LOCUS       NM_001376648            5925 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens MAP kinase activating death domain (MADD), transcript
            variant 82, mRNA.
ACCESSION   NM_001376648
VERSION     NM_001376648.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5925)
  AUTHORS   Abdel-Salam,G.M.H. and Abdel-Hamid,M.S.
  TITLE     New insights into the clinical and molecular spectrum of the
            MADD-related neurodevelopmental disorder
  JOURNAL   J Hum Genet 69 (6), 263-270 (2024)
   PUBMED   38459224
  REMARK    GeneRIF: New insights into the clinical and molecular spectrum of
            the MADD-related neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 5925)
  AUTHORS   Medlyn,M.J., Maeder,E., Bradley,C., Phatarpekar,P., Ham,H. and
            Billadeau,D.D.
  TITLE     MADD regulates natural killer cell degranulation through Rab27a
            activation
  JOURNAL   J Cell Sci 137 (7) (2024)
   PUBMED   38506245
  REMARK    GeneRIF: MADD regulates natural killer cell degranulation through
            Rab27a activation.
REFERENCE   3  (bases 1 to 5925)
  AUTHORS   Darouich,S. and Darouich,S.
  TITLE     Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency
  JOURNAL   Am J Med Genet A 194 (3), e63463 (2024)
   PUBMED   37932938
  REMARK    GeneRIF: Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency.
REFERENCE   4  (bases 1 to 5925)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   5  (bases 1 to 5925)
  AUTHORS   Abu-Libdeh,B., Mor-Shaked,H., Atawna,A.A., Gillis,D., Halstuk,O.,
            Shaul-Lotan,N., Slae,M., Sultan,M., Meiner,V., Elpeleg,O. and
            Harel,T.
  TITLE     Homozygous variant in MADD, encoding a Rab guanine nucleotide
            exchange factor, results in pleiotropic effects and a multisystemic
            disorder
  JOURNAL   Eur J Hum Genet 29 (6), 977-987 (2021)
   PUBMED   33723354
  REMARK    GeneRIF: Homozygous variant in MADD, encoding a Rab guanine
            nucleotide exchange factor, results in pleiotropic effects and a
            multisystemic disorder.
REFERENCE   6  (bases 1 to 5925)
  AUTHORS   Telliez,J.B., Bean,K.M. and Lin,L.L.
  TITLE     LRDD, a novel leucine rich repeat and death domain containing
            protein
  JOURNAL   Biochim Biophys Acta 1478 (2), 280-288 (2000)
   PUBMED   10825539
REFERENCE   7  (bases 1 to 5925)
  AUTHORS   Chow,V.T., Lim,K.M. and Lim,D.
  TITLE     The human DENN gene: genomic organization, alternative splicing,
            and localization to chromosome 11p11.21-p11.22
  JOURNAL   Genome 41 (4), 543-552 (1998)
   PUBMED   9796103
REFERENCE   8  (bases 1 to 5925)
  AUTHORS   Zhang,Y., Zhou,L. and Miller,C.A.
  TITLE     A splicing variant of a death domain protein that is regulated by a
            mitogen-activated kinase is a substrate for c-Jun N-terminal kinase
            in the human central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2586-2591 (1998)
   PUBMED   9482930
REFERENCE   9  (bases 1 to 5925)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   10 (bases 1 to 5925)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018410.24 and AC090582.9.
            
            Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling
            molecule that interacts with one of two receptors on cells targeted
            for apoptosis. The apoptotic signal is transduced inside these
            cells by cytoplasmic adaptor proteins. The protein encoded by this
            gene is a death domain-containing adaptor protein that interacts
            with the death domain of TNF-alpha receptor 1 to activate
            mitogen-activated protein kinase (MAPK) and propagate the apoptotic
            signal. It is membrane-bound and expressed at a higher level in
            neoplastic cells than in normal cells. Several transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.143683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC018410.24        93392-93635         c
            245-841             AC018410.24        88139-88735         c
            842-1145            AC018410.24        87096-87399         c
            1146-1277           AC018410.24        86435-86566         c
            1278-1391           AC018410.24        85020-85133         c
            1392-1472           AC018410.24        84219-84299         c
            1473-1651           AC018410.24        81545-81723         c
            1652-1887           AC018410.24        80682-80917         c
            1888-2044           AC018410.24        80329-80485         c
            2045-2148           AC018410.24        79017-79120         c
            2149-2339           AC018410.24        78733-78923         c
            2340-2593           AC018410.24        78104-78357         c
            2594-2733           AC018410.24        77708-77847         c
            2734-2835           AC018410.24        76764-76865         c
            2836-2895           AC018410.24        74271-74330         c
            2896-2998           AC018410.24        73805-73907         c
            2999-3185           AC018410.24        73245-73431         c
            3186-3336           AC018410.24        72999-73149         c
            3337-3543           AC018410.24        72482-72688         c
            3544-3597           AC018410.24        70702-70755         c
            3598-3698           AC018410.24        69315-69415         c
            3699-3770           AC018410.24        67731-67802         c
            3771-3929           AC018410.24        67243-67401         c
            3930-4038           AC018410.24        54599-54707         c
            4039-4101           AC018410.24        54256-54318         c
            4102-4222           AC018410.24        53897-54017         c
            4223-4328           AC018410.24        53686-53791         c
            4329-4439           AC090582.9         111-221
            4440-4547           AC090582.9         3599-3706
            4548-4712           AC090582.9         12050-12214
            4713-4785           AC090582.9         12644-12716
            4786-4892           AC090582.9         12850-12956
            4893-4939           AC090582.9         17037-17083
            4940-5925           AC090582.9         17425-18410
FEATURES             Location/Qualifiers
     source          1..5925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..5925
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="MAP kinase activating death domain"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
     exon            1..244
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            245..841
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..4916
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="isoform 61 is encoded by transcript variant 82; MAP
                     kinase-activating death domain protein; Rab3 GDP/GTP
                     exchange factor; differentially expressed in normal and
                     neoplastic cells; insulinoma glucagonoma clone 20; rab3
                     GDP/GTP exchange protein; Insuloma-Glucagonoma protein 20"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 61"
                     /protein_id="NP_001363577.1"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
                     /translation="MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEG
                     GAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSR
                     NSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFT
                     GSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPD
                     PSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY
                     PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSN
                     RVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR
                     PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPR
                     PVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALI
                     GDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSS
                     YSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENS
                     QENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSN
                     VDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKL
                     LRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNL
                     TLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTV
                     KREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSK
                     LNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
                     LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSA
                     TGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPVFDLGETEEKK
                     SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSN
                     AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSE
                     DVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVML
                     EREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDI
                     RKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTD
                     TNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLN
                     KFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGI
                     NLKFMHNQFLKLKKW"
     exon            842..1145
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1277
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1391
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1472
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1651
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1887
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2044
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2148
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2339
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2593
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2733
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2835
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2895
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2998
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3185
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3336
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3543
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3597
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3698
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3770
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3929
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4038
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4101
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4222
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..4328
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4439
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4547
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4712
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4713..4785
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..4892
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..4939
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5925
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5906..5911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      5925
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 ccccctctgc ccccgctgcc caggattggt aggctccacc gctcggcagc cggcttccct
       61 gctcggacgc cgagcaccgc caaagcgcgt gagtgggggg tggggactgg gggatgggga
      121 gcccgtcagg aagtctcagg ggccgattat cttgggaagt gactttcaga ggaatcccca
      181 tgtcgtcgaa acgggcgcta tgaccccgtc gggtgagagt ctctctgagc aacccaaaca
      241 gaaggcaccc gagcagtgat agcgtggccc agactcctga attgctacgg cgatacccct
      301 tggaggatca cactgagttt cccctgcccc cagatgtagt gttcttctgc cagcccgagg
      361 gctgcctgag cgtgcggcag cggcgcatga gccttcggga tgatacctct tttgtcttca
      421 ccctcactga caaggacact ggagtcacgc gatatggcat ctgtgttaac ttctaccgct
      481 ccttccaaaa gcgaatctct aaggagaagg gggaaggtgg ggcagggtcc cgtgggaagg
      541 aaggaaccca tgccacctgt gcctcagaag agggtggcac tgagagctca gagagtggct
      601 catccctgca gcctctcagt gctgactcta cccctgatgt gaaccagtct cctcggggca
      661 aacgccgggc caaggcgggg agccgctccc gcaacagtac tctcacgtcc ctgtgcgtgc
      721 tcagccacta ccctttcttc tccaccttcc gagagtgttt gtatactctc aagcgcctgg
      781 tggactgctg tagtgagcgc cttctgggca agaaactggg catccctcga ggcgtacaaa
      841 gggacaccat gtggcggatc tttactggat cgctgctggt agaggagaag tcaagtgccc
      901 ttctgcatga ccttcgagag attgaggcct ggatctatcg attgctgcgc tccccagtac
      961 ccgtctctgg gcagaagcga gtagacatcg aggtcctacc ccaagagctc cagccagctc
     1021 tgacctttgc tcttccagac ccatctcgat tcaccctagt ggatttccca ctgcaccttc
     1081 ccttggaact tctaggtgtg gacgcctgtc tccaggtgct aacctgcatt ctgttagagc
     1141 acaaggtggt gctacagtcc cgagactaca atgcactctc catgtctgtg atggcattcg
     1201 tggcaatgat ctacccactg gagtatatgt ttcctgtcat cccgctgcta cccacctgca
     1261 tggcatcagc agagcagctg ctgttggctc caaccccgta catcattggg gttcctgcca
     1321 gcttcttcct ctacaaactg gacttcaaaa tgcctgatga tgtatggcta gtggatctgg
     1381 acagcaatag ggtgattgcc cccaccaatg cagaagtgct gcctatcctg ccagaaccag
     1441 aatcactaga gctgaaaaag catttaaagc aggccttggc cagcatgagt ctcaacaccc
     1501 agcccatcct caatctggag aaatttcatg agggccagga gatccccctt ctcttgggaa
     1561 ggccttctaa tgacctgcag tccacaccgt ccactgaatt caacccactc atctatggca
     1621 atgatgtgga ttctgtggat gttgcaacca gggttgccat ggtacggttc ttcaattccg
     1681 ccaacgtgct gcagggattt cagatgcaca cgcgtaccct gcgcctcttt cctcggcctg
     1741 tggtagcttt tcaagctggc tcctttctag cctcacgtcc ccggcagact ccttttgccg
     1801 agaaattggc caggactcag gctgtggagt actttgggga atggatcctt aaccccacca
     1861 actatgcctt tcagcgaatt cacaacaata tgtttgatcc agccctgatt ggtgacaagc
     1921 caaagtggta tgctcatcag ctgcagccta tccactatcg cgtctatgac agcaattccc
     1981 agctggctga ggccctgagt gtaccaccag agcgggactc tgactccgaa cctactgatg
     2041 atagtggcag tgatagtatg gattatgacg attcaagctc ttcttactcc tcccttggtg
     2101 actttgtcag tgaaatgatg aaatgtgaca ttaatggtga tactcccaat gtggaccctc
     2161 tgacacatgc agcactgggg gatgccagcg aggtggagat tgacgagctg cagaatcaga
     2221 aggaagcaga agagcctggc ccagacagtg agaactctca ggaaaacccc ccactgcgct
     2281 ccagctctag caccacagcc agcagcagcc ccagcactgt catccacgga gccaactctg
     2341 aacctgctga ctctacggag atggatgata aggcagcagt aggcgtctcc aagcccctcc
     2401 cttccgtgcc tcccagcatt ggcaaatcga acgtggacag acgtcaggca gaaattggag
     2461 aggggtcagt gcgccggcga atctatgaca atccatactt cgagccccaa tatggctttc
     2521 cccctgagga agatgaggat gagcaggggg aaagttacac tccccgattc agccaacatg
     2581 tcagtggcaa tcgggctcaa aagctgctgc ggcccaacag cttgagactg gcaagtgact
     2641 cagatgcaga gtcagactct cgggcaagct ctcccaactc caccgtctcc aacaccagca
     2701 ccgagggctt cgggggcatc atgtcttttg ccagcagcct ctatcggaac cacagtacca
     2761 gcttcagtct ttcaaacctc acactgccca ccaaaggtgc ccgagagaag gccacgccct
     2821 tccccagtct gaaagtattt gggctaaata ctctaatgga gattgttact gaagccggcc
     2881 ccgggagtgg tgaaggaaac aggagggcgt tagtggatca gaagtcatct gtcattaaac
     2941 acagcccaac agtgaaaaga gaacctccat caccccaggg tcgatccagc aattctagtg
     3001 agaaccagca gttcctgaag gaggtggtgc acagcgtgct ggacggccag ggagttggct
     3061 ggctcaacat gaaaaaggtg cgccggctgc tggagagcga gcagctgcga gtctttgtcc
     3121 tgagcaagct gaaccgcatg gtgcagtcag aggacgatgc ccggcaggac atcatcccgg
     3181 atgtggagat cagtcggaag gtgtacaagg gaatgttaga cctcctcaag tgtacagtcc
     3241 tcagcttgga gcagtcctat gcccacgcgg gtctgggtgg catggccagc atctttgggc
     3301 ttttggagat tgcccagacc cactactata gtaaagaacc agacaagcgg aagagaagtc
     3361 caacagaaag tgtaaatacc ccagttggca aggatcctgg cctagctggg cggggggacc
     3421 caaaggctat ggcacaactg agagttccac aactgggacc tcgggcacca agtgccacag
     3481 gaaagggtcc taaggaactg gacaccagaa gtttaaagga agaaaatttt atagcatcta
     3541 ttgaattgtg gaacaagcac caggaagtga aaaagcaaaa agctttggaa aaacagaggc
     3601 ctgaagtaat caaacctgtc tttgaccttg gtgagacaga ggagaaaaag tcccagatca
     3661 gcgcagacag tggtgtgagc ctgacgtcta gttcccagag gactgatcaa gactctgtca
     3721 tcggcgtgag tccagctgtt atgatccgca gctcaagtca ggattctgaa gtgagtaata
     3781 gctctggaga gacccttgga gctgacagtg acttgagcag caatgcaggt gatggaccag
     3841 gtggcgaggg cagtgttcac ctggcaagct ctcggggcac tttgtctgat agtgaaattg
     3901 agaccaactc tgccacaagc accatctttg gtaaagccca cagcttgaag ccaagcataa
     3961 aggagaagct ggcaggcagc cccattcgta cttctgaaga tgtgagccag cgagtctatc
     4021 tctatgaggg actcctagga agggacaaag gatccatgtg ggaccagtta gaggatgcag
     4081 ctatggagac cttttctata agcaaagagc gttctacttt atgggaccaa atgcaattct
     4141 gggaagatgc cttcttagat gctgtgatgt tggagagaga agggatgggt atggaccagg
     4201 gtccccagga aatgatcgac aggtacctgt cccttggaga acatgaccgg aagcgcctgg
     4261 aagatgatga agatcgcttg ttggccacac ttctgcacaa cctcatctcc tacatgctgc
     4321 tgatgaaggt aaataagaat gacatccgca agaaggtgag gcgcctaatg ggaaagtcgc
     4381 acattgggct tgtgtacagc cagcaaatca atgaggtgct tgatcagctg gcgaacctga
     4441 atggacgcga tctctctatc tggtccagtg gcagccggca catgaagaag cagacatttg
     4501 tggtacatgc agggacagat acaaacggag atatcttttt catggaggtg tgcgatgact
     4561 gtgtggtgtt gcgtagtaac atcggaacag tgtatgagcg ctggtggtac gagaagctca
     4621 tcaacatgac ctactgtccc aagacgaagg tgttgtgctt gtggcgtaga aatggctctg
     4681 agacccagct caacaagttc tatactaaaa agtgtcggga gctgtactac tgtgtgaagg
     4741 acagcatgga gcgcgctgcc gcccgacagc aaagcatcaa acccggacct gaattgggtg
     4801 gcgagttccc tgtgcaggac ctgaagactg gtgagggtgg cctgctgcag gtgaccctgg
     4861 aagggatcaa cctcaaattc atgcacaatc agttcctgaa attaaagaag tggtgagcca
     4921 caagtacaag acaccaatgg cccacgaaat ctgctactcc gtattatgtc tcttctcgta
     4981 cgtggctgca gttcatagca gtgaggaaga tctcagaacc ccgccccggc ctgtctctag
     5041 ctgatggaga ggggctacgc agctgcccca gcccagggca cgcccctggc cccttgctgt
     5101 tcccaagtgc acgatgctgc tgtgactgag gagtggatga tgctcgtgtg tcctctgcaa
     5161 gccccctgct gtggcttggt tggttaccgg ttatgtgtcc ctctgagtgt gtcttgagcg
     5221 tgtccacctt ctccctctcc actcccagaa gaccaaactg ccttcccctc agggctcaag
     5281 aatgtgtaca gtctgtgggg ccggtgtgaa cccactattt tgtgtccttg agacatttgt
     5341 gttgtggttc cttgtccttg tccctggcgt tataactgtc cactgcaaga gtctggctct
     5401 cccttctctg tgacccggca tgactgggcg cctggagcag tttcactctg tgaggagtga
     5461 gggaaccctg gggctcaccc tctcagagga agggcacaga gaggaaggga agaattgggg
     5521 ggcagccgga gtgagtggca gcctccctgc ttccttctgc attcccaagc cggcagctac
     5581 tgcccagggc ccgcagtgtt ggctgctgcc tgccacagcc tctgtgactg cagtggagcg
     5641 gcgaattccc tgtggcctgc catgccttcg gcatcagagg atggagtggt cgaggctagt
     5701 ggagtcccag ggaccgctgg ctgctctgcc tgagcatcag ggagggggca ggaaagacca
     5761 agctgggttt gcacatctgt ctgcaggctg tctctccagg cacggggtgt caggagggag
     5821 agacagcctg ggtatgggca agaaatgact gtaaatattt cagccccaca ttatttatag
     5881 aaaatgtaca gttgtgtgaa tgtgaaataa atgtcctcaa ctccc
//
