LOCUS       NM_130760               1541 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens mucosal vascular addressin cell adhesion molecule 1
            (MADCAM1), transcript variant 1, mRNA.
ACCESSION   NM_130760 NM_007164 NM_130761
VERSION     NM_130760.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Jagtap,D., Bhor,V.M., Bhowmick,S., Kasarpalkar,N., Sagvekar,P.,
            Kulkarni,B., Pathak,M., Chatterjee,N., Dolas,P., Palav,H.,
            Kaginkar,S., Bhagat,S., Munshi,I., Parikh,S., Agrawal,S., Pawar,C.,
            Kaneria,M., Mahale,S.D., Shastri,J. and Patel,V.
  TITLE     sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral
            Responses in SARS-CoV-2 Infection
  JOURNAL   Front Immunol 12, 619906 (2021)
   PUBMED   34194420
  REMARK    GeneRIF: sMAdCAM: IL-6 Ratio Influences Disease Progression and
            Anti-Viral Responses in SARS-CoV-2 Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Kasarpalkar,N.J., Bhowmick,S., Patel,V., Savardekar,L., Agrawal,S.,
            Shastri,J. and Bhor,V.M.
  TITLE     Frequency of Effector Memory Cells Expressing Integrin alpha4beta7
            Is Associated With TGF-beta1 Levels in Therapy Naive HIV Infected
            Women With Low CD4+ T Cell Count
  JOURNAL   Front Immunol 12, 651122 (2021)
   PUBMED   33828560
  REMARK    GeneRIF: Frequency of Effector Memory Cells Expressing Integrin
            alpha4beta7 Is Associated With TGF-beta1 Levels in Therapy Naive
            HIV Infected Women With Low CD4(+) T Cell Count.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Allner,C., Melde,M., Becker,E., Fuchs,F., Muhl,L., Klenske,E.,
            Muller,L., Morgenstern,N., Fietkau,K., Hirschmann,S., Atreya,R.,
            Atreya,I., Neurath,M.F. and Zundler,S.
  TITLE     Baseline levels of dynamic CD4+ T cell adhesion to MAdCAM-1
            correlate with clinical response to vedolizumab treatment in
            ulcerative colitis: a cohort study
  JOURNAL   BMC Gastroenterol 20 (1), 103 (2020)
   PUBMED   32293299
  REMARK    GeneRIF: Baseline levels of dynamic CD4(+) T cell adhesion to
            MAdCAM-1 correlate with clinical response to vedolizumab treatment
            in ulcerative colitis: a cohort study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Satoh,T., Oikawa,H., Yashima-Abo,A., Nishiya,M. and Masuda,T.
  TITLE     Expression of mucosal addressin cell adhesion molecule-1 on the
            reticular framework between white pulp and the marginal zone in the
            human spleen
  JOURNAL   J Clin Exp Hematop 59 (4), 187-195 (2019)
   PUBMED   31866620
  REMARK    GeneRIF: n the present study, mucosal addressin cell adhesion
            molecule-1 was selectively expressed on alpha-smooth muscle
            actin-positive reticular framework. The reticular framework may
            function in lymphocyte homing and segregation into the
            periarteriolar lymphoid sheath, lymph follicle and marginal zone.
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Wang,J., Ma,L., Tang,X., Zhang,X., Qiao,Y., Shi,Y., Xu,Y., Wang,Z.,
            Yu,Y. and Sun,F.
  TITLE     Doxorubicin induces apoptosis by targeting Madcam1 and AKT and
            inhibiting protein translation initiation in hepatocellular
            carcinoma cells
  JOURNAL   Oncotarget 6 (27), 24075-24091 (2015)
   PUBMED   26124182
  REMARK    GeneRIF: Doxo-induced apoptosis has a role in inhibiting
            hepatocellular carcinoma by targeting Madcam1 and AKT and blocking
            protein translation initiation
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Leung,E., Berg,R.W., Langley,R., Greene,J., Raymond,L.A.,
            Augustus,M., Ni,J., Carter,K.C., Spurr,N., Choo,K.H. and
            Krissansen,G.W.
  TITLE     Genomic organization, chromosomal mapping, and analysis of the 5'
            promoter region of the human MAdCAM-1 gene
  JOURNAL   Immunogenetics 46 (2), 111-119 (1997)
   PUBMED   9162097
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Leung,E., Greene,J., Ni,J., Raymond,L.G., Lehnert,K., Langley,R.
            and Krissansen,G.W.
  TITLE     Cloning of the mucosal addressin MAdCAM-1 from human brain:
            identification of novel alternatively spliced transcripts
  JOURNAL   Immunol Cell Biol 74 (6), 490-496 (1996)
   PUBMED   8989586
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Shyjan,A.M., Bertagnolli,M., Kenney,C.J. and Briskin,M.J.
  TITLE     Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1)
            demonstrates structural and functional similarities to the alpha 4
            beta 7-integrin binding domains of murine MAdCAM-1, but extreme
            divergence of mucin-like sequences
  JOURNAL   J Immunol 156 (8), 2851-2857 (1996)
   PUBMED   8609404
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Briskin,M.J., McEvoy,L.M. and Butcher,E.C.
  TITLE     MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion
            receptors and to IgA1
  JOURNAL   Nature 363 (6428), 461-464 (1993)
   PUBMED   8502297
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Picker,L.J., Nakache,M. and Butcher,E.C.
  TITLE     Monoclonal antibodies to human lymphocyte homing receptors define a
            novel class of adhesion molecules on diverse cell types
  JOURNAL   J Cell Biol 109 (2), 927-937 (1989)
   PUBMED   2474557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005775.1, U82483.1, U43628.1
            and DB323303.1.
            
            On Nov 22, 2018 this sequence version replaced NM_130760.2.
            
            Summary: The protein encoded by this gene is an endothelial cell
            adhesion molecule that interacts preferentially with the leukocyte
            beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4
            (alpha4beta1) on myeloid cells to direct leukocytes into mucosal
            and inflamed tissues. It is a member of the immunoglobulin family
            and is similar to ICAM1 and VCAM1. At least seven alternatively
            spliced transcripts encoding different protein isoforms have been
            found for this gene, but the full-length nature of some variants
            has not been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer, predominant
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U82483.1, AY819760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215637.8/ ENSP00000215637.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC005775.1         32365-32368
            5-774               U82483.1           1-770
            775-798             U43628.1           785-808
            799-1027            U82483.1           795-1023
            1028-1408           DB323303.1         134-514             c
            1409-1541           U82483.1           1405-1537
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1541
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /note="mucosal vascular addressin cell adhesion molecule
                     1"
                     /db_xref="GeneID:8174"
                     /db_xref="HGNC:HGNC:6765"
                     /db_xref="MIM:102670"
     exon            1..66
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1163
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mucosal addressin cell adhesion molecule 1;
                     MAdCAM-1; hMAdCAM-1"
                     /codon_start=1
                     /product="mucosal addressin cell adhesion molecule 1
                     isoform a precursor"
                     /protein_id="NP_570116.2"
                     /db_xref="CCDS:CCDS12028.1"
                     /db_xref="GeneID:8174"
                     /db_xref="HGNC:HGNC:6765"
                     /db_xref="MIM:102670"
                     /translation="MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQ
                     LTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRT
                     FQHTVQLLVYAFPDQLTVSPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEG
                     AQALGPEVQEEEEEPQGDEDVLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHR
                     QAIPVLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQ
                     GSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLL
                     ALPTYHLWKRCRHLAEDDTHPPASLRLLPQVSAWAGLRGTGQVGISPS"
     exon            67..351
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..681
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..942
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1541
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /note="hexamer: AATAAA"
     polyA_site      1541
                     /gene="MADCAM1"
                     /gene_synonym="MACAM1"
                     /note="major polyA site"
ORIGIN      
        1 agaggggact gagcatggat ttcggactgg ccctcctgct ggcggggctt ctggggctcc
       61 tcctcggcca gtccctccag gtgaagcccc tgcaggtgga gcccccggag ccggtggtgg
      121 ccgtggcctt gggcgcctcg cgccagctca cctgccgcct ggcctgcgcg gaccgcgggg
      181 cctcggtgca gtggcggggc ctggacacca gcctgggcgc ggtgcagtcg gacacgggcc
      241 gcagcgtcct caccgtgcgc aacgcctcgc tgtcggcggc cgggacccgc gtgtgcgtgg
      301 gctcctgcgg gggccgcacc ttccagcaca ccgtgcagct ccttgtgtac gccttcccgg
      361 accagctgac cgtctcccca gcagccctgg tgcctggtga cccggaggtg gcctgtacgg
      421 cccacaaagt cacgcccgtg gaccccaacg cgctctcctt ctccctgctc gtcgggggcc
      481 aggaactgga gggggcgcaa gccctgggcc cggaggtgca ggaggaggag gaggagcccc
      541 agggggacga ggacgtgctg ttcagggtga cagagcgctg gcggctgccg cccctgggga
      601 cccctgtccc gcccgccctc tactgccagg ccacgatgag gctgcctggc ttggagctca
      661 gccaccgcca ggccatcccc gtcctgcaca gcccgacctc cccggagcct cccgacacca
      721 cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc tcccaggagc
      781 ctcccgacac cacctccccg gagcctcccg acaagacctc cccggagccc gccccccagc
      841 agggctccac acacaccccc aggagcccag gctccaccag gactcgccgc cctgagatct
      901 cccaggctgg gcccacgcag ggagaagtga tcccaacagg ctcgtccaaa cctgcgggtg
      961 accagctgcc cgcggctctg tggaccagca gtgcggtgct gggactgctg ctcctggcct
     1021 tgcccaccta tcacctctgg aaacgctgcc ggcacctggc tgaggacgac acccacccac
     1081 cagcttctct gaggcttctg ccccaggtgt cggcctgggc tgggttaagg gggaccggcc
     1141 aggtcgggat cagcccctcc tgagtggcca gcctttcccc ctgtgaaagc aaaatagctt
     1201 ggaccccttc aagttgagaa ctggtcaggg caaacctgcc tcccattcta ctcaaagtca
     1261 tccctctgtt cacagagatg gatgcatgtt ctgattgcct ctttggagaa gctcatcaga
     1321 aactcaaaag aaggccactg tttgtctcac ctacccatga cctgaagccc ctccctgagt
     1381 ggtccccacc tttctggacg gaaccacgta ctttttacat acattgattc atgtctcacg
     1441 tctccctaaa aatgcgtaag accaagctgt gccctgacca ccctgggccc ctgtcgtcag
     1501 gacctcctga ggctttggca aataaacctc ctaaaatgat a
//
