LOCUS       NM_001376658            5654 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens MAP kinase activating death domain (MADD), transcript
            variant 92, mRNA.
ACCESSION   NM_001376658
VERSION     NM_001376658.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5654)
  AUTHORS   Abdel-Salam,G.M.H. and Abdel-Hamid,M.S.
  TITLE     New insights into the clinical and molecular spectrum of the
            MADD-related neurodevelopmental disorder
  JOURNAL   J Hum Genet 69 (6), 263-270 (2024)
   PUBMED   38459224
  REMARK    GeneRIF: New insights into the clinical and molecular spectrum of
            the MADD-related neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 5654)
  AUTHORS   Medlyn,M.J., Maeder,E., Bradley,C., Phatarpekar,P., Ham,H. and
            Billadeau,D.D.
  TITLE     MADD regulates natural killer cell degranulation through Rab27a
            activation
  JOURNAL   J Cell Sci 137 (7) (2024)
   PUBMED   38506245
  REMARK    GeneRIF: MADD regulates natural killer cell degranulation through
            Rab27a activation.
REFERENCE   3  (bases 1 to 5654)
  AUTHORS   Darouich,S. and Darouich,S.
  TITLE     Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency
  JOURNAL   Am J Med Genet A 194 (3), e63463 (2024)
   PUBMED   37932938
  REMARK    GeneRIF: Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency.
REFERENCE   4  (bases 1 to 5654)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   5  (bases 1 to 5654)
  AUTHORS   Abu-Libdeh,B., Mor-Shaked,H., Atawna,A.A., Gillis,D., Halstuk,O.,
            Shaul-Lotan,N., Slae,M., Sultan,M., Meiner,V., Elpeleg,O. and
            Harel,T.
  TITLE     Homozygous variant in MADD, encoding a Rab guanine nucleotide
            exchange factor, results in pleiotropic effects and a multisystemic
            disorder
  JOURNAL   Eur J Hum Genet 29 (6), 977-987 (2021)
   PUBMED   33723354
  REMARK    GeneRIF: Homozygous variant in MADD, encoding a Rab guanine
            nucleotide exchange factor, results in pleiotropic effects and a
            multisystemic disorder.
REFERENCE   6  (bases 1 to 5654)
  AUTHORS   Telliez,J.B., Bean,K.M. and Lin,L.L.
  TITLE     LRDD, a novel leucine rich repeat and death domain containing
            protein
  JOURNAL   Biochim Biophys Acta 1478 (2), 280-288 (2000)
   PUBMED   10825539
REFERENCE   7  (bases 1 to 5654)
  AUTHORS   Chow,V.T., Lim,K.M. and Lim,D.
  TITLE     The human DENN gene: genomic organization, alternative splicing,
            and localization to chromosome 11p11.21-p11.22
  JOURNAL   Genome 41 (4), 543-552 (1998)
   PUBMED   9796103
REFERENCE   8  (bases 1 to 5654)
  AUTHORS   Zhang,Y., Zhou,L. and Miller,C.A.
  TITLE     A splicing variant of a death domain protein that is regulated by a
            mitogen-activated kinase is a substrate for c-Jun N-terminal kinase
            in the human central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2586-2591 (1998)
   PUBMED   9482930
REFERENCE   9  (bases 1 to 5654)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   10 (bases 1 to 5654)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018410.24 and AC090582.9.
            
            Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling
            molecule that interacts with one of two receptors on cells targeted
            for apoptosis. The apoptotic signal is transduced inside these
            cells by cytoplasmic adaptor proteins. The protein encoded by this
            gene is a death domain-containing adaptor protein that interacts
            with the death domain of TNF-alpha receptor 1 to activate
            mitogen-activated protein kinase (MAPK) and propagate the apoptotic
            signal. It is membrane-bound and expressed at a higher level in
            neoplastic cells than in normal cells. Several transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.238994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC018410.24        93052-93165         c
            115-264             AC018410.24        89322-89471         c
            265-861             AC018410.24        88139-88735         c
            862-1165            AC018410.24        87096-87399         c
            1166-1297           AC018410.24        86435-86566         c
            1298-1411           AC018410.24        85020-85133         c
            1412-1492           AC018410.24        84219-84299         c
            1493-1671           AC018410.24        81545-81723         c
            1672-1907           AC018410.24        80682-80917         c
            1908-2064           AC018410.24        80329-80485         c
            2065-2168           AC018410.24        79017-79120         c
            2169-2359           AC018410.24        78733-78923         c
            2360-2484           AC018410.24        78233-78357         c
            2485-2624           AC018410.24        77708-77847         c
            2625-2727           AC018410.24        73805-73907         c
            2728-2914           AC018410.24        73245-73431         c
            2915-3065           AC018410.24        72999-73149         c
            3066-3272           AC018410.24        72482-72688         c
            3273-3326           AC018410.24        70702-70755         c
            3327-3427           AC018410.24        69315-69415         c
            3428-3499           AC018410.24        67731-67802         c
            3500-3658           AC018410.24        67243-67401         c
            3659-3767           AC018410.24        54599-54707         c
            3768-3830           AC018410.24        54256-54318         c
            3831-3951           AC018410.24        53897-54017         c
            3952-4057           AC018410.24        53686-53791         c
            4058-4168           AC090582.9         111-221
            4169-4276           AC090582.9         3599-3706
            4277-4441           AC090582.9         12050-12214
            4442-4514           AC090582.9         12644-12716
            4515-4621           AC090582.9         12850-12956
            4622-4668           AC090582.9         17037-17083
            4669-5654           AC090582.9         17425-18410
FEATURES             Location/Qualifiers
     source          1..5654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..5654
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="MAP kinase activating death domain"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
     exon            1..114
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            115..264
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4645
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="isoform 69 is encoded by transcript variant 92; MAP
                     kinase-activating death domain protein; Rab3 GDP/GTP
                     exchange factor; differentially expressed in normal and
                     neoplastic cells; insulinoma glucagonoma clone 20; rab3
                     GDP/GTP exchange protein; Insuloma-Glucagonoma protein 20"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 69"
                     /protein_id="NP_001363587.1"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
                     /translation="MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHT
                     EFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQ
                     KRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGK
                     RRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGV
                     QRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEL
                     QPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSM
                     SVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPD
                     DVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHE
                     GQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQM
                     HTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRI
                     HNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSD
                     SMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEA
                     EEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLP
                     SVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTE
                     GFGGIMSFARNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVL
                     DGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGM
                     LDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVG
                     KDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQ
                     EVKKQKALEKQRPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPA
                     VMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNS
                     ATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAM
                     ETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRL
                     EDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLA
                     NLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
                     YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIK
                     PGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW"
     exon            265..861
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1165
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1297
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1411
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1492
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1671
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1907
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2064
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2168
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2359
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2484
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2624
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2727
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2914
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3065
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3272
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3326
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3427
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3499
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3658
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3767
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3830
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3951
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4057
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4168
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4276
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4441
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4514
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..4621
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4668
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4669..5654
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5635..5640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      5654
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagacg cggaactggc gcccgctcgg agcggcgccg cgctggggag cgactgacgc
       61 cccgctgccg ggggacgtcg ggctgggcct ggccagtccc ccagagcttg ggagacttcg
      121 attttcagaa ttcctcctgg gaatgctgac tccttgcttg gtgccctgat gcttctctga
      181 gataaactga tgaattggaa ccatggtgca aaagaagaag ttctgtcctc ggttacttga
      241 ctatctagtg atcgtagggg ccaggcaccc gagcagtgat agcgtggccc agactcctga
      301 attgctacgg cgatacccct tggaggatca cactgagttt cccctgcccc cagatgtagt
      361 gttcttctgc cagcccgagg gctgcctgag cgtgcggcag cggcgcatga gccttcggga
      421 tgatacctct tttgtcttca ccctcactga caaggacact ggagtcacgc gatatggcat
      481 ctgtgttaac ttctaccgct ccttccaaaa gcgaatctct aaggagaagg gggaaggtgg
      541 ggcagggtcc cgtgggaagg aaggaaccca tgccacctgt gcctcagaag agggtggcac
      601 tgagagctca gagagtggct catccctgca gcctctcagt gctgactcta cccctgatgt
      661 gaaccagtct cctcggggca aacgccgggc caaggcgggg agccgctccc gcaacagtac
      721 tctcacgtcc ctgtgcgtgc tcagccacta ccctttcttc tccaccttcc gagagtgttt
      781 gtatactctc aagcgcctgg tggactgctg tagtgagcgc cttctgggca agaaactggg
      841 catccctcga ggcgtacaaa gggacaccat gtggcggatc tttactggat cgctgctggt
      901 agaggagaag tcaagtgccc ttctgcatga ccttcgagag attgaggcct ggatctatcg
      961 attgctgcgc tccccagtac ccgtctctgg gcagaagcga gtagacatcg aggtcctacc
     1021 ccaagagctc cagccagctc tgacctttgc tcttccagac ccatctcgat tcaccctagt
     1081 ggatttccca ctgcaccttc ccttggaact tctaggtgtg gacgcctgtc tccaggtgct
     1141 aacctgcatt ctgttagagc acaaggtggt gctacagtcc cgagactaca atgcactctc
     1201 catgtctgtg atggcattcg tggcaatgat ctacccactg gagtatatgt ttcctgtcat
     1261 cccgctgcta cccacctgca tggcatcagc agagcagctg ctgttggctc caaccccgta
     1321 catcattggg gttcctgcca gcttcttcct ctacaaactg gacttcaaaa tgcctgatga
     1381 tgtatggcta gtggatctgg acagcaatag ggtgattgcc cccaccaatg cagaagtgct
     1441 gcctatcctg ccagaaccag aatcactaga gctgaaaaag catttaaagc aggccttggc
     1501 cagcatgagt ctcaacaccc agcccatcct caatctggag aaatttcatg agggccagga
     1561 gatccccctt ctcttgggaa ggccttctaa tgacctgcag tccacaccgt ccactgaatt
     1621 caacccactc atctatggca atgatgtgga ttctgtggat gttgcaacca gggttgccat
     1681 ggtacggttc ttcaattccg ccaacgtgct gcagggattt cagatgcaca cgcgtaccct
     1741 gcgcctcttt cctcggcctg tggtagcttt tcaagctggc tcctttctag cctcacgtcc
     1801 ccggcagact ccttttgccg agaaattggc caggactcag gctgtggagt actttgggga
     1861 atggatcctt aaccccacca actatgcctt tcagcgaatt cacaacaata tgtttgatcc
     1921 agccctgatt ggtgacaagc caaagtggta tgctcatcag ctgcagccta tccactatcg
     1981 cgtctatgac agcaattccc agctggctga ggccctgagt gtaccaccag agcgggactc
     2041 tgactccgaa cctactgatg atagtggcag tgatagtatg gattatgacg attcaagctc
     2101 ttcttactcc tcccttggtg actttgtcag tgaaatgatg aaatgtgaca ttaatggtga
     2161 tactcccaat gtggaccctc tgacacatgc agcactgggg gatgccagcg aggtggagat
     2221 tgacgagctg cagaatcaga aggaagcaga agagcctggc ccagacagtg agaactctca
     2281 ggaaaacccc ccactgcgct ccagctctag caccacagcc agcagcagcc ccagcactgt
     2341 catccacgga gccaactctg aacctgctga ctctacggag atggatgata aggcagcagt
     2401 aggcgtctcc aagcccctcc cttccgtgcc tcccagcatt ggcaaatcga acgtggacag
     2461 acgtcaggca gaaattggag agggggctca aaagctgctg cggcccaaca gcttgagact
     2521 ggcaagtgac tcagatgcag agtcagactc tcgggcaagc tctcccaact ccaccgtctc
     2581 caacaccagc accgagggct tcgggggcat catgtctttt gccagaaaca ggagggcgtt
     2641 agtggatcag aagtcatctg tcattaaaca cagcccaaca gtgaaaagag aacctccatc
     2701 accccagggt cgatccagca attctagtga gaaccagcag ttcctgaagg aggtggtgca
     2761 cagcgtgctg gacggccagg gagttggctg gctcaacatg aaaaaggtgc gccggctgct
     2821 ggagagcgag cagctgcgag tctttgtcct gagcaagctg aaccgcatgg tgcagtcaga
     2881 ggacgatgcc cggcaggaca tcatcccgga tgtggagatc agtcggaagg tgtacaaggg
     2941 aatgttagac ctcctcaagt gtacagtcct cagcttggag cagtcctatg cccacgcggg
     3001 tctgggtggc atggccagca tctttgggct tttggagatt gcccagaccc actactatag
     3061 taaagaacca gacaagcgga agagaagtcc aacagaaagt gtaaataccc cagttggcaa
     3121 ggatcctggc ctagctgggc ggggggaccc aaaggctatg gcacaactga gagttccaca
     3181 actgggacct cgggcaccaa gtgccacagg aaagggtcct aaggaactgg acaccagaag
     3241 tttaaaggaa gaaaatttta tagcatctat tgaattgtgg aacaagcacc aggaagtgaa
     3301 aaagcaaaaa gctttggaaa aacagaggcc tgaagtaatc aaacctgtct ttgaccttgg
     3361 tgagacagag gagaaaaagt cccagatcag cgcagacagt ggtgtgagcc tgacgtctag
     3421 ttcccagagg actgatcaag actctgtcat cggcgtgagt ccagctgtta tgatccgcag
     3481 ctcaagtcag gattctgaag tgagtaatag ctctggagag acccttggag ctgacagtga
     3541 cttgagcagc aatgcaggtg atggaccagg tggcgagggc agtgttcacc tggcaagctc
     3601 tcggggcact ttgtctgata gtgaaattga gaccaactct gccacaagca ccatctttgg
     3661 taaagcccac agcttgaagc caagcataaa ggagaagctg gcaggcagcc ccattcgtac
     3721 ttctgaagat gtgagccagc gagtctatct ctatgaggga ctcctaggaa gggacaaagg
     3781 atccatgtgg gaccagttag aggatgcagc tatggagacc ttttctataa gcaaagagcg
     3841 ttctacttta tgggaccaaa tgcaattctg ggaagatgcc ttcttagatg ctgtgatgtt
     3901 ggagagagaa gggatgggta tggaccaggg tccccaggaa atgatcgaca ggtacctgtc
     3961 ccttggagaa catgaccgga agcgcctgga agatgatgaa gatcgcttgt tggccacact
     4021 tctgcacaac ctcatctcct acatgctgct gatgaaggta aataagaatg acatccgcaa
     4081 gaaggtgagg cgcctaatgg gaaagtcgca cattgggctt gtgtacagcc agcaaatcaa
     4141 tgaggtgctt gatcagctgg cgaacctgaa tggacgcgat ctctctatct ggtccagtgg
     4201 cagccggcac atgaagaagc agacatttgt ggtacatgca gggacagata caaacggaga
     4261 tatctttttc atggaggtgt gcgatgactg tgtggtgttg cgtagtaaca tcggaacagt
     4321 gtatgagcgc tggtggtacg agaagctcat caacatgacc tactgtccca agacgaaggt
     4381 gttgtgcttg tggcgtagaa atggctctga gacccagctc aacaagttct atactaaaaa
     4441 gtgtcgggag ctgtactact gtgtgaagga cagcatggag cgcgctgccg cccgacagca
     4501 aagcatcaaa cccggacctg aattgggtgg cgagttccct gtgcaggacc tgaagactgg
     4561 tgagggtggc ctgctgcagg tgaccctgga agggatcaac ctcaaattca tgcacaatca
     4621 gttcctgaaa ttaaagaagt ggtgagccac aagtacaaga caccaatggc ccacgaaatc
     4681 tgctactccg tattatgtct cttctcgtac gtggctgcag ttcatagcag tgaggaagat
     4741 ctcagaaccc cgccccggcc tgtctctagc tgatggagag gggctacgca gctgccccag
     4801 cccagggcac gcccctggcc ccttgctgtt cccaagtgca cgatgctgct gtgactgagg
     4861 agtggatgat gctcgtgtgt cctctgcaag ccccctgctg tggcttggtt ggttaccggt
     4921 tatgtgtccc tctgagtgtg tcttgagcgt gtccaccttc tccctctcca ctcccagaag
     4981 accaaactgc cttcccctca gggctcaaga atgtgtacag tctgtggggc cggtgtgaac
     5041 ccactatttt gtgtccttga gacatttgtg ttgtggttcc ttgtccttgt ccctggcgtt
     5101 ataactgtcc actgcaagag tctggctctc ccttctctgt gacccggcat gactgggcgc
     5161 ctggagcagt ttcactctgt gaggagtgag ggaaccctgg ggctcaccct ctcagaggaa
     5221 gggcacagag aggaagggaa gaattggggg gcagccggag tgagtggcag cctccctgct
     5281 tccttctgca ttcccaagcc ggcagctact gcccagggcc cgcagtgttg gctgctgcct
     5341 gccacagcct ctgtgactgc agtggagcgg cgaattccct gtggcctgcc atgccttcgg
     5401 catcagagga tggagtggtc gaggctagtg gagtcccagg gaccgctggc tgctctgcct
     5461 gagcatcagg gagggggcag gaaagaccaa gctgggtttg cacatctgtc tgcaggctgt
     5521 ctctccaggc acggggtgtc aggagggaga gacagcctgg gtatgggcaa gaaatgactg
     5581 taaatatttc agccccacat tatttataga aaatgtacag ttgtgtgaat gtgaaataaa
     5641 tgtcctcaac tccc
//
