LOCUS       NM_004988               1711 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MAGE family member A1 (MAGEA1), mRNA.
ACCESSION   NM_004988
VERSION     NM_004988.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Mastutik,G., Rahniayu,A., Marhana,I.A., Amin,M., Ruslan,S.E.N. and
            Trianto,H.F.
  TITLE     Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and
            Bronchoalveolar Lavage Specimens from Patients with the Central
            Lung Tumor
  JOURNAL   Asian Pac J Cancer Prev 25 (1), 159-167 (2024)
   PUBMED   38285780
  REMARK    GeneRIF: Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy
            and Bronchoalveolar Lavage Specimens from Patients with the Central
            Lung Tumor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Mao,Y., Fan,W., Hu,H., Zhang,L., Michel,J., Wu,Y., Wang,J., Jia,L.,
            Tang,X., Xu,L., Chen,Y., Zhu,J., Feng,Z., Xu,L., Yin,R. and Tang,Q.
  TITLE     MAGE-A1 in lung adenocarcinoma as a promising target of chimeric
            antigen receptor T cells
  JOURNAL   J Hematol Oncol 12 (1), 106 (2019)
   PUBMED   31640756
  REMARK    GeneRIF: These data suggest that MAGE-A1 is a promising candidate
            marker for lung adenocarcinoma (LUAD) therapy and the
            MAGE-A1-specific CAR-T cell immunotherapy may be an effective
            strategy for the treatment of MAGE-A1-positive LUAD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Fanipakdel,A., Seilanian Toussi,M., Rezazadeh,F., Mohamadian
            Roshan,N. and Javadinia,S.A.
  TITLE     Overexpression of cancer-testis antigen melanoma-associated antigen
            A1 in lung cancer: A novel biomarker for prognosis, and a possible
            target for immunotherapy
  JOURNAL   J Cell Physiol 234 (7), 12080-12086 (2019)
   PUBMED   30569450
  REMARK    GeneRIF: MAGE-A1 was found in several lung cancer patients
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1711)
  AUTHORS   Takahashi,K., Shichijo,S., Noguchi,M., Hirohata,M. and Itoh,K.
  TITLE     Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and
            primary spermatocytes of testis
  JOURNAL   Cancer Res 55 (16), 3478-3482 (1995)
   PUBMED   7627949
REFERENCE   7  (bases 1 to 1711)
  AUTHORS   Celis,E., Fikes,J., Wentworth,P., Sidney,J., Southwood,S.,
            Maewal,A., Del Guercio,M.F., Sette,A. and Livingston,B.
  TITLE     Identification of potential CTL epitopes of tumor-associated
            antigen MAGE-1 for five common HLA-A alleles
  JOURNAL   Mol Immunol 31 (18), 1423-1430 (1994)
   PUBMED   7823968
REFERENCE   8  (bases 1 to 1711)
  AUTHORS   Schultz-Thater,E., Juretic,A., Dellabona,P., Luscher,U.,
            Siegrist,W., Harder,F., Heberer,M., Zuber,M. and Spagnoli,G.C.
  TITLE     MAGE-1 gene product is a cytoplasmic protein
  JOURNAL   Int J Cancer 59 (3), 435-439 (1994)
   PUBMED   7927954
REFERENCE   9  (bases 1 to 1711)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
REFERENCE   10 (bases 1 to 1711)
  AUTHORS   van der Bruggen,P., Traversari,C., Chomez,P., Lurquin,C., De
            Plaen,E., Van den Eynde,B., Knuth,A. and Boon,T.
  TITLE     A gene encoding an antigen recognized by cytolytic T lymphocytes on
            a human melanoma
  JOURNAL   Science 254 (5038), 1643-1647 (1991)
   PUBMED   1840703
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB053667.1, BC017555.1,
            BP314195.1, CA428506.1 and AC236972.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004988.4.
            
            Summary: This gene is a member of the MAGEA gene family. The
            members of this family encode proteins with 50 to 80% sequence
            identity to each other. The promoters and first exons of the MAGEA
            genes show considerable variability, suggesting that the existence
            of this gene family enables the same function to be expressed under
            different transcriptional controls. The MAGEA genes are clustered
            at chromosomal location Xq28. They have been implicated in some
            hereditary disorders, such as dyskeratosis congenita. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.81782.1,
                                           SRR5189667.200285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356661.7/ ENSP00000349085.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB053667.1         15-47
            34-313              BC017555.1         1-280
            314-656             BP314195.1         235-577
            657-1032            BC017555.1         624-999
            1033-1698           CA428506.1         13-678              c
            1699-1709           BC017555.1         1666-1676
            1710-1711           AC236972.3         49866-49867
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1711
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="MAGE family member A1"
                     /db_xref="GeneID:4100"
                     /db_xref="HGNC:HGNC:6796"
                     /db_xref="MIM:300016"
     exon            1..82
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..155
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..1711
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1150
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="cancer/testis antigen family 1, member 1; melanoma
                     antigen MAGE-1; melanoma-associated antigen MZ2-E;
                     melanoma antigen family A 1; MAGE-1 antigen; cancer/testis
                     antigen 1.1; melanoma antigen family A, 1 (directs
                     expression of antigen MZ2-E); melanoma antigen family A1"
                     /codon_start=1
                     /product="melanoma-associated antigen 1"
                     /protein_id="NP_004979.3"
                     /db_xref="CCDS:CCDS76051.1"
                     /db_xref="GeneID:4100"
                     /db_xref="HGNC:HGNC:6796"
                     /db_xref="MIM:300016"
                     /translation="MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLE
                     EVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVI
                     TKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVK
                     EADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEEL
                     SVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSY
                     VKVLEYVIKVSARVRFFFPSLREAALREEEEGV"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="hexamer: ATTAAA"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="major polyA site"
     polyA_site      1711
                     /gene="MAGEA1"
                     /gene_synonym="CT1.1; MAGE1"
                     /note="major polyA site"
ORIGIN      
        1 agagagaagc gaggtttcca ttctgaggga cggcgtagag ttcggccgaa ggaacctgac
       61 ccaggctctg tgaggaggca aggttttcag gggacaggcc aacccagagg acaggattcc
      121 ctggaggcca cagaggagca ccaaggagaa gatctgcctg tgggtcttca ttgcccagct
      181 cctgcccaca ctcctgcctg ctgccctgac gagagtcatc atgtctcttg agcagaggag
      241 tctgcactgc aagcctgagg aagcccttga ggcccaacaa gaggccctgg gcctggtgtg
      301 tgtgcaggct gccacctcct cctcctctcc tctggtcctg ggcaccctgg aggaggtgcc
      361 cactgctggg tcaacagatc ctccccagag tcctcaggga gcctccgcct ttcccactac
      421 catcaacttc actcgacaga ggcaacccag tgagggttcc agcagccgtg aagaggaggg
      481 gccaagcacc tcttgtatcc tggagtcctt gttccgagca gtaatcacta agaaggtggc
      541 tgatttggtt ggttttctgc tcctcaaata tcgagccagg gagccagtca caaaggcaga
      601 aatgctggag agtgtcatca aaaattacaa gcactgtttt cctgagatct tcggcaaagc
      661 ctctgagtcc ttgcagctgg tctttggcat tgacgtgaag gaagcagacc ccaccggcca
      721 ctcctatgtc cttgtcacct gcctaggtct ctcctatgat ggcctgctgg gtgataatca
      781 gatcatgccc aagacaggct tcctgataat tgtcctggtc atgattgcaa tggagggcgg
      841 ccatgctcct gaggaggaaa tctgggagga gctgagtgtg atggaggtgt atgatgggag
      901 ggagcacagt gcctatgggg agcccaggaa gctgctcacc caagatttgg tgcaggaaaa
      961 gtacctggag taccggcagg tgccggacag tgatcccgca cgctatgagt tcctgtgggg
     1021 tccaagggcc ctcgctgaaa ccagctatgt gaaagtcctt gagtatgtga tcaaggtcag
     1081 tgcaagagtt cgctttttct tcccatccct gcgtgaagca gctttgagag aggaggaaga
     1141 gggagtctga gcatgagttg cagccaaggc cagtgggagg gggactgggc cagtgcacct
     1201 tccagggccg cgtccagcag cttcccctgc ctcgtgtgac atgaggccca ttcttcactc
     1261 tgaagagagc ggtcagtgtt ctcagtagta ggtttctgtt ctattgggtg acttggagat
     1321 ttatctttgt tctcttttgg aattgttcaa atgttttttt ttaagggatg gttgaatgaa
     1381 cttcagcatc caagtttatg aatgacagca gtcacacagt tctgtgtata tagtttaagg
     1441 gtaagagtct tgtgttttat tcagattggg aaatccattc tattttgtga attgggataa
     1501 taacagcagt ggaataagta cttagaaatg tgaaaaatga gcagtaaaat agatgagata
     1561 aagaactaaa gaaattaaga gatagtcaat tcttgcctta tacctcagtc tattctgtaa
     1621 aatttttaaa gatatatgca tacctggatt tccttggctt ctttgagaat gtaagagaaa
     1681 ttaaatctga ataaagaatt cttcctgttc a
//
