LOCUS       NM_002358               5227 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens mitotic arrest deficient 2 like 1 (MAD2L1), mRNA.
ACCESSION   NM_002358
VERSION     NM_002358.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5227)
  AUTHORS   Makinoya,M., Miyatani,K., Matsumi,Y., Sakano,Y., Shimizu,S.,
            Shishido,Y., Hanaki,T., Kihara,K., Matsunaga,T., Yamamoto,M.,
            Tokuyasu,N., Takano,S., Sakamoto,T., Hasegawa,T., Saito,H.,
            Nakayama,Y., Osaki,M., Okada,F. and Fujiwara,Y.
  TITLE     Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to
            intraperitoneal paclitaxel therapy in gastric cancer patients with
            peritoneal metastasis
  JOURNAL   Sci Rep 14 (1), 10075 (2024)
   PUBMED   38698201
  REMARK    GeneRIF: Exosomal miR-493 suppresses MAD2L1 and induces
            chemoresistance to intraperitoneal paclitaxel therapy in gastric
            cancer patients with peritoneal metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5227)
  AUTHORS   Park,S.E., Chung,K.S., Heo,S.W., Kim,S.Y., Lee,J.H., Hassan,A.H.E.,
            Lee,Y.S., Lee,J.Y. and Lee,K.T.
  TITLE     Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting
            microtubule dynamics and Wnt/beta-catenin/EMT signaling in human
            colorectal cancer cells
  JOURNAL   Life Sci 334, 122227 (2023)
   PUBMED   37926298
REFERENCE   3  (bases 1 to 5227)
  AUTHORS   Jiang,W., Yang,X., Shi,K., Zhang,Y., Shi,X., Wang,J., Wang,Y.,
            Chenyan,A., Shan,J., Wang,Y., Chang,J., Chen,R., Zhou,T., Zhu,Y.,
            Yu,Y., Li,C. and Li,X.
  TITLE     MAD2 activates IGF1R/PI3K/AKT pathway and promotes
            cholangiocarcinoma progression by interfering USP44/LIMA1 complex
  JOURNAL   Oncogene 42 (45), 3344-3357 (2023)
   PUBMED   37752233
  REMARK    GeneRIF: MAD2 activates IGF1R/PI3K/AKT pathway and promotes
            cholangiocarcinoma progression by interfering USP44/LIMA1 complex.
REFERENCE   4  (bases 1 to 5227)
  AUTHORS   Chuah,Y.H., Tay,E.X.Y., Grinchuk,O.V., Yoon,J., Feng,J., Kannan,S.,
            Robert,M., Jakhar,R., Liang,Y., Lee,B.W.L., Wang,L.C., Lim,Y.T.,
            Zhao,T., Sobota,R.M., Lu,G., Low,B.C., Crasta,K.C., Verma,C.S.,
            Lin,Z. and Ong,D.S.T.
  TITLE     CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to
            induce mitotic checkpoint in glioma
  JOURNAL   Cell Death Differ 30 (8), 1973-1987 (2023)
   PUBMED   37468549
  REMARK    GeneRIF: CAMK2D serves as a molecular scaffold for RNF8-MAD2
            complex to induce mitotic checkpoint in glioma.
REFERENCE   5  (bases 1 to 5227)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5227)
  AUTHORS   Krishnan,R., Goodman,B., Jin,D.Y., Jeang,K.T., Collins,C.,
            Stetten,G. and Spencer,F.
  TITLE     Map location and gene structure of the Homo sapiens mitotic arrest
            deficient 2 (MAD2L1) gene at 4q27
  JOURNAL   Genomics 49 (3), 475-478 (1998)
   PUBMED   9615237
REFERENCE   7  (bases 1 to 5227)
  AUTHORS   Jin,D.Y., Spencer,F. and Jeang,K.T.
  TITLE     Human T cell leukemia virus type 1 oncoprotein Tax targets the
            human mitotic checkpoint protein MAD1
  JOURNAL   Cell 93 (1), 81-91 (1998)
   PUBMED   9546394
REFERENCE   8  (bases 1 to 5227)
  AUTHORS   O'Neill,T.J., Zhu,Y. and Gustafson,T.A.
  TITLE     Interaction of MAD2 with the carboxyl terminus of the insulin
            receptor but not with the IGFIR. Evidence for release from the
            insulin receptor after activation
  JOURNAL   J Biol Chem 272 (15), 10035-10040 (1997)
   PUBMED   9092546
REFERENCE   9  (bases 1 to 5227)
  AUTHORS   Xu,L., Deng,H.X., Yang,Y., Xia,J.H., Hung,W.Y. and Siddque,T.
  TITLE     Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human
            chromosome band 5q23.3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 78 (1), 63-64 (1997)
   PUBMED   9345911
REFERENCE   10 (bases 1 to 5227)
  AUTHORS   Li,Y. and Benezra,R.
  TITLE     Identification of a human mitotic checkpoint gene: hsMAD2
  JOURNAL   Science 274 (5285), 246-248 (1996)
   PUBMED   8824189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA443733.1, AK313827.1,
            AK223433.1, BC000356.2 and AC097173.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002358.3.
            
            Summary: MAD2L1 is a component of the mitotic spindle assembly
            checkpoint that prevents the onset of anaphase until all
            chromosomes are properly aligned at the metaphase plate.  MAD2L1 is
            related to the MAD2L2 gene located on chromosome 1.  A MAD2
            pseudogene has been mapped to chromosome 14. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1576249.1,
                                           SRR14038196.1848721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296509.11/ ENSP00000296509.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AA443733.1         11-38
            29-732              AK313827.1         1-704
            733-1080            AK223433.1         704-1051
            1081-1428           BC000356.2         1041-1388
            1429-5227           AC097173.1         126556-130354       c
FEATURES             Location/Qualifiers
     source          1..5227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..5227
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="mitotic arrest deficient 2 like 1"
                     /db_xref="GeneID:4085"
                     /db_xref="HGNC:HGNC:6763"
                     /db_xref="MIM:601467"
     exon            1..187
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..732
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="mitotic arrest deficient, yeast, homolog-like 1;
                     MAD2 (mitotic arrest deficient, yeast, homolog)-like 1;
                     MAD2-like protein 1; mitotic arrest deficient 2-like
                     protein 1; MAD2 mitotic arrest deficient-like 1"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD2A"
                     /protein_id="NP_002349.1"
                     /db_xref="CCDS:CCDS3715.1"
                     /db_xref="GeneID:4085"
                     /db_xref="HGNC:HGNC:6763"
                     /db_xref="MIM:601467"
                     /translation="MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFT
                     RVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQF
                     DIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKD
                     LVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND"
     exon            188..334
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..455
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..559
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..5227
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="hexamer: AATAAA"
     polyA_site      1416
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="major polyA site"
     regulatory      4838..4843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="hexamer: AATAAA"
     polyA_site      4857
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
     regulatory      5206..5211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
                     /note="hexamer: GATAAA"
     polyA_site      5227
                     /gene="MAD2L1"
                     /gene_synonym="HSMAD2; MAD2"
ORIGIN      
        1 ctgacgacgt gctgcgtcgt tacttttgaa acgcttggcg gggaagtgct gttggagccg
       61 ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt ttgtgtccct ggccatggcg
      121 ctgcagctct cccgggagca gggaatcacc ctgcgcggga gcgccgaaat cgtggccgag
      181 ttcttctcat tcggcatcaa cagcatttta tatcagcgtg gcatatatcc atctgaaacc
      241 tttactcgag tgcagaaata cggactcacc ttgcttgtaa ctactgatct tgagctcata
      301 aaatacctaa ataatgtggt ggaacaactg aaagattggt tatacaagtg ttcagttcag
      361 aaactggttg tagttatctc aaatattgaa agtggtgagg tcctggaaag atggcagttt
      421 gatattgagt gtgacaagac tgcaaaagat gacagtgcac ccagagaaaa gtctcagaaa
      481 gctatccagg atgaaatccg ttcagtgatc agacagatca cagctacggt gacatttctg
      541 ccactgttgg aagtttcttg ttcatttgat ctgctgattt atacagacaa agatttggtt
      601 gtacctgaaa aatgggaaga gtcgggacca cagtttatta ccaattctga ggaagtccgc
      661 cttcgttcat ttactactac aatccacaaa gtaaatagca tggtggccta caaaattcct
      721 gtcaatgact gaggatgaca tgaggaaaat aatgtaattg taattttgaa atgtggtttt
      781 cctgaaatca agtcatctat agttgatatg ttttatttca ttggttaatt tttacatgga
      841 gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt ccttttattt ttttggtacc
      901 tatttgactt accatggagt taacatcatg aatttattgc acattgttca aaaggaacca
      961 ggaggttttt ttgtcaacat tgtgatgtat attcctttga agatagtaac tgtagatgga
     1021 aaaacttgtg ctataaagct agatgctttc ctaaatcaga tgttttggtc aagtagtttg
     1081 actcagtata ggtagggaga tatttaagta taaaatacaa caaaggaagt ctaaatattc
     1141 agaatctttg ttaaggtcct gaaagtaact cataatctat aaacaatgaa atattgctgt
     1201 atagctcctt ttgaccttca tttcatgtat agttttccct attgaatcag tttccaatta
     1261 tttgacttta atttatgtaa cttgaaccta tgaagcaatg gatatttgta ctgtttaatg
     1321 ttctgtgata cagaactctt aaaaatgttt tttcatgtgt tttataaaat caagttttaa
     1381 gtgaaagtga ggaaataaag ttaagtttgt tttaaatttg tcttaaaaca ttttgatact
     1441 ggtttggtgt tgatatagtt aaatggtaat tagaattgat tcagcatagc taatgaattc
     1501 ttgttcctac gaagttatag aacttaaggg tccaaagttg agtgagtctt gaggtgtctt
     1561 caatctaatg gataaacttt gatcacatcc tgttcatctc atagcaatag acttaaggct
     1621 attacttcat cattgtgaaa agataaatgt cctttggaat tagtccaaca attccagttg
     1681 aacaagtgtt gattttagta ctttactata ctcttagcct tattgtcagc ctacttttcc
     1741 ttatatactt aaatactatg cttattcctg tgctttcatt aataccctca tctggtacat
     1801 gctttctatc cagttctcac ctgtttttcc aaggtcagtt taaggcagat ttgtaaagtc
     1861 ttctctaatc tctaatctaa atctgacctc attttgtaaa aattcagttt attaatgttt
     1921 attattagac actaagttct ttatgtgtat taacttattt aaccttcact atttttaagt
     1981 aattgcacat agtctgaatc tgttcattca gaaattacat attgagcaaa tactgtggat
     2041 cagtggcagt ttctgggttc tcagtgacaa atttgtagac tcttcatatc tttatggaat
     2101 aagtggacca ctggtgttac caacctagat gatttcaaga aaagtggcaa ttaaatgctt
     2161 catttgtatt ttaactattt gagaagtcag actaaattct gcgaaatcac ttttcccccc
     2221 caagatggag tcttattctg tcgcccaggc tggagtacag tgacgcagct cagctcacta
     2281 cagcctctgc ctcccggatt ccagccattc ttccgtctca gcctcctgag tagctgggat
     2341 tacaggcacg tgccaccaca cctggctaat ttttatattt ttagtagaga gagggtttca
     2401 ccatgttggc caggctagtc ttgaactcct gacctcatga tctgcccgcc ttgacctcac
     2461 aaagcattgg gattacaggc gtgagccact gcgcccggct gaaatcacat ttttaaaggt
     2521 tgtgtgtata ctctggtcat ttcaactcag ctaccaatat taacaggatt aaattcttag
     2581 atttttgtat catttgcatg ctactattta ctctgaggtt tctggagagc tagtcatgat
     2641 gagtcatttt accccttaca gattatataa tcaattaaga aatacacatt ttgggctggg
     2701 cgcagtggct cgcgcctgta atcccagcac tttgggaggc cgaggcaggt ggatcacgag
     2761 atcaggagtt tgagaccagc ctggccaaga tggtcaaacc ccgtctctac taaaaatata
     2821 aaaattagct gggcgtggtg gcgggcgcat ctcagctact tgggaggctg aggcaggaga
     2881 aatcgcttga acccatgagg tggaggttgc ggtgagccaa gaccgtgcca ctgtactcta
     2941 gcctgggcga cagagcaagg ctccatctca aaaaataata aataaaaaag aaatacacat
     3001 tttggagctg agtgggagcc aaactatgag ttttattgag gtgaagctat actggaaaag
     3061 ctttgccctg tagctccaag tggactgtcc catcctcttt ctagaccttg aggcttacct
     3121 caggaggatg atgtttaaat caacagctga aagacttgtg agtggtttct acaccatgtt
     3181 aaagagaagg ttctaagaca gcatgatagg cctctaggcc tggcctggac tctggctcag
     3241 tgttgcttac catatgtaga ggatgaacag aggttaagcc catcaaggtc tgaagtagag
     3301 cccaggagga actgaactgt atctggcttt caggatcctt ttcccagtgt catcaatcag
     3361 agaagtcaaa cctctgtgag aatgcttgtg cagaggtata acagtctcat gtattggttg
     3421 gcttttgctg cacctttctc attctgttgg agggacattg gttagtcagg actctgaagg
     3481 ccagcttttt cacactgacc aaagcaagtg aaggtcaagc ctaactttaa tgggaccagg
     3541 aagtatactc ctcccatgga ggtggtggga atggcaccga gaagtttgat gacagttatc
     3601 taatggacta gaggttggca aactttctgt aaatggccag gtagtaaata gttctgcttt
     3661 tgaaggcata tggtctcttg cacctactcg aggctgaaag cagctataga caatacataa
     3721 atgaatgagc gtgagtgtgt tccaataaga aaaaaacatg gctgtttgct tcggccccag
     3781 ggttgtagct taccagtcct gtaacagatc acagtttgct cttttggtca caaatacttg
     3841 aacccctccc tagttcagag catttgatac cgtaatattt aaagctcact tgtaaaacat
     3901 cgtttgttgc ctccatccat agtatctcaa acagaatgtc tctcccaaat atacctaaat
     3961 tccatattct ctgaagcaca accagctatt ttcttgacat acttcctaac acaccccaca
     4021 gttcacaatt tgatctgaaa acttgttaag ggaggttctt tggcatgtga tgccataaaa
     4081 agagaggtat gggctctcct ttaaaaaaga gacccttttt atgagactca caataggata
     4141 aagagcccat gcctattttt aatcattttt tcactatata gacatgcatg ctgaaaaatg
     4201 tttttattag tataatgcta attatactga cttcctatat attttagcat atagattcaa
     4261 agattattag cacaataagg tagataactt catagaccat ttcttcatct tgttttcatt
     4321 tagtatgtaa aatttatcta aaatttacat gaaagatcag aatagctatg taatgctact
     4381 ttgtaactct tatattttcc accagatgtc actaatgctg taatattcaa attaagatga
     4441 ctttcttttg gttctaaagg ctgtaagctt attggaaaag caaggttact cagcattgga
     4501 attcctggca acaaatatat aaatacatta ggggaataaa cacttagcat ttattattta
     4561 ctagtcactt cacatgaatt tttatttaat tctcatgctt ttgtgcacaa gtaaaactgg
     4621 gggtcaatgg gcatgcaaat tgtgtcgtgg tttttgaagt ttagtggtct ctcctatccc
     4681 tggccaagga agtatgcaaa ttgtattgtg gtttttgaag tttaggtgat ctcttccttc
     4741 tatccctagc caaggaagtt catcctgact ccccaacaag catatcaaaa ggagtgtttc
     4801 gtcacctttt tcctcttacc ctttacatcc ttttagcaat aaagtgttca gaacaaactg
     4861 gttttccttt actgtgcttt gcaaaactta ttcatgtttt attgggtgac tttgtattta
     4921 cactttcctc agatagtctg ttgtcagatg actttgacca atgattggga ggaaccaaat
     4981 acagaggatt ttatcctatg cctaatctat attgtctaca gagtaaatca ggtatgaatt
     5041 tgtgaacagt aatgaaacaa ttttccaact aatcagaaga attgtttgtt aagtaacctt
     5101 aattactcag tttttggtga attgtttgcg gcttaacttg taaataattt cttattcttt
     5161 ttttaaatgt atgaaatatt tctagttatt ttgttcaatg tgactgataa aagtttatat
     5221 tggaata
//
