LOCUS       NM_005360               2669 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor (MAF), transcript
            variant 1, mRNA.
ACCESSION   NM_005360
VERSION     NM_005360.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Yang,L., Song,Y., Wang,T., Cui,Z., Wu,J., Shi,Y., Yu,Z. and Song,B.
  TITLE     Transcription factor c-Maf drives macrophages to promote
            hypertrophic scar formation
  JOURNAL   J Cosmet Dermatol 23 (2), 639-647 (2024)
   PUBMED   37710417
  REMARK    GeneRIF: Transcription factor c-Maf drives macrophages to promote
            hypertrophic scar formation.
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Li,L., Yue,J.F., Kong,D.Q., Sun,M.M., Li,K. and Zheng,G.Y.
  TITLE     Novel cataract-causing variant c.177dupC in c-MAF regulates the
            expression of crystallin genes for cell apoptosis via a
            mitochondria-dependent pathway
  JOURNAL   Mol Genet Genomics 298 (2), 495-506 (2023)
   PUBMED   36719481
  REMARK    GeneRIF: Novel cataract-causing variant c.177dupC in c-MAF
            regulates the expression of crystallin genes for cell apoptosis via
            a mitochondria-dependent pathway.
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Trabanelli,S., Ercolano,G., Wyss,T., Gomez-Cadena,A., Falquet,M.,
            Cropp,D., Imbratta,C., Leblond,M.M., Salvestrini,V., Curti,A.,
            Adotevi,O., Jandus,C. and Verdeil,G.
  TITLE     c-Maf enforces cytokine production and promotes memory-like
            responses in mouse and human type 2 innate lymphoid cells
  JOURNAL   EMBO J 41 (12), e109300 (2022)
   PUBMED   35467036
  REMARK    GeneRIF: c-Maf enforces cytokine production and promotes
            memory-like responses in mouse and human type 2 innate lymphoid
            cells.
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Chen,X., Cai,Y., Hu,X., Ding,C., He,L., Zhang,X., Chen,F. and
            Yan,J.
  TITLE     Differential metabolic requirement governed by transcription factor
            c-Maf dictates innate gammadeltaT17 effector functionality in mice
            and humans
  JOURNAL   Sci Adv 8 (21), eabm9120 (2022)
   PUBMED   35613277
  REMARK    GeneRIF: Differential metabolic requirement governed by
            transcription factor c-Maf dictates innate gammadeltaT17 effector
            functionality in mice and humans.
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Smith,A.R. and Gouon-Evans,V.
  TITLE     c-Maf: The magic wand that turns on LSEC fate
  JOURNAL   Cell Stem Cell 29 (4), 491-493 (2022)
   PUBMED   35395181
  REMARK    GeneRIF: c-Maf: The magic wand that turns on LSEC fate.
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Chesi,M., Bergsagel,P.L., Shonukan,O.O., Martelli,M.L.,
            Brents,L.A., Chen,T., Schrock,E., Ried,T. and Kuehl,W.M.
  TITLE     Frequent dysregulation of the c-maf proto-oncogene at 16q23 by
            translocation to an Ig locus in multiple myeloma
  JOURNAL   Blood 91 (12), 4457-4463 (1998)
   PUBMED   9616139
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Hedge,S.P., Kumar,A., Kurschner,C. and Shapiro,L.H.
  TITLE     c-Maf interacts with c-Myb to regulate transcription of an early
            myeloid gene during differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2729-2737 (1998)
   PUBMED   9566892
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Kurschner,C. and Morgan,J.I.
  TITLE     USF2/FIP associates with the b-Zip transcription factor, c-Maf, via
            its bHLH domain and inhibits c-Maf DNA binding activity
  JOURNAL   Biochem Biophys Res Commun 231 (2), 333-339 (1997)
   PUBMED   9070273
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Apr 7;233(1):293]
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Kerppola,T.K. and Curran,T.
  TITLE     Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos
            and Jun
  JOURNAL   Oncogene 9 (3), 675-684 (1994)
   PUBMED   8108109
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Amudhavalli,S.M., Gadea,R. and Gripp,K.
  TITLE     Ayme-Gripp Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32027476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009159.12, BC038438.1,
            BF726289.1, AF055377.1, BC081542.1 and BE644986.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005360.4.
            
            Summary: The protein encoded by this gene is a DNA-binding, leucine
            zipper-containing transcription factor that acts as a homodimer or
            as a heterodimer. Depending on the binding site and binding
            partner, the encoded protein can be a transcriptional activator or
            repressor. This protein plays a role in the regulation of several
            cellular processes, including embryonic lens fiber cell
            development, increased T-cell susceptibility to apoptosis, and
            chondrocyte terminal differentiation. Defects in this gene are a
            cause of juvenile-onset pulverulent cataract as well as congenital
            cerulean cataract 4 (CCA4). Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) is spliced and encodes the
            longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055377.1, SRR3476690.389351.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326043.5/ ENSP00000327048.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC009159.12        98820-98831
            13-826              BC038438.1         1-814
            827-1159            BF726289.1         98-430
            1160-1350           BC038438.1         1145-1335
            1351-2078           AF055377.1         1323-2050
            2079-2173           BC081542.1         5591-5685
            2174-2659           BE644986.1         10-495              c
            2660-2669           AC009159.12        105710-105719
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..2669
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="MAF bZIP transcription factor"
                     /db_xref="GeneID:4094"
                     /db_xref="HGNC:HGNC:6776"
                     /db_xref="MIM:177075"
     exon            1..1953
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2669
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: AATAAA"
     polyA_site      2173
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="major polyA site"
     regulatory      2181..2186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: ATTAAA"
     polyA_site      2203
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: AATACA"
     polyA_site      2669
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
ORIGIN      
        1 cttgctggat cagaggcttt aaaatctttt ttcatcttct agctgtagct cgggctgctt
       61 gtcggcttgg cctccccctc ccccctttgc tctctgcctc gtctttcccc aggacttcgc
      121 tattttgctt ttttaaaaaa aggcaagaaa gaactaaact cccccctccc tctcctccag
      181 tcgggctgca cctctgcctt gcactttgca cagaggtaga gagcgcgcga gggagagaga
      241 ggaaagaaaa aaaataataa agagagccaa gcagaagagg aggcgagaag catgaagtgt
      301 taactccccc gtgccaaggc ccgcgccgcc cggacagacg cccgccgcgc ctccagcccc
      361 gagcggacgc cgcgcgcgcc ctgcctgcag cccgggccgg cgaggcgagc ccttccttat
      421 gcaaagcgcg cagcggagcg gcgagcgggg gacgccgcgc accgggccgg gctcctccag
      481 cttcgccgcc gcagccacca ccgccgccac cgcagctcgc ggaggatctt cccgagcctg
      541 aagccgccgg ctcggcgcgc aaggaggcga gcgagcaagg aggggccggg gcgagcgagg
      601 gagcacattg gcgtgagcag gggggaggga gggcgggcgc ggggggcgcg ggcagggcgg
      661 gggggtgtgt gtgtgagcgc gctcggaggt ttcgggccag ccaccgccgc gcaagctaga
      721 agcgccccag cccggcaagc tggctcaccc gctggccacc cagcacagcc cgctggcccc
      781 tctcctgcag cccatctggc ggagcggcgg cggcggcggc ggcggcggca ggagaatggc
      841 atcagaactg gcaatgagca actccgacct gcccaccagt cccctggcca tggaatatgt
      901 taatgacttc gatctgatga agtttgaagt gaaaaaggaa ccggtggaga ccgaccgcat
      961 catcagccag tgcggccgtc tcatcgccgg gggctcgctg tcctccaccc ccatgagcac
     1021 gccgtgcagc tcggtgcccc cttcccccag cttctcggcg cccagcccgg gctcgggcag
     1081 cgagcagaag gcgcacctgg aagactacta ctggatgacc ggctacccgc agcagctgaa
     1141 ccccgaggcg ctgggcttca gccccgagga cgcggtcgag gcgctcatca gcaacagcca
     1201 ccagctccag ggcggcttcg atggctacgc gcgcggggcg cagcagctgg ccgcggcggc
     1261 cggggccggt gccggcgcct ccttgggcgg cagcggcgag gagatgggcc ccgccgccgc
     1321 cgtggtgtcc gccgtgatcg ccgcggccgc cgcgcagagc ggcgcgggcc cgcactacca
     1381 ccaccaccac caccacgccg ccggccacca ccaccacccg acggccggcg cgcccggcgc
     1441 cgcgggcagc gcggccgcct cggccggtgg cgctgggggc gcgggcggcg gtggcccggc
     1501 cagcgctggg ggcggcggcg gcggcggcgg cggcggaggc ggcgggggcg cggcgggggc
     1561 ggggggcgcc ctgcacccgc accacgccgc cggcggcctg cacttcgacg accgcttctc
     1621 cgacgagcag ctggtgacca tgtctgtgcg cgagctgaac cggcagctgc gcggggtcag
     1681 caaggaggag gtgatccggc tgaagcagaa gaggcggacc ctgaaaaacc gcggctatgc
     1741 ccagtcctgc cgcttcaaga gggtgcagca gagacacgtc ctggagtcgg agaagaacca
     1801 gctgctgcag caagtcgacc acctcaagca ggagatctcc aggctggtgc gcgagaggga
     1861 cgcgtacaag gagaaatacg agaagttggt gagcagcggc ttccgagaaa acggctcgag
     1921 cagcgacaac ccgtcctctc ccgagttttt cataactgag cccactcgca agttggagcc
     1981 atcagtggga tacgccacat tttggaagcc ccagcatcgt gtacttacca gtgtgttcac
     2041 aaaatgaaat ttgtgtgaga gctgtacatt aaaaaaaatc atcattatta ttattatttg
     2101 cagtcatgga gaaccaccta cccctgactt ctgtttagtc tcctttttaa ataaaaatta
     2161 ctgtgttaga gaagaaggct attaaatgta gtagttaact atgcctcttg tctgggggtt
     2221 tcatagagac cggtaggaaa gcgcactcct gcttttcgat ttatggtgtg tgcaagtaaa
     2281 caggtgcatt gctttcaacc tgccatacta gttttaaaaa ttcactgaaa ttacaaagat
     2341 acatatatat gcatatatat aatggaaagt ttcccggaat gcaacaatta gcattttaaa
     2401 atcatatata ggcatgcaca ttctaaatag tactttttca tgcttcattg tttctctggc
     2461 agataatttt actaagaaga aaaatagata ttcgactccc cttccctaaa caaatccacg
     2521 ggcagaggct ccagcggagc cgagccccct ggttttctcg taggccctag acggtgttgc
     2581 atttatcagt gatgtcaaac gtgctcattt gtcagacata gctgtaaatg aaaacaatgt
     2641 gtggcaaaat acaaagttag ttaaataca
//
