LOCUS       NM_018202               3940 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens macoilin 1 (MACO1), transcript variant 1, mRNA.
ACCESSION   NM_018202 XM_351243
VERSION     NM_018202.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Guo,T., Yin,R.X., Lin,Q.Z., Wu,J., Shen,S.W., Sun,J.Q., Shi,G.Y.,
            Wu,J.Z., Li,H. and Wang,Y.M.
  TITLE     Polymorphism of rs873308 near the transmembrane protein 57 gene is
            associated with serum lipid levels
  JOURNAL   Biosci Rep 34 (2), e00095 (2014)
   PUBMED   27919029
  REMARK    GeneRIF: these results indicate that PAK4 confers CDDP resistance
            via the activation of MEK/ERK and PI3K/Akt pathways. PAK4 and
            PI3K/Akt pathways can reciprocally activate each other.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Kullo,I.J., Ding,K., Shameer,K., McCarty,C.A., Jarvik,G.P.,
            Denny,J.C., Ritchie,M.D., Ye,Z., Crosslin,D.R., Chisholm,R.L.,
            Manolio,T.A. and Chute,C.G.
  TITLE     Complement receptor 1 gene variants are associated with erythrocyte
            sedimentation rate
  JOURNAL   Am J Hum Genet 89 (1), 131-138 (2011)
   PUBMED   21700265
REFERENCE   5  (bases 1 to 3940)
  AUTHORS   Miyara,A., Ohta,A., Okochi,Y., Tsukada,Y., Kuhara,A. and Mori,I.
  TITLE     Novel and conserved protein macoilin is required for diverse
            neuronal functions in Caenorhabditis elegans
  JOURNAL   PLoS Genet 7 (5), e1001384 (2011)
   PUBMED   21589894
REFERENCE   6  (bases 1 to 3940)
  AUTHORS   Arellano-Carbajal,F., Briseno-Roa,L., Couto,A., Cheung,B.H.,
            Labouesse,M. and de Bono,M.
  TITLE     Macoilin, a conserved nervous system-specific ER membrane protein
            that regulates neuronal excitability
  JOURNAL   PLoS Genet 7 (3), e1001341 (2011)
   PUBMED   21437263
REFERENCE   7  (bases 1 to 3940)
  AUTHORS   Kuvbachieva,A., Bestel,A.M., Tissir,F., Maloum,I., Guimiot,F.,
            Ramoz,N., Bourgeois,F., Moalic,J.M., Goffinet,A.M. and Simonneau,M.
  TITLE     Identification of a novel brain-specific and Reelin-regulated gene
            that encodes a protein colocalized with synapsin
  JOURNAL   Eur J Neurosci 20 (3), 603-610 (2004)
   PUBMED   15255972
REFERENCE   8  (bases 1 to 3940)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 3940)
  AUTHORS   Kumada,M., Iwamoto,S., Kamesaki,T., Okuda,H. and Kajii,E.
  TITLE     Entire sequence of a mouse chromosomal segment containing the gene
            Rhced and a comparative analysis of the homologous human sequence
  JOURNAL   Gene 299 (1-2), 165-172 (2002)
   PUBMED   12459264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB455940.1, BC032427.1, BX572623.8 and AA827805.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018202.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY845015.1, SRR1660805.142087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374343.5/ ENSP00000363463.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                DB455940.1         40-132
            94-2463             BC032427.1         1-2370
            2464-3853           BX572623.8         46607-47996
            3854-3940           AA827805.1         28-114              c
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..3940
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="macoilin 1"
                     /db_xref="GeneID:55219"
                     /db_xref="HGNC:HGNC:25572"
                     /db_xref="MIM:610301"
     exon            1..282
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2197
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane protein 57"
                     /codon_start=1
                     /product="macoilin isoform a"
                     /protein_id="NP_060672.2"
                     /db_xref="CCDS:CCDS30638.1"
                     /db_xref="GeneID:55219"
                     /db_xref="HGNC:HGNC:25572"
                     /db_xref="MIM:610301"
                     /translation="MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLA
                     DFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFF
                     AASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIG
                     YPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEA
                     AKGLPDMDSSILIHHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNLGINNNNIL
                     QPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSKNYKNASGVVNSSPR
                     SHSATNGSIPSSSSKNEKKQKCTSKSPSTHKDLMENCIPNNQLSKPDALVRLEQDIKK
                     LKADLQASRQVEQELRSQISSLSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDK
                     QNISQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRN
                     RIRELEAEGKKLTMDMKVKEDQIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQ
                     HLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSI
                     TYSAATSPLSPVSPHYSSKFVETSPSGLDPNASVYQPLKK"
     exon            283..424
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            425..551
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            676..854
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1356
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1515
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1698
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1819
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1994
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..3940
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="hexamer: ATTAAA"
     polyA_site      2463
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="major polyA site"
     regulatory      3916..3921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="hexamer: AATAAA"
     polyA_site      3940
                     /gene="MACO1"
                     /gene_synonym="MACOILIN; TMEM57"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttctt tgtttccgaa ggcggaggag gctccgagcc ccccctcccc gtgctacccc
       61 ctccccccgg gtgctggctc catgtctgtg tgaccggcct caggggtaga gtccaggccc
      121 gacgcggggc gggccagcgg cggcggcagc tgaggtgaga gacggcggcg gcggcgcggg
      181 cacccggccc cccagcggga ggatgaagcg gcggaacgcc gactgcagta agctccgccg
      241 ccccctaaag cggaaccgga tcaccgaggg catttacggc agtacatttt tatacctgaa
      301 attcctggtg gtgtgggcac ttgtcctcct agcagatttt gtcctggagt tcagatttga
      361 atacctgtgg ccattctggc ttttcatcag aagcgtctat gattccttca gataccaggg
      421 actggccttc tcagtatttt ttgtttgtgt agcattcacg tcaaatataa tatgcctgct
      481 gttcatcccc atacagtggc ttttttttgc tgctagcaca tatgtatggg ttcagtacgt
      541 atggcacaca gaaaggggag tgtgtttgcc tacagtgtct ctctggatcc tctttgttta
      601 tattgaagca gccattagat ttaaagatct caaaaacttt catgtagacc tttgtcgtcc
      661 atttgctgct cactgtattg ggtaccctgt ggtaactttg gggtttggct tcaaaagtta
      721 cgtaagctac aaaatgcggt taaggaagca aaaagaagta caaaaagaga acgagtttta
      781 catgcaactt cttcaacaag ctctccctcc agagcaacag atgctacaga agcaagaaaa
      841 agaggccgag gaagcagcca aaggattacc tgatatggat tcttcgatcc ttatacacca
      901 caatggaggt atcccagcca acaaaaaact ctccacaact ttgccagaga tagaataccg
      961 agaaaaaggg aaagaaaagg acaaggatgc caaaaaacac aaccttggaa taaataacaa
     1021 caatattcta caacctgtag actctaaaat acaagagatt gagtatatgg aaaaccatat
     1081 caatagtaaa agattaaata atgatcttgt gggaagtaca gaaaatctct tgaaagagga
     1141 ctcatgcact gcttcctcaa aaaattacaa aaatgccagt ggagttgtga actcttcacc
     1201 tcgaagtcat agcgccacaa atgggagcat tccttcctca tctagtaaaa atgagaagaa
     1261 gcagaaatgc actagcaaga gcccaagtac acacaaggac ttaatggaaa actgtattcc
     1321 taataaccag ctaagcaaac cagacgcact ggtcaggctg gaacaagaca ttaaaaagtt
     1381 aaaggctgac ctgcaagcca gcagacaagt ggaacaagag ctccgcagtc agatcagctc
     1441 cctttcgagc accgagcgag ggatccgctc agaaatgggc cagcttcggc aggagaacga
     1501 gctgctgcag aacaagttac ataatgctgt gcaaatgaag caaaaagaca agcagaatat
     1561 cagccagttg gagaaaaagc taaaagctga gcaggaagcc cgaagttttg tagagaaaca
     1621 gttaatggaa gagaaaaaga ggaagaagtt agaagaagcc actgctgccc gggctgttgc
     1681 gtttgctgct gcatctaggg gagaatgcac cgaaacctta cggaatcgga tcagagaact
     1741 agaagcagag ggcaagaagc tcacgatgga catgaaggtg aaagaagacc aaatcagaga
     1801 actagaacta aaagtccagg agcttcggaa atataaggaa aatgagaagg acactgaggt
     1861 gttaatgtca gccctctcag ccatgcaaga caaaacacag cacctggaga acagcttaag
     1921 tgcagagacg agaatcaagc tggacctgtt ctccgcactg ggcgatgcaa agcggcagct
     1981 cgagattgcc caaggacaaa tccttcagaa agatcaggaa atcaaggacc taaaacagaa
     2041 gatagccgaa gtcatggccg tcatgcccag cataacatac agtgccgcca ccagccccct
     2101 gagccctgtt tccccccact actcttccaa atttgtggag accagcccct ctggacttga
     2161 ccccaatgcc tctgtttacc agcccctgaa gaaatgaagg ccagctgtgt gttgtgccca
     2221 aaaatttggt taccggaagg cattgcaaag gagcgtctct ggcagtcaag ataaaaaaac
     2281 agtttctatt gtattttgtg gaactgtatc tgttgtcatt tttaaaaagg ggggaaaaga
     2341 taacatccaa gtctgattag aactgcccat cagtttttct tgtaaatttt tagaagacct
     2401 cacagaactt tacagtttat ttttctcggc caacacatta aaaccattct tggatttcaa
     2461 gtagccaact ttgcctttta tgtattctta catagtttcc tcttgaagaa aaaaaaagca
     2521 gagtttttgt ttttcaaccc tttatgtttg ttttgtttta ttcttaaata agcaagcaaa
     2581 acctgcacat tggattcacg tgagatgata atgaaaactt ttagtttaag agtgaagggt
     2641 taagtaacct aacagagctt tgatgttata gctgcattaa agaaggtgat tgtcaatatt
     2701 acagaaaaca aaaatggatt gcccctccaa ggaccaaaca gattcaagga gcatcattta
     2761 agctaagaag agacctaagt gatgaaacta gctgtaagaa tgtaacaggg gttgtgtttg
     2821 aaatatttat attcccatcg gtgtgtttag tcctagaaaa ttgctagcag cagtcttctt
     2881 cacagtgcct tgggaaaaga catttcaaga ggaaacttga taattttaaa ctcttttccc
     2941 cctttaccgt catctatcct ctatctgtat caagctcact gcggatcctg ctgtaaaact
     3001 ggtgggtagc tgggctgtcc gttaccacca cagctacatc ttctgtttct ttgaatagaa
     3061 agcaccacag tgttttgcac ttgcctccag taaagtgccc tgggaaggga gctgggcagt
     3121 gtttgtggac gagagactgt aacgatggct aataaaagct gcgggtctag gttttttttt
     3181 ttttgttttg ttttttcatt tcatttaact gtgctttctc cacttttcat cattttgtgt
     3241 ttgatgattt aaaagaagct tgactattcc tcagctcttg tgccaaggag ggtttttttt
     3301 ttttaagact cttaaactca aaactctgca caaagatttc agtttcaaat gtgtattata
     3361 catgggtaga aaagtgtttg cacaggcaac ttttggaagt gtttaagaat cagggtgggg
     3421 gtggcgggag ggaccgggtg ggggcaatgc aaaattgtat ttggaaacta ggaaaaatta
     3481 agaaaccaaa taaattggtt ttgcttcctt gccatggatt ctggaaggac atagttcttc
     3541 taaaatttcc tgttaattgg catgtacgtc tcatttaaag caaattaagt aggacaagca
     3601 agtcagtaaa atagaagtat taaaaagaat catcctttaa atcacagatc ttattttgag
     3661 attaaaaaaa atacttctag ctttagccag gtgtgcatgt tgctgccatt ttgcattttt
     3721 gaatcatctt gtgtaattgt caccatgaaa gtgttactca gaattgtcat agattttctc
     3781 ttctttgtgc aaaaacatgg aaaattgtca ctgactttgt tttgaggttt cccccatttt
     3841 gctgcctttt gggacacttc gttaaatact ggtcttggct gcattctttt ttttttttcc
     3901 tgtggggttc aaaagaataa acattttctt acagataaaa
//
