LOCUS       NM_001376647            5676 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens MAP kinase activating death domain (MADD), transcript
            variant 81, mRNA.
ACCESSION   NM_001376647
VERSION     NM_001376647.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5676)
  AUTHORS   Abdel-Salam,G.M.H. and Abdel-Hamid,M.S.
  TITLE     New insights into the clinical and molecular spectrum of the
            MADD-related neurodevelopmental disorder
  JOURNAL   J Hum Genet 69 (6), 263-270 (2024)
   PUBMED   38459224
  REMARK    GeneRIF: New insights into the clinical and molecular spectrum of
            the MADD-related neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 5676)
  AUTHORS   Medlyn,M.J., Maeder,E., Bradley,C., Phatarpekar,P., Ham,H. and
            Billadeau,D.D.
  TITLE     MADD regulates natural killer cell degranulation through Rab27a
            activation
  JOURNAL   J Cell Sci 137 (7) (2024)
   PUBMED   38506245
  REMARK    GeneRIF: MADD regulates natural killer cell degranulation through
            Rab27a activation.
REFERENCE   3  (bases 1 to 5676)
  AUTHORS   Darouich,S. and Darouich,S.
  TITLE     Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency
  JOURNAL   Am J Med Genet A 194 (3), e63463 (2024)
   PUBMED   37932938
  REMARK    GeneRIF: Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency.
REFERENCE   4  (bases 1 to 5676)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   5  (bases 1 to 5676)
  AUTHORS   Abu-Libdeh,B., Mor-Shaked,H., Atawna,A.A., Gillis,D., Halstuk,O.,
            Shaul-Lotan,N., Slae,M., Sultan,M., Meiner,V., Elpeleg,O. and
            Harel,T.
  TITLE     Homozygous variant in MADD, encoding a Rab guanine nucleotide
            exchange factor, results in pleiotropic effects and a multisystemic
            disorder
  JOURNAL   Eur J Hum Genet 29 (6), 977-987 (2021)
   PUBMED   33723354
  REMARK    GeneRIF: Homozygous variant in MADD, encoding a Rab guanine
            nucleotide exchange factor, results in pleiotropic effects and a
            multisystemic disorder.
REFERENCE   6  (bases 1 to 5676)
  AUTHORS   Telliez,J.B., Bean,K.M. and Lin,L.L.
  TITLE     LRDD, a novel leucine rich repeat and death domain containing
            protein
  JOURNAL   Biochim Biophys Acta 1478 (2), 280-288 (2000)
   PUBMED   10825539
REFERENCE   7  (bases 1 to 5676)
  AUTHORS   Chow,V.T., Lim,K.M. and Lim,D.
  TITLE     The human DENN gene: genomic organization, alternative splicing,
            and localization to chromosome 11p11.21-p11.22
  JOURNAL   Genome 41 (4), 543-552 (1998)
   PUBMED   9796103
REFERENCE   8  (bases 1 to 5676)
  AUTHORS   Zhang,Y., Zhou,L. and Miller,C.A.
  TITLE     A splicing variant of a death domain protein that is regulated by a
            mitogen-activated kinase is a substrate for c-Jun N-terminal kinase
            in the human central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2586-2591 (1998)
   PUBMED   9482930
REFERENCE   9  (bases 1 to 5676)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   10 (bases 1 to 5676)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018410.24 and AC090582.9.
            
            Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling
            molecule that interacts with one of two receptors on cells targeted
            for apoptosis. The apoptotic signal is transduced inside these
            cells by cytoplasmic adaptor proteins. The protein encoded by this
            gene is a death domain-containing adaptor protein that interacts
            with the death domain of TNF-alpha receptor 1 to activate
            mitogen-activated protein kinase (MAPK) and propagate the apoptotic
            signal. It is membrane-bound and expressed at a higher level in
            neoplastic cells than in normal cells. Several transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.94458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC018410.24        93052-93165         c
            115-711             AC018410.24        88139-88735         c
            712-1015            AC018410.24        87096-87399         c
            1016-1147           AC018410.24        86435-86566         c
            1148-1261           AC018410.24        85020-85133         c
            1262-1342           AC018410.24        84219-84299         c
            1343-1521           AC018410.24        81545-81723         c
            1522-1757           AC018410.24        80682-80917         c
            1758-1914           AC018410.24        80329-80485         c
            1915-2018           AC018410.24        79017-79120         c
            2019-2209           AC018410.24        78733-78923         c
            2210-2334           AC018410.24        78233-78357         c
            2335-2474           AC018410.24        77708-77847         c
            2475-2576           AC018410.24        76764-76865         c
            2577-2679           AC018410.24        73805-73907         c
            2680-2866           AC018410.24        73245-73431         c
            2867-3017           AC018410.24        72999-73149         c
            3018-3224           AC018410.24        72482-72688         c
            3225-3278           AC018410.24        70702-70755         c
            3279-3379           AC018410.24        69315-69415         c
            3380-3451           AC018410.24        67731-67802         c
            3452-3610           AC018410.24        67243-67401         c
            3611-3719           AC018410.24        54599-54707         c
            3720-3782           AC018410.24        54256-54318         c
            3783-3903           AC018410.24        53897-54017         c
            3904-4009           AC018410.24        53686-53791         c
            4010-4120           AC090582.9         111-221
            4121-4228           AC090582.9         3599-3706
            4229-4393           AC090582.9         12050-12214
            4394-4466           AC090582.9         12644-12716
            4467-4573           AC090582.9         12850-12956
            4574-4643           AC090582.9         15117-15186
            4644-4690           AC090582.9         17037-17083
            4691-5676           AC090582.9         17425-18410
FEATURES             Location/Qualifiers
     source          1..5676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..5676
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="MAP kinase activating death domain"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
     exon            1..114
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            115..711
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..4795
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="isoform 60 is encoded by transcript variant 81; MAP
                     kinase-activating death domain protein; Rab3 GDP/GTP
                     exchange factor; differentially expressed in normal and
                     neoplastic cells; insulinoma glucagonoma clone 20; rab3
                     GDP/GTP exchange protein; Insuloma-Glucagonoma protein 20"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 60"
                     /protein_id="NP_001363576.1"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
                     /translation="MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEG
                     GAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSR
                     NSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFT
                     GSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPD
                     PSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY
                     PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSN
                     RVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR
                     PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPR
                     PVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALI
                     GDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSS
                     YSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENS
                     QENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSN
                     VDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFAS
                     SLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPP
                     SPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMV
                     QSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQ
                     THYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGP
                     KELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPVFDLGETEEKKSQISA
                     DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGP
                     GGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
                     VYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGM
                     GMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVR
                     RLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDI
                     FFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTK
                     KCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFM
                     HNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVA
                     AVHSSEEDLRTPPRPVSS"
     exon            712..1015
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1147
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1261
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1342
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1521
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1757
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1914
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2018
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2209
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2334
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2474
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2576
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2679
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2866
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3017
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3224
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3278
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3379
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3451
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3610
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3719
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3782
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3903
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4009
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4120
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4228
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4393
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4466
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4573
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..4643
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4690
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..5676
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5657..5662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      5676
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagacg cggaactggc gcccgctcgg agcggcgccg cgctggggag cgactgacgc
       61 cccgctgccg ggggacgtcg ggctgggcct ggccagtccc ccagagcttg ggaggcaccc
      121 gagcagtgat agcgtggccc agactcctga attgctacgg cgatacccct tggaggatca
      181 cactgagttt cccctgcccc cagatgtagt gttcttctgc cagcccgagg gctgcctgag
      241 cgtgcggcag cggcgcatga gccttcggga tgatacctct tttgtcttca ccctcactga
      301 caaggacact ggagtcacgc gatatggcat ctgtgttaac ttctaccgct ccttccaaaa
      361 gcgaatctct aaggagaagg gggaaggtgg ggcagggtcc cgtgggaagg aaggaaccca
      421 tgccacctgt gcctcagaag agggtggcac tgagagctca gagagtggct catccctgca
      481 gcctctcagt gctgactcta cccctgatgt gaaccagtct cctcggggca aacgccgggc
      541 caaggcgggg agccgctccc gcaacagtac tctcacgtcc ctgtgcgtgc tcagccacta
      601 ccctttcttc tccaccttcc gagagtgttt gtatactctc aagcgcctgg tggactgctg
      661 tagtgagcgc cttctgggca agaaactggg catccctcga ggcgtacaaa gggacaccat
      721 gtggcggatc tttactggat cgctgctggt agaggagaag tcaagtgccc ttctgcatga
      781 ccttcgagag attgaggcct ggatctatcg attgctgcgc tccccagtac ccgtctctgg
      841 gcagaagcga gtagacatcg aggtcctacc ccaagagctc cagccagctc tgacctttgc
      901 tcttccagac ccatctcgat tcaccctagt ggatttccca ctgcaccttc ccttggaact
      961 tctaggtgtg gacgcctgtc tccaggtgct aacctgcatt ctgttagagc acaaggtggt
     1021 gctacagtcc cgagactaca atgcactctc catgtctgtg atggcattcg tggcaatgat
     1081 ctacccactg gagtatatgt ttcctgtcat cccgctgcta cccacctgca tggcatcagc
     1141 agagcagctg ctgttggctc caaccccgta catcattggg gttcctgcca gcttcttcct
     1201 ctacaaactg gacttcaaaa tgcctgatga tgtatggcta gtggatctgg acagcaatag
     1261 ggtgattgcc cccaccaatg cagaagtgct gcctatcctg ccagaaccag aatcactaga
     1321 gctgaaaaag catttaaagc aggccttggc cagcatgagt ctcaacaccc agcccatcct
     1381 caatctggag aaatttcatg agggccagga gatccccctt ctcttgggaa ggccttctaa
     1441 tgacctgcag tccacaccgt ccactgaatt caacccactc atctatggca atgatgtgga
     1501 ttctgtggat gttgcaacca gggttgccat ggtacggttc ttcaattccg ccaacgtgct
     1561 gcagggattt cagatgcaca cgcgtaccct gcgcctcttt cctcggcctg tggtagcttt
     1621 tcaagctggc tcctttctag cctcacgtcc ccggcagact ccttttgccg agaaattggc
     1681 caggactcag gctgtggagt actttgggga atggatcctt aaccccacca actatgcctt
     1741 tcagcgaatt cacaacaata tgtttgatcc agccctgatt ggtgacaagc caaagtggta
     1801 tgctcatcag ctgcagccta tccactatcg cgtctatgac agcaattccc agctggctga
     1861 ggccctgagt gtaccaccag agcgggactc tgactccgaa cctactgatg atagtggcag
     1921 tgatagtatg gattatgacg attcaagctc ttcttactcc tcccttggtg actttgtcag
     1981 tgaaatgatg aaatgtgaca ttaatggtga tactcccaat gtggaccctc tgacacatgc
     2041 agcactgggg gatgccagcg aggtggagat tgacgagctg cagaatcaga aggaagcaga
     2101 agagcctggc ccagacagtg agaactctca ggaaaacccc ccactgcgct ccagctctag
     2161 caccacagcc agcagcagcc ccagcactgt catccacgga gccaactctg aacctgctga
     2221 ctctacggag atggatgata aggcagcagt aggcgtctcc aagcccctcc cttccgtgcc
     2281 tcccagcatt ggcaaatcga acgtggacag acgtcaggca gaaattggag agggggctca
     2341 aaagctgctg cggcccaaca gcttgagact ggcaagtgac tcagatgcag agtcagactc
     2401 tcgggcaagc tctcccaact ccaccgtctc caacaccagc accgagggct tcgggggcat
     2461 catgtctttt gccagcagcc tctatcggaa ccacagtacc agcttcagtc tttcaaacct
     2521 cacactgccc accaaaggtg cccgagagaa ggccacgccc ttccccagtc tgaaaggaaa
     2581 caggagggcg ttagtggatc agaagtcatc tgtcattaaa cacagcccaa cagtgaaaag
     2641 agaacctcca tcaccccagg gtcgatccag caattctagt gagaaccagc agttcctgaa
     2701 ggaggtggtg cacagcgtgc tggacggcca gggagttggc tggctcaaca tgaaaaaggt
     2761 gcgccggctg ctggagagcg agcagctgcg agtctttgtc ctgagcaagc tgaaccgcat
     2821 ggtgcagtca gaggacgatg cccggcagga catcatcccg gatgtggaga tcagtcggaa
     2881 ggtgtacaag ggaatgttag acctcctcaa gtgtacagtc ctcagcttgg agcagtccta
     2941 tgcccacgcg ggtctgggtg gcatggccag catctttggg cttttggaga ttgcccagac
     3001 ccactactat agtaaagaac cagacaagcg gaagagaagt ccaacagaaa gtgtaaatac
     3061 cccagttggc aaggatcctg gcctagctgg gcggggggac ccaaaggcta tggcacaact
     3121 gagagttcca caactgggac ctcgggcacc aagtgccaca ggaaagggtc ctaaggaact
     3181 ggacaccaga agtttaaagg aagaaaattt tatagcatct attgaattgt ggaacaagca
     3241 ccaggaagtg aaaaagcaaa aagctttgga aaaacagagg cctgaagtaa tcaaacctgt
     3301 ctttgacctt ggtgagacag aggagaaaaa gtcccagatc agcgcagaca gtggtgtgag
     3361 cctgacgtct agttcccaga ggactgatca agactctgtc atcggcgtga gtccagctgt
     3421 tatgatccgc agctcaagtc aggattctga agtgagtaat agctctggag agacccttgg
     3481 agctgacagt gacttgagca gcaatgcagg tgatggacca ggtggcgagg gcagtgttca
     3541 cctggcaagc tctcggggca ctttgtctga tagtgaaatt gagaccaact ctgccacaag
     3601 caccatcttt ggtaaagccc acagcttgaa gccaagcata aaggagaagc tggcaggcag
     3661 ccccattcgt acttctgaag atgtgagcca gcgagtctat ctctatgagg gactcctagg
     3721 aagggacaaa ggatccatgt gggaccagtt agaggatgca gctatggaga ccttttctat
     3781 aagcaaagag cgttctactt tatgggacca aatgcaattc tgggaagatg ccttcttaga
     3841 tgctgtgatg ttggagagag aagggatggg tatggaccag ggtccccagg aaatgatcga
     3901 caggtacctg tcccttggag aacatgaccg gaagcgcctg gaagatgatg aagatcgctt
     3961 gttggccaca cttctgcaca acctcatctc ctacatgctg ctgatgaagg taaataagaa
     4021 tgacatccgc aagaaggtga ggcgcctaat gggaaagtcg cacattgggc ttgtgtacag
     4081 ccagcaaatc aatgaggtgc ttgatcagct ggcgaacctg aatggacgcg atctctctat
     4141 ctggtccagt ggcagccggc acatgaagaa gcagacattt gtggtacatg cagggacaga
     4201 tacaaacgga gatatctttt tcatggaggt gtgcgatgac tgtgtggtgt tgcgtagtaa
     4261 catcggaaca gtgtatgagc gctggtggta cgagaagctc atcaacatga cctactgtcc
     4321 caagacgaag gtgttgtgct tgtggcgtag aaatggctct gagacccagc tcaacaagtt
     4381 ctatactaaa aagtgtcggg agctgtacta ctgtgtgaag gacagcatgg agcgcgctgc
     4441 cgcccgacag caaagcatca aacccggacc tgaattgggt ggcgagttcc ctgtgcagga
     4501 cctgaagact ggtgagggtg gcctgctgca ggtgaccctg gaagggatca acctcaaatt
     4561 catgcacaat caggttttca tagagctgaa tcacattaaa aagtgcaata cagttcgagg
     4621 cgtctttgtc ctggaggaat ttgttcctga aattaaagaa gtggtgagcc acaagtacaa
     4681 gacaccaatg gcccacgaaa tctgctactc cgtattatgt ctcttctcgt acgtggctgc
     4741 agttcatagc agtgaggaag atctcagaac cccgccccgg cctgtctcta gctgatggag
     4801 aggggctacg cagctgcccc agcccagggc acgcccctgg ccccttgctg ttcccaagtg
     4861 cacgatgctg ctgtgactga ggagtggatg atgctcgtgt gtcctctgca agccccctgc
     4921 tgtggcttgg ttggttaccg gttatgtgtc cctctgagtg tgtcttgagc gtgtccacct
     4981 tctccctctc cactcccaga agaccaaact gccttcccct cagggctcaa gaatgtgtac
     5041 agtctgtggg gccggtgtga acccactatt ttgtgtcctt gagacatttg tgttgtggtt
     5101 ccttgtcctt gtccctggcg ttataactgt ccactgcaag agtctggctc tcccttctct
     5161 gtgacccggc atgactgggc gcctggagca gtttcactct gtgaggagtg agggaaccct
     5221 ggggctcacc ctctcagagg aagggcacag agaggaaggg aagaattggg gggcagccgg
     5281 agtgagtggc agcctccctg cttccttctg cattcccaag ccggcagcta ctgcccaggg
     5341 cccgcagtgt tggctgctgc ctgccacagc ctctgtgact gcagtggagc ggcgaattcc
     5401 ctgtggcctg ccatgccttc ggcatcagag gatggagtgg tcgaggctag tggagtccca
     5461 gggaccgctg gctgctctgc ctgagcatca gggagggggc aggaaagacc aagctgggtt
     5521 tgcacatctg tctgcaggct gtctctccag gcacggggtg tcaggaggga gagacagcct
     5581 gggtatgggc aagaaatgac tgtaaatatt tcagccccac attatttata gaaaatgtac
     5641 agttgtgtga atgtgaaata aatgtcctca actccc
//
