LOCUS       NM_003682               6001 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens MAP kinase activating death domain (MADD), transcript
            variant 4, mRNA.
ACCESSION   NM_003682
VERSION     NM_003682.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6001)
  AUTHORS   Abdel-Salam,G.M.H. and Abdel-Hamid,M.S.
  TITLE     New insights into the clinical and molecular spectrum of the
            MADD-related neurodevelopmental disorder
  JOURNAL   J Hum Genet 69 (6), 263-270 (2024)
   PUBMED   38459224
  REMARK    GeneRIF: New insights into the clinical and molecular spectrum of
            the MADD-related neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 6001)
  AUTHORS   Medlyn,M.J., Maeder,E., Bradley,C., Phatarpekar,P., Ham,H. and
            Billadeau,D.D.
  TITLE     MADD regulates natural killer cell degranulation through Rab27a
            activation
  JOURNAL   J Cell Sci 137 (7) (2024)
   PUBMED   38506245
  REMARK    GeneRIF: MADD regulates natural killer cell degranulation through
            Rab27a activation.
REFERENCE   3  (bases 1 to 6001)
  AUTHORS   Darouich,S. and Darouich,S.
  TITLE     Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency
  JOURNAL   Am J Med Genet A 194 (3), e63463 (2024)
   PUBMED   37932938
  REMARK    GeneRIF: Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency.
REFERENCE   4  (bases 1 to 6001)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   5  (bases 1 to 6001)
  AUTHORS   Abu-Libdeh,B., Mor-Shaked,H., Atawna,A.A., Gillis,D., Halstuk,O.,
            Shaul-Lotan,N., Slae,M., Sultan,M., Meiner,V., Elpeleg,O. and
            Harel,T.
  TITLE     Homozygous variant in MADD, encoding a Rab guanine nucleotide
            exchange factor, results in pleiotropic effects and a multisystemic
            disorder
  JOURNAL   Eur J Hum Genet 29 (6), 977-987 (2021)
   PUBMED   33723354
  REMARK    GeneRIF: Homozygous variant in MADD, encoding a Rab guanine
            nucleotide exchange factor, results in pleiotropic effects and a
            multisystemic disorder.
REFERENCE   6  (bases 1 to 6001)
  AUTHORS   Telliez,J.B., Bean,K.M. and Lin,L.L.
  TITLE     LRDD, a novel leucine rich repeat and death domain containing
            protein
  JOURNAL   Biochim Biophys Acta 1478 (2), 280-288 (2000)
   PUBMED   10825539
REFERENCE   7  (bases 1 to 6001)
  AUTHORS   Chow,V.T., Lim,K.M. and Lim,D.
  TITLE     The human DENN gene: genomic organization, alternative splicing,
            and localization to chromosome 11p11.21-p11.22
  JOURNAL   Genome 41 (4), 543-552 (1998)
   PUBMED   9796103
REFERENCE   8  (bases 1 to 6001)
  AUTHORS   Zhang,Y., Zhou,L. and Miller,C.A.
  TITLE     A splicing variant of a death domain protein that is regulated by a
            mitogen-activated kinase is a substrate for c-Jun N-terminal kinase
            in the human central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2586-2591 (1998)
   PUBMED   9482930
REFERENCE   9  (bases 1 to 6001)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   10 (bases 1 to 6001)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018410.24 and AC090582.9.
            
            On Jun 2, 2019 this sequence version replaced NM_003682.3.
            
            Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling
            molecule that interacts with one of two receptors on cells targeted
            for apoptosis. The apoptotic signal is transduced inside these
            cells by cytoplasmic adaptor proteins. The protein encoded by this
            gene is a death domain-containing adaptor protein that interacts
            with the death domain of TNF-alpha receptor 1 to activate
            mitogen-activated protein kinase (MAPK) and propagate the apoptotic
            signal. It is membrane-bound and expressed at a higher level in
            neoplastic cells than in normal cells. Several transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC018410.24        93548-93635         c
            89-238              AC018410.24        89322-89471         c
            239-835             AC018410.24        88139-88735         c
            836-1139            AC018410.24        87096-87399         c
            1140-1271           AC018410.24        86435-86566         c
            1272-1385           AC018410.24        85020-85133         c
            1386-1466           AC018410.24        84219-84299         c
            1467-1645           AC018410.24        81545-81723         c
            1646-1881           AC018410.24        80682-80917         c
            1882-2038           AC018410.24        80329-80485         c
            2039-2142           AC018410.24        79017-79120         c
            2143-2333           AC018410.24        78733-78923         c
            2334-2587           AC018410.24        78104-78357         c
            2588-2727           AC018410.24        77708-77847         c
            2728-2829           AC018410.24        76764-76865         c
            2830-2889           AC018410.24        74271-74330         c
            2890-2992           AC018410.24        73805-73907         c
            2993-3179           AC018410.24        73245-73431         c
            3180-3330           AC018410.24        72999-73149         c
            3331-3537           AC018410.24        72482-72688         c
            3538-3591           AC018410.24        70702-70755         c
            3592-3692           AC018410.24        69315-69415         c
            3693-3776           AC018410.24        67719-67802         c
            3777-3935           AC018410.24        67243-67401         c
            3936-4044           AC018410.24        54599-54707         c
            4045-4107           AC018410.24        54256-54318         c
            4108-4228           AC018410.24        53897-54017         c
            4229-4334           AC018410.24        53686-53791         c
            4335-4445           AC090582.9         111-221
            4446-4553           AC090582.9         3599-3706
            4554-4718           AC090582.9         12050-12214
            4719-4791           AC090582.9         12644-12716
            4792-4898           AC090582.9         12850-12956
            4899-4968           AC090582.9         15117-15186
            4969-5015           AC090582.9         17037-17083
            5016-6001           AC090582.9         17425-18410
FEATURES             Location/Qualifiers
     source          1..6001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..6001
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="MAP kinase activating death domain"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
     exon            1..88
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            89..238
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..5120
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="isoform 4 is encoded by transcript variant 4; MAP
                     kinase-activating death domain protein; Rab3 GDP/GTP
                     exchange factor; differentially expressed in normal and
                     neoplastic cells; insulinoma glucagonoma clone 20; rab3
                     GDP/GTP exchange protein; Insuloma-Glucagonoma protein 20"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 4"
                     /protein_id="NP_003673.3"
                     /db_xref="CCDS:CCDS7930.1"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
                     /translation="MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHT
                     EFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQ
                     KRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGK
                     RRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGV
                     QRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEL
                     QPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSM
                     SVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPD
                     DVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHE
                     GQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQM
                     HTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRI
                     HNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSD
                     SMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEA
                     EEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLP
                     SVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQ
                     HVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRN
                     HSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQK
                     SSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLES
                     EQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAG
                     LGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRV
                     PQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPV
                     FDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNS
                     SGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPS
                     IKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ
                     MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNL
                     ISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSR
                     HMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKV
                     LCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLK
                     TGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYK
                     TPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS"
     exon            239..835
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1139
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1271
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1385
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1466
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1645
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1881
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2038
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2142
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2333
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2587
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2727
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2829
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2889
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2992
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3179
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3330
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3537
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3591
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3692
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3776
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3935
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4044
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4107
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4228
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4334
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4445
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4553
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4718
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4791
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4792..4898
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..4968
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5015
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5016..6001
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5982..5987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      6001
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 ccccctctgc ccccgctgcc caggattggt aggctccacc gctcggcagc cggcttccct
       61 gctcggacgc cgagcaccgc caaagcgcac ttcgattttc agaattcctc ctgggaatgc
      121 tgactccttg cttggtgccc tgatgcttct ctgagataaa ctgatgaatt ggaaccatgg
      181 tgcaaaagaa gaagttctgt cctcggttac ttgactatct agtgatcgta ggggccaggc
      241 acccgagcag tgatagcgtg gcccagactc ctgaattgct acggcgatac cccttggagg
      301 atcacactga gtttcccctg cccccagatg tagtgttctt ctgccagccc gagggctgcc
      361 tgagcgtgcg gcagcggcgc atgagccttc gggatgatac ctcttttgtc ttcaccctca
      421 ctgacaagga cactggagtc acgcgatatg gcatctgtgt taacttctac cgctccttcc
      481 aaaagcgaat ctctaaggag aagggggaag gtggggcagg gtcccgtggg aaggaaggaa
      541 cccatgccac ctgtgcctca gaagagggtg gcactgagag ctcagagagt ggctcatccc
      601 tgcagcctct cagtgctgac tctacccctg atgtgaacca gtctcctcgg ggcaaacgcc
      661 gggccaaggc ggggagccgc tcccgcaaca gtactctcac gtccctgtgc gtgctcagcc
      721 actacccttt cttctccacc ttccgagagt gtttgtatac tctcaagcgc ctggtggact
      781 gctgtagtga gcgccttctg ggcaagaaac tgggcatccc tcgaggcgta caaagggaca
      841 ccatgtggcg gatctttact ggatcgctgc tggtagagga gaagtcaagt gcccttctgc
      901 atgaccttcg agagattgag gcctggatct atcgattgct gcgctcccca gtacccgtct
      961 ctgggcagaa gcgagtagac atcgaggtcc taccccaaga gctccagcca gctctgacct
     1021 ttgctcttcc agacccatct cgattcaccc tagtggattt cccactgcac cttcccttgg
     1081 aacttctagg tgtggacgcc tgtctccagg tgctaacctg cattctgtta gagcacaagg
     1141 tggtgctaca gtcccgagac tacaatgcac tctccatgtc tgtgatggca ttcgtggcaa
     1201 tgatctaccc actggagtat atgtttcctg tcatcccgct gctacccacc tgcatggcat
     1261 cagcagagca gctgctgttg gctccaaccc cgtacatcat tggggttcct gccagcttct
     1321 tcctctacaa actggacttc aaaatgcctg atgatgtatg gctagtggat ctggacagca
     1381 atagggtgat tgcccccacc aatgcagaag tgctgcctat cctgccagaa ccagaatcac
     1441 tagagctgaa aaagcattta aagcaggcct tggccagcat gagtctcaac acccagccca
     1501 tcctcaatct ggagaaattt catgagggcc aggagatccc ccttctcttg ggaaggcctt
     1561 ctaatgacct gcagtccaca ccgtccactg aattcaaccc actcatctat ggcaatgatg
     1621 tggattctgt ggatgttgca accagggttg ccatggtacg gttcttcaat tccgccaacg
     1681 tgctgcaggg atttcagatg cacacgcgta ccctgcgcct ctttcctcgg cctgtggtag
     1741 cttttcaagc tggctccttt ctagcctcac gtccccggca gactcctttt gccgagaaat
     1801 tggccaggac tcaggctgtg gagtactttg gggaatggat ccttaacccc accaactatg
     1861 cctttcagcg aattcacaac aatatgtttg atccagccct gattggtgac aagccaaagt
     1921 ggtatgctca tcagctgcag cctatccact atcgcgtcta tgacagcaat tcccagctgg
     1981 ctgaggccct gagtgtacca ccagagcggg actctgactc cgaacctact gatgatagtg
     2041 gcagtgatag tatggattat gacgattcaa gctcttctta ctcctccctt ggtgactttg
     2101 tcagtgaaat gatgaaatgt gacattaatg gtgatactcc caatgtggac cctctgacac
     2161 atgcagcact gggggatgcc agcgaggtgg agattgacga gctgcagaat cagaaggaag
     2221 cagaagagcc tggcccagac agtgagaact ctcaggaaaa ccccccactg cgctccagct
     2281 ctagcaccac agccagcagc agccccagca ctgtcatcca cggagccaac tctgaacctg
     2341 ctgactctac ggagatggat gataaggcag cagtaggcgt ctccaagccc ctcccttccg
     2401 tgcctcccag cattggcaaa tcgaacgtgg acagacgtca ggcagaaatt ggagaggggt
     2461 cagtgcgccg gcgaatctat gacaatccat acttcgagcc ccaatatggc tttccccctg
     2521 aggaagatga ggatgagcag ggggaaagtt acactccccg attcagccaa catgtcagtg
     2581 gcaatcgggc tcaaaagctg ctgcggccca acagcttgag actggcaagt gactcagatg
     2641 cagagtcaga ctctcgggca agctctccca actccaccgt ctccaacacc agcaccgagg
     2701 gcttcggggg catcatgtct tttgccagca gcctctatcg gaaccacagt accagcttca
     2761 gtctttcaaa cctcacactg cccaccaaag gtgcccgaga gaaggccacg cccttcccca
     2821 gtctgaaagt atttgggcta aatactctaa tggagattgt tactgaagcc ggccccggga
     2881 gtggtgaagg aaacaggagg gcgttagtgg atcagaagtc atctgtcatt aaacacagcc
     2941 caacagtgaa aagagaacct ccatcacccc agggtcgatc cagcaattct agtgagaacc
     3001 agcagttcct gaaggaggtg gtgcacagcg tgctggacgg ccagggagtt ggctggctca
     3061 acatgaaaaa ggtgcgccgg ctgctggaga gcgagcagct gcgagtcttt gtcctgagca
     3121 agctgaaccg catggtgcag tcagaggacg atgcccggca ggacatcatc ccggatgtgg
     3181 agatcagtcg gaaggtgtac aagggaatgt tagacctcct caagtgtaca gtcctcagct
     3241 tggagcagtc ctatgcccac gcgggtctgg gtggcatggc cagcatcttt gggcttttgg
     3301 agattgccca gacccactac tatagtaaag aaccagacaa gcggaagaga agtccaacag
     3361 aaagtgtaaa taccccagtt ggcaaggatc ctggcctagc tgggcggggg gacccaaagg
     3421 ctatggcaca actgagagtt ccacaactgg gacctcgggc accaagtgcc acaggaaagg
     3481 gtcctaagga actggacacc agaagtttaa aggaagaaaa ttttatagca tctattgaat
     3541 tgtggaacaa gcaccaggaa gtgaaaaagc aaaaagcttt ggaaaaacag aggcctgaag
     3601 taatcaaacc tgtctttgac cttggtgaga cagaggagaa aaagtcccag atcagcgcag
     3661 acagtggtgt gagcctgacg tctagttccc agaggactga tcaagactct gtcatcggcg
     3721 tgagtccagc tgttatgatc cgcagctcaa gtcaggattc tgaagttagc accgtggtga
     3781 gtaatagctc tggagagacc cttggagctg acagtgactt gagcagcaat gcaggtgatg
     3841 gaccaggtgg cgagggcagt gttcacctgg caagctctcg gggcactttg tctgatagtg
     3901 aaattgagac caactctgcc acaagcacca tctttggtaa agcccacagc ttgaagccaa
     3961 gcataaagga gaagctggca ggcagcccca ttcgtacttc tgaagatgtg agccagcgag
     4021 tctatctcta tgagggactc ctaggaaggg acaaaggatc catgtgggac cagttagagg
     4081 atgcagctat ggagaccttt tctataagca aagagcgttc tactttatgg gaccaaatgc
     4141 aattctggga agatgccttc ttagatgctg tgatgttgga gagagaaggg atgggtatgg
     4201 accagggtcc ccaggaaatg atcgacaggt acctgtccct tggagaacat gaccggaagc
     4261 gcctggaaga tgatgaagat cgcttgttgg ccacacttct gcacaacctc atctcctaca
     4321 tgctgctgat gaaggtaaat aagaatgaca tccgcaagaa ggtgaggcgc ctaatgggaa
     4381 agtcgcacat tgggcttgtg tacagccagc aaatcaatga ggtgcttgat cagctggcga
     4441 acctgaatgg acgcgatctc tctatctggt ccagtggcag ccggcacatg aagaagcaga
     4501 catttgtggt acatgcaggg acagatacaa acggagatat ctttttcatg gaggtgtgcg
     4561 atgactgtgt ggtgttgcgt agtaacatcg gaacagtgta tgagcgctgg tggtacgaga
     4621 agctcatcaa catgacctac tgtcccaaga cgaaggtgtt gtgcttgtgg cgtagaaatg
     4681 gctctgagac ccagctcaac aagttctata ctaaaaagtg tcgggagctg tactactgtg
     4741 tgaaggacag catggagcgc gctgccgccc gacagcaaag catcaaaccc ggacctgaat
     4801 tgggtggcga gttccctgtg caggacctga agactggtga gggtggcctg ctgcaggtga
     4861 ccctggaagg gatcaacctc aaattcatgc acaatcaggt tttcatagag ctgaatcaca
     4921 ttaaaaagtg caatacagtt cgaggcgtct ttgtcctgga ggaatttgtt cctgaaatta
     4981 aagaagtggt gagccacaag tacaagacac caatggccca cgaaatctgc tactccgtat
     5041 tatgtctctt ctcgtacgtg gctgcagttc atagcagtga ggaagatctc agaaccccgc
     5101 cccggcctgt ctctagctga tggagagggg ctacgcagct gccccagccc agggcacgcc
     5161 cctggcccct tgctgttccc aagtgcacga tgctgctgtg actgaggagt ggatgatgct
     5221 cgtgtgtcct ctgcaagccc cctgctgtgg cttggttggt taccggttat gtgtccctct
     5281 gagtgtgtct tgagcgtgtc caccttctcc ctctccactc ccagaagacc aaactgcctt
     5341 cccctcaggg ctcaagaatg tgtacagtct gtggggccgg tgtgaaccca ctattttgtg
     5401 tccttgagac atttgtgttg tggttccttg tccttgtccc tggcgttata actgtccact
     5461 gcaagagtct ggctctccct tctctgtgac ccggcatgac tgggcgcctg gagcagtttc
     5521 actctgtgag gagtgaggga accctggggc tcaccctctc agaggaaggg cacagagagg
     5581 aagggaagaa ttggggggca gccggagtga gtggcagcct ccctgcttcc ttctgcattc
     5641 ccaagccggc agctactgcc cagggcccgc agtgttggct gctgcctgcc acagcctctg
     5701 tgactgcagt ggagcggcga attccctgtg gcctgccatg ccttcggcat cagaggatgg
     5761 agtggtcgag gctagtggag tcccagggac cgctggctgc tctgcctgag catcagggag
     5821 ggggcaggaa agaccaagct gggtttgcac atctgtctgc aggctgtctc tccaggcacg
     5881 gggtgtcagg agggagagac agcctgggta tgggcaagaa atgactgtaa atatttcagc
     5941 cccacattat ttatagaaaa tgtacagttg tgtgaatgtg aaataaatgt cctcaactcc
     6001 c
//
