LOCUS       NM_014067               1257 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mono-ADP ribosylhydrolase 1 (MACROD1), transcript
            variant 1, mRNA.
ACCESSION   NM_014067
VERSION     NM_014067.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1257)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1257)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1257)
  AUTHORS   Yang,X., Ma,Y., Li,Y., Dong,Y., Yu,L.L., Wang,H., Guo,L., Wu,C.,
            Yu,X. and Liu,X.
  TITLE     Molecular basis for the MacroD1-mediated hydrolysis of
            ADP-ribosylation
  JOURNAL   DNA Repair (Amst) 94, 102899 (2020)
   PUBMED   32683309
  REMARK    GeneRIF: Molecular basis for the MacroD1-mediated hydrolysis of
            ADP-ribosylation.
REFERENCE   4  (bases 1 to 1257)
  AUTHORS   Zaja,R., Aydin,G., Lippok,B.E., Feederle,R., Luscher,B. and
            Feijs,K.L.H.
  TITLE     Comparative analysis of MACROD1, MACROD2 and TARG1 expression,
            localisation and interactome
  JOURNAL   Sci Rep 10 (1), 8286 (2020)
   PUBMED   32427867
  REMARK    GeneRIF: Comparative analysis of MACROD1, MACROD2 and TARG1
            expression, localisation and interactome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1257)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1257)
  AUTHORS   Calinisan,V., Gravem,D., Chen,R.P., Brittin,S., Mohandas,N.,
            Lecomte,M.C. and Gascard,P.
  TITLE     New insights into potential functions for the protein 4.1
            superfamily of proteins in kidney epithelium
  JOURNAL   Front Biosci 11, 1646-1666 (2006)
   PUBMED   16368544
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1257)
  AUTHORS   Zhao,Y.L., Han,W.D., Li,Q., Mu,Y.M., Lu,X.C., Yu,L., Song,H.J.,
            Li,X., Lu,J.M. and Pan,C.Y.
  TITLE     Mechanism of transcriptional regulation of LRP16 gene expression by
            17-beta estradiol in MCF-7 human breast cancer cells
  JOURNAL   J Mol Endocrinol 34 (1), 77-89 (2005)
   PUBMED   15691879
  REMARK    GeneRIF: ERalpha and Sp1 play a role in activation of the promoter
REFERENCE   8  (bases 1 to 1257)
  AUTHORS   Han,W.D., Mu,Y.M., Lu,X.C., Xu,Z.M., Li,X.J., Yu,L., Song,H.J.,
            Li,M., Lu,J.M., Zhao,Y.L. and Pan,C.Y.
  TITLE     Up-regulation of LRP16 mRNA by 17beta-estradiol through activation
            of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion
            of human breast cancer MCF-7 cell proliferation: a preliminary
            report
  JOURNAL   Endocr Relat Cancer 10 (2), 217-224 (2003)
   PUBMED   12790785
REFERENCE   9  (bases 1 to 1257)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1257)
  AUTHORS   Han,W.D., Yu,L., Lou,F.D., Wang,Q.S., Zhao,Y., Shi,Z.J. and
            Jin,H.J.
  TITLE     [The Application of RACE Technique to Clone the Full-Length cDNA of
            A Novel Leukemia Associated Gene LRP16]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 9 (1), 18-21 (2001)
   PUBMED   12578638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ637198.1, AF202922.2 and BC003188.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014067.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279858.814.1, SRR1163658.302629.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255681.7/ ENSP00000255681.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BQ637198.1         23-89
            68-832              AF202922.2         1-765
            833-1257            BC003188.1         587-1011
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1257
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /note="mono-ADP ribosylhydrolase 1"
                     /db_xref="GeneID:28992"
                     /db_xref="HGNC:HGNC:29598"
                     /db_xref="MIM:610400"
     exon            1..417
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1097
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /EC_number="3.1.1.106"
                     /note="isoform 1 is encoded by transcript variant 1; MACRO
                     domain-containing protein 1; O-acetyl-ADP-ribose
                     deacetylase MACROD1; [Protein ADP-ribosylglutamate]
                     hydrolase; MACRO domain containing 1; [Protein
                     ADP-ribosylaspartate] hydrolase MACROD1; [Protein
                     ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose
                     glycohydrolase MACROD1"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD1 isoform 1"
                     /protein_id="NP_054786.2"
                     /db_xref="CCDS:CCDS8056.1"
                     /db_xref="GeneID:28992"
                     /db_xref="HGNC:HGNC:29598"
                     /db_xref="MIM:610400"
                     /translation="MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGP
                     PAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLSTSTDWKEAKSFL
                     KGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSD
                     ITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGPLLTDECRTLQSCKTGKAKITGGYRL
                     PAKYVIHTVGPIAYGEPSASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPC
                     EAAAEIVLATLREWLEQHKDKVDRLIICVFLEKDEDIYRSRLPHYFPVA"
     exon            418..519
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            520..636
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            637..666
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            667..783
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            784..905
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            906..936
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1010
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1092
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1127
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1257
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1237..1242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /note="hexamer: AATAAA"
     polyA_site      1257
                     /gene="MACROD1"
                     /gene_synonym="LRP16"
                     /note="major polyA site"
ORIGIN      
        1 gagcaggtcg ccgctggctg gcagtcgcca cccggtccca gagtaaataa gggagagaca
       61 ctcccgagcg ccgtaaatag agtccaagtg ggcggagagc cgtcccgcgc cgcccgctca
      121 tgtctctaca gagccgactg tccggccgcc tggcacagct gcgcgcggcg gggcagctgc
      181 tcgtcccccc gcgcccccgg cccggacact tggcgggtgc cacgaggacc cgcagcagca
      241 cgtgcggtcc cccggcgttc ctgggcgtgt tcggccgccg tgcgcggacc tcggcgggag
      301 ttggggcgtg gggggcggcg gcggtggggc ggacagccgg ggtgcgcact tgggcccccc
      361 tggccatggc ggcgaaggtg gacctgagca cctccaccga ctggaaggag gcgaaatcct
      421 ttctgaaggg cctgagtgac aagcagcggg aggaacatta cttctgcaag gactttgtca
      481 ggctgaagaa gatcccgaca tggaaggaga tggcgaaagg ggtggctgtg aaggtggagg
      541 agcccaggta taaaaaggac aagcagctca atgagaaaat ctccctgctc cgcagcgaca
      601 tcaccaagct ggaggtggac gccatcgtca acgccgccaa cagctccctg ctcggaggcg
      661 gtggcgtgga cggctgcatt catcgggccg ccggccccct gcttaccgac gagtgccgga
      721 ccctgcagag ctgtaagact ggcaaggcca agatcaccgg cggctatcgg ctcccggcca
      781 agtacgtcat ccacacagtg gggcccatcg cctacgggga gcccagcgcc agtcaggctg
      841 ccgagctccg cagctgctac ctgagcagtc tggacctgct gctggagcac cggctccgct
      901 cggtggcgtt cccctgcatc tccaccggcg tgtttggcta cccctgtgag gcggccgccg
      961 agatcgtgct ggccacgctg cgagagtggc tggagcagca caaggacaag gtggaccggc
     1021 tgatcatctg cgtgttcctc gagaaggacg aggacatcta ccggagccgg ctcccccact
     1081 acttccccgt ggcctgaggc tcccgcagcc caccctgacc gggactgacc cgccttcggg
     1141 accccgctcc cagctctgag aggtcgccaa agcctgcagc ctggcctggg cctggccacc
     1201 ccttctttcc ctccgcgccc cgcccccgag gagcctaata aagatctcgt tgtggca
//
