LOCUS       NM_001376571            6036 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens MAP kinase activating death domain (MADD), transcript
            variant 11, mRNA.
ACCESSION   NM_001376571 XM_024448745
VERSION     NM_001376571.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6036)
  AUTHORS   Abdel-Salam,G.M.H. and Abdel-Hamid,M.S.
  TITLE     New insights into the clinical and molecular spectrum of the
            MADD-related neurodevelopmental disorder
  JOURNAL   J Hum Genet 69 (6), 263-270 (2024)
   PUBMED   38459224
  REMARK    GeneRIF: New insights into the clinical and molecular spectrum of
            the MADD-related neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 6036)
  AUTHORS   Medlyn,M.J., Maeder,E., Bradley,C., Phatarpekar,P., Ham,H. and
            Billadeau,D.D.
  TITLE     MADD regulates natural killer cell degranulation through Rab27a
            activation
  JOURNAL   J Cell Sci 137 (7) (2024)
   PUBMED   38506245
  REMARK    GeneRIF: MADD regulates natural killer cell degranulation through
            Rab27a activation.
REFERENCE   3  (bases 1 to 6036)
  AUTHORS   Darouich,S. and Darouich,S.
  TITLE     Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency
  JOURNAL   Am J Med Genet A 194 (3), e63463 (2024)
   PUBMED   37932938
  REMARK    GeneRIF: Calloso-adreno-scrotal agenesis associated with biallelic
            MAPK-activating death domain protein (MADD) variant: Further
            phenotypic delineation of MADD deficiency.
REFERENCE   4  (bases 1 to 6036)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   5  (bases 1 to 6036)
  AUTHORS   Abu-Libdeh,B., Mor-Shaked,H., Atawna,A.A., Gillis,D., Halstuk,O.,
            Shaul-Lotan,N., Slae,M., Sultan,M., Meiner,V., Elpeleg,O. and
            Harel,T.
  TITLE     Homozygous variant in MADD, encoding a Rab guanine nucleotide
            exchange factor, results in pleiotropic effects and a multisystemic
            disorder
  JOURNAL   Eur J Hum Genet 29 (6), 977-987 (2021)
   PUBMED   33723354
  REMARK    GeneRIF: Homozygous variant in MADD, encoding a Rab guanine
            nucleotide exchange factor, results in pleiotropic effects and a
            multisystemic disorder.
REFERENCE   6  (bases 1 to 6036)
  AUTHORS   Telliez,J.B., Bean,K.M. and Lin,L.L.
  TITLE     LRDD, a novel leucine rich repeat and death domain containing
            protein
  JOURNAL   Biochim Biophys Acta 1478 (2), 280-288 (2000)
   PUBMED   10825539
REFERENCE   7  (bases 1 to 6036)
  AUTHORS   Chow,V.T., Lim,K.M. and Lim,D.
  TITLE     The human DENN gene: genomic organization, alternative splicing,
            and localization to chromosome 11p11.21-p11.22
  JOURNAL   Genome 41 (4), 543-552 (1998)
   PUBMED   9796103
REFERENCE   8  (bases 1 to 6036)
  AUTHORS   Zhang,Y., Zhou,L. and Miller,C.A.
  TITLE     A splicing variant of a death domain protein that is regulated by a
            mitogen-activated kinase is a substrate for c-Jun N-terminal kinase
            in the human central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2586-2591 (1998)
   PUBMED   9482930
REFERENCE   9  (bases 1 to 6036)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   10 (bases 1 to 6036)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018410.24 and AC090582.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 18, 2019 this sequence version replaced XM_024448745.1.
            
            Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling
            molecule that interacts with one of two receptors on cells targeted
            for apoptosis. The apoptotic signal is transduced inside these
            cells by cytoplasmic adaptor proteins. The protein encoded by this
            gene is a death domain-containing adaptor protein that interacts
            with the death domain of TNF-alpha receptor 1 to activate
            mitogen-activated protein kinase (MAPK) and propagate the apoptotic
            signal. It is membrane-bound and expressed at a higher level in
            neoplastic cells than in normal cells. Several transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000706887.1/ ENSP00000516604.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC018410.24        93052-93165         c
            115-264             AC018410.24        89322-89471         c
            265-861             AC018410.24        88139-88735         c
            862-1165            AC018410.24        87096-87399         c
            1166-1297           AC018410.24        86435-86566         c
            1298-1411           AC018410.24        85020-85133         c
            1412-1492           AC018410.24        84219-84299         c
            1493-1671           AC018410.24        81545-81723         c
            1672-1907           AC018410.24        80682-80917         c
            1908-2064           AC018410.24        80329-80485         c
            2065-2168           AC018410.24        79017-79120         c
            2169-2359           AC018410.24        78733-78923         c
            2360-2613           AC018410.24        78104-78357         c
            2614-2753           AC018410.24        77708-77847         c
            2754-2855           AC018410.24        76764-76865         c
            2856-2915           AC018410.24        74271-74330         c
            2916-3018           AC018410.24        73805-73907         c
            3019-3205           AC018410.24        73245-73431         c
            3206-3356           AC018410.24        72999-73149         c
            3357-3563           AC018410.24        72482-72688         c
            3564-3617           AC018410.24        70702-70755         c
            3618-3718           AC018410.24        69315-69415         c
            3719-3802           AC018410.24        67719-67802         c
            3803-3961           AC018410.24        67243-67401         c
            3962-4070           AC018410.24        54599-54707         c
            4071-4133           AC018410.24        54256-54318         c
            4134-4254           AC018410.24        53897-54017         c
            4255-4360           AC018410.24        53686-53791         c
            4361-4471           AC090582.9         111-221
            4472-4579           AC090582.9         3599-3706
            4580-4744           AC090582.9         12050-12214
            4745-4817           AC090582.9         12644-12716
            4818-4924           AC090582.9         12850-12956
            4925-4933           AC090582.9         14923-14931
            4934-5003           AC090582.9         15117-15186
            5004-5050           AC090582.9         17037-17083
            5051-6036           AC090582.9         17425-18410
FEATURES             Location/Qualifiers
     source          1..6036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..6036
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="MAP kinase activating death domain"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
     exon            1..114
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            115..264
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..5155
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="isoform 11 is encoded by transcript variant 11; MAP
                     kinase-activating death domain protein; Rab3 GDP/GTP
                     exchange factor; differentially expressed in normal and
                     neoplastic cells; insulinoma glucagonoma clone 20; rab3
                     GDP/GTP exchange protein; Insuloma-Glucagonoma protein 20"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 11"
                     /protein_id="NP_001363500.1"
                     /db_xref="GeneID:8567"
                     /db_xref="HGNC:HGNC:6766"
                     /db_xref="MIM:603584"
                     /translation="MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHT
                     EFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQ
                     KRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGK
                     RRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGV
                     QRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEL
                     QPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSM
                     SVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPD
                     DVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHE
                     GQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQM
                     HTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRI
                     HNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSD
                     SMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEA
                     EEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLP
                     SVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQ
                     HVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRN
                     HSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQK
                     SSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLES
                     EQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAG
                     LGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRV
                     PQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPV
                     FDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNS
                     SGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPS
                     IKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ
                     MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNL
                     ISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSR
                     HMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKV
                     LCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLK
                     TGEGGLLQVTLEGINLKFMHNQERKVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSH
                     KYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS"
     exon            265..861
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1165
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1297
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1411
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1492
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1671
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1907
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2064
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2168
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2359
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2613
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2753
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2855
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2915
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3018
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3205
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3356
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3563
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3617
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3718
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3802
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3961
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4070
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4133
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4254
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4360
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4471
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4579
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4744
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4817
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4924
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..4933
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4934..5003
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5050
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..6036
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6017..6022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      6036
                     /gene="MADD"
                     /gene_synonym="DEEAH; DENN; IG20; NEDDISH; RAB3GEP;
                     RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagacg cggaactggc gcccgctcgg agcggcgccg cgctggggag cgactgacgc
       61 cccgctgccg ggggacgtcg ggctgggcct ggccagtccc ccagagcttg ggagacttcg
      121 attttcagaa ttcctcctgg gaatgctgac tccttgcttg gtgccctgat gcttctctga
      181 gataaactga tgaattggaa ccatggtgca aaagaagaag ttctgtcctc ggttacttga
      241 ctatctagtg atcgtagggg ccaggcaccc gagcagtgat agcgtggccc agactcctga
      301 attgctacgg cgatacccct tggaggatca cactgagttt cccctgcccc cagatgtagt
      361 gttcttctgc cagcccgagg gctgcctgag cgtgcggcag cggcgcatga gccttcggga
      421 tgatacctct tttgtcttca ccctcactga caaggacact ggagtcacgc gatatggcat
      481 ctgtgttaac ttctaccgct ccttccaaaa gcgaatctct aaggagaagg gggaaggtgg
      541 ggcagggtcc cgtgggaagg aaggaaccca tgccacctgt gcctcagaag agggtggcac
      601 tgagagctca gagagtggct catccctgca gcctctcagt gctgactcta cccctgatgt
      661 gaaccagtct cctcggggca aacgccgggc caaggcgggg agccgctccc gcaacagtac
      721 tctcacgtcc ctgtgcgtgc tcagccacta ccctttcttc tccaccttcc gagagtgttt
      781 gtatactctc aagcgcctgg tggactgctg tagtgagcgc cttctgggca agaaactggg
      841 catccctcga ggcgtacaaa gggacaccat gtggcggatc tttactggat cgctgctggt
      901 agaggagaag tcaagtgccc ttctgcatga ccttcgagag attgaggcct ggatctatcg
      961 attgctgcgc tccccagtac ccgtctctgg gcagaagcga gtagacatcg aggtcctacc
     1021 ccaagagctc cagccagctc tgacctttgc tcttccagac ccatctcgat tcaccctagt
     1081 ggatttccca ctgcaccttc ccttggaact tctaggtgtg gacgcctgtc tccaggtgct
     1141 aacctgcatt ctgttagagc acaaggtggt gctacagtcc cgagactaca atgcactctc
     1201 catgtctgtg atggcattcg tggcaatgat ctacccactg gagtatatgt ttcctgtcat
     1261 cccgctgcta cccacctgca tggcatcagc agagcagctg ctgttggctc caaccccgta
     1321 catcattggg gttcctgcca gcttcttcct ctacaaactg gacttcaaaa tgcctgatga
     1381 tgtatggcta gtggatctgg acagcaatag ggtgattgcc cccaccaatg cagaagtgct
     1441 gcctatcctg ccagaaccag aatcactaga gctgaaaaag catttaaagc aggccttggc
     1501 cagcatgagt ctcaacaccc agcccatcct caatctggag aaatttcatg agggccagga
     1561 gatccccctt ctcttgggaa ggccttctaa tgacctgcag tccacaccgt ccactgaatt
     1621 caacccactc atctatggca atgatgtgga ttctgtggat gttgcaacca gggttgccat
     1681 ggtacggttc ttcaattccg ccaacgtgct gcagggattt cagatgcaca cgcgtaccct
     1741 gcgcctcttt cctcggcctg tggtagcttt tcaagctggc tcctttctag cctcacgtcc
     1801 ccggcagact ccttttgccg agaaattggc caggactcag gctgtggagt actttgggga
     1861 atggatcctt aaccccacca actatgcctt tcagcgaatt cacaacaata tgtttgatcc
     1921 agccctgatt ggtgacaagc caaagtggta tgctcatcag ctgcagccta tccactatcg
     1981 cgtctatgac agcaattccc agctggctga ggccctgagt gtaccaccag agcgggactc
     2041 tgactccgaa cctactgatg atagtggcag tgatagtatg gattatgacg attcaagctc
     2101 ttcttactcc tcccttggtg actttgtcag tgaaatgatg aaatgtgaca ttaatggtga
     2161 tactcccaat gtggaccctc tgacacatgc agcactgggg gatgccagcg aggtggagat
     2221 tgacgagctg cagaatcaga aggaagcaga agagcctggc ccagacagtg agaactctca
     2281 ggaaaacccc ccactgcgct ccagctctag caccacagcc agcagcagcc ccagcactgt
     2341 catccacgga gccaactctg aacctgctga ctctacggag atggatgata aggcagcagt
     2401 aggcgtctcc aagcccctcc cttccgtgcc tcccagcatt ggcaaatcga acgtggacag
     2461 acgtcaggca gaaattggag aggggtcagt gcgccggcga atctatgaca atccatactt
     2521 cgagccccaa tatggctttc cccctgagga agatgaggat gagcaggggg aaagttacac
     2581 tccccgattc agccaacatg tcagtggcaa tcgggctcaa aagctgctgc ggcccaacag
     2641 cttgagactg gcaagtgact cagatgcaga gtcagactct cgggcaagct ctcccaactc
     2701 caccgtctcc aacaccagca ccgagggctt cgggggcatc atgtcttttg ccagcagcct
     2761 ctatcggaac cacagtacca gcttcagtct ttcaaacctc acactgccca ccaaaggtgc
     2821 ccgagagaag gccacgccct tccccagtct gaaagtattt gggctaaata ctctaatgga
     2881 gattgttact gaagccggcc ccgggagtgg tgaaggaaac aggagggcgt tagtggatca
     2941 gaagtcatct gtcattaaac acagcccaac agtgaaaaga gaacctccat caccccaggg
     3001 tcgatccagc aattctagtg agaaccagca gttcctgaag gaggtggtgc acagcgtgct
     3061 ggacggccag ggagttggct ggctcaacat gaaaaaggtg cgccggctgc tggagagcga
     3121 gcagctgcga gtctttgtcc tgagcaagct gaaccgcatg gtgcagtcag aggacgatgc
     3181 ccggcaggac atcatcccgg atgtggagat cagtcggaag gtgtacaagg gaatgttaga
     3241 cctcctcaag tgtacagtcc tcagcttgga gcagtcctat gcccacgcgg gtctgggtgg
     3301 catggccagc atctttgggc ttttggagat tgcccagacc cactactata gtaaagaacc
     3361 agacaagcgg aagagaagtc caacagaaag tgtaaatacc ccagttggca aggatcctgg
     3421 cctagctggg cggggggacc caaaggctat ggcacaactg agagttccac aactgggacc
     3481 tcgggcacca agtgccacag gaaagggtcc taaggaactg gacaccagaa gtttaaagga
     3541 agaaaatttt atagcatcta ttgaattgtg gaacaagcac caggaagtga aaaagcaaaa
     3601 agctttggaa aaacagaggc ctgaagtaat caaacctgtc tttgaccttg gtgagacaga
     3661 ggagaaaaag tcccagatca gcgcagacag tggtgtgagc ctgacgtcta gttcccagag
     3721 gactgatcaa gactctgtca tcggcgtgag tccagctgtt atgatccgca gctcaagtca
     3781 ggattctgaa gttagcaccg tggtgagtaa tagctctgga gagacccttg gagctgacag
     3841 tgacttgagc agcaatgcag gtgatggacc aggtggcgag ggcagtgttc acctggcaag
     3901 ctctcggggc actttgtctg atagtgaaat tgagaccaac tctgccacaa gcaccatctt
     3961 tggtaaagcc cacagcttga agccaagcat aaaggagaag ctggcaggca gccccattcg
     4021 tacttctgaa gatgtgagcc agcgagtcta tctctatgag ggactcctag gaagggacaa
     4081 aggatccatg tgggaccagt tagaggatgc agctatggag accttttcta taagcaaaga
     4141 gcgttctact ttatgggacc aaatgcaatt ctgggaagat gccttcttag atgctgtgat
     4201 gttggagaga gaagggatgg gtatggacca gggtccccag gaaatgatcg acaggtacct
     4261 gtcccttgga gaacatgacc ggaagcgcct ggaagatgat gaagatcgct tgttggccac
     4321 acttctgcac aacctcatct cctacatgct gctgatgaag gtaaataaga atgacatccg
     4381 caagaaggtg aggcgcctaa tgggaaagtc gcacattggg cttgtgtaca gccagcaaat
     4441 caatgaggtg cttgatcagc tggcgaacct gaatggacgc gatctctcta tctggtccag
     4501 tggcagccgg cacatgaaga agcagacatt tgtggtacat gcagggacag atacaaacgg
     4561 agatatcttt ttcatggagg tgtgcgatga ctgtgtggtg ttgcgtagta acatcggaac
     4621 agtgtatgag cgctggtggt acgagaagct catcaacatg acctactgtc ccaagacgaa
     4681 ggtgttgtgc ttgtggcgta gaaatggctc tgagacccag ctcaacaagt tctatactaa
     4741 aaagtgtcgg gagctgtact actgtgtgaa ggacagcatg gagcgcgctg ccgcccgaca
     4801 gcaaagcatc aaacccggac ctgaattggg tggcgagttc cctgtgcagg acctgaagac
     4861 tggtgagggt ggcctgctgc aggtgaccct ggaagggatc aacctcaaat tcatgcacaa
     4921 tcaggagcgg aaggttttca tagagctgaa tcacattaaa aagtgcaata cagttcgagg
     4981 cgtctttgtc ctggaggaat ttgttcctga aattaaagaa gtggtgagcc acaagtacaa
     5041 gacaccaatg gcccacgaaa tctgctactc cgtattatgt ctcttctcgt acgtggctgc
     5101 agttcatagc agtgaggaag atctcagaac cccgccccgg cctgtctcta gctgatggag
     5161 aggggctacg cagctgcccc agcccagggc acgcccctgg ccccttgctg ttcccaagtg
     5221 cacgatgctg ctgtgactga ggagtggatg atgctcgtgt gtcctctgca agccccctgc
     5281 tgtggcttgg ttggttaccg gttatgtgtc cctctgagtg tgtcttgagc gtgtccacct
     5341 tctccctctc cactcccaga agaccaaact gccttcccct cagggctcaa gaatgtgtac
     5401 agtctgtggg gccggtgtga acccactatt ttgtgtcctt gagacatttg tgttgtggtt
     5461 ccttgtcctt gtccctggcg ttataactgt ccactgcaag agtctggctc tcccttctct
     5521 gtgacccggc atgactgggc gcctggagca gtttcactct gtgaggagtg agggaaccct
     5581 ggggctcacc ctctcagagg aagggcacag agaggaaggg aagaattggg gggcagccgg
     5641 agtgagtggc agcctccctg cttccttctg cattcccaag ccggcagcta ctgcccaggg
     5701 cccgcagtgt tggctgctgc ctgccacagc ctctgtgact gcagtggagc ggcgaattcc
     5761 ctgtggcctg ccatgccttc ggcatcagag gatggagtgg tcgaggctag tggagtccca
     5821 gggaccgctg gctgctctgc ctgagcatca gggagggggc aggaaagacc aagctgggtt
     5881 tgcacatctg tctgcaggct gtctctccag gcacggggtg tcaggaggga gagacagcct
     5941 gggtatgggc aagaaatgac tgtaaatatt tcagccccac attatttata gaaaatgtac
     6001 agttgtgtga atgtgaaata aatgtcctca actccc
//
