LOCUS       NM_005461               3389 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor B (MAFB), mRNA.
ACCESSION   NM_005461 NM_152258
VERSION     NM_005461.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Simon-Fuentes,M., Rios,I., Herrero,C., Lasala,F., Labiod,N.,
            Luczkowiak,J., Roy-Vallejo,E., Fernandez de Cordoba-Onate,S.,
            Delgado-Wicke,P., Bustos,M., Fernandez-Ruiz,E., Colmenares,M.,
            Puig-Kroger,A., Delgado,R., Vega,M.A., Corbi,A.L. and
            Dominguez-Soto,A.
  TITLE     MAFB shapes human monocyte-derived macrophage response to
            SARS-CoV-2 and controls severe COVID-19 biomarker expression
  JOURNAL   JCI Insight 8 (24), e172862 (2023)
   PUBMED   37917179
  REMARK    GeneRIF: MAFB shapes human monocyte-derived macrophage response to
            SARS-CoV-2 and controls severe COVID-19 biomarker expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Negri,A., Ward,C., Bucci,A., D'Angelo,G., Cauchy,P., Radesco,A.,
            Ventura,A.B., Walton,D.S., Clarke,M., Mandriani,B.,
            Pappagallo,S.A., Mondelli,P., Liao,K., Gargano,G., Zaccaria,G.M.,
            Viggiano,L., Lasorsa,F.M., Ahmed,A., Di Molfetta,D., Fiermonte,G.,
            Cives,M., Guarini,A., Vegliante,M.C., Ciavarella,S., Frampton,J.
            and Volpe,G.
  TITLE     Reversal of MYB-dependent suppression of MAFB expression overrides
            leukaemia phenotype in MLL-rearranged AML
  JOURNAL   Cell Death Dis 14 (11), 763 (2023)
   PUBMED   37996430
  REMARK    GeneRIF: Reversal of MYB-dependent suppression of MAFB expression
            overrides leukaemia phenotype in MLL-rearranged AML.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Asadollahi,S., Hadizadeh,M., Namiranian,N., Kalantar,S.M.,
            Firoozabadi,A.D. and Injinari,N.
  TITLE     Misexpression of LINC01410, FOSL1, and MAFB in peripheral blood
            mononuclear cells associated with diabetic nephropathy
  JOURNAL   Gene 862, 147265 (2023)
   PUBMED   36764337
  REMARK    GeneRIF: Misexpression of LINC01410, FOSL1, and MAFB in peripheral
            blood mononuclear cells associated with diabetic nephropathy.
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   de la Aleja,A.G., Herrero,C., Torres-Torresano,M., Schiaffino,M.T.,
            Del Castillo,A., Alonso,B., Vega,M.A., Puig-Kroger,A., Castrillo,A.
            and Corbi,A.L.
  TITLE     Inhibition of LXR controls the polarization of human inflammatory
            macrophages through upregulation of MAFB
  JOURNAL   Cell Mol Life Sci 80 (4), 96 (2023)
   PUBMED   36930354
  REMARK    GeneRIF: Inhibition of LXR controls the polarization of human
            inflammatory macrophages through upregulation of MAFB.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Bsharat,S., Monni,E., Singh,T., Johansson,J.K., Achanta,K.,
            Bertonnier-Brouty,L., Schmidt-Christensen,A., Holmberg,D.,
            Kokaia,Z., Prasad,R.B. and Artner,I.
  TITLE     MafB-dependent neurotransmitter signaling promotes beta cell
            migration in the developing pancreas
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36897571
  REMARK    GeneRIF: MafB-dependent neurotransmitter signaling promotes beta
            cell migration in the developing pancreas.
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Li,R., Pei,H., Watson,D.K. and Papas,T.S.
  TITLE     EAP1/Daxx interacts with ETS1 and represses transcriptional
            activation of ETS1 target genes
  JOURNAL   Oncogene 19 (6), 745-753 (2000)
   PUBMED   10698492
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Wang,P.W., Eisenbart,J.D., Cordes,S.P., Barsh,G.S., Stoffel,M. and
            Le Beau,M.M.
  TITLE     Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation
            as a candidate tumor suppressor gene in myeloid leukemias
  JOURNAL   Genomics 59 (3), 275-281 (1999)
   PUBMED   10444328
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Stoffel,M., Le Beau,M.M., Espinosa,R. 3rd, Bohlander,S.F., Le
            Paslier,D., Cohen,D., Xiang,K.S., Cox,N.J., Fajans,S.S. and
            Bell,G.I.
  TITLE     A yeast artificial chromosome-based map of the region of chromosome
            20 containing the diabetes-susceptibility gene, MODY1, and a
            myeloid leukemia related gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 3937-3941 (1996)
   PUBMED   8632993
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Sieweke,M.H., Tekotte,H., Frampton,J. and Graf,T.
  TITLE     MafB is an interaction partner and repressor of Ets-1 that inhibits
            erythroid differentiation
  JOURNAL   Cell 85 (1), 49-60 (1996)
   PUBMED   8620536
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Barry,B.J., Whitman,M.C., Hunter,D.G. and Engle,E.C.
  TITLE     Duane Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301369
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA719830.1, BC028098.1,
            AF134157.1 and BQ271704.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005461.4.
            
            Summary: The protein encoded by this gene is a basic leucine zipper
            (bZIP) transcription factor that plays an important role in the
            regulation of lineage-specific hematopoiesis. The encoded nuclear
            protein represses ETS1-mediated transcription of erythroid-specific
            genes in myeloid cells. This gene contains no introns. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC036689.1, AF134157.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373313.3/ ENSP00000362410.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               DA719830.1         6-370
            366-2275            BC028098.1         1-1910
            2276-3362           AF134157.1         1969-3055
            3363-3389           BQ271704.1         3-29                c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q12"
     gene            1..3389
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="MAF bZIP transcription factor B"
                     /db_xref="GeneID:9935"
                     /db_xref="HGNC:HGNC:6408"
                     /db_xref="MIM:608968"
     exon            1..3389
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1358
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="Kreisler maf-related leucine zipper homolog;
                     MAFB/Kreisler basic region/leucine zipper transcription
                     factor; v-maf avian musculoaponeurotic fibrosarcoma
                     oncogene homolog B"
                     /codon_start=1
                     /product="transcription factor MafB"
                     /protein_id="NP_005452.2"
                     /db_xref="CCDS:CCDS13311.1"
                     /db_xref="GeneID:9935"
                     /db_xref="HGNC:HGNC:6408"
                     /db_xref="MIM:608968"
                     /translation="MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGR
                     PCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNL
                     TPEDAVEALIGSHPVPQPLQSFDSFRGAHHHHHHHHPHPHHAYPGAGVAHDELGPHAH
                     PHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATASATAAGGNGSVEDRFSDDQLVS
                     MSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQ
                     VEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="hexamer: ATTAAA"
     polyA_site      3304
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="major polyA site"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="hexamer: ATTAAA"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="hexamer: ATTAAA"
     polyA_site      3362
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
                     /note="major polyA site"
     polyA_site      3389
                     /gene="MAFB"
                     /gene_synonym="DURS3; KRML; MCTO"
ORIGIN      
        1 acagctgcac cgccgagctg cgagcggctg cgagcgagag agcgtaagag caagagagct
       61 agagagcgag caacgggcac tcgccccacg cctcccctca gccccaccgc gcgctccgct
      121 tgcctctcca ccccgcccga ctctacccgg cccggtccct gcgcgggcac agcccagagc
      181 tctggggcgg tgcaggcagc ctcgggactc tccggcgcgc cgccgcgtcc ccagacaaag
      241 gcttggccgg cggccccggc ccgctgcgcc ctcgctcccc gcctccccag ctcttctccg
      301 ctcttccccc ccgcgcttgg ctcggcgcgc tccggccggc cgcaaagttt cccgggcggc
      361 agcggcggct gcgcctcgct tcagcgatgg ccgcggagct gagcatgggg ccagagctgc
      421 ccaccagccc gctggccatg gagtatgtca acgacttcga cctgctcaag ttcgacgtga
      481 agaaggagcc actggggcgc gcggagcgtc cgggcaggcc ctgcacacgc ctgcagccag
      541 ccggctcggt gtcctccaca ccgctcagca ctccgtgtag ctccgtgccc tcgtcgccca
      601 gcttcagccc gaccgaacag aagacacacc tcgaggatct gtactggatg gcgagcaact
      661 accagcagat gaaccccgag gcgctcaacc tgacgcccga ggacgcggtg gaagcgctca
      721 tcggctcgca cccagtgcca cagccgctgc aaagcttcga cagctttcgc ggcgctcacc
      781 accaccacca tcaccaccac cctcacccgc accacgcgta cccgggcgcc ggcgtggccc
      841 acgacgagct gggcccgcac gctcacccgc accatcacca tcatcaccaa gcgtcgccgc
      901 cgccgtccag cgccgctagc ccggcgcaac agctgcccac tagccacccc gggcccgggc
      961 cgcacgcgac ggcctcggcg acggcggcgg gcggcaacgg cagcgtggag gaccgcttct
     1021 ccgacgacca gctcgtgtcc atgtccgtgc gcgagctgaa ccgccacctg cggggcttca
     1081 ccaaggacga ggtgatccgc ctgaagcaga agcggcggac cctgaagaac cggggctacg
     1141 cccagtcttg caggtataaa cgcgtccagc agaagcacca cctggagaat gagaagacgc
     1201 agctcattca gcaggtggag cagcttaagc aggaggtgtc ccggctggcc cgcgagagag
     1261 acgcctacaa ggtcaagtgc gagaaactcg ccaactccgg cttcagggag gcgggctcca
     1321 ccagcgacag cccctcctct cccgagttct ttctgtgagt cgtggccggt cctggccccc
     1381 gcccttgccc cggcccggac tccctgtccc acgtccctag tcccagacta ccccggaccc
     1441 tgtccctgcc gcggccccag ccttgacctg tttgacttga gcgagaggga ggaagggcgc
     1501 gcgggccgcg ggcgacgggc gggtgcgcgg gcgggcaggg gaccttggct aaggcgagag
     1561 tagcgcacgc cagcgccgcc tcctagactc gagcagagcc ggagagagag acgagagggt
     1621 gggaggtccc ggagtaactt ctctccaggc tgaagggcgg cgaggcatag tcccgagaag
     1681 tcaccaaggc catctggaga ctcctggctt tctgaacttt gcgcgttaag ccgggacagc
     1741 tgctttgctg cccggagagt agtccgcgcc aggaagagag caacgaggaa aggagaggga
     1801 ctctggcgtc ccggcaggcg agaggcgagg ctgagcgaaa gaaggaagga cagacggacc
     1861 tgtctgtcag agttcggaga acactggctc tcagccctga gacacaggcc tcagttagga
     1921 cgctcggcgc ccaaatctca tcagttttat tgcctgctcg attatataga aaaatacaaa
     1981 aaatctgcat taaaaatatt aatcctgcat gctggacatg tatggtaata atttctattt
     2041 tgtaccattt tcttgtttaa ctttagcatg ttgttgatca tggatcatac tccccttgtt
     2101 tctttgggtg agaagggatc gcagtttgga aactccggcg gctgcgtgcg gggtttcagt
     2161 cccagctgta ggcttgtaaa tacccgcccc gccaaaccgc atagagaacg tggcagcaag
     2221 ctgagggtct ttgtttgggt ttattattac ggtatttttg tttgtaagtt aaaaagaaaa
     2281 aaaaaaagaa aaagttccgg gcattttgca tcagaaaaca actttgtctt ggggcacact
     2341 tggaagttgc atgttttctt tccttccctt atccccattc ggtcctcttt ttcctctctc
     2401 gctttagttt tcaaccttgt tggtgctgag agagagaacc gagaggtccc agtacaaggg
     2461 cagggcaggg cagggaagct gccaagctcc gcaccccaga ggagtgttct ggactacagc
     2521 cttgtcttat ggtcaaattg atacccttaa taagaaagga aaggaaagga aaacagatcc
     2581 tcccctctgc tttttattgt aaccagaatc accctgaggt cccttctgaa ccctctgggc
     2641 ctgcgctaat tgtaggagcc acagcgctcc tagggtgaga ggcttagcca tccctgaccc
     2701 tggcagtgca ctggtaagca gacactgcac tgaaccaact gctatgctca gaatgtacca
     2761 gaaacccaaa cattggcaag taattttgca actttcaagt gcgttcttta gaccaatgca
     2821 ttgcgtttct ttccctgctt ttgagatagt aggaagagtt cttggtggtg tcccccccct
     2881 tcaattcttc agttgtatag tagttatagg gaagatatgg gtgtttttct ttattattac
     2941 tttttttttt ctgcaggtca gtaaaaggat ttaagttgca ctgacaaaaa taccaaaata
     3001 aaagtgtatt tttaagttcc catttgaaat tgctggcgct gctggccgga tgcatttttg
     3061 agtttgtatt agttgataaa ttaacagtaa taacaagatt gtatgaaccg catggtgctt
     3121 gcagttttaa atattgtgga tatttgtcct gcatcagaaa cgagctttgg tttttacaga
     3181 ttcaactgtg ttgaaatcaa acctgccgca acagaaattg tttttatttc atgtaaaata
     3241 agggatcaat ttcaaaccct gcttatgata tgaaaatatt aaaacctagt ctattgtagt
     3301 tttattcaga ctggtttctg ttttttggtt attaaaatgg tttcctattt tgcttattaa
     3361 aaccatggaa atggtgttta tttagagga
//
