LOCUS       NM_033211               2988 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens macrophage immunometabolism regulator (MACIR),
            transcript variant 2, mRNA.
ACCESSION   NM_033211
VERSION     NM_033211.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Dorris,E.R., Linehan,E., Trenkmann,M., Veale,D.J., Fearon,U. and
            Wilson,A.G.
  TITLE     Association of the Rheumatoid Arthritis Severity Variant rs26232
            with the Invasive Activity of Synovial Fibroblasts
  JOURNAL   Cells 8 (10), 1300 (2019)
   PUBMED   31652652
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2988)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   7  (bases 1 to 2988)
  AUTHORS   Teare,M.D., Knevel,R., Morgan,M.D., Kleszcz,A., Emery,P.,
            Moore,D.J., Conaghan,P., Huizinga,T.W., Morgan,A.W., van der
            Helm-van Mil,A.H. and Wilson,A.G.
  TITLE     Allele-dose association of the C5orf30 rs26232 variant with joint
            damage in rheumatoid arthritis
  JOURNAL   Arthritis Rheum 65 (10), 2555-2561 (2013)
   PUBMED   23817893
  REMARK    GeneRIF: The variant rs26232, in the first intron of the C5orf30
            locus, is associated with the severity of radiologic damage in
            rheumatoid arthritis and is independent of established prognostic
            biomarkers.
REFERENCE   8  (bases 1 to 2988)
  AUTHORS   Viatte,S., Plant,D., Bowes,J., Lunt,M., Eyre,S., Barton,A. and
            Worthington,J.
  TITLE     Genetic markers of rheumatoid arthritis susceptibility in
            anti-citrullinated peptide antibody negative patients
  JOURNAL   Ann Rheum Dis 71 (12), 1984-1990 (2012)
   PUBMED   22661644
REFERENCE   9  (bases 1 to 2988)
  AUTHORS   Wright,K.J., Baye,L.M., Olivier-Mason,A., Mukhopadhyay,S., Sang,L.,
            Kwong,M., Wang,W., Pretorius,P.R., Sheffield,V.C., Sengupta,P.,
            Slusarski,D.C. and Jackson,P.K.
  TITLE     An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the
            primary cilium
  JOURNAL   Genes Dev 25 (22), 2347-2360 (2011)
   PUBMED   22085962
REFERENCE   10 (bases 1 to 2988)
  AUTHORS   Stahl,E.A., Raychaudhuri,S., Remmers,E.F., Xie,G., Eyre,S.,
            Thomson,B.P., Li,Y., Kurreeman,F.A., Zhernakova,A., Hinks,A.,
            Guiducci,C., Chen,R., Alfredsson,L., Amos,C.I., Ardlie,K.G.,
            Barton,A., Bowes,J., Brouwer,E., Burtt,N.P., Catanese,J.J.,
            Coblyn,J., Coenen,M.J., Costenbader,K.H., Criswell,L.A.,
            Crusius,J.B., Cui,J., de Bakker,P.I., De Jager,P.L., Ding,B.,
            Emery,P., Flynn,E., Harrison,P., Hocking,L.J., Huizinga,T.W.,
            Kastner,D.L., Ke,X., Lee,A.T., Liu,X., Martin,P., Morgan,A.W.,
            Padyukov,L., Posthumus,M.D., Radstake,T.R., Reid,D.M.,
            Seielstad,M., Seldin,M.F., Shadick,N.A., Steer,S., Tak,P.P.,
            Thomson,W., van der Helm-van Mil,A.H., van der Horst-Bruinsma,I.E.,
            van der Schoot,C.E., van Riel,P.L., Weinblatt,M.E., Wilson,A.G.,
            Wolbink,G.J., Wordsworth,B.P., Wijmenga,C., Karlson,E.W.,
            Toes,R.E., de Vries,N., Begovich,A.B., Worthington,J.,
            Siminovitch,K.A., Gregersen,P.K., Klareskog,L. and Plenge,R.M.
  CONSRTM   BIRAC Consortium; YEAR Consortium
  TITLE     Genome-wide association study meta-analysis identifies seven new
            rheumatoid arthritis risk loci
  JOURNAL   Nat Genet 42 (6), 508-514 (2010)
   PUBMED   20453842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009203.2.
            
            On Nov 22, 2018 this sequence version replaced NM_033211.3.
            
            Summary: This gene, MACIR (previously known as C5orf30), has been
            associated with rheumatoid arthritis, functioning as a negative
            regulator of tissue damage and modulating the activity of synovial
            fibroblasts and macrophages. The encoded protein is highly
            conserved in vertebrate genomes but has no significant similarity
            to any other human protein. [provided by RefSeq, Dec 2019].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All nine variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009203.2, AK058020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319933.7/ ENSP00000326110.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2988              BC009203.2         23-3010
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..2988
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /note="macrophage immunometabolism regulator"
                     /db_xref="GeneID:90355"
                     /db_xref="HGNC:HGNC:25052"
                     /db_xref="MIM:616608"
     exon            1..134
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /inference="alignment:Splign:2.1.0"
     exon            135..224
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /inference="alignment:Splign:2.1.0"
     exon            225..2988
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..868
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /note="UPF0684 protein C5orf30; UNC119-binding protein
                     C5orf30"
                     /codon_start=1
                     /product="macrophage immunometabolism regulator"
                     /protein_id="NP_149988.1"
                     /db_xref="CCDS:CCDS4095.1"
                     /db_xref="GeneID:90355"
                     /db_xref="HGNC:HGNC:25052"
                     /db_xref="MIM:616608"
                     /translation="MEVDINGESRSTLTTLPFPGAEANSPGKAEAEKPRCSSTPCSPM
                     RRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKAEAMPSLRSKQLDAGLAR
                     SSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKG
                     KRAHSKSLDYLNLDKMIKEPADTEVLQYQLQHLTLRGDRVFARNNT"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /note="hexamer: AATAAA"
     polyA_site      2700
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /note="major polyA site"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
                     /note="hexamer: AATAAA"
     polyA_site      2988
                     /gene="MACIR"
                     /gene_synonym="C5orf30"
ORIGIN      
        1 aggagagggt acccggctgg ctcggctggc ggcctctgcc tggatctcgg cgccgcagtc
       61 ctgcgcctct cccgcccctg tctcccgctc cgcagccccg ggcacggcgg aggcagcgga
      121 gccctgggcc atcgtacctg gagtagaaca gaaaaattat tatgtctgtg ttcccttggg
      181 actcattgga aattgtacag tgacatcttc tgggatttag tctggattgt gcagactggt
      241 gcttaaaatg gaagtcgata ttaatggaga gtctagaagt accctgacca ccttgccctt
      301 ccctggggct gaggccaact ccccgggaaa ggcggaggca gagaagcccc gctgctccag
      361 cacaccctgc tccccgatgc ggaggaccgt gtcaggctac cagatcctac acatggactc
      421 taactatttg gttggcttca cgactggcga ggaactcctg aagttagctc agaagtgcac
      481 aggaggtgaa gagagcaaag cagaagccat gccatcctta cgctccaaac agctagatgc
      541 aggacttgcc cgttcctctc gtttgtataa aaccagaagt aggtactacc agccatacga
      601 gattccagct gtcaatggca ggaggcgaag gcggatgcca agctcaggag acaagtgcac
      661 taaatcttta ccttatgaac cttacaaggc cctccatggg cctctgcctc tttgtcttct
      721 taaaggtaag agggctcact ccaaatctct ggactacctc aatctagata aaatgatcaa
      781 ggagccagct gatacagaag tgctacagta ccagcttcaa cacctaaccc tccgagggga
      841 ccgtgtgttt gctaggaata atacatgaat gacttggaga gagcttaaac caatttaggt
      901 cagcctacgc ttggctagaa aaaacccact gctgtactct gtacatgact cttcacacta
      961 tagatggtta tatcagctaa gtgttcctgg aacataaaaa ttgtttgggt caaatttgaa
     1021 tacaggaatg aaatcacagg tacttggggg ggggatatca ttctagagca cgcaactgca
     1081 aagaaaacag aatgttgact gttagtttgt atagcttttt agctaggaaa aaaaggcttt
     1141 ggtacagtaa tttcatcttt atgattctga cactcaaatt gggaatgtta cctgcttggt
     1201 tgttgctgac ttgatatgat tcattagaaa tttatatctt cagtactcaa gtacttcttg
     1261 aatctctgta ttttactata aaatgtatgt aatgatttgt tttatgaaat ttagaacttg
     1321 aacattgctg aattggacca ctttttattt ttaaatattg agtttaaata ttttataact
     1381 ggttttgcac tgaaaaaatt aacatttcag attgacaaga gagtaatctt tcttcacttg
     1441 cctcaataat gttattgagc aatgaatttt ttatttccgc atggaaagtt attgatctct
     1501 atggctgtaa aatatttctt tatagcgtta ttaaagtgtg tcttaataaa attaaatttg
     1561 ggatacaaag tatttatttt acaatgggtg ggcgggggaa acttttccag aaagtttcca
     1621 atatgacgtt ttcataagtt gaaaaaactc tccttagtgc ttattttcta acttaaaatt
     1681 cacctggaac tttaaatggg aaaggattct tttaattgtg gattataggc ataatactgt
     1741 ttgcatctga attttctgta agtgaataat agtttaatag aggaactcat gatttgtact
     1801 attgaatgat taaactaagt atgaagtgat accattcagc atggcatcag gtcattgcag
     1861 ttttagttct gtgtaacaca agcactcact gaaattccag tttctaggat tagtgtagga
     1921 gcctaacgtg cttctactgt tttaatgggt taatcctgga ttacttaaca atttatgtca
     1981 attgcactgg tttaatttgt tgctaaagaa ataatgccct gggtttagta acaaatacag
     2041 ctcaactatt cttgaatata ttttgaaaaa aaaatgtatg taacttacct tttgtaaacg
     2101 ttccatttct tttttccctc atttttgact cttaaaggtg caatttatta ctgaattggg
     2161 atttctggca gcacagaact gctttttatt ttggggtctg tgagtttctt aggtattagc
     2221 aatcttgctt ataaaataag aacacctttt aattaatgag tgggtcattc ctggtgcaat
     2281 tgtgattttt ctttagccag aatgaatggc aaactctatt tagagcaaag taagtattag
     2341 aaaaccctag gaactcttaa tcaacgttta ttacactttc attaaggcaa actacgtgaa
     2401 agagccttgg ggaagttggc ccatatctta ctaagttgat cagatttctc gttgggctgg
     2461 aaatgtttcg ctgttgtata ttttaaagta aattgcacct ttgtaacata ttgtattgac
     2521 gaatgatcac taagattagc tatatctata cagtcattag tttgacaaga aatagaatcc
     2581 tgtcagatgc caaagagtgg gatttttatg tttaatgatt aaacaccatt atttattgac
     2641 aatttaccct gtggaactgt attatttcta actatgaaat aaaggggtga tgtaaacaca
     2701 cattgttgtg tggtgcttta aactaggtcc actatcaaca ggctacttac tgttcaagaa
     2761 ttccactgaa gcacttattt taaggcccta tttttcttaa acaaaacagt gacaacaaca
     2821 atcaaaccat ttacttttga tgctcattgg cattttatga taaaagatgt attcatggca
     2881 atgatatgta ttcaccctat taggaaacac aactggttac ctatgagacc tgttctgtcc
     2941 gtgtgcctac gttccttaat aatagctaaa taaaaatttg tagctttt
//
