LOCUS       NM_002360               3380 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.
ACCESSION   NM_002360 NM_152561
VERSION     NM_002360.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Xu,S., Hu,G., Wu,D., Kan,X., Oishi,H., Takahashi,S., Fu,S., Liu,J.
            and Zhang,C.
  TITLE     MafK accelerates Salmonella mucosal infection through caspase-3
            activation
  JOURNAL   Aging (Albany NY) 14 (5), 2287-2303 (2022)
   PUBMED   35260530
  REMARK    GeneRIF: MafK accelerates Salmonella mucosal infection through
            caspase-3 activation.
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Hushpulian,D.M., Ammal Kaidery,N., Ahuja,M., Poloznikov,A.A.,
            Sharma,S.M., Gazaryan,I.G. and Thomas,B.
  TITLE     Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for
            Neurotherapeutics: Bach1 De-Repression to the Rescue
  JOURNAL   Front Aging Neurosci 13, 673205 (2021)
   PUBMED   33897412
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   Hayashi,T., Shibata,T., Nakamura,M., Sakurai,N., Takano,H., Ota,M.,
            Nomura-Horita,T., Hayashi,R., Shimasaki,T., Ostuka,T., Tahara,T.
            and Arisawa,T.
  TITLE     MAFK Polymorphisms Located in 3'-UTR are Associated with Severity
            of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa
  JOURNAL   Genet Test Mol Biomarkers 25 (4), 255-262 (2021)
   PUBMED   33877894
  REMARK    GeneRIF: MAFK Polymorphisms Located in 3'-UTR are Associated with
            Severity of Atrophy and CDKN2A Methylation Status in the Gastric
            Mucosa.
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Toki,T., Itoh,J., Kitazawa,J., Arai,K., Hatakeyama,K., Akasaka,J.,
            Igarashi,K., Nomura,N., Yokoyama,M., Yamamoto,M. and Ito,E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Armstrong,J.A. and Emerson,B.M.
  TITLE     NF-E2 disrupts chromatin structure at human beta-globin locus
            control region hypersensitive site 2 in vitro
  JOURNAL   Mol Cell Biol 16 (10), 5634-5644 (1996)
   PUBMED   8816476
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   Ney,P.A., Andrews,N.C., Jane,S.M., Safer,B., Purucker,M.E.,
            Weremowicz,S., Morton,C.C., Goff,S.C., Orkin,S.H. and Nienhuis,A.W.
  TITLE     Purification of the human NF-E2 complex: cDNA cloning of the
            hematopoietic cell-specific subunit and evidence for an associated
            partner
  JOURNAL   Mol Cell Biol 13 (9), 5604-5612 (1993)
   PUBMED   8355703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093734.3 and AF059194.1.
            
            On Nov 24, 2018 this sequence version replaced NM_002360.3.
            
            Summary: The developmentally regulated expression of the globin
            genes depends on upstream regulatory elements termed locus control
            regions (LCRs). LCRs are associated with powerful enhancer activity
            that is mediated by the transcription factor NFE2 (nuclear factor
            erythroid-2). NFE2 recognition sites are also present in the gene
            promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase
            (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2
            DNA-binding activity consists of a heterodimer containing an 18-kD
            Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM
            601490). Both subunits are members of the activator protein-1
            superfamily of basic leucine zipper (bZIP) proteins (see MIM
            165160). Maf homodimers suppress transcription at NFE2
            sites.[supplied by OMIM, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.455354.1,
                                           ERR279825.9361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343242.9/ ENSP00000344903.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC093734.3         37122-37151
            31-931              AF059194.1         2-902
            932-3380            AC093734.3         47015-49463
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..3380
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /note="MAF bZIP transcription factor K"
                     /db_xref="GeneID:7975"
                     /db_xref="HGNC:HGNC:6782"
                     /db_xref="MIM:600197"
     exon            1..197
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /inference="alignment:Splign:2.1.0"
     exon            198..277
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..712
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /note="v-maf avian musculoaponeurotic fibrosarcoma
                     oncogene family, protein K; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog K; basic-leucine zipper
                     transcription factor MafK; erythroid transcription factor
                     NF-E2 p18 subunit; nuclear factor erythroid-2, ubiquitous
                     (p18); v-maf musculoaponeurotic fibrosarcoma oncogene
                     homolog K; NF-E2 ubiquitous subunit"
                     /codon_start=1
                     /product="transcription factor MafK"
                     /protein_id="NP_002351.1"
                     /db_xref="CCDS:CCDS5325.1"
                     /db_xref="GeneID:7975"
                     /db_xref="HGNC:HGNC:6782"
                     /db_xref="MIM:600197"
                     /translation="MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGL
                     TKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRL
                     ELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS"
     exon            278..3380
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /note="hexamer: AATAAA"
     polyA_site      3380
                     /gene="MAFK"
                     /gene_synonym="NFE2U; P18"
                     /note="major polyA site"
ORIGIN      
        1 gtcagatgct ggggagccgg gcgggcgggt gcggtggcgg cgggcggcgc gggggcactt
       61 gttgttcttc gcgaagtcgg agcccgagcg ccaggcggcg gcggcggccg aggggagcgc
      121 gacagtgagc gccggcgcga ggacagcgcg tgcccgcgag gagccgccgc gcgcccgcgc
      181 cctccgcgcg acgccagcta cgagttccag ggagctctgt cctggtgacc gtgcccgggt
      241 tatgacgact aatcccaaac cgaataaggc attaaaggtc aagaaggagg cgggcgagaa
      301 cgccccggtg ctcagcgatg atgagctggt gtccatgtcg gtgcgggagc tgaaccagca
      361 cctgcggggt ctcaccaagg aggaggtgac ccgcctgaag cagcgtcggc gcacactcaa
      421 gaaccgcggc tacgcggcca gctgccgcat caagcgggtg acgcagaagg aggagctgga
      481 gcggcagcgc gtggagctgc agcaggaggt ggagaagctg gcgcgtgaga acagcagcat
      541 gcggctggag ctggacgccc tgcgctccaa gtacgaggcg ctgcagacct tcgcgcgcac
      601 cgtggcccgg ggacctgtgg cgccctccaa ggtggccacc accagcgtca tcaccatcgt
      661 caagtccacc gagctctcct ccacctccgt gcccttctcg gctgcatcct agtgccggcc
      721 gggggcgggg ggtggcgggc ggcgggcggc gggcaggcgg gtgggggcac acccctcgta
      781 cctgtcactg ggatgcagac tctcgacatc cgagtccaag cgcaggcccc tcgggcgcag
      841 gcagctcaca ccaggaagag actgtattgc agggtgaaga gtgggctccc gtgggcccag
      901 agctgcacgc cggtccacag acacactcac gcccgccacc tgctccccgc aggatgtgtc
      961 tgtgtgtggg aattggtatc ttgcacccgt gggagtcggg acatataatg gaaaggccct
     1021 cgggaagttc cgcgtcctct gtgggggctg ccggaagaca cggccccagg agtcaggccc
     1081 ctgtggtcag gtctagcatg gggcttgttt tccactcctg ctgtaagcag ccttcgacac
     1141 ctgtcctgcc acggcctccc agccggtgcg ggagcccctc actgccctga ccgactccgc
     1201 agtccccggg gaggagcatg gatggtgtgt cggcagctcc gtccttccag ctgtcccgtt
     1261 gcagtgcccg tgatccgcgt ctgccttagc aggggcctgc gtgagtgggc acggtgtggg
     1321 aggtcgcctg cgtggggtgg tgtctgtgtg tgtgcacgca cgcctgccat caaagcagca
     1381 gggctgaggg ggtgcagctt gctggtgttc actgggggag ggcctgtggg cacacatggc
     1441 agagagagtg gctcacacgt cgtgaggtct cccctgtgct ctggtgaccc gaggaggtcg
     1501 tgcagcacag cgcagaagcc cctgcccacg ggatccggcc ccccagacac cgaccccaca
     1561 ggccgtcccg gatctcagcg gacacaggca ggagcgcccc atcatttgac ggtgagcagg
     1621 actcaggctg tgtgtcctgg agctacttct caccaactgt ggtcagtgca gggggaacga
     1681 ggaggtcttt tgggggcctg gcgaggggaa gggctgctgc agtctaggga gagggggtgc
     1741 agcctggggg atgttggtgg acatggatgt ggaggtggaa ggaggaggac gttgcgtgga
     1801 gtggtgggag gaggcgggag ccgtgtgcga gagcaggtgg aaagccttga ggggcaggac
     1861 caggatgcag ctggcttgta gaagagctca ggagtgagcc tggcactcca gagggcgcgg
     1921 cgggtgggga ggcagcaggc accagtccag gagagcttcg tggacgtggc tcctgcgcgc
     1981 acacccccag gagcacagcc acgggctgca ggtgtggctg gcctcagcac tcagtcctca
     2041 cccggagcct ttgcctgctc ctccttccaa gagcactgag gcaccagtgg gcttggcact
     2101 ccaccttggg cttccttttc ctggagagcc gccttgaggg tccctcctgt gactggggtc
     2161 tctgcagcga gagccgcggg ggttgcggag cccctgcctg ggggagctgg cggaatgtga
     2221 gccgccggcc gggggccgcc acataagacc tgcaaggtgg tgcctggggc cctggctcct
     2281 tctcggctgc ccctgcccac ccagtaacag cccccaccag ctacagagcc caggcgggtg
     2341 ccagccacgc tgggagggca gaggacagac agccccgggg ctgcgacttg gttctgtgtc
     2401 tactgttaga agttgagtgg gaagctgcag gcccgccagg accactgggt ccctacagag
     2461 caaaggcctg cgtgttccca aacagccgtt gcccccgtgg ccgtggtagg taatccatat
     2521 tggatgtcat aaggaccagg gggatattta aagagagaaa cagaaaatat atagagatat
     2581 aaaattatat tcacagttta tctacagatt tttcgtaaca atctttcttt tccagtttga
     2641 tactgtaaat ctatcagagc agagccgggg gcacgggcac aggtgggagt tgggagcaaa
     2701 gcggaggccc gggctgcccg ccgtccccct tcatctcccc acggactgta ccaggcagct
     2761 gggccccgca ggacaggccg cagcgggtgg ccggttctgt cccgtcttgg ggttcttggt
     2821 gtccacgtct tgtgggccgt gggcttctac ctgcccttgg cctgcagtgc tttgctggag
     2881 aagggactcc ctggtcccca gggtggacgg agccgctgtc accgcccaga gctgggccgg
     2941 ggaagcacgg tgtgttctgc ttttcttttc agattgttga aatttcattg tcatgattta
     3001 atatatggat ttttttattt aagaaaaaga cgagggactc tttgtcacgt gggtttgttt
     3061 tctgtctccg tgcctccggc ttcccaaaga gatccaggtc tttgcgtttc cagggcgtgg
     3121 ggaccccggc cccctatgcc gccacgccgc cacaccgcct caccctggct tctgtgctac
     3181 ttggcagttc catttcatta tttatttttt gtgctgcttt ttatcatgat ataaattatt
     3241 gaaaacagat cacatgtggg cccgtgtctg gccgccgccg ccctgccccg tccctgcggc
     3301 caccacctaa tttattgccg tgcgtcctgc tgctgtgact gcttttgtac ctttgcaata
     3361 aagaattttc tggtttcaga
//
