LOCUS       NM_006341               1053 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens mitotic arrest deficient 2 like 2 (MAD2L2), transcript
            variant 2, mRNA.
ACCESSION   NM_006341
VERSION     NM_006341.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1053)
  AUTHORS   Li,L., Jiang,P., Hu,W., Zou,F., Li,M., Rao,T., Ruan,Y., Yu,W.,
            Ning,J. and Cheng,F.
  TITLE     AURKB promotes bladder cancer progression by deregulating the p53
            DNA damage response pathway via MAD2L2
  JOURNAL   J Transl Med 22 (1), 295 (2024)
   PUBMED   38515112
  REMARK    GeneRIF: AURKB promotes bladder cancer progression by deregulating
            the p53 DNA damage response pathway via MAD2L2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1053)
  AUTHORS   Biller,M., Kabir,S., Boado,C., Nipper,S., Saffa,A., Tal,A.,
            Allen,S., Sasanuma,H., Dreau,D., Vaziri,C. and Tomida,J.
  TITLE     REV7-p53 interaction inhibits ATM-mediated DNA damage signaling
  JOURNAL   Cell Cycle 23 (4), 339-352 (2024)
   PUBMED   38557443
  REMARK    GeneRIF: REV7-p53 interaction inhibits ATM-mediated DNA damage
            signaling.
REFERENCE   3  (bases 1 to 1053)
  AUTHORS   Xu,K., Zheng,X., Shi,H., Ou,J. and Ding,H.
  TITLE     MAD2L2, a key regulator in ovarian cancer and promoting tumor
            progression
  JOURNAL   Sci Rep 14 (1), 130 (2024)
   PUBMED   38167649
  REMARK    GeneRIF: MAD2L2, a key regulator in ovarian cancer and promoting
            tumor progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1053)
  AUTHORS   Liu,Z., Wang,S., Yu,K., Chen,K., Zhao,L., Zhang,J., Dai,K. and
            Zhao,P.
  TITLE     The promoting effect and mechanism of MAD2L2 on stemness
            maintenance and malignant progression in glioma
  JOURNAL   J Transl Med 21 (1), 863 (2023)
   PUBMED   38017538
  REMARK    GeneRIF: The promoting effect and mechanism of MAD2L2 on stemness
            maintenance and malignant progression in glioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1053)
  AUTHORS   Shimada,Y., Kato,T., Sakurai,Y., Watanabe,H., Nonaka,M.,
            Nanaura,N., Ichinoe,M. and Murakumo,Y.
  TITLE     Identification of the promoter region regulating the transcription
            of the REV7 gene
  JOURNAL   Biochem Biophys Res Commun 662, 8-17 (2023)
   PUBMED   37094431
  REMARK    GeneRIF: Identification of the promoter region regulating the
            transcription of the REV7 gene.
REFERENCE   6  (bases 1 to 1053)
  AUTHORS   Murakumo,Y., Roth,T., Ishii,H., Rasio,D., Numata,S., Croce,C.M. and
            Fishel,R.
  TITLE     A human REV7 homolog that interacts with the polymerase zeta
            catalytic subunit hREV3 and the spindle assembly checkpoint protein
            hMAD2
  JOURNAL   J Biol Chem 275 (6), 4391-4397 (2000)
   PUBMED   10660610
REFERENCE   7  (bases 1 to 1053)
  AUTHORS   Nelson,K.K., Schlondorff,J. and Blobel,C.P.
  TITLE     Evidence for an interaction of the metalloprotease-disintegrin
            tumour necrosis factor alpha convertase (TACE) with mitotic arrest
            deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9
            with a novel MAD2-related protein, MAD2beta
  JOURNAL   Biochem J 343 Pt 3 (Pt 3), 673-680 (1999)
   PUBMED   10527948
REFERENCE   8  (bases 1 to 1053)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   9  (bases 1 to 1053)
  AUTHORS   Cahill,D.P., da Costa,L.T., Carson-Walter,E.B., Kinzler,K.W.,
            Vogelstein,B. and Lengauer,C.
  TITLE     Characterization of MAD2B and other mitotic spindle checkpoint
            genes
  JOURNAL   Genomics 58 (2), 181-187 (1999)
   PUBMED   10366450
REFERENCE   10 (bases 1 to 1053)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF157482.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006341.3.
            
            Summary: The protein encoded by this gene is a component of the
            mitotic spindle assembly checkpoint that prevents the onset of
            anaphase until all chromosomes are properly aligned at the
            metaphase plate. The encoded protein, which is similar to MAD2L1,
            is capable of interacting with ADAM9, ADAM15, REV1, and REV3
            proteins. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF157482.1, AF072933.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376692.9/ ENSP00000365882.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1053              AF157482.1         67-1119
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1053
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /note="mitotic arrest deficient 2 like 2"
                     /db_xref="GeneID:10459"
                     /db_xref="HGNC:HGNC:6764"
                     /db_xref="MIM:604094"
     exon            1..110
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..162
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..758
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /note="MAD2 (mitotic arrest deficient, yeast,
                     homolog)-like 2; mitotic arrest deficient homolog-like 2;
                     hREV7; MAD2 mitotic arrest deficient-like 2; REV7 homolog;
                     MAD2-like protein 2; mitotic arrest deficient 2-like
                     protein 2; polymerase (DNA-directed), zeta 2, accessory
                     subunit"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD2B"
                     /protein_id="NP_006332.3"
                     /db_xref="CCDS:CCDS134.1"
                     /db_xref="GeneID:10459"
                     /db_xref="HGNC:HGNC:6764"
                     /db_xref="MIM:604094"
                     /translation="MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQK
                     RKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEI
                     TQPPLLSISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNM
                     EKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKGS"
     exon            163..281
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            282..353
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            354..454
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            455..549
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            550..623
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            624..716
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1053
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /note="hexamer: AATAAA"
     polyA_site      1053
                     /gene="MAD2L2"
                     /gene_synonym="FANCV; MAD2B; POLZ2; REV7"
                     /note="major polyA site"
ORIGIN      
        1 accgagcggc gccgaggccc cgggttgagc gggaggcgcg atcggtccgg tcggtggctc
       61 cccgcggcgg ggccgggccc gatctcgggc gggaaccgag cgcagagccg gtagcgggaa
      121 ggatgaccac gctcacacga caagacctca actttggcca agtggtggcc gatgtgctct
      181 gcgagttcct ggaggtggct gtgcatctca tcctctacgt gcgcgaggtc taccccgtgg
      241 gcatcttcca gaaacgcaag aagtacaacg tgccggtcca gatgtcctgc cacccggagc
      301 tgaatcagta tatccaggac acgctgcact gcgtcaagcc actcctggag aagaatgatg
      361 tggagaaagt ggtggtggtg attttggata aagagcaccg cccagtggag aaattcgtct
      421 ttgagatcac ccagcctcca ctgctgtcca tcagctcaga ctcgctgttg tctcatgtgg
      481 agcagctgct ccgggccttc atcctgaaga tcagcgtgtg cgatgccgtc ctggaccaca
      541 accccccagg ctgtaccttc acagtcctgg tgcacacgag agaagccgcc actcgcaaca
      601 tggagaagat ccaggtcatc aaggatttcc cctggatcct ggcggatgag caggatgtcc
      661 acatgcatga cccccggctg ataccactaa aaaccatgac gtcggacatt ttaaagatgc
      721 agctttacgt ggaagagcgc gctcataaag gcagctgagg gggcacctgc caccccactg
      781 atgcccaaac tgtcagactt tgggggatcc ccgcctaggg cagtgctgca tggctgccct
      841 gattccaagt gctcttatcg cctctgtgtg tggatcgccc gccccagccc ggggccgctc
      901 aggtctgctt ggaggatgcc tcccccagga gggcagtgag ggatgccgca acctcgactt
      961 ctcagcctcc tggggttccg ccggccaaca ctgtctgtct caaatactgt gctgtgagtt
     1021 gtttcaataa aggggcccca agggctgggc tga
//
