LOCUS       NM_002359               5061 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor G (MAFG), transcript
            variant 1, mRNA.
ACCESSION   NM_002359
VERSION     NM_002359.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5061)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5061)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 5061)
  AUTHORS   Xiang,L., Zeng,Q., Liu,J., Xiao,M., He,D., Zhang,Q., Xie,D.,
            Deng,M., Zhu,Y., Liu,Y., Bo,H., Liu,X., Zhou,M., Xiong,W., Zhou,Y.,
            Zhou,J., Li,X. and Cao,K.
  TITLE     MAFG-AS1/MAFG positive feedback loop contributes to cisplatin
            resistance in bladder urothelial carcinoma through antagonistic
            ferroptosis
  JOURNAL   Sci Bull (Beijing) 66 (17), 1773-1788 (2021)
   PUBMED   36654385
  REMARK    GeneRIF: MAFG-AS1/MAFG positive feedback loop contributes to
            cisplatin resistance in bladder urothelial carcinoma through
            antagonistic ferroptosis.
REFERENCE   4  (bases 1 to 5061)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5061)
  AUTHORS   Fu,Y., Wen,J., Li,X., Gong,M., Guo,Z. and Wang,G.
  TITLE     LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505
            to Promote Gastric Adenocarcinoma Cell Proliferation
  JOURNAL   Crit Rev Eukaryot Gene Expr 31 (5), 27-32 (2021)
   PUBMED   34591387
  REMARK    GeneRIF: LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging
            miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation.
REFERENCE   6  (bases 1 to 5061)
  AUTHORS   Marini,M.G., Chan,K., Casula,L., Kan,Y.W., Cao,A. and Moi,P.
  TITLE     hMAF, a small human transcription factor that heterodimerizes
            specifically with Nrf1 and Nrf2
  JOURNAL   J Biol Chem 272 (26), 16490-16497 (1997)
   PUBMED   9195958
REFERENCE   7  (bases 1 to 5061)
  AUTHORS   Blank,V., Kim,M.J. and Andrews,N.C.
  TITLE     Human MafG is a functional partner for p45 NF-E2 in activating
            globin gene expression
  JOURNAL   Blood 89 (11), 3925-3935 (1997)
   PUBMED   9166829
REFERENCE   8  (bases 1 to 5061)
  AUTHORS   Toki,T., Itoh,J., Kitazawa,J., Arai,K., Hatakeyama,K., Akasaka,J.,
            Igarashi,K., Nomura,N., Yokoyama,M., Yamamoto,M. and Ito,E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   9  (bases 1 to 5061)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   10 (bases 1 to 5061)
  AUTHORS   Armstrong,J.A. and Emerson,B.M.
  TITLE     NF-E2 disrupts chromatin structure at human beta-globin locus
            control region hypersensitive site 2 in vitro
  JOURNAL   Mol Cell Biol 16 (10), 5634-5644 (1996)
   PUBMED   8816476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145207.2, DR156847.1, BC103722.1 and AA775797.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002359.3.
            
            Summary: Globin gene expression is regulated through nuclear factor
            erythroid-2 (NFE2) elements located in enhancer-like locus control
            regions positioned many kb upstream of alpha- and beta-gene
            clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2
            DNA-binding activity consists of a heterodimer containing a
            ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM
            600197) and the tissue-restricted protein p45 NFE2 (MIM 601490).
            Both subunits are members of the activator protein-1-like
            superfamily of basic leucine zipper (bZIP) proteins (see MIM
            165160).[supplied by OMIM, Mar 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.491875.1, AF059195.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357736.9/ ENSP00000350369.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC145207.2         59245-59268
            25-766              DR156847.1         1-742
            767-3378            AC145207.2         64416-67027
            3379-5057           BC103722.1         13-1691
            5058-5061           AA775797.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..5061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..5061
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /note="MAF bZIP transcription factor G"
                     /db_xref="GeneID:4097"
                     /db_xref="HGNC:HGNC:6781"
                     /db_xref="MIM:602020"
     exon            1..208
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /inference="alignment:Splign:2.1.0"
     exon            209..273
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..726
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /note="basic leucine zipper transcription factor MafG;
                     v-maf avian musculoaponeurotic fibrosarcoma oncogene
                     homolog G"
                     /codon_start=1
                     /product="transcription factor MafG"
                     /protein_id="NP_002350.1"
                     /db_xref="CCDS:CCDS11793.1"
                     /db_xref="GeneID:4097"
                     /db_xref="HGNC:HGNC:6781"
                     /db_xref="MIM:602020"
                     /translation="MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGL
                     SKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKL
                     ELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDA
                     RS"
     exon            274..5061
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5043..5048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /note="hexamer: AATAAA"
     polyA_site      5061
                     /gene="MAFG"
                     /gene_synonym="hMAF"
                     /note="major polyA site"
ORIGIN      
        1 atgtgacgtc tgtggagcgg cggcggcggc ggcggatccc gagcctggtc cggcccggcc
       61 ttcccagtgc gctcggcccg gcccgcgcag gcggcgagtc ctccgagccc cgggcccgga
      121 cccctcgcgc cggtccctgc cccgcgcggc ctcggagcgc gcgcggcccc gccccgcccc
      181 ggcctcggcc cgccgggccc gcagtgtgag agcgcctgct cgctgtgccc ccgggttatg
      241 acgaccccca ataaaggaaa caaggccttg aaggtgaagc gggagccggg tgagaatggc
      301 accagcctga cggatgagga gctggtgacc atgtcggtgc gggagctgaa ccagcacctg
      361 cggggcctgt ccaaggagga gatcgtccag ctgaagcagc gccggcgcac gctcaagaac
      421 cgcggctacg ctgccagctg ccgcgtgaag cgggtgacgc agaaggagga gctggagaag
      481 cagaaggcgg agctgcagca ggaggtggag aagctggcct cagagaacgc cagcatgaag
      541 ctggagctcg acgcgctgcg ctccaagtac gaggcgctgc agaccttcgc ccggacggtg
      601 gcccgcagcc ccgtggcgcc agcccggggc ccccttgccg ccggcctggg gcccctcgtc
      661 ccaggcaagg tggccgccac cagcgtcatc acaatagtaa agtccaagac ggatgcccga
      721 tcgtagggac gcgcgtctgc ccaggcgggt ctttgcgggg ccactaggca catggcgaat
      781 ttggctgccc tgtccctctg tttccttctc ttctctttcc tccctctctt ccccaccctt
      841 ctctcttccc tgcaaagcac aacctgtacc ccaggggcgc cgggctgagc ccctttgatc
      901 tcgtcattgt cgtcgtgtgt tttgtatgtt gggattggtc agttcggcgg tgacgtgggg
      961 tcgccccaac cccttttgta ccagggccat gcaggcttgg agtccagagt tggtgctgtg
     1021 ggaacggact agagagagtt gcgggagaga gaaggagcag gcacgctggg cctcgcgtgt
     1081 ccccgagcag tgagggtccc agtgttccct ccactcccga gtggccacag gctcgcgggc
     1141 tgggaaggat tcactctctt tagccccagg ggagcagctc agcttagccc agcatgaaga
     1201 gatgggctct gctctgagag tagggcgggc ttgaaggccc tgatgggtgg accaccagcc
     1261 tgggcgcagt ggtgctgggg gcgtgcagct gggcccaggg gctgtgcact caggcctgac
     1321 ccgttgcact gaacaagacc aaatctctgg ttgtgcgctt aacgtgaggg tgggtccagt
     1381 gtgccctgcg atgggtcccg tgtcactgtt tacatgacct atttgtgtgg ttatatagcc
     1441 ctttatttaa aagagagaag ttccttttac aaagttatta aattaattat atgtttaaaa
     1501 gttaaagaaa aaagagctgc agagtattta taaaactgtc ttttagaaaa aaaacaagca
     1561 agaagaccat ttgaccatat gaatggaaaa gggaagaaag tataatagaa actttgctag
     1621 ttaaaaaaaa aagaaaaaaa aagaaaaaaa atccctttct tgtaaactta cggacacctc
     1681 tttgtggctg ttggagttta gtttttatat acacagagtt atcagacatt atttataaaa
     1741 cttagtttaa aaaaaagaca aaaaaaaaaa agccaagccg tgagccgacc agaaggccgt
     1801 cctctttgat atcttttgca attgtaccga aagtgactta ctcctctgcc cttcctgctt
     1861 ccgtctcttg ccggtgccgt ggtgtcgtcc gtgcctggtg aggttttgtg cagcggtaaa
     1921 gtgctggtgc ttctggtgac ctttgacctg tgggtgtcac ttcttgtgtc tgttttcccg
     1981 tgttcgtttt ttgggtttag ttgtgctttt gcttctgctg gcttgctgga cctgggctgg
     2041 ggtgccaagt ggcgcctgct gcgtcagagc tcaaggaatc tgtgcccacc accagctcct
     2101 ggtccgtagg aggtgagaca tggggttctg tcatgccccc ctccactgag ccttggctac
     2161 atctgtgtct agggcttggg ctgatctagt ggcggggtag gtgaaactgg ggtcccttgg
     2221 ggcgccccac gctgcttcca cacccaccac ctctggcctt gggtggtggc attacaggga
     2281 tgagggagtc actgtgggtg gccacagggc tatggccaag cgttccctgg ccgtcttcct
     2341 ctggcctcag ctttgttcct ataggctgcc cgcgccgtgg gctgcaggtc tcgccgcccg
     2401 cttgatccct gaggtgtttc catgctgcgg gtggtgcttc caggcagagt gggtgggggc
     2461 ccaccgggca ccgccctttc ttccttgtcc ctgcctcact ctgagagcct tgggggtctc
     2521 caccagtgca gacaagggct acagtctcca gggccgggtc ttgtccctct tctccgctgg
     2581 tccacgctgg cagctcttgg cttcgggcct gccttctgcc tccctttggg atctgtgtct
     2641 tccagggatc agctgcttgg cttctgctgg aggtgcctcc ctgtgggggc gcagcctgcc
     2701 tcctgctctc agttcctcgc cagaggctgc tgcccttcct ggctgggctc aggaggctcc
     2761 ttgtaggcat atgatgggga gggggtgccc ctacccacct ccaagaggct acagccctgt
     2821 gtctggccat gtgagccctg gcctttcacc gggttgctgg tttcttttct gtggggccca
     2881 gacttctgta aagcacacag atgtgggtaa gatgaaaaac tgtggcccaa cagggcttaa
     2941 ccctatggat ggtgggattt ttatccaata gtttggcctg gtgtgcccac aggatgggaa
     3001 cagggaggca ccatcaacac ttgtcatgtt aatgagcttt tctttgctcg aggtgttcag
     3061 agacaagtcc tgtgtctacc tgcgtcagcc tgaaaatgga aatattggct gttgactctt
     3121 gtcatttagt gacttcatcc ccctcccctc agtctgatct tgtctaagta gaatccaggc
     3181 gttagttgga atcatatcat aagtatccat gaagaaaacg tcatgatctg cctcggagtg
     3241 gggagaaaca ggccctcctt gtccttgtgc agcccccact tttgtcctgg ctgtgggtgg
     3301 ccatccattt tgagcacctc tgccaggctg cagacctgga ggcgaaggga gtgtggaaga
     3361 ggagggtgta agggtcgacg cgtgctgaat gggaggtgca ggtcctcggt gcgttggcag
     3421 aagaggcttc tggagtttcg aggccatacc tcctttcaag agctttggat ttggggcgac
     3481 ttccctgggt ctaggggagt gttcctgtcc cctgtcaggt cagccctgcg gagccactcc
     3541 acccctcttc cccttcccct ggatttcctg acatagatgg tgtgttcatg tgcaggtgtg
     3601 agtgtgctgt ccttctgatc tctgttgatc ccgctttcct actgagaggg tggtggagag
     3661 ggtggtggtc tcttctcacc tcagtttttc tgacacagcg aatcgagggc tttggccaag
     3721 gccaggtctc tcaaacttgt ccgccaagta aaccatgata tatgtcttcc cttccacctt
     3781 aactttgccc caactcctct tttatcctaa catggacgct cagatttcag aggaataccc
     3841 agcagggaca ggtcagctct caccaggaga gtgaggcccc tggctgctgc tcggggtggc
     3901 actggtgttg ctggctcagc tcttggtgca tgtttcagat atgtgtgtac acttctgact
     3961 ggtgatcagg gcccggccca cggccctgag cggctgcagc ctgctttggg acgatggtca
     4021 ggtcccatgt tgtccctgct gcctccctct ggagtggcca cttggccaaa gcgcccatcc
     4081 acatctggaa agtcggagcc gcagcctgct gcaccgtttc cgctctggga tcttgtgagt
     4141 tactttttta ggctgtggtt tggtgaaagg aaccaacaca ttaacgattt ttcccccaga
     4201 agccactgaa taattctttt tggtgtattt ttgccttcct gttggctgtc tggccttgga
     4261 gcaggtcggg agagtagagt acataatcag tgccacacag aggcagggcg tgtctgagag
     4321 actaatgcct gtcctgcctc tggcctgtgt cctgggtgtg taccatacct gctgggccag
     4381 tcccacacat ttccaccctg cccctggagc agcagctttg ataccatggg tgtcccttga
     4441 gtctgagcta gagtgtgtcc ccgataaact gtgagacctc cctgttcttg gtgaccccag
     4501 ttgggctttg gcccctccag caaccttgtg tcccagccct gcccttcttc ccaccccctc
     4561 aatctgctag tccctgaagc ctttaaccaa acgggagtgg gcacagaaag ccttctcctg
     4621 gcaacaggac aagggctgcc cgcgtgtcca gccctgttgc tctcctggcg ctgagaggtg
     4681 ggtccaagca gagttgatca gtccctgcct gccctgccta ggtctagcca ggggaggttg
     4741 tgtgtgtggg agaagacccc gggatctgct ggggtgggat ggaggttatt aaagatctaa
     4801 gtgaggaggg gctggggttt ggatgcgggg tgaggcccga gcgctcacac ttcgtgtagg
     4861 gcgggcaggg gcctgacctc ttgcagggca gtggccttgg tgccctaccc ctgccctgcg
     4921 cagtatttat tgctaaatta ttgtccagga ggggcagcac tgggcctggc cccccgggta
     4981 tttattgctg tacatagtgt atgtttgtga tatataaggt tttctttatt ttgtatatga
     5041 tcaataaacc ttttaaagag a
//
