LOCUS       NM_001031804            6900 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens MAF bZIP transcription factor (MAF), transcript
            variant 2, mRNA.
ACCESSION   NM_001031804 XM_001134279 XM_001134280
VERSION     NM_001031804.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6900)
  AUTHORS   Yang,L., Song,Y., Wang,T., Cui,Z., Wu,J., Shi,Y., Yu,Z. and Song,B.
  TITLE     Transcription factor c-Maf drives macrophages to promote
            hypertrophic scar formation
  JOURNAL   J Cosmet Dermatol 23 (2), 639-647 (2024)
   PUBMED   37710417
  REMARK    GeneRIF: Transcription factor c-Maf drives macrophages to promote
            hypertrophic scar formation.
REFERENCE   2  (bases 1 to 6900)
  AUTHORS   Li,L., Yue,J.F., Kong,D.Q., Sun,M.M., Li,K. and Zheng,G.Y.
  TITLE     Novel cataract-causing variant c.177dupC in c-MAF regulates the
            expression of crystallin genes for cell apoptosis via a
            mitochondria-dependent pathway
  JOURNAL   Mol Genet Genomics 298 (2), 495-506 (2023)
   PUBMED   36719481
  REMARK    GeneRIF: Novel cataract-causing variant c.177dupC in c-MAF
            regulates the expression of crystallin genes for cell apoptosis via
            a mitochondria-dependent pathway.
REFERENCE   3  (bases 1 to 6900)
  AUTHORS   Trabanelli,S., Ercolano,G., Wyss,T., Gomez-Cadena,A., Falquet,M.,
            Cropp,D., Imbratta,C., Leblond,M.M., Salvestrini,V., Curti,A.,
            Adotevi,O., Jandus,C. and Verdeil,G.
  TITLE     c-Maf enforces cytokine production and promotes memory-like
            responses in mouse and human type 2 innate lymphoid cells
  JOURNAL   EMBO J 41 (12), e109300 (2022)
   PUBMED   35467036
  REMARK    GeneRIF: c-Maf enforces cytokine production and promotes
            memory-like responses in mouse and human type 2 innate lymphoid
            cells.
REFERENCE   4  (bases 1 to 6900)
  AUTHORS   Chen,X., Cai,Y., Hu,X., Ding,C., He,L., Zhang,X., Chen,F. and
            Yan,J.
  TITLE     Differential metabolic requirement governed by transcription factor
            c-Maf dictates innate gammadeltaT17 effector functionality in mice
            and humans
  JOURNAL   Sci Adv 8 (21), eabm9120 (2022)
   PUBMED   35613277
  REMARK    GeneRIF: Differential metabolic requirement governed by
            transcription factor c-Maf dictates innate gammadeltaT17 effector
            functionality in mice and humans.
REFERENCE   5  (bases 1 to 6900)
  AUTHORS   Smith,A.R. and Gouon-Evans,V.
  TITLE     c-Maf: The magic wand that turns on LSEC fate
  JOURNAL   Cell Stem Cell 29 (4), 491-493 (2022)
   PUBMED   35395181
  REMARK    GeneRIF: c-Maf: The magic wand that turns on LSEC fate.
REFERENCE   6  (bases 1 to 6900)
  AUTHORS   Chesi,M., Bergsagel,P.L., Shonukan,O.O., Martelli,M.L.,
            Brents,L.A., Chen,T., Schrock,E., Ried,T. and Kuehl,W.M.
  TITLE     Frequent dysregulation of the c-maf proto-oncogene at 16q23 by
            translocation to an Ig locus in multiple myeloma
  JOURNAL   Blood 91 (12), 4457-4463 (1998)
   PUBMED   9616139
REFERENCE   7  (bases 1 to 6900)
  AUTHORS   Hedge,S.P., Kumar,A., Kurschner,C. and Shapiro,L.H.
  TITLE     c-Maf interacts with c-Myb to regulate transcription of an early
            myeloid gene during differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2729-2737 (1998)
   PUBMED   9566892
REFERENCE   8  (bases 1 to 6900)
  AUTHORS   Kurschner,C. and Morgan,J.I.
  TITLE     USF2/FIP associates with the b-Zip transcription factor, c-Maf, via
            its bHLH domain and inhibits c-Maf DNA binding activity
  JOURNAL   Biochem Biophys Res Commun 231 (2), 333-339 (1997)
   PUBMED   9070273
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Apr 7;233(1):293]
REFERENCE   9  (bases 1 to 6900)
  AUTHORS   Kerppola,T.K. and Curran,T.
  TITLE     Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos
            and Jun
  JOURNAL   Oncogene 9 (3), 675-684 (1994)
   PUBMED   8108109
REFERENCE   10 (bases 1 to 6900)
  AUTHORS   Amudhavalli,S.M., Gadea,R. and Gripp,K.
  TITLE     Ayme-Gripp Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32027476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009159.12, BC038438.1,
            BF726289.1, BC081542.1 and BE644986.1.
            
            On May 31, 2019 this sequence version replaced NM_001031804.2.
            
            Summary: The protein encoded by this gene is a DNA-binding, leucine
            zipper-containing transcription factor that acts as a homodimer or
            as a heterodimer. Depending on the binding site and binding
            partner, the encoded protein can be a transcriptional activator or
            repressor. This protein plays a role in the regulation of several
            cellular processes, including embryonic lens fiber cell
            development, increased T-cell susceptibility to apoptosis, and
            chondrocyte terminal differentiation. Defects in this gene are a
            cause of juvenile-onset pulverulent cataract as well as congenital
            cerulean cataract 4 (CCA4). Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) represents an unspliced
            transcript compared to variant 1, which results in a frame-shift
            and a shorter isoform (b) with a distinct C-terminus compared to
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC081542.1, AF055376.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC009159.12        98820-98831
            13-826              BC038438.1         1-814
            827-1159            BF726289.1         98-430
            1160-1350           BC038438.1         1145-1335
            1351-2127           BC081542.1         631-1407
            2128-6404           AC009159.12        100947-105223
            6405-6890           BE644986.1         10-495              c
            6891-6900           AC009159.12        105710-105719
FEATURES             Location/Qualifiers
     source          1..6900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..6900
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="MAF bZIP transcription factor"
                     /db_xref="GeneID:4094"
                     /db_xref="HGNC:HGNC:6776"
                     /db_xref="MIM:177075"
     exon            1..6900
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4238..4243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: AATAAA"
     polyA_site      4259
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="major polyA site"
     regulatory      6381..6386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: AATAAA"
     polyA_site      6404
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
     regulatory      6412..6417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: ATTAAA"
     polyA_site      6434
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
     regulatory      6879..6884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
                     /note="hexamer: AATACA"
     polyA_site      6900
                     /gene="MAF"
                     /gene_synonym="AYGRP; c-MAF; CCA4; CTRCT21"
ORIGIN      
        1 cttgctggat cagaggcttt aaaatctttt ttcatcttct agctgtagct cgggctgctt
       61 gtcggcttgg cctccccctc ccccctttgc tctctgcctc gtctttcccc aggacttcgc
      121 tattttgctt ttttaaaaaa aggcaagaaa gaactaaact cccccctccc tctcctccag
      181 tcgggctgca cctctgcctt gcactttgca cagaggtaga gagcgcgcga gggagagaga
      241 ggaaagaaaa aaaataataa agagagccaa gcagaagagg aggcgagaag catgaagtgt
      301 taactccccc gtgccaaggc ccgcgccgcc cggacagacg cccgccgcgc ctccagcccc
      361 gagcggacgc cgcgcgcgcc ctgcctgcag cccgggccgg cgaggcgagc ccttccttat
      421 gcaaagcgcg cagcggagcg gcgagcgggg gacgccgcgc accgggccgg gctcctccag
      481 cttcgccgcc gcagccacca ccgccgccac cgcagctcgc ggaggatctt cccgagcctg
      541 aagccgccgg ctcggcgcgc aaggaggcga gcgagcaagg aggggccggg gcgagcgagg
      601 gagcacattg gcgtgagcag gggggaggga gggcgggcgc ggggggcgcg ggcagggcgg
      661 gggggtgtgt gtgtgagcgc gctcggaggt ttcgggccag ccaccgccgc gcaagctaga
      721 agcgccccag cccggcaagc tggctcaccc gctggccacc cagcacagcc cgctggcccc
      781 tctcctgcag cccatctggc ggagcggcgg cggcggcggc ggcggcggca ggagaatggc
      841 atcagaactg gcaatgagca actccgacct gcccaccagt cccctggcca tggaatatgt
      901 taatgacttc gatctgatga agtttgaagt gaaaaaggaa ccggtggaga ccgaccgcat
      961 catcagccag tgcggccgtc tcatcgccgg gggctcgctg tcctccaccc ccatgagcac
     1021 gccgtgcagc tcggtgcccc cttcccccag cttctcggcg cccagcccgg gctcgggcag
     1081 cgagcagaag gcgcacctgg aagactacta ctggatgacc ggctacccgc agcagctgaa
     1141 ccccgaggcg ctgggcttca gccccgagga cgcggtcgag gcgctcatca gcaacagcca
     1201 ccagctccag ggcggcttcg atggctacgc gcgcggggcg cagcagctgg ccgcggcggc
     1261 cggggccggt gccggcgcct ccttgggcgg cagcggcgag gagatgggcc ccgccgccgc
     1321 cgtggtgtcc gccgtgatcg ccgcggccgc cgcgcagagc ggcgcgggcc cgcactacca
     1381 ccaccaccac caccacgccg ccggccacca ccaccacccg acggccggcg cgcccggcgc
     1441 cgcgggcagc gcggccgcct cggccggtgg cgctgggggc gcgggcggcg gtggcccggc
     1501 cagcgctggg ggcggcggcg gcggcggcgg cggcggaggc ggcgggggcg cggcgggggc
     1561 ggggggcgcc ctgcacccgc accacgccgc cggcggcctg cacttcgacg accgcttctc
     1621 cgacgagcag ctggtgacca tgtctgtgcg cgagctgaac cggcagctgc gcggggtcag
     1681 caaggaggag gtgatccggc tgaagcagaa gaggcggacc ctgaaaaacc gcggctatgc
     1741 ccagtcctgc cgcttcaaga gggtgcagca gagacacgtc ctggagtcgg agaagaacca
     1801 gctgctgcag caagtcgacc acctcaagca ggagatctcc aggctggtgc gcgagaggga
     1861 cgcgtacaag gagaaatacg agaagttggt gagcagcggc ttccgagaaa acggctcgag
     1921 cagcgacaac ccgtcctctc ccgagttttt catgtgagtc tgacacgcga ttccagctag
     1981 ccaccctgat aagtgctccg cgggggtccg gctcgggtgt gggcttgcta gttctagagc
     2041 catgctcgcc accacctcac cacccccacc cccaccgagt ttggccccct tggcccccta
     2101 cacacacaca aacccgcacg cacacaccac acacacacac acacacacac acacacccca
     2161 caccctgctc gagtttgtgg tggtggtggc tgttttaaac tggggaggga atgggtgtct
     2221 ggctcatgga ttgccaatct gaaattctcc ataacttgct agcttgtttt tttttttttt
     2281 ttacaccccc ccgccccacc cccggacttg cacaatgttc aatgatctca gcagagttct
     2341 tcatgtgaaa cgttgatcac ctttgaagcc tgcatcattc acatattttt tcttcttctt
     2401 ccccttcagt tcatgaactg gtgttcattt tctgtgtgtg tgtgtgtttt attttgtttg
     2461 gatttttttt tttaatttta cttttagagc ttgctgtgtt gcccaccttt tttccaacct
     2521 ccaccctcac tccttctcaa cccatctctt ccgagatgaa agaaaaaaaa aagcaaagtt
     2581 tttttttctt ctcctgagtt cttcatgtga gattgagctt gcaaaggaaa aaaaaatgtg
     2641 aaatgttata gacttgcagc gtgccgagtt ccatcgggtt ttttttttag cattgttatg
     2701 ctaaaataga gaaaaaaatc ctcatgaacc ttccacaatc aagcctgcat caaccttctg
     2761 ggtgtgactt gtgagttttg gccttgtgat gccaaatctg agagtttagt ctgccattaa
     2821 aaaaactcat tctcatctca tgcattatta tgcttgctac tttgtcttag caacaatgaa
     2881 ctataactgt ttcaaagact ttatggaaaa gagacattat attaataaaa aaaaaaagcc
     2941 tgcatgctgg acatgtatgg tataattatt ttttcctttt tttttccttt tggcttggaa
     3001 atggacgttc gaagacttat agcatggcat tcatactttt gttttattgc ctcatgactt
     3061 ttttgagttt agaacaaaac agtgcaaccg tagagccttc ttcccatgaa attttgcatc
     3121 tgctccaaaa ctgctttgag ttactcagaa cttcaacctc ccaatgcact gaaggcattc
     3181 cttgtcaaag ataccagaat gggttacaca tttaacctgg caaacattga agaactctta
     3241 atgttttctt tttaataaga atgacgcccc actttgggga ctaaaattgt gctattgccg
     3301 agaagcagtc taaaatttat tttttaaaaa gagaaactgc cccattattt ttggtttgtt
     3361 ttatttttat tttatatttt ttggcttttg gtcattgtca aatgtggaat gctctgggtt
     3421 tctagtatat aatttaattc tagtttttat aatctgttag cccagttaaa atgtatgcta
     3481 cagataaagg aatgttatag ataaatttga aagagttagg tctgtttagc tgtagatttt
     3541 ttaaacgatt gatgcactaa attgtttact attgtgatgt taaggggggt agagtttgca
     3601 aggggactgt ttaaaaaaag tagcttatac agcatgtgct tgcaacttaa atataagttg
     3661 ggtatgtgta gtctttgcta taccactgac tgtattgaaa accaaagtat taagagggga
     3721 aacgcccctg tttatatctg taggggtatt ttacattcaa aaatgtatgt ttttttttct
     3781 tttcaaaatt aaagtatttg ggactgaatt gcactaagat ataacctgca agcatataat
     3841 acaaaaaaaa attgcaaaac tgtttagaac gctaataaaa tttatgcagt tataaaaatg
     3901 gcattactgc acagttttaa gatgatgcag atttttttac agttgtattg tggtgcagaa
     3961 ctggattttc tgtaacttaa aaaaaaatcc acagttttaa aggcaataat cagtaaatgt
     4021 tattttcagg gactgacatc ctgtctttaa aaagaaatga aaagtaaatc ttaccacaat
     4081 aaatataaaa aaatcttgtc agttactttt cttttacata ttttgctgtg caaaattgtt
     4141 ttatatcttg agttactaac taaccacgcg tgttgttcct atgtgctttt ctttcatttt
     4201 caattctggt tatatcaaga aaagaataat ctacaataat aaacggcatt tttttttgat
     4261 tctgtactca gtttcttagt gtacagttta actgggccca acaacctcgt taaaagtgta
     4321 aaatgcatcc ttttctccag tggaaggatt cctggaggaa tagggagaca gtaattcagg
     4381 gtgaaattat aggctgtttt ttgaagtgag gaggctggcc ccatatactg attagcaata
     4441 tttaatatag atgtaaatta tgacctcatt tttttctccc caaagttttc agttttcaaa
     4501 tgagttgagc cataattgcc cttggtagga aaaacaaaac aaaacagtgg aactaggctt
     4561 cctgagcatg gccctacact tctgatcagg agcaaagcca tccatagaca gaggagccgg
     4621 acaaatatgg cgcatcagag gtggcttgcg cacatatgca ttgaacggta aagagaaaca
     4681 gcgcttgcct tttcactaaa gttgactatt tttccttctt ctcttacaca ccgagatttt
     4741 cttgttagca aggcctgaca agatttaaca taaacatgac aaatcatagt tgtttgtttt
     4801 gttttgcttt tctctttaac actgaagatc atttgtctta aataggaaaa agaaaatcca
     4861 ctccttactt ccatatttcc aagtacatat ctggtttaaa ctatgttatc aaatcatatt
     4921 tcaccgtgaa tattcagtgg agaacttctc tacctggatg agctagtaat gatttcagat
     4981 catgctatcc ccagaaataa aagcaaaaaa taatacctgt gtggaatata ggctgtgctt
     5041 tgatttactg gtatttaccc caaaataggc tgtgtatggg ggctgactta aagatccctt
     5101 ggaaagactc aaaactacct tcactagtag gactcctaag cgctgaccta tttttaaatg
     5161 acacaaattc atgaaactaa tgttacaaat tcatgcagtt tgcactctta gtcatcttcc
     5221 cctagcacac caatagaatg ttagacaaag ccagcactgt tttgaaaata cagccaaaca
     5281 cgatgacttt tgttttgttt tctgccgttc ttaaaagaaa aaaagataat attgcaactc
     5341 tgactgaaag acttattttt aagaaaacag gttgtgtttg gtgctgctaa gttctggcca
     5401 gtttatcatc tggccttcct gcctattttt tacaaaacac gaagacagtg tgtaacctcg
     5461 acattttgac cttcctttat gtgctagttt agacaggctc ctgaatccac acttaatttt
     5521 gcttaacaaa agtcttaata gtaaacctcc cctcatgagc ttgaagtcaa gtgttcttga
     5581 cttcagatat ttctttcctt tttttttttt tttcctcatc acaactaaga gatacacaaa
     5641 ctctgaagaa gcagaaatgg agagaatgct tttaacaaaa aagcatctga tgaaagattt
     5701 taggcaaaca ttctcaaaat aagagtgata ttctggatgt agttattgca gttatctcat
     5761 gacaaatgag gcctggattg gaaggaaaat atagttgtgt agaattaagc attttgatag
     5821 gaatctacaa ggtagttgaa tataataagc aggtttgggc ccccaaactt tagaaaatca
     5881 aatgcaaagg tgctggcaaa aatgaggttt gagtggctgg ctgtaagaga aggttaactc
     5941 ctagtaaaag gcatttttag aaataacaat tactgaaaac tttgaagtat agtgggagta
     6001 gcaaacaaat acatgttttt tttttcttac aaagaactcc taaatcctga gtaagtgcca
     6061 ttcattacaa taagtctcta aatttaaaaa aaaaaaaatc atatgaggaa atctagcttt
     6121 cccctttacg ctgcgtttga tctttgtcta aatagtgtta aaattccttt cattccaatt
     6181 acagaactga gcccactcgc aagttggagc catcagtggg atacgccaca ttttggaagc
     6241 cccagcatcg tgtacttacc agtgtgttca caaaatgaaa tttgtgtgag agctgtacat
     6301 taaaaaaaat catcattatt attattattt gcagtcatgg agaaccacct acccctgact
     6361 tctgtttagt ctccttttta aataaaaatt actgtgttag agaagaaggc tattaaatgt
     6421 agtagttaac tatgcctctt gtctgggggt ttcatagaga ccggtaggaa agcgcactcc
     6481 tgcttttcga tttatggtgt gtgcaagtaa acaggtgcat tgctttcaac ctgccatact
     6541 agttttaaaa attcactgaa attacaaaga tacatatata tgcatatata taatggaaag
     6601 tttcccggaa tgcaacaatt agcattttaa aatcatatat aggcatgcac attctaaata
     6661 gtactttttc atgcttcatt gtttctctgg cagataattt tactaagaag aaaaatagat
     6721 attcgactcc ccttccctaa acaaatccac gggcagaggc tccagcggag ccgagccccc
     6781 tggttttctc gtaggcccta gacggtgttg catttatcag tgatgtcaaa cgtgctcatt
     6841 tgtcagacat agctgtaaat gaaaacaatg tgtggcaaaa tacaaagtta gttaaataca
//
