LOCUS       NM_012323               2374 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor F (MAFF), transcript
            variant 1, mRNA.
ACCESSION   NM_012323
VERSION     NM_012323.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 2374)
  AUTHORS   Moon,E.J., Mello,S.S., Li,C.G., Chi,J.T., Thakkar,K.,
            Kirkland,J.G., Lagory,E.L., Lee,I.J., Diep,A.N., Miao,Y., Rafat,M.,
            Vilalta,M., Castellini,L., Krieg,A.J., Graves,E.E., Attardi,L.D.
            and Giaccia,A.J.
  TITLE     The HIF target MAFF promotes tumor invasion and metastasis through
            IL11 and STAT3 signaling
  JOURNAL   Nat Commun 12 (1), 4308 (2021)
   PUBMED   34262028
  REMARK    GeneRIF: The HIF target MAFF promotes tumor invasion and metastasis
            through IL11 and STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2374)
  AUTHORS   Ibrahim,M.K., Abdelhafez,T.H., Takeuchi,J.S., Wakae,K.,
            Sugiyama,M., Tsuge,M., Ito,M., Watashi,K., El Kassas,M., Kato,T.,
            Murayama,A., Suzuki,T., Chayama,K., Shimotohno,K., Muramatsu,M.,
            Aly,H.H. and Wakita,T.
  TITLE     MafF Is an Antiviral Host Factor That Suppresses Transcription from
            Hepatitis B Virus Core Promoter
  JOURNAL   J Virol 95 (15), e0076721 (2021)
   PUBMED   33980595
  REMARK    GeneRIF: MafF Is an Antiviral Host Factor That Suppresses
            Transcription from Hepatitis B Virus Core Promoter.
REFERENCE   4  (bases 1 to 2374)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2374)
  AUTHORS   Hushpulian,D.M., Ammal Kaidery,N., Ahuja,M., Poloznikov,A.A.,
            Sharma,S.M., Gazaryan,I.G. and Thomas,B.
  TITLE     Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for
            Neurotherapeutics: Bach1 De-Repression to the Rescue
  JOURNAL   Front Aging Neurosci 13, 673205 (2021)
   PUBMED   33897412
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2374)
  AUTHORS   Kataoka,K., Yoshitomo-Nakagawa,K., Shioda,S. and Nishizawa,M.
  TITLE     A set of Hox proteins interact with the Maf oncoprotein to inhibit
            its DNA binding, transactivation, and transforming activities
  JOURNAL   J Biol Chem 276 (1), 819-826 (2001)
   PUBMED   11036080
REFERENCE   7  (bases 1 to 2374)
  AUTHORS   Kimura,T., Ivell,R., Rust,W., Mizumoto,Y., Ogita,K., Kusui,C.,
            Matsumura,Y., Azuma,C. and Murata,Y.
  TITLE     Molecular cloning of a human MafF homologue, which specifically
            binds to the oxytocin receptor gene in term myometrium
  JOURNAL   Biochem Biophys Res Commun 264 (1), 86-92 (1999)
   PUBMED   10527846
REFERENCE   8  (bases 1 to 2374)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   9  (bases 1 to 2374)
  AUTHORS   Armstrong,J.A. and Emerson,B.M.
  TITLE     NF-E2 disrupts chromatin structure at human beta-globin locus
            control region hypersensitive site 2 in vitro
  JOURNAL   Mol Cell Biol 16 (10), 5634-5644 (1996)
   PUBMED   8816476
REFERENCE   10 (bases 1 to 2374)
  AUTHORS   Igarashi,K., Kataoka,K., Itoh,K., Hayashi,N., Nishizawa,M. and
            Yamamoto,M.
  TITLE     Regulation of transcription by dimerization of erythroid factor
            NF-E2 p45 with small Maf proteins
  JOURNAL   Nature 367 (6463), 568-572 (1994)
   PUBMED   8107826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA209378.1, DA654696.1,
            AK002001.1, DB319587.1, AJ010857.1 and AI610651.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012323.3.
            
            Summary: The protein encoded by this gene is a basic leucine zipper
            (bZIP) transcription factor that lacks a transactivation domain. It
            is known to bind the US-2 DNA element in the promoter of the
            oxytocin receptor (OTR) gene and most likely heterodimerizes with
            other leucine zipper-containing proteins to enhance expression of
            the OTR gene during term pregnancy. The encoded protein can also
            form homodimers, and since it lacks a transactivation domain, the
            homodimer may act as a repressor of transcription. This gene may
            also be involved in the cellular stress response. Multiple
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 3, and 4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067751.1, AJ010857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338483.7/ ENSP00000345393.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               DA209378.1         63-566
            505-526             DA654696.1         535-556
            527-1906            AK002001.1         530-1909
            1907-2076           DB319587.1         2-171               c
            2077-2371           AJ010857.1         2055-2349
            2372-2374           AI610651.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2374
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /note="MAF bZIP transcription factor F"
                     /db_xref="GeneID:23764"
                     /db_xref="HGNC:HGNC:6780"
                     /db_xref="MIM:604877"
     exon            1..219
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /inference="alignment:Splign:2.1.0"
     exon            220..286
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..745
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /note="isoform a is encoded by transcript variant 1; v-maf
                     avian musculoaponeurotic fibrosarcoma oncogene family
                     protein F; transcription factor MAFF; v-maf avian
                     musculoaponeurotic fibrosarcoma oncogene homolog F"
                     /codon_start=1
                     /product="transcription factor MafF isoform a"
                     /protein_id="NP_036455.1"
                     /db_xref="CCDS:CCDS13968.1"
                     /db_xref="GeneID:23764"
                     /db_xref="HGNC:HGNC:6780"
                     /db_xref="MIM:604877"
                     /translation="MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGL
                     SAEEVTRLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRL
                     ELDALRGKCEALQGFARSVAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGP
                     ASCS"
     exon            287..2374
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /note="hexamer: AATAAA"
     polyA_site      2374
                     /gene="MAFF"
                     /gene_synonym="hMafF; U-MAF"
                     /note="major polyA site"
ORIGIN      
        1 aattccggga agctcgcctt acaactccgc gcggcctcgg ccccctgcgc cgcccgcccc
       61 acaacaaaac tcagcgcagc gctcccgggc gcccggttca gagcgacctg cggctcagag
      121 cggaggggag actgaccgga gcgcggatcg ggacagcggc cgggacagcg gcgagacgcg
      181 cgtgtgtgag cgcgccggac caagcgggcc cagaagcggg tctgcagccc agagggcacc
      241 ttctgcaaac atgtctgtgg atcccctatc cagcaaagct ctaaagatca agcgagagct
      301 gagcgagaac acgccgcacc tgtcggacga ggcgctgatg gggctgtcgg tgcgcgagct
      361 gaaccggcat ctgcgcgggc tctccgccga ggaggtgaca cggctcaagc agcggcgccg
      421 cacactcaaa aaccgtggct acgccgccag ctgccgcgtg aagcgcgtgt gccagaagga
      481 ggagctgcag aagcagaagt cggagctgga gcgcgaggtg gacaagctgg cgcgcgagaa
      541 cgccgccatg cgcctggagc tcgacgcgct gcgcggcaag tgcgaggcgc tgcagggctt
      601 cgcgcgctcc gtggccgccg cccgcgggcc cgccacgctc gtggcgccgg ccagcgtcat
      661 caccatcgtc aagtccaccc cgggctcggg gtctggcccc gcccacggcc cggaccccgc
      721 ccacggcccg gcctcctgct cctagtgccc gcccccgcca tgcctcagcc acgcccctcc
      781 ggcctcagct ccctccccaa agtgcctgag cgccgcctct gtgcccaggt cccatttctc
      841 tgcagcactg gccccttggt gcacacacat tcccttcgtg ggccctgtct tcctcttgca
      901 gccccccaaa ctgggaccga atgaccctgg gaaggggaac ttgggtaggt tggggatggg
      961 gcagaggtct ggatctggga tcgcccttgg ctgaaagttt agccttttta gattgagaga
     1021 tacagagccg gcttagagaa cagctgttgg gggagaagag ggcacccctc atcttggaaa
     1081 ctgctcttat tgtgccaata tgccctccaa accctcccag gattcaaagc taggtttggc
     1141 tgtctgtgac ttacgggacc gtcctgctga gaaattgcac tgaagagatg cccccacctc
     1201 tggttgggcc tgggggtgcc tggccttccg aaactaaaag agtgggtggg aagactagtg
     1261 aaacccagtt cacggatggg gaaacaggcc tgaggtcaca tttcacttag tggttgtgtt
     1321 gggaccaaaa cctgggtgtc ctcactgctg ccctgagtcc agccatggtt ttcaggggga
     1381 cagtggacag ggactcagaa atgtggtggg agggcctccc tggcttggga gaccgctctc
     1441 tgcaagggag ggggagagaa gcagagggag agagaaggtg acacggatgg aagagtggga
     1501 aggagctggc ctggctcagc cctaggctgt ccctgcagcc agggtgtccg ggggctggcc
     1561 agtcagagaa agggggccat ggactgctgt ggcaaatagg gagacaagga gacagaccct
     1621 gcagtcctac tacagtctgg agtggggtcc taagaagaag ggtcccacct caacccctgt
     1681 cagtgtccac tgtggggtgg gggctgaccc ctgcctttga ttgtcattct cctgggaagc
     1741 ccagtctcag tccctccccc aacactgtcc acactgcccc tccccactgt ttatttattg
     1801 cacggatcta agttattctc cccagccaga gcccgagctc ctgctccctg ggaaaagtgg
     1861 cgtatggccc tgagctgggc tttatatttt atatctgcaa ataaatcaca ttttatctta
     1921 tatttaggga aagccggaga gcaacaacaa aaaatgttta agccgggcgc ggtggctcac
     1981 atctgtaatc ccagcacttt gggagtccaa ggagggggat cgcttgagtc caggagtttg
     2041 agaccagcct ggacaacatg gtgaaacccc atctctacaa aaaatacaaa aattagccat
     2101 gcatggtggc tcatgcctgt agtcccagct acttgggagg ctgaggcagg aggatcactt
     2161 aagcccagaa ggcagaggtt gtagtgagct gagatcgcac cactgcactc cagcctgggc
     2221 aacatagcaa aatcctgtct caaaaaaaaa gttaaaaaat attgcccggc tcctagaatt
     2281 tatttatttc ctgacttaca gcaagcgagt tatcgtcttc tgtattttgt agactttcta
     2341 aataaagtca aattctttct ttttccacag agaa
//
