LOCUS       NM_001351661            4916 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens mono-ADP ribosylhydrolase 2 (MACROD2), transcript
            variant 3, mRNA.
ACCESSION   NM_001351661 XM_017027677
VERSION     NM_001351661.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4916)
  AUTHORS   Gelemanovic,A., Catipovic Ardalic,T., Pribisalic,A., Hayward,C.,
            Kolcic,I. and Polasek,O.
  TITLE     Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants
            to Predict Common Human Infectious Diseases Risk
  JOURNAL   Int J Mol Sci 24 (8), 7006 (2023)
   PUBMED   37108169
  REMARK    GeneRIF: Genome-Wide Meta-Analysis Identifies Multiple Novel Rare
            Variants to Predict Common Human Infectious Diseases Risk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4916)
  AUTHORS   Zhao,J., Zheng,W., Wang,L., Jiang,H., Wang,X., Hou,J., Xu,A. and
            Cong,J.
  TITLE     Human papillomavirus (HPV) integration signature in cervical
            lesions: identification of MACROD2 gene as HPV hot spot integration
            site
  JOURNAL   Arch Gynecol Obstet 307 (4), 1115-1123 (2023)
   PUBMED   36008642
  REMARK    GeneRIF: Human papillomavirus (HPV) integration signature in
            cervical lesions: identification of MACROD2 gene as HPV hot spot
            integration site.
REFERENCE   3  (bases 1 to 4916)
  AUTHORS   Yang,J., Han,Y., Lee,J.H. and Yoo,H.J.
  TITLE     Association of the MACROD2 rs6110695 A>G polymorphism with an
            increasing WBC count in a Korean population
  JOURNAL   Immun Inflamm Dis 10 (7), e669 (2022)
   PUBMED   35759225
  REMARK    GeneRIF: Association of the MACROD2 rs6110695 A>G polymorphism with
            an increasing WBC count in a Korean population.
REFERENCE   4  (bases 1 to 4916)
  AUTHORS   Kim,H.R., Jin,H.S. and Eom,Y.B.
  TITLE     Association of MACROD2 gene variants with obesity and physical
            activity in a Korean population
  JOURNAL   Mol Genet Genomic Med 9 (4), e1635 (2021)
   PUBMED   33624934
  REMARK    GeneRIF: Association of MACROD2 gene variants with obesity and
            physical activity in a Korean population.
REFERENCE   5  (bases 1 to 4916)
  AUTHORS   Kamal,M., Lameiras,S., Deloger,M., Morel,A., Vacher,S., Lecerf,C.,
            Dupain,C., Jeannot,E., Girard,E., Baulande,S., Dubot,C., Kenter,G.,
            Jordanova,E.S., Berns,E.M.J.J., Bataillon,G., Popovic,M.,
            Rouzier,R., Cacheux,W., Le Tourneau,C., Nicolas,A., Servant,N.,
            Scholl,S.M. and Bieche,I.
  CONSRTM   RAIDs Consortium
  TITLE     Human papilloma virus (HPV) integration signature in Cervical
            Cancer: identification of MACROD2 gene as HPV hot spot integration
            site
  JOURNAL   Br J Cancer 124 (4), 777-785 (2021)
   PUBMED   33191407
  REMARK    GeneRIF: Human papilloma virus (HPV) integration signature in
            Cervical Cancer: identification of MACROD2 gene as HPV hot spot
            integration site.
            Erratum:[Br J Cancer. 2023 May;128(9):1790. doi:
            10.1038/s41416-023-02261-7.. PMID: 37055522]
REFERENCE   6  (bases 1 to 4916)
  AUTHORS   Soranzo,N., Spector,T.D., Mangino,M., Kuhnel,B., Rendon,A.,
            Teumer,A., Willenborg,C., Wright,B., Chen,L., Li,M., Salo,P.,
            Voight,B.F., Burns,P., Laskowski,R.A., Xue,Y., Menzel,S.,
            Altshuler,D., Bradley,J.R., Bumpstead,S., Burnett,M.S., Devaney,J.,
            Doring,A., Elosua,R., Epstein,S.E., Erber,W., Falchi,M.,
            Garner,S.F., Ghori,M.J., Goodall,A.H., Gwilliam,R.,
            Hakonarson,H.H., Hall,A.S., Hammond,N., Hengstenberg,C., Illig,T.,
            Konig,I.R., Knouff,C.W., McPherson,R., Melander,O., Mooser,V.,
            Nauck,M., Nieminen,M.S., O'Donnell,C.J., Peltonen,L., Potter,S.C.,
            Prokisch,H., Rader,D.J., Rice,C.M., Roberts,R., Salomaa,V.,
            Sambrook,J., Schreiber,S., Schunkert,H., Schwartz,S.M.,
            Serbanovic-Canic,J., Sinisalo,J., Siscovick,D.S., Stark,K.,
            Surakka,I., Stephens,J., Thompson,J.R., Volker,U., Volzke,H.,
            Watkins,N.A., Wells,G.A., Wichmann,H.E., Van Heel,D.A.,
            Tyler-Smith,C., Thein,S.L., Kathiresan,S., Perola,M., Reilly,M.P.,
            Stewart,A.F., Erdmann,J., Samani,N.J., Meisinger,C., Greinacher,A.,
            Deloukas,P., Ouwehand,W.H. and Gieger,C.
  TITLE     A genome-wide meta-analysis identifies 22 loci associated with
            eight hematological parameters in the HaemGen consortium
  JOURNAL   Nat Genet 41 (11), 1182-1190 (2009)
   PUBMED   19820697
REFERENCE   7  (bases 1 to 4916)
  AUTHORS   Cotsapas,C., Speliotes,E.K., Hatoum,I.J., Greenawalt,D.M.,
            Dobrin,R., Lum,P.Y., Suver,C., Chudin,E., Kemp,D., Reitman,M.,
            Voight,B.F., Neale,B.M., Schadt,E.E., Hirschhorn,J.N., Kaplan,L.M.
            and Daly,M.J.
  CONSRTM   GIANT Consortium
  TITLE     Common body mass index-associated variants confer risk of extreme
            obesity
  JOURNAL   Hum Mol Genet 18 (18), 3502-3507 (2009)
   PUBMED   19553259
  REMARK    Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1]
REFERENCE   8  (bases 1 to 4916)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 4916)
  AUTHORS   Kuniba,H., Tsuda,M., Nakashima,M., Miura,S., Miyake,N., Kondoh,T.,
            Matsumoto,T., Moriuchi,H., Ohashi,H., Kurosawa,K., Tonoki,H.,
            Nagai,T., Okamoto,N., Kato,M., Fukushima,Y., Naritomi,K.,
            Matsumoto,N., Kinoshita,A., Yoshiura,K.I. and Niikawa,N.
  TITLE     Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki
            syndrome in Japan
  JOURNAL   J Med Genet 45 (7), 479-480 (2008)
   PUBMED   18593871
  REMARK    GeneRIF: Authors describe the results of a deletion assay for the
            exon 5 in C20orf133 and a mutation analysis of C20orf133 and FLRT3
            in patients with Kabuki Syndrome.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4916)
  AUTHORS   Maas,N.M., Van de Putte,T., Melotte,C., Francis,A.,
            Schrander-Stumpel,C.T., Sanlaville,D., Genevieve,D., Lyonnet,S.,
            Dimitrov,B., Devriendt,K., Fryns,J.P. and Vermeesch,J.R.
  TITLE     The C20orf133 gene is disrupted in a patient with Kabuki syndrome
  JOURNAL   J Med Genet 44 (9), 562-569 (2007)
   PUBMED   17586838
  REMARK    GeneRIF: A 250 kb de novo microdeletion at 20p12.1, deleting exon 5
            of C20orf133, was seen in a Kabuki syndrome case. The de novo
            deletion, the expression data & the fact that C20orf133 has a macro
            domain make it a likely candidate to cause KS in this patient.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117333.26, AL353798.9,
            AL121582.19, AL354773.8, AL049633.3, AL158088.6, AL121584.24,
            AL079338.16, AL357654.9 and AL136991.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001351661.1.
            
            Summary: The protein encoded by this gene is a deacetylase involved
            in removing ADP-ribose from mono-ADP-ribosylated proteins. The
            encoded protein has been shown to translocate from the nucleus to
            the cytoplasm upon DNA damage. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4561137.1,
                                           SRR14038193.112686.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN03568911
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684519.1/ ENSP00000507484.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AL117333.26        92213-92506
            295-411             AL117333.26        98985-99101
            412-519             AL353798.9         25605-25712
            520-549             AL121582.19        68525-68554
            550-666             AL354773.8         51655-51771
            667-788             AL049633.3         60493-60614         c
            789-819             AL158088.6         44603-44633
            820-893             AL121584.24        60907-60980
            894-975             AL079338.16        19831-19912
            976-1023            AL079338.16        42850-42897
            1024-1086           AL079338.16        90362-90424
            1087-1155           AL079338.16        94562-94630
            1156-1233           AL357654.9         2273-2350
            1234-1308           AL357654.9         21447-21521
            1309-1401           AL357654.9         21786-21878
            1402-1479           AL136991.26        53370-53447
            1480-1548           AL136991.26        56740-56808
            1549-4916           AL136991.26        61999-65366
FEATURES             Location/Qualifiers
     source          1..4916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..4916
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /note="mono-ADP ribosylhydrolase 2"
                     /db_xref="GeneID:140733"
                     /db_xref="HGNC:HGNC:16126"
                     /db_xref="MIM:611567"
     exon            1..294
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1595
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /note="isoform 3 is encoded by transcript variant 3; MACRO
                     domain-containing protein 2; O-acetyl-ADP-ribose
                     deacetylase MACROD2; [Protein ADP-ribosylglutamate]
                     hydrolase; MACRO domain containing 2; [Protein
                     ADP-ribosylaspartate] hydrolase MACROD2; [Protein
                     ADP-ribosylglutamate] hydrolase MACROD2; ADP-ribose
                     glycohydrolase MACROD2"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD2 isoform 3"
                     /protein_id="NP_001338590.1"
                     /db_xref="CCDS:CCDS93008.1"
                     /db_xref="GeneID:140733"
                     /db_xref="HGNC:HGNC:16126"
                     /db_xref="MIM:611567"
                     /translation="MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWK
                     EEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVD
                     GCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKED
                     LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDR
                     IIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQS
                     QDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDS
                     TKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPR
                     MPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRNGTK"
     exon            295..411
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            412..519
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            520..549
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            550..666
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            667..788
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            789..819
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            820..893
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            894..975
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1023
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1086
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1155
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1233
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1308
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1401
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1479
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1548
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..4916
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4880..4885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /note="hexamer: AATACA"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /note="hexamer: AATAAA"
     polyA_site      4896
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
     polyA_site      4916
                     /gene="MACROD2"
                     /gene_synonym="C20orf133; C2orf133"
                     /note="major polyA site"
ORIGIN      
        1 gacaggctct gaggtgctgc tgtggcggcg tccgcggggc tgaggcgggt gggagccgga
       61 gccgagcgcg ggctgaggga ggagggcggc gactggagag cggcgagcgg cgagcagcgc
      121 aggacgcaga gcctctttca ctttttccct gctgagtgcc ccctcccacc cctcccactc
      181 cacacacacc ctgtttgccc gtgagcctgg ggaacttgca gcttaaagcc agccaccccc
      241 acggcaacat gtaccccagc aacaagaaga aaaaggtgtg gagagaggag aaagaacgtt
      301 tattgaagat gaccttagaa gagagacgca aagaatacct aagagactat attcccctga
      361 acagcattct atcatggaag gaggagatga agggcaaggg ccaaaatgat gaagaaaata
      421 ctcaggaaac atcccaggtg aagaaaagtt tgactgaaaa agtttctctc tatagaggtg
      481 acatcacatt gctagaggta gatgctatag tcaatgccgc aaatgccagt cttcttggag
      541 gaggaggtgt ggatggctgt attcatagag cagccggccc ctgtttgcta gctgaatgtc
      601 gtaacctgaa tggctgtgat actggacatg caaaaatcac atgtggctat gaccttcctg
      661 caaaatatgt catccatact gtagggccaa tagccagggg ccatattaat ggttcccaca
      721 aggaagacct tgcaaattgc tataaatcat ctctgaagct cgtgaaagaa aataacatcc
      781 gatcagttgc atttccctgc atctcaacag gcatttatgg ctttcccaac gagcctgctg
      841 cagtcattgc cctcaacacc attaaggaat ggcttgccaa gaatcaccat gaggtggatc
      901 ggatcatttt ctgtgtcttc ttagaagttg acttcaaaat ctacaaaaag aaaatgaatg
      961 agtttttctc cgtagacgat aataatgaag aagaagagga tgttgaaatg aaagaagatt
     1021 cagatgagaa cggtccagag gagaagcaaa gtgtggaaga aatggaagag cagagccaag
     1081 atgcagatgg tgtcaacact gtcactgtgc ccggccctgc ttcagaagag gcagttgaag
     1141 actgtaaaga tgaagatttt gcaaaggatg aaaatattac aaaaggcggt gaagtgacag
     1201 atcattctgt gcgtgaccaa gatcatcccg atggacaaga gaatgattca acgaagaatg
     1261 aaataaaaat tgaaacagaa tcgcagagct catatatgga aacagaagaa ctttcatcaa
     1321 accaagaaga tgccgtgatt gtggagcaac cagaagtgat tccattaaca gaggaccaag
     1381 aagaaaaaga aggtgaaaaa gctccaggcg aggacacacc taggatgcct gggaaaagtg
     1441 aaggctccag tgacctagaa aatactccag gtcctgatgt tgaaatgaat agtcaggttg
     1501 acaaggtaaa tgacccaaca gagagtcaac aagaagatca actaatagca ggggcacaag
     1561 atgaagcgaa ggaacaaaga aatggaacta aatgacaatc ctcagcatcg caaggcctct
     1621 cctggctctg ggggagctcg ggaagatagc agcacacgct gtggaggagg gtgggggtgg
     1681 ggggaaggca agtcccatgg aaggacgggg aatcctttac tctaatttct ccagctgcat
     1741 tttgttccgt ttatctgcag aaaaagaaag aaaaaaaaga aaaaaaaagt ttcctttaat
     1801 ttggtggagg gacccatgtt gacgcatctt tcaggcatta tccttgtaat ttctgtcttt
     1861 tctcttacaa ctttgcccca gggtcacagt ggcttgattg aacactcaca tgtgtatcct
     1921 ggcccctgtc tgctttcttg gttatttcac aaagctggtc acacagtggt ttattcaaag
     1981 gaaggggagg aagacagtgg tttgataagc tgcaggataa attttaggaa tcaatgagcc
     2041 cagcagcagt ataatcccca gacagaggag gcaggataga aaatgggcaa aagcctcgga
     2101 aaccacttgg aaaaggtctg gacaatgagg tgaaaatatt ttcttcaggg ttcccaaggc
     2161 acaatttgtt ccaagtggct aatgagaaat atggaagctg aattttttcc agagcagagt
     2221 gcagaggcat aacagaaggg tgggccctgg cagccatctg ggtctcttcc ttcctaacca
     2281 tggtggcagg tgcatccttc tttgacactg actttcagca gagcttactt ggttcatgag
     2341 gtcttcacat ggagactacc agcaagaggt gactctctgc tgcataactg taaaggatgg
     2401 ccctttgcta ggtgttacag ttaaaagcta agaaaagggg cagtgcattt aggacccaaa
     2461 catatgccta tgaatatcaa aagctcctcc tgaaattgct gtgagttttc cataaaagaa
     2521 tatcctgtct tcacccaagg cttgacagcc cacagagtgg tctcatttga aattacagga
     2581 aattagagct tttgcttgca gttctgcctt cctggcctgt gtttaaatgc tgtcacttgt
     2641 ttatgccaag ttcaaggctg attcaatggt tggtcccctc acccagaaaa ccctgaaggg
     2701 gaggatacag ctctgaaggg gggcagcagt actaaaaacc caagatgcca gtggtatagt
     2761 gggcacaagg gatggcgacc atgaggatgc caggcatcat caccaatatc tatcctagag
     2821 ccagtataag gccagatgcc tacttcccac agcctccccg ggttccaaag tcatgtcatt
     2881 gttttcagtg gaaacatatc gtttgttgca tatcttctta aatccatctt ccttgtaagg
     2941 gctttagaac taaaacttac ttatattgtt tttccttaac agagggagaa aaatagtgga
     3001 ttattatttc taaaataaaa ggatgttctg ctttctaaat atcccatcaa aatcttcagt
     3061 tttgcacttt tttgatggaa aattcatctt atcttcctat gactttggtt ttagcctttc
     3121 tgaatttgtt accccttctg gatggcttat ttgatatact ggaatagtta acaagctata
     3181 cttcagcata tgcactatat tctaacaaat tttttttaat aaaatcaaga catcagcaag
     3241 aatgacattt acgtgacctc ataatgtggg attatggcct tctgttgcta ttccagtttg
     3301 atatggaagc atctatatcc tctattgccg ttagatgttg ttgcttttca gaaaagtaac
     3361 gaaaaggctc attttaaaga atccaagaaa cgatgtcatc caaatattga cagtttctac
     3421 atttcatgcc atctttataa ctcaattgaa agttgccgtc attcttgtga agtatttgac
     3481 aagtgcaatc tgctagaagc tcgtttttct tgtgactccc aaatgttagt gctacttagc
     3541 ctcagtaatg agttacagtt gaaaaaaaca tgagggaaac agagggacag agattttcta
     3601 atgaacaatg atggaagaga cctaatgtcc ttgctagaaa cagccaggat ggaaattatc
     3661 cagccctggc attctcctta tcatcaatga cagtcatttt attcatttat ttcaaatgtg
     3721 ggtgggctag aagtggaagg agggaattct ctctgcctaa aaattctaga agaatgaaag
     3781 taatctttgt atccaggaaa ctaagagaat gaggaataaa tatcttcagc ccgactcctg
     3841 aatttgttta ttcttccatc tataattaga ttgtgttttc atttttgctt tgtcatgctt
     3901 tttggttgtt atttggctat acagttttat gctttaaaac aaatgataaa gttaatttcc
     3961 aattcaatag tgaaatatta acaatctaac tatagccaga tcaaagacac ctgaacacag
     4021 aaaaccttta tttgctggtg ctgccattgc acaggctgta caatgaaata gatttgaaaa
     4081 gctgattgat tttcccgcac ataaattctg gatgtcaatt tccaaccaaa ctccaataca
     4141 gctatgtggc atgaagagtt acaggaggga gggaggaaaa tagccctatg ttagtcatgt
     4201 ttgcatacag aggatcaaag taggccttca ccataatagt tctaattaaa atggtcctcg
     4261 ctgtaggaga gacaaagggg cttttcctct agctggtaac tattcagatg atggacaagt
     4321 cttctttcat aaaagattac aaagaaggca tccgaatcac tgtctgtgat actgggtcac
     4381 atattaatca ctgcagctaa ttgtaaatct ttctatgaaa cactgaaaag cctctttgtg
     4441 aattaataca gttctgcttg atgcacttga tttgaaaaga catttctctg tatgtggcgc
     4501 atgtcggctt tgctttgaaa aataacaaag ttagcagaat atgttcaata tattttcttg
     4561 gggaataggg tttttattac atgattcatt aaggatttgc cttaccctga catttgtgat
     4621 ataaaggaaa atcagaaaaa aagtaatttt cttgatcaag atatgttttt acttaatgca
     4681 aataaatgta gtctgttgct tgcaaggaaa aaaaaatggc ttctgatatc tggtataaac
     4741 tgctaaatag gataatacgt gcctcttttg ttaaaccggc atttaaatgc tggactgctt
     4801 ctaaatctgt ttgtttcttt tcatctgtgc catacactaa aaaacaactg ttgccttcat
     4861 actatatttg ttagagcaga atacaaataa aatttgtttg agaggataat gtgaaa
//
