacaaagt
     2041 ctcactctat tgctctggca ggagtgcagt ggtgcagtct cggctcactg caacttccgc
     2101 ctcctgggtt caagcgattc tcctgcctca gtctcctgag tagctgggat tacaagtgtg
     2161 caccaccata cccggctaat tttgtatttt ttagtagaga tggggtttca ccatgttggc
     2221 caggctggtc tcaaactcct gacctcaggt aatctgcccg cctcagcctc ccaaagtgct
     2281 gggataacag gtgtgagcca ctgcacccag cctcttcttg gtattttaaa atgttgttac
     2341 ttttactaga atgtttatga gcttcagaat ctaaggtcac acgttcgttt ctgtttatcc
     2401 agtttaagaa acagttttgc tattttgtaa aacaaattgg gaacccttcc atcatatttg
     2461 taatctgtaa taaaataaca tggaattgga atagtaattt tcttggaaat atgaaaaaaa
     2521 tagtaaaata gagaaaataa ttttaagtgt tagtattttt atttctttat tatttttagt
     2581 ttatcatcct gcaaaattaa aagttatatc cctggatctt gttaagtcga aattaaactg
     2641 taataaatga aa
//
